Aerosolized amiloride: dose effect on nasal bioelectric properties, pharmacokinetics, and effect on sputum expectoration in patients with cystic fibrosis.

Author: BittnerP, HofmannT, HülsG, LindemannH, SchwandtH J, SenierI

Paper Details 
Original Abstract of the Article :
Aerosolized amiloride normalizes the excessive sodium absorption cystic fibrosis (CF) respiratory epithelium. The aims of this study were to assess the dose-effect relationship and the duration for which amiloride inhibits Na+ transport, to determine acute and chronic pharmacokinetics, and to test t...See full text at original site
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引用元:
https://doi.org/10.1089/jam.1997.10.147

データ提供:米国国立医学図書館(NLM)

Aerosolized Amiloride: A Breath of Fresh Air for Cystic Fibrosis

Cystic fibrosis (CF) is a genetic disorder that affects the lungs and other organs. It's like a persistent desert sandstorm, causing chronic inflammation and airway obstruction. This study investigates the effectiveness of aerosolized amiloride in treating CF.

The researchers explored the dose-effect relationship of aerosolized amiloride, its pharmacokinetics (how the body absorbs and eliminates the drug), and its impact on sputum expectoration (coughing up mucus). The study found that aerosolized amiloride effectively inhibited sodium transport in the respiratory epithelium, leading to increased sputum expectoration.

Aerosolized Amiloride: A Potential Breakthrough for CF Treatment

This research suggests that aerosolized amiloride could be a valuable tool for managing CF symptoms. By reducing sodium transport and promoting mucus clearance, amiloride may help to improve lung function and reduce exacerbations.

Living with CF: Finding Relief in the Sandstorm

CF can be a challenging condition, but advancements in treatment and management strategies have significantly improved the lives of patients. It's essential to work closely with your doctor to develop a personalized treatment plan that addresses your specific needs and symptoms.

Dr. Camel's Conclusion

Aerosolized amiloride, like a refreshing oasis in the desert of CF, offers a new hope for improved lung function and better management of symptoms.

Date :
  1. Date Completed 1997-08-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10168532

DOI: Digital Object Identifier

10.1089/jam.1997.10.147

Related Literature

SNS
PICO Info
in preparation
Languages

English

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