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Aerosolized amiloride: dose effect on nasal bioelectric properties, pharmacokinetics, and effect on sputum expectoration in patients with cystic fibrosis.
Author: BittnerP, HofmannT, HülsG, LindemannH, SchwandtH J, SenierI
Original Abstract of the Article :
Aerosolized amiloride normalizes the excessive sodium absorption cystic fibrosis (CF) respiratory epithelium. The aims of this study were to assess the dose-effect relationship and the duration for which amiloride inhibits Na+ transport, to determine acute and chronic pharmacokinetics, and to test t...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1089/jam.1997.10.147
データ提供:米国国立医学図書館(NLM)
Aerosolized Amiloride: A Breath of Fresh Air for Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disorder that affects the lungs and other organs. It's like a persistent desert sandstorm, causing chronic inflammation and airway obstruction. This study investigates the effectiveness of aerosolized amiloride in treating CF.
The researchers explored the dose-effect relationship of aerosolized amiloride, its pharmacokinetics (how the body absorbs and eliminates the drug), and its impact on sputum expectoration (coughing up mucus). The study found that aerosolized amiloride effectively inhibited sodium transport in the respiratory epithelium, leading to increased sputum expectoration.
Aerosolized Amiloride: A Potential Breakthrough for CF Treatment
This research suggests that aerosolized amiloride could be a valuable tool for managing CF symptoms. By reducing sodium transport and promoting mucus clearance, amiloride may help to improve lung function and reduce exacerbations.
Living with CF: Finding Relief in the Sandstorm
CF can be a challenging condition, but advancements in treatment and management strategies have significantly improved the lives of patients. It's essential to work closely with your doctor to develop a personalized treatment plan that addresses your specific needs and symptoms.
Dr. Camel's Conclusion
Aerosolized amiloride, like a refreshing oasis in the desert of CF, offers a new hope for improved lung function and better management of symptoms.
Date :
- Date Completed 1997-08-15
- Date Revised 2013-11-21
Further Info :
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