Paper Details

  1. Home
  2. Paper Details

Topical ofloxacin versus systemic amoxicillin/clavulanate in purulent otorrhea in children with tympanostomy tubes.

Author: DoharJ, GoldbergT, GoldblattE L, NielsenR W, NozzaR J, SeidlinM, SidmanJ D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topical ofloxacin 0.3% otic solution was as effective and better tolerated than systemic therapy with Augmentin oral suspension in treating AOM in children with tympanostomy tubes. OFLX had a greater overall pathogen eradication rate than AUG (96% vs. 67%).
Paper Details　
Original Abstract of the Article :
Acute otitis media (AOM) in children with tympanostomy tubes in place typically presents with otorrhea (draining ear). Because therapy is not standardized, various topical and systemic antibiotics of unproven efficacy and safety have been used in this indication. This study compared the safety and e...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0165-5876(98)00150-5

データ提供：米国国立医学図書館（NLM）

Otitis Media in Children: Finding the Right Route to Recovery

Acute otitis media (AOM) is a common ailment in children, often presenting as ear drainage, or otorrhea, when tympanostomy tubes are in place. This study investigates the effectiveness and safety of different treatment options for AOM in children with tympanostomy tubes.

The researchers compared two common treatments: topical ofloxacin otic solution (OFLX) and systemic amoxicillin/clavulanate (AUG). The participants, 1-12 year old children with tympanostomy tubes and acute purulent otorrhea, were randomly assigned to receive either OFLX or AUG for 10 days. They assessed the cure rates, pathogen eradication rates, and adverse events, along with the impact of the treatment on hearing acuity.

The study demonstrated comparable overall cure rates for OFLX and AUG. However, OFLX showed superior pathogen eradication rates for Staphylococcus aureus and Pseudomonas aeruginosa. Interestingly, OFLX was also better tolerated than AUG, with a significantly lower rate of treatment-related adverse events.

Topical Treatment: A More Comfortable Ride

The results of this study suggest that topical ofloxacin may be an effective and well-tolerated alternative to systemic amoxicillin/clavulanate for treating AOM in children with tympanostomy tubes. It's like a camel caravan choosing a smoother, less bumpy path through the desert, avoiding unnecessary discomfort and potential hazards.

Navigating Ear Infections: Seeking Expert Guidance

This study emphasizes the importance of seeking professional medical guidance for ear infections in children. It's crucial to consult a healthcare professional to determine the most appropriate treatment option for each individual child, ensuring a comfortable and safe journey to recovery.

Dr.Camel's Conclusion

This study provides valuable insights into the treatment of AOM in children with tympanostomy tubes, suggesting that topical ofloxacin may be a more effective and well-tolerated alternative to systemic antibiotics. This research reinforces the importance of personalized treatment approaches, ensuring a smoother and more comfortable journey for children navigating the challenges of ear infections.

Date :
  1. Date Completed 1999-05-17
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

10190709

DOI: Digital Object Identifier

10.1016/s0165-5876(98)00150-5

Related Literature

Article Analysis
・Effects of ofloxacin otic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.