Paper Details

  1. Home
  2. Paper Details

Adverse effects and sero-responses to an acellular pertussis/diphtheria/tetanus vaccine when combined with Haemophilus influenzae type b vaccine in an accelerated schedule.

Author: BellF, DiggleL, FinnA, GriffithsH, HeathP, MacLennanJ, MoxonE R, ShackleyF, ShearstoneN, ThorntonC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Acellular pertussis vaccines provide protection against pertussis with fewer adverse effects than whole-cell vaccines. This study assessed the immunogenicity and reactogenicity of an acellular pertussis, diphtheria, tetanus vaccine mixed with Haemophilus influenzae type b (Hib) vaccine (PRP-T) in infants. Results showed that the acellular combination was less reactogenic, with lower antibody responses to diphtheria and tetanus toxoids but higher and more uniform responses to pertussis antigens.
Paper Details　
Original Abstract of the Article :
Acellular pertussis vaccines provide protection against pertussis with few adverse effects. Differences in the reactogenicity and immunogenicity of available pertussis vaccines may be influenced by the immunisation schedule employed. We assessed responses to an acellular pertussis, diphtheria, tetan...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s004310051083

データ提供：米国国立医学図書館（NLM）

Acellular Pertussis Vaccine: A Safe and Effective Oasis in the Desert of Childhood Immunization

The field of [vaccination] has witnessed a remarkable evolution, with the advent of acellular pertussis vaccines offering a safer and more effective alternative to traditional whole-cell vaccines. This research investigates the safety and immunogenicity of an acellular pertussis, diphtheria, tetanus vaccine, combined with Haemophilus influenzae type b (Hib) vaccine, when administered in an accelerated schedule. The study found that the acellular combination resulted in fewer systemic and local reactions compared to historical controls who received a whole-cell combination. Furthermore, the acellular vaccine elicited higher and more uniform antibody responses to pertussis antigens, suggesting a more robust and potentially more effective immune response.

Acellular Pertussis Vaccine: A Promising Path to Herd Immunity

The study's findings reinforce the safety and efficacy of acellular pertussis vaccines, highlighting their potential to reduce adverse reactions and enhance immune protection against pertussis. These findings support the use of acellular pertussis vaccines as a crucial tool in achieving herd immunity and protecting vulnerable populations.

Navigating the Path to a Healthier Future

This study underscores the importance of ongoing research and development in vaccination, with the aim of creating safer and more effective vaccines for children. The findings highlight the value of acellular pertussis vaccines in protecting children and contributing to a healthier future for all. Just as a camel navigates the desert with resilience and adaptability, we must continue striving to develop and implement the most effective and safe vaccination strategies.

Dr. Camel's Conclusion

This study reinforces the safety and efficacy of acellular pertussis vaccines, highlighting their potential to minimize adverse reactions and enhance immune protection against pertussis. These findings provide valuable insights for clinicians and public health officials, supporting the use of acellular pertussis vaccines as a crucial tool in achieving herd immunity and safeguarding vulnerable populations.

Date :
  1. Date Completed 1999-05-25
  2. Date Revised 2019-08-14
Further Info :

Pubmed ID

10206134

DOI: Digital Object Identifier

10.1007/s004310051083

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.