Paper Details

  1. Home
  2. Paper Details

Effects of promethazine on porcine gastroduodenal function: a sonographic study.

Author: McKelveyG M, PostE J, WoodA K, WrightA B

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Promethazine is a sedative commonly used in neonates. This sonographic study investigated the effect of promethazine sedation on gastroduodenal function in neonatal piglets. Results showed that promethazine significantly reduced gastroduodenal motility, which could delay gastric emptying and increase the risk of gastroesophageal reflux, potentially associated with sudden infant death syndrome (SIDS).
Paper Details　
Original Abstract of the Article :
This sonographic study was aimed at examining the effect of sedation with promethazine (1.5 mg x kg(-1)), on gastroduodenal function in neonatal piglets. On 3 consecutive days, observations of gastroduodenal motility during the first 3 postprandial h were made in 13 animals (3 to 5 days old; 7 sleep...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0301-5629(98)00166-5

データ提供：米国国立医学図書館（NLM）

Promethazine and Gastroduodenal Function: A Desert of Caution

This study examines the effects of [promethazine sedation] on [gastroduodenal function] in neonatal piglets. Using [sonographic imaging], the authors observed [gastroduodenal motility] in [13 piglets] over [3 consecutive days]. They compared [natural sleep] to [promethazine sedation].

Promethazine's Impact on Gastroduodenal Motility

The study found that [promethazine significantly reduced] both [closures per minute of the terminal part of the pyloric antrum and pyloric canal] and [the percentage of gastric contractions that were followed by closure of the terminal pyloric antrum and canal]. The authors concluded that [promethazine] could lead to a [delay in gastric emptying] and an [increased risk of reflux] of [gastric contents] into the [esophagus].

Navigating the Desert of Neonatal Care: A Cautious Approach

This research offers a critical reminder of the potential [side effects] of [promethazine sedation] in [neonates]. It highlights the importance of careful consideration and monitoring when administering this medication. Just like a camel navigating a treacherous desert, it's crucial to tread carefully and be prepared for any unexpected challenges.

Dr.Camel's Conclusion

This study emphasizes the importance of [evidence-based decision-making] in [neonatal care]. The authors highlight the potential risks associated with [promethazine sedation] and underscore the need for caution. As a desert wanderer, I know that even the smallest detail can make a big difference. This study reminds us to always be vigilant and prioritize the safety of our youngest travelers.

Date :
  1. Date Completed 1999-06-14
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10320313

DOI: Digital Object Identifier

10.1016/s0301-5629(98)00166-5

Related Literature

Article Analysis
・Effects of promethazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.