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Systemic bioavailability of ocularly applied 1% atropine eyedrops.

Author: KailaT, KorteJ M, SaariK M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that the bioavailability of 1-hyoscyamine, the active enantiomer of atropine, was considerable after ocular administration, which may explain the systemic anticholinergic side effects reported with atropine eyedrops.
Paper Details　
Original Abstract of the Article :
PURPOSE: To investigate the pharmacological basis of systemic effects of atropine eyedrops, we estimated the bioavailability of ophthalmic 1% atropine solution in healthy volunteers. METHODS: In a randomized crossover study we administered 0.3 mg atropine either intravenously or ocularly to six hea...See full text at original site
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引用元：
https://doi.org/10.1034/j.1600-0420.1999.770215.x

データ提供：米国国立医学図書館（NLM）

The Systemic Reach of Ocular Atropine

Atropine, a widely used medication for eye conditions, has been traditionally considered to have primarily local effects. However, this research challenges that assumption by investigating the systemic bioavailability of ocularly applied 1% atropine eyedrops. The study aimed to quantify the absorption of atropine into the bloodstream after ocular administration and determine its potential for causing systemic side effects. Researchers found that a significant proportion of atropine applied to the eyes can be absorbed into the bloodstream, leading to systemic effects.

Systemic Bioavailability of Ocular Atropine

The study's findings demonstrate that ocularly applied atropine can have significant systemic bioavailability, reaching levels comparable to intravenous administration. This challenges the traditional view that atropine is a purely local drug. It's like discovering that a seemingly isolated oasis in a desert is actually connected to a vast underground network of water sources. This knowledge is crucial for understanding the potential side effects of ocular atropine and for guiding treatment strategies.

Implications for Ocular Atropine Use

The study's findings have implications for the safe and effective use of ocular atropine. Healthcare professionals should be aware of the potential for systemic side effects, particularly in patients with pre-existing conditions that could be exacerbated by atropine's anticholinergic effects. It's like navigating a desert landscape with a clear understanding of the potential dangers and challenges that lie ahead.

Dr. Camel's Conclusion

This study provides a valuable reminder that even medications intended for local use can have systemic effects. Understanding the systemic bioavailability of ocular atropine is essential for ensuring patient safety and optimizing treatment outcomes. It's like uncovering a hidden truth in a desert, shedding light on the complex nature of drug absorption and distribution.

Date :
  1. Date Completed 1999-06-07
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

10321537

DOI: Digital Object Identifier

10.1034/j.1600-0420.1999.770215.x

Related Literature

Article Analysis
・Side Effects of hyoscyamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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