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Cognitive abilities and adjustment with gabapentin: results of a multisite study.

Author: ArnettJ L, DodrillC B, GarofaloE A, GreeleyC A, GreinerM J, HayesA G, PierceM W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Gabapentin was found to be well tolerated and associated with improvements in emotional and interpersonal adjustment in patients with uncontrolled complex partial seizures. Gabapentin did not show any significant cognitive effects compared to placebo.
Paper Details　
Original Abstract of the Article :
The cognitive and quality of life effects of gabapentin are not yet well explored. While preliminary work in the area has provided positive findings, a large double-blinded study has been needed to explore this area more thoroughly. From 24 sites in North America, 201 adults were studied who had unc...See full text at original site
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引用元：
https://doi.org/10.1016/s0920-1211(99)00006-6

データ提供：米国国立医学図書館（NLM）

Gabapentin's Impact on Cognition and Adjustment: A Journey Through Epilepsy Treatment

Epilepsy, a condition that disrupts the delicate balance of brain activity, can significantly impact a patient's quality of life. This multisite study, published in the journal *[Journal Name]*, investigates the effects of gabapentin, a medication commonly used to treat epilepsy, on cognitive abilities and adjustment in patients with complex partial seizures. The study, conducted at 24 sites across North America, involved 201 adults who were transitioned from other antiepileptic drugs to gabapentin monotherapy. The study employed a double-blinded design, comparing the effects of different doses of gabapentin to a placebo group.

Gabapentin's Impact on Cognition and Adjustment

The study revealed that gabapentin did not have a significant impact on cognitive functioning, providing reassurance for patients concerned about the potential cognitive side effects of this medication. However, the study did uncover significant improvements in emotional and interpersonal adjustment among patients taking gabapentin, suggesting potential benefits beyond seizure control.

Navigating the Epilepsy Treatment Landscape

This study provides valuable insights into the effects of gabapentin on cognition and adjustment in patients with epilepsy. It highlights the importance of considering both seizure control and quality of life when selecting treatment options. The study's findings also underscore the need for further research to understand the long-term impact of gabapentin on cognitive function and overall well-being.

Dr. Camel's Conclusion

Like a caravan navigating a challenging desert terrain, patients with epilepsy often face a journey with unpredictable twists and turns. This study sheds light on the effects of gabapentin, providing valuable insights into its impact on cognitive function and emotional well-being. The findings highlight the importance of a holistic approach to epilepsy care, considering both seizure control and the patient's overall quality of life.

Date :
  1. Date Completed 1999-12-23
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

10372564

DOI: Digital Object Identifier

10.1016/s0920-1211(99)00006-6

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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