Effects of glucagon nasal powder: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Main Research Findings

Gabapentin, an anti-epileptic drug, has been shown to have a positive impact on mood and adjustment in patients with various conditions. 7 found that gabapentin, when used as monotherapy for complex partial seizures, did not negatively affect cognitive function compared to a placebo group. 3 highlights gabapentin's effectiveness as an add-on therapy for patients with refractory partial seizures, showcasing its good tolerance and lack of significant side effects. Moreover, 11 suggests that gabapentin can improve mood in patients experiencing alcohol withdrawal, particularly those with co-morbid mild depression. This research indicates that gabapentin might be a safe and effective treatment option for a range of conditions.

Benefits and Risks

Benefits Summary

Gabapentin has shown potential benefits in improving mood, particularly for patients with alcohol withdrawal, especially those with co-morbid mild depression. 11 It has also demonstrated effectiveness in treating partial seizures with a good tolerance profile. 3 Furthermore, gabapentin appears to have a minimal impact on cognitive functions. 7

Risks Summary

While gabapentin seems relatively safe, the research on its potential risks is still limited. More extensive studies are needed to fully understand its long-term effects.

Comparison Across Studies

Commonalities Across Studies

All of these studies aim to evaluate the safety and efficacy of gabapentin for different medical conditions. They consistently suggest that gabapentin could be a promising therapeutic option for a range of disorders.

Differences Across Studies

The studies differ in their research designs, target conditions, dosage of gabapentin used, and patient populations. This makes direct comparisons challenging, emphasizing the need for further research to understand the full scope of gabapentin's effects.

Consistency and Contradictions in Findings

While the studies indicate the potential benefits of gabapentin, there is some variability in the results. Factors such as dosage, patient characteristics, and specific conditions being treated could influence the outcomes. More research is needed to clarify these differences and provide a more comprehensive understanding.

Considerations for Real-World Applications

Given its potential benefits, gabapentin could be a valuable treatment option for patients with certain conditions. However, it is crucial to consult with a healthcare professional before using gabapentin, as they can determine the appropriate dosage and assess any potential risks or interactions with other medications.

Limitations of Current Research

The studies discussed have certain limitations, including the size of the study populations, the differences in research designs, and the limited exploration of all potential side effects. More extensive and controlled research is necessary to address these limitations and provide a more comprehensive understanding of gabapentin's effects.

Future Research Directions

Future research should focus on larger sample sizes, standardized research designs, and investigations across a wider range of dosages and conditions. Long-term studies are also essential to evaluate the long-term effects and potential side effects of gabapentin.

Conclusion

The research suggests that gabapentin holds promise as a treatment option for conditions such as partial seizures, alcohol withdrawal, and mood disorders. However, it is essential to consult with a healthcare professional before using gabapentin. More research is needed to fully understand its potential benefits, risks, and optimize its application in clinical settings.

Literature analysis of 13 papers
Positive Content
12
Neutral Content
0
Negative Content
1
Article Type
10
3
3
3
13
1.

Evaluation of encephalotropic and psychotropic properties of gabapentin in man by pharmaco-EEG and psychometry.

Author: SaletuB, GrünbergerJ, LinzmayerL

Good tolerability
Improved concentration
Improved memory

Gabapentin, a new GABA analogue, showed moderate CNS-inhibitory effects in doses of 200-400 mg. It also demonstrated subtle psychotropic effects, characterized by improvements in concentration and memory.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Efficacy and tolerance of long-term, high-dose gabapentin: additional observations.

Author: HandforthA, TreimanD M

Treat partial-onset seizures
Similar side effects to other AEDs

This study evaluated the long-term efficacy and tolerability of gabapentin in treating intractable partial-onset seizures. Gabapentin was effective in controlling seizures and well tolerated, suggesting its potential benefit in managing epilepsy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Gabapentin (Neurontin): a new possibility in the add-on therapy of partial epilepsies].

Author: KrämerG

Antiepileptic effect
Abortion

Gabapentin, a new antiepileptic drug, is effective in treating refractory partial seizures in patients over 12 years old. It has favorable pharmacokinetic data with no major drug interactions. Three placebo-controlled trials showed efficacy in reducing seizures. Tolerance is good with no serious side effects reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

4.

Effect of gabapentin (Neurontin) [corrected] on mood and well-being in patients with epilepsy.

Author: DimondK R, PandeA C, LamoreauxL, PierceM W

Improved mood

This review of five clinical trials found that gabapentin, used as add-on therapy in patients with epilepsy, was associated with improvements in general well-being. These findings suggest that further study of gabapentin in psychiatric populations may be warranted.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Gabapentin and carbamazepine affect eye movements and posture control differently: a placebo-controlled investigation of acute CNS side effects in healthy volunteers.

Author: NoachtarS, von MaydellB, FuhryL, BüttnerU

Antiepileptic
Eye movement effects
Posture control effects

This study compared the effects of gabapentin (GBP), carbamazepine (CBZ), and placebo (PLA) on eye movements, posture, and finger force control in healthy volunteers. Both GBP and CBZ reduced saccade velocity, but CBZ significantly prolonged saccade duration. GBP increased body sway more than CBZ.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults.

Author: MartinR, KuznieckyR, HoS, HetheringtonH, PanJ, SinclairK, GilliamF, FaughtE

Tolerable AEDs
Cognitive effects

Topiramate had significant adverse cognitive effects in healthy adults, while gabapentin and lamotrigine had minimal effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Cognitive abilities and adjustment with gabapentin: results of a multisite study.

Author: DodrillC B, ArnettJ L, HayesA G, GarofaloE A, GreeleyC A, GreinerM J, PierceM W

Interpersonal adjustment
Mood improvement

Gabapentin was found to be well tolerated and associated with improvements in emotional and interpersonal adjustment in patients with uncontrolled complex partial seizures. Gabapentin did not show any significant cognitive effects compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Gabapentin for neuropathic pain: systematic review of controlled and uncontrolled literature.

Author: MellegersM A, FurlanA D, MailisA

Neuropathic pain relief
Central nervous system side effects

Gabapentin is an effective treatment for various neuropathic pain conditions, including diabetic neuropathy and post-herpetic neuralgia. The effectiveness of gabapentin may be reduced if low doses are used, and rapid dose escalation may be associated with increased central nervous system side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers.

Author: SalinskyM C, StorzbachD, SpencerD C, OkenB S, LandryT, DodrillC B

Gabapentin tolerability
Cognitive impairment

Topiramate significantly impaired cognitive performance in healthy volunteers, while gabapentin had minimal effects, suggesting that topiramate may affect daily and occupational function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

The analgesic effects of perioperative gabapentin on postoperative pain: a meta-analysis.

Author: HurleyRobert W, CohenSteven P, WilliamsKayode A, RowlingsonAndrew J, WuChristopher L

Reduced opioid use
Reduced pain
Anxiolysis
Sedation

Perioperative oral gabapentin was effective in reducing postoperative pain and opioid use, but it was associated with sedation and anxiolysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Gabapentin's acute effect on mood profile -- a controlled study on patients with alcohol withdrawal.

Author: BonnetUdo, SpeckaMichael, LewekeF Markus, NyhuisPeter, BangerMarkus

Improved mood

Gabapentin selectively accelerated the improvement of the vigor-subscore of patients with acute alcohol withdrawal within 48 hours. This effect was independent from the subjective severity of withdrawal and especially marked in patients with co-morbid mild depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Use of gabapentin for perioperative pain control -- a meta-analysis.

Author: PengP W, WijeysunderaD N, LiC Cf

Reduced opioid use
Reduced pain
Reduced pruritus
Reduced vomiting
Dizziness
Sedation

Gabapentin reduced opioid consumption by 35% and pain scores, but increased dizziness and sedation in patients after surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety.

Author: TiippanaElina M, HamunenKatri, KontinenVesa K, KalsoEija

Neuropathic pain treatment
Postoperative pain treatment

This study reviewed randomized controlled trials examining the analgesic efficacy, adverse effects, and clinical value of gabapentinoids (gabapentin and pregabalin) in postoperative pain. Gabapentinoids have demonstrated antiallodynic and antihyperalgesic properties, suggesting their potential benefit in managing acute postoperative pain.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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