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Raloxifene lowers serum lipoprotein(A) in healthy postmenopausal women: a randomized, double-blind, placebo-controlled comparison with conjugated equine estrogens.

Author: KenemansP, MijatovicV, NetelenbosC, de Valk-de RooG W, van der MoorenM J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Raloxifene, a selective estrogen receptor modulator, has antiestrogenic effects on the endometrium and breast, and estrogenic effects on bone and lipid metabolism. In a 24-month study of healthy postmenopausal women who had undergone hysterectomy, raloxifene (60 mg and 150 mg daily) and conjugated equine estrogens (0.625 mg daily) were found to have no significant effect on serum lipoprotein(a) levels.
Paper Details　
Original Abstract of the Article :
Long-term postmenopausal estrogen replacement therapy lowers the risk of osteoporotic fractures and coronary artery disease but increases the risk of endometrial cancer and probably breast cancer. Raloxifene, a nonsteroidal estrogen receptor ligand, seems to have a tissue-specific antiestrogenic act...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10374220

データ提供：米国国立医学図書館（NLM）

Raloxifene: A New Oasis in the Desert of Postmenopausal Health

Postmenopausal women face a unique set of health challenges, often likened to navigating a vast and unpredictable desert landscape. This study explores the effects of raloxifene, a selective estrogen receptor modulator, on serum lipoprotein(a) levels in healthy postmenopausal women. The researchers seek to understand the potential benefits of raloxifene in managing cardiovascular risk and improving overall health.

Raloxifene: A Potential Boon for Postmenopausal Health

The study found that raloxifene effectively lowered serum lipoprotein(a) levels in postmenopausal women, suggesting a potential role in reducing cardiovascular risk. These findings offer a glimmer of hope for women navigating the challenges of postmenopausal health.

A Brighter Future for Postmenopausal Women

This study highlights the importance of personalized medicine in addressing the unique health needs of women during menopause. By understanding the potential benefits of drugs like raloxifene, we can develop tailored treatment strategies that address individual risks and promote optimal health outcomes. It's like finding a hidden oasis in the desert of postmenopausal health, a place where well-being and vitality can thrive.

Dr.Camel's Conclusion

This study provides valuable insights into the potential benefits of raloxifene for postmenopausal women, offering a promising avenue for managing cardiovascular risk and promoting overall health. It's a reminder that the desert of postmenopausal health can be navigated with greater ease when we have access to effective treatments and personalized care, ensuring a smoother and more fulfilling journey.

Date :
  1. Date Completed 1999-07-22
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

10374220

DOI: Digital Object Identifier

10374220

Related Literature

Article Analysis
・Effects of raloxifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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