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Efficacy of omeprazole versus ranitidine for symptomatic treatment of poorly responsive acid reflux disease-a prospective, controlled trial.

Author: JoelssonB, MatonP N, OrlandoR

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that omeprazole was significantly more effective than ranitidine in resolving heartburn in patients with gastro-oesophageal reflux disease (GERD) who remained symptomatic after a 6-week course of ranitidine therapy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: H2-receptor antagonists are widely used in patients with gastro-oesophageal reflux disease (GERD) and are frequently continued when symptoms persist. AIM: To compare the efficacy of omeprazole 20 mg once daily with that of ranitidine 150 mg twice daily in relieving GERD symptoms, in pat...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.1999.00527.x

データ提供：米国国立医学図書館（NLM）

Omeprazole vs. Ranitidine: A Refreshing Oasis for Acid Reflux

The desert of gastrointestinal research is a vast landscape, constantly seeking new ways to alleviate the discomfort of acid reflux disease (GERD). This research, like a thirsty traveler searching for a cool spring, explores the efficacy of omeprazole, a proton pump inhibitor, compared to ranitidine, an H2-receptor antagonist, in relieving GERD symptoms.

A New Path to Relief

The researchers, like skilled desert guides, conducted a two-phase, prospective trial, carefully evaluating the effectiveness of each drug in patients with GERD. They discovered that omeprazole, like a refreshing oasis in the desert, significantly outperformed ranitidine in resolving heartburn symptoms, even in patients who had not responded well to ranitidine alone. This finding underscores the potential of omeprazole as a more effective treatment option for GERD.

Finding Relief in the Desert of GERD

This research, like a well-stocked caravan venturing through a challenging landscape, provides valuable information for patients with GERD. The findings suggest that omeprazole, with its superior efficacy in resolving heartburn symptoms, could offer a more effective and potentially life-changing treatment option. As we continue our journey through the desert of GERD research, this study serves as a valuable guidepost, directing us towards a path of greater relief and improved quality of life for patients.

Dr.Camel's Conclusion

This research, like a shimmering oasis in the vast desert of GERD treatment, highlights the significant benefits of omeprazole in providing relief for acid reflux. The study's findings suggest that omeprazole, with its greater efficacy in resolving heartburn symptoms, could offer a more effective and potentially life-changing treatment option for patients struggling with GERD. It's important to consult with a healthcare professional to determine the best course of treatment for your individual needs.
Date :
  1. Date Completed 1999-07-20
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10383513

DOI: Digital Object Identifier

10.1046/j.1365-2036.1999.00527.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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