Effective treatment of gerd: A Synthesis of Findings from 65 Studies

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Original Abstract of the Article

Key Research Findings

Gastroesophageal reflux disease (GERD) is a common condition affecting approximately one-third of the global population. 53 Traditionally, proton pump inhibitors (PPIs) have been the mainstay treatment for GERD, but concerns about long-term side effects and the long-term effectiveness of fundoplication have led to renewed interest in alternative therapies. 53 Stretta therapy, a radiofrequency ablation procedure, is one such alternative that has gained attention. 53

The response to GERD treatment in primary care settings is variable. 41 Patients with GERD can experience a range of symptoms, including heartburn, acid reflux, chronic cough, and even asthma. 34 These symptoms can significantly impact a patient's quality of life. 25

Treatment options for GERD include medication, lifestyle modifications, endoscopic procedures, and surgery. 65 Endoscopic procedures such as transoral incisionless fundoplication (TIF) and Stretta therapy are being explored as alternatives. 43 TIF aims to mimic the surgical fundoplication procedure and has received FDA approval. 43 Stretta therapy involves using radiofrequency ablation to strengthen the junction between the esophagus and stomach. 53 Surgical options include the traditional fundoplication and robotic-assisted surgery. 59

The effectiveness of GERD treatment depends on various factors, including the type and dosage of PPIs used. 44 It's crucial to tailor treatment plans to individual patient needs and lifestyle factors. 24

treatment summary

Treatment options for GERD include medication, lifestyle changes, endoscopic procedures, and surgery. 3 65 43 53 59 44 24 PPIs are the most common GERD treatment, but long-term use raises concerns about potential side effects. 16 22 36 15 Fundoplication, while a potentially effective surgical option, may not always provide long-lasting relief. 53 38 59 28 7 Stretta therapy is a newer treatment option, but its long-term effectiveness and safety require further research. 53 TIF, while FDA-approved, still requires additional research on its safety and durability. 43 It's crucial to choose the best treatment based on individual symptoms and lifestyle factors. 24

Benefits and Risks

Benefit Summary

GERD treatment options include medication, endoscopic procedures, and surgery. 3 43 59 Proper treatment can help improve GERD symptoms and enhance a patient's quality of life. 25 39

Risk Summary

Each GERD treatment option comes with its own risks. 16 22 36 Long-term PPI use may increase the risk of osteoporosis and infections. 53 Fundoplication carries risks associated with surgery. 38 59 The long-term effectiveness and safety of newer treatments like Stretta therapy and TIF are still being studied. 53 43 It's essential to weigh the benefits and risks of each GERD treatment before making a decision. 24

Comparison Across Studies

Commonalities

Many studies indicate that GERD is a widespread issue affecting people globally. 53 41 Across these studies, a consistent finding is that GERD symptoms can significantly diminish a patient's quality of life. 25 39 20

Differences

Research studies on GERD can vary in their methodologies, treatment approaches, and evaluation criteria. 53 41 16 4 26 43 44 11 22 59 13 27 10 37 40 2 9 51 34 28 25 42 36 15 38 46 24 3 7 30 65 39 20 23 58 48 50 47 61

Consistency and Contradictions in Findings

Many studies suggest that the most effective GERD treatment approach involves tailoring the chosen method to individual symptoms and lifestyle factors. 24 However, definitive conclusions about which treatment is most effective overall, or which treatment is best suited for specific patient groups, are still elusive. 53 41 16 4 26 43 44 11 22 59 13 27 10 37 40 2 9 51 34 28 25 42 36 15 38 46 24 3 7 30 65 39 20 23 58 48 50 47 61

Considerations for Real-World Application

GERD can have a significant impact on daily life. 25 39 20 If you're experiencing GERD symptoms, consulting a doctor for proper diagnosis and treatment is essential. 3 65 43 53 59 44 24

Limitations of Current Research

Research on GERD treatments is still ongoing. 53 41 16 4 26 43 44 11 22 59 13 27 10 37 40 2 9 51 34 28 25 42 36 15 38 46 24 3 7 30 65 39 20 23 58 48 50 47 61 Specifically, research on newer treatments like Stretta therapy and TIF is limited in terms of long-term effectiveness and safety data. 53 43 Furthermore, GERD symptoms can vary significantly between individuals, and even the same treatment can have different outcomes for different patients. 24

Future Research Directions

Future research should prioritize evaluating the long-term effectiveness and safety of newer treatments like Stretta therapy and TIF. 53 43 Developing targeted treatments based on specific GERD symptom profiles and tailoring treatments to individual lifestyles are also critical areas for exploration. 24

Conclusion

GERD is a prevalent condition impacting a significant portion of the global population. 53 Treatment decisions should be tailored to each patient's unique symptoms and lifestyle habits. 24 65 If you are experiencing GERD symptoms, seeking medical advice from a healthcare professional for proper diagnosis and treatment is strongly recommended. 3

Treatment List

Proton Pump Inhibitors (PPIs), Lifestyle Modifications, Endoscopic Procedures, Surgery, Stretta Therapy, Transoral Incisionless Fundoplication (TIF), Fundoplication, Robotic-Assisted Surgery, PPI Dosage Adjustment, PPI Type Adjustment

Keywords
Benefit Keywords
GERD symptom relief
1
Reduced heartburn
Reduced other GERD symptoms
2
Improved gastrointestinal symptoms
Improved general health
Improved general well-being
Improved vitality
Reduced depression
3
GERD treatment
Reduced symptoms
4
GERD treatment
5
Effective GERD treatment
6
Controlled heartburn
Improved cough
7
Heartburn relief
8
GERD symptom relief
9
Symptom severity assessment
10
GERD symptom relief
11
Effective treatment
Symptom relief
Tolerable treatment
13
Open fundoplication
Proton-pump inhibitor
14
Prevents GERD relapse
15
GERD treatment
16
GERD treatment
17
Effective for GERD
18
Increased pH
19
Improve GERD symptoms
20
Fewer symptom episodes
GERD symptom relief
Reduced relapse risk
21
GERD management
22
Asthma symptom relief
GERD treatment
Improved quality of life
23
Improved GERD treatment
Improved HRQL
24
GERD symptom management
25
BE treatment
GERD treatment
26
Heartburn relief
Regurgitation relief
27
GERD treatment
28
Asthma symptom relief
Improved quality of life
29
GERD treatment
30
Improved quality of life
31
Improved GERD
32
Reduced GERD symptoms
33
GERD diagnosis
GERD treatment
34
Improved acid inhibition
35
Reduced gastric acidity
36
GERD remission
Reduced acid regurgitation
Reduced heartburn
37
Treatment of GERD
38
GERD treatment
39
Cost effective
GERD treatment
40
GERD management
41
GERD treatment
43
Reduced endoscopic relapse
44
Heartburn improvement
Regurgitation improvement
45
Proton pump inhibitors
46
Laparoscopic Toupet fundoplication
47
Reduced GERD symptoms
48
GERD treatment
49
Reduced GERD symptoms
50
Improved GERD symptoms
Reduced PPI use
Reduced erosive esophagitis
52
GERD treatment
53
ST-GERD treatment
Surgical treatment
54
GERD treatment
55
Heal EE
Reduce heartburn
56
GERD treatment
57
Prokinetic-PPI combination therapy
58
GERD treatment
59
Asthma control
60
GERD treatment
61
GERD symptom relief
62
GERD treatment
63
GERD treatment
64
GERD treatment
65
Risk Keywords
Significant impact on quality of life
3
Suture perforation
4
Bloating
Epigastric fullness
Respiratory complications
Wound complications
6
GERD treatment cost
12
Infectious illnesses
Sickle cell anemia
13
Gastroesophageal reflux disease
14
Gastroesophageal reflux disease
24
Limited recommendations
Possible side effects
Scant data
29
None reported
31
Temporal decrease in well-being
33
Ineffective for infants
Lack of long-term safety data
36
Bloating
Dysphagia
Flatulence
37
Not superior
40
Overtreatment
42
Gastroesophageal reflux disease
46
GERD
Quality of life
47
Long-term PPI concerns
50
ST-GERD failure
54
Persistence of symptoms
55
Literature analysis of 65 papers
Positive Content
62
Neutral Content
1
Negative Content
2
Article Type
35
13
23
23
63
1.

Efficacy of omeprazole versus ranitidine for symptomatic treatment of poorly responsive acid reflux disease-a prospective, controlled trial.

Author: MatonP N, OrlandoR, JoelssonB

GERD symptom relief

This study found that omeprazole was significantly more effective than ranitidine in resolving heartburn in patients with gastro-oesophageal reflux disease (GERD) who remained symptomatic after a 6-week course of ranitidine therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Efficacy of omeprazole for the treatment of symptomatic acid reflux disease without esophagitis.

Author: RichterJ E, PeuraD, BenjaminS B, JoelssonB, WhippleJ

Reduced heartburn
Reduced other GERD symptoms

Patients with symptomatic GERD require profound acid suppression to achieve symptomatic relief. Omeprazole, 20 mg once daily, was superior to omeprazole, 10 mg once daily, and to placebo in providing early and sustained resolution of heartburn, as well as treatment of other troublesome GERD symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

The evaluation and treatment of adults with gastroesophageal reflux disease.

Author: FlynnC A

Improved gastrointestinal symptoms
Improved general health
Improved general well-being
Improved vitality
Reduced depression
Significant impact on quality of life

Gastroesophageal reflux disease (GERD), characterized by stomach acid backing up into the esophagus, affects 21-59% of people annually. While only 20% of people with weekly symptoms seek medical attention, GERD accounts for almost 1% of visits to family doctors. GERD significantly impacts quality of life, but treatment leads to improvement in symptoms, well-being, and overall health.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Transoral, flexible endoscopic suturing for treatment of GERD: a multicenter trial.

Author: FilipiC J, LehmanG A, RothsteinR I, RaijmanI, StiegmannG V, WaringJ P, HunterJ G, GostoutC J, EdmundowiczS A, DunneD P, WatsonP A, CornetD A

GERD treatment
Reduced symptoms
Suture perforation

Endoscopic gastroplasty is safe and associated with reduced symptoms and medication use at 6 months in patients with uncomplicated GERD.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Healing and relapse rates in gastroesophageal reflux disease treated with the newer proton-pump inhibitors lansoprazole, rabeprazole, and pantoprazole compared with omeprazole, ranitidine, and placebo: evidence from randomized clinical trials.

Author: CaroJ J, SalasM, WardA

GERD treatment

Newer proton pump inhibitors (PPIs) lansoprazole, rabeprazole, and pantoprazole were similar in efficacy to omeprazole in terms of heartburn control, healing rates, and relapse rates in acute and maintenance treatment of GERD. All PPIs were superior to ranitidine and placebo in healing erosive esophagitis and decreasing relapse rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Laparoscopic vs open approach for Nissen fundoplication. A comparative study.

Author: ChrysosE, TsiaoussisJ, AthanasakisE, ZorasO, VassilakisJ S, XynosE

Effective GERD treatment
Bloating
Epigastric fullness
Respiratory complications
Wound complications

The open and laparoscopic approaches for the Nissen fundoplication are equally effective in controlling GERD. The open approach is associated with a significantly higher rate of wound and respiratory complications and, at early stages, an increased rate of postprandial epigastric fullness and abdominal bloating.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Preoperative symptom evaluation and esophageal acid infusion predict response to laparoscopic Nissen fundoplication in gastroesophageal reflux patients who present with cough.

Author: AllenC J, AnvariM

Controlled heartburn
Improved cough

Laparoscopic Nissen fundoplication (LNF) controlled heartburn in 93% and improved cough in 81%. The preoperative cough score and change in cough on and off PPI predicted improvement after surgery. A positive result on a randomized acid infusion test was associated with a greater improvement in cough after surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Short-term treatment of gastroesophageal reflux disease.

Author: van PinxterenBart, NumansMattijs E, LauJoseph, de WitNiek J, HunginA Pali S, BonisPeter A L

Heartburn relief

Acid suppressant therapy with either PPIs or H2RAs was more effective than placebo for short-term relief of heartburn in patients with persistent symptoms who are treated empirically for GERD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Once-daily pantoprazole 40 mg and esomeprazole 40 mg have equivalent overall efficacy in relieving GERD-related symptoms.

Author: ScholtenT, GatzG, HoleU

GERD symptom relief

Treatment with pantoprazole resulted in significantly faster first-time relief from daytime and night-time GERD-related symptoms than esomeprazole.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Systematic review: do we need a new gastro-oesophageal reflux disease questionnaire?

Author: StanghelliniV, ArmstrongD, MönnikesH, BardhanK D

Symptom severity assessment

Gastro-oesophageal reflux disease (GERD) is common in Western countries, and self-assessed symptom questionnaires are becoming increasingly important for evaluating symptom severity, quality of life, and treatment response.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Efficacy and safety of pantoprazole versus ranitidine in the treatment of patients with symptomatic gastroesophageal reflux disease.

Author: van ZylJ, van RensburgC, ViewegW, FischerR

GERD symptom relief

Pantoprazole, a proton pump inhibitor, was found to be more effective than ranitidine, an H2 antagonist, in relieving GERD symptoms, including heartburn, acid eructation, pain on swallowing, and other gastrointestinal symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Review article: prevalence and epidemiology of gastro-oesophageal reflux disease.

Author: DelaneyB C

GERD treatment cost

This review discusses the uncertainties around the definition and clinical diagnostic criteria for gastro-oesophageal reflux disease (GERD), highlighting the challenges of prevalence studies due to varying symptom definitions and timeframes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Nizatidine for the treatment of pediatric gastroesophageal reflux symptoms: an open-label, multiple-dose, randomized, multicenter clinical trial in 210 children.

Author: OrensteinSusan R, GremseDavid A, PantaleonCarmela D, KlingDouglas F, RotenbergKeith S

Effective treatment
Symptom relief
Tolerable treatment
Infectious illnesses
Sickle cell anemia

This large study supports the tolerability and effectiveness of nizatidine in children aged 5 days through 18 years with GERD. Approximately 30% of patients became asymptomatic after 8 weeks of treatment, regardless of dosing or formulation, with an overall improvement in symptoms and a decrease in antacid use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Long-term outcome of surgically and medically treated patients with gastroesophageal reflux disease: a matched-pair follow-up study.

Author: OlbergPetter, JohannessenRune, JohnsenGjermund, MyrvoldHelge E, BjerkesetTormod, FjösneUlf, PetersenHermod

Open fundoplication
Proton-pump inhibitor
Gastroesophageal reflux disease

This study compared the long-term effects of anti-reflux surgery to those of medical care in treating gastroesophageal reflux disease (GERD), finding comparable results between the two approaches.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Long-term prevention of erosive or ulcerative gastro-oesophageal reflux disease relapse with rabeprazole 10 or 20 mg vs. placebo: results of a 5-year study in the United States.

Author: CaosA, BreiterJ, PerdomoC, BarthJ

Prevents GERD relapse

Five-year maintenance therapy with rabeprazole is effective in preventing relapse of erosive or ulcerative GERD and is well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Management of symptoms in step-down therapy of gastroesophageal reflux disease.

Author: MineShinichiro, IidaTakeshi, TabataTakahiro, KishikawaHirofumi, TanakaYoshiya

GERD treatment

This study investigates the differences in the quality of gastroesophageal reflux disease (GERD) treatment using proton pump inhibitors (PPIs) and H(2)-receptor antagonists (H(2)-RAs) in a step-down protocol.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Endoscopic therapy for gastroesophageal reflux disease: a systematic review.

Author: SgourosSpiros N, BergeleChristina

GERD treatment

This study reviews the effectiveness of different endoscopic procedures used to treat gastroesophageal reflux disease (GERD), a common condition that affects many people. The study highlights the need for further research to compare these new endoscopic techniques with existing medical and surgical treatments. The review emphasizes the importance of careful data analysis to ensure the accuracy of the findings, particularly considering the limited amount of research and variability between studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Pantoprazole 40 mg is as effective as esomeprazole 40 mg to relieve symptoms of gastroesophageal reflux disease after 4 weeks of treatment and superior regarding the prevention of symptomatic relapse.

Author: GlatzelDirk, Abdel-QaderMuwafeg, GatzGudrun, PfaffenbergerBernd

Effective for GERD

Pantoprazole 40 mg was as effective as esomeprazole 40 mg in relieving gastroesophageal reflux disease (GERD) symptoms. Pantoprazole was associated with a lower risk of relapse and fewer symptom episodes after treatment ended.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Pharmacodynamic effects of single doses of rabeprazole 20 mg and pantoprazole 40 mg in patients with GERD and nocturnal heartburn.

Author: WarringtonS, BaisleyK, LeeD, LomaxK, DelemosB, BoyceM, MorocuttiA

Increased pH

This open-label, randomized, two-way crossover, clinical pharmacology study compared the antisecretory effects of single doses of rabeprazole and pantoprazole in patients with GERD and a history of nocturnal heartburn. The study found that a single oral dose of rabeprazole 20 mg increased intragastric pH more than pantoprazole 40 mg did throughout the 24 h after dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Systematic review: do we need a new gastro-oesophageal reflux disease questionnaire?

Author: StanghelliniV, ArmstrongD, MönnikesH, BardhanK D

Improve GERD symptoms

This study highlights the importance of self-assessed symptom questionnaires in evaluating symptom severity, quality of life, and treatment response in gastro-oesophageal reflux disease (GERD) patients, as most don't have endoscopic abnormalities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Pantoprazole 40 mg is as effective as esomeprazole 40 mg to relieve symptoms of gastroesophageal reflux disease after 4 weeks of treatment and superior regarding the prevention of symptomatic relapse.

Author: GlatzelDirk, Abdel-QaderMuwafeg, GatzGudrun, PfaffenbergerBernd

Fewer symptom episodes
GERD symptom relief
Reduced relapse risk

Pantoprazole was at least as effective as esomeprazole for relieving GERD symptoms and had a significantly lower risk of relapse and fewer symptom episodes after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Systematic review: maintenance treatment of gastro-oesophageal reflux disease with proton pump inhibitors taken 'on-demand'.

Author: PaceF, ToniniM, PallottaS, MolteniP, PorroG B

GERD management

On-demand therapy with PPI appears to be effective in the long-term management of patients with NERD or mild and uninvestigated forms of GERD, but not in patients with (severe) erosive oesophagitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Evaluation of pantoprazol treatment response of patients with asthma and gastroesophageal reflux: a randomized prospective double-blind placebo-controlled study.

Author: dos SantosLeandro Heusi, RibeiroIana Oliveira e Silva, SánchezPablo Gerardo, HetzelJorge Lima, FelicettiJosé Carlos, CardosoPaulo Francisco Guerreiro

Asthma symptom relief
GERD treatment
Improved quality of life

Effective treatment of gastroesophageal reflux disease (GERD) in patients with asthma significantly improved their quality of life and reduced asthma symptoms. However, there was no change in pulmonary function parameters. This study emphasizes the importance of considering GERD in patients with asthma and highlights the potential benefits of treating GERD for improving asthma management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Management strategy for patients with gastroesophageal reflux disease: a comparison between empirical treatment with esomeprazole and endoscopy-oriented treatment.

Author: GianniniEdoardo G, ZentilinPatrizia, DulbeccoPietro, VigneriSergio, ScarlataPamela, SavarinoVincenzo

Improved GERD treatment
Improved HRQL
Gastroesophageal reflux disease

This study compares two approaches to treating typical heartburn symptoms without warning signs of serious problems: starting treatment right away (empirical) versus having an endoscopy first. The study assesses the effectiveness of each approach, as well as the costs and impact on quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Systematic review: health-related quality of life (HRQOL) questionnaires in gastro-oesophageal reflux disease.

Author: ChassanyO, HoltmannG, MalageladaJ, GebauerU, DoerflerH, DevaultK

GERD symptom management

Health-related quality of life (HRQOL) questionnaires are being used to evaluate the effect of treatment for gastro-oesophageal reflux disease (GERD).

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Medical or surgical management of GERD patients with Barrett's esophagus: the LOTUS trial 3-year experience.

Author: AttwoodS E, LundellL, HatlebakkJ G, EklundS, JunghardO, GalmicheJ-P, EllC, FioccaR, LindT

BE treatment
GERD treatment

Laparoscopic antireflux surgery (LARS) was equally successful in patients with or without Barrett's esophagus (BE) and comparable to optimized medical therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Clinical trial: the treatment of gastro-oesophageal reflux disease in primary care--prospective randomized comparison of rabeprazole 20 mg with esomeprazole 20 and 40 mg.

Author: EgglestonA, KatelarisP H, NandurkarS, ThorpeP, HoltmannG,

Heartburn relief
Regurgitation relief

Rabeprazole 20 mg was non-inferior to esomeprazole 40 mg for complete resolution of regurgitation and satisfactory resolution of heartburn and regurgitation. Rabeprazole 20 mg was also non-inferior to esomeprazole 20 mg for all outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Predictors of clinical outcomes following fundoplication for gastroesophageal reflux disease remain insufficiently defined: a systematic review.

Author: IpStanley, TatsioniAthina, ConantAlene, KaragozianRaffi, FuLinda, ChewPriscilla, RamanGowri, LauJoseph, BonisPeter

GERD treatment

This review examined the literature on prognostic factors for patients with GERD treated with fundoplication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? A systematic review.

Author: SopoS Miceli, RadzikD, CalvaniM

Asthma symptom relief
Improved quality of life
Limited recommendations
Possible side effects
Scant data

While limited evidence exists, treatment of asthma symptoms with a proton pump inhibitor (PPI) may be considered in cases where asthma does not respond to standard treatment and a reflux index greater than or equal to 10 is present.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Control of esophageal and intragastric pH with compounded and manufactured omeprazole in patients with reflux esophagitis: a pilot study.

Author: MoretzsohnLuciana D, CarvalhoEmanuella B, FrancoJunia D, SoaresMarcela P, BritoEliza M, BelarminoK, CoelhoLuiz G

GERD treatment

This study found that different omeprazole formulations, both compounded and manufactured, had similar effects on gastric acid secretion and esophageal acid exposure in patients with reflux esophagitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Long-term quality of life improvement in subjects with healed erosive esophagitis: treatment with lansoprazole.

Author: KovacsThomas O, FrestonJames W, HaberMarian M, AtkinsonStuart, HuntBarbara, PeuraDavid A

Improved quality of life
None reported

Lansoprazole maintenance treatment for 12 months in healed erosive esophagitis subjects produced significantly greater improvements in quality of life indicators than ranitidine. These improvements were sustained during dose-titrated, open-label lansoprazole treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Systematic review: the effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease.

Author: De GrootN L, BurgerhartJ S, Van De MeebergP C, de VriesD R, SmoutA J P M, SiersemaP D

Improved GERD

Dietary and lifestyle intervention may improve gastro-oesophageal reflux disease (GERD) in obese patients. Bariatric surgery, especially after Roux-en-Y gastric bypass, has the most favorable effect on GERD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Pharmacological dependency in chronic treatment of gastroesophageal reflux disease: a randomized controlled clinical trial.

Author: van der VeldenA W, de WitN J, QuarteroA O, GrobbeeD E, NumansM E

Reduced GERD symptoms
Temporal decrease in well-being

Long-term users of acid suppressive medication for gastroesophageal reflux disease (GERD) may benefit from switching to on-demand treatment. While 19% of patients could discontinue treatment completely, 71% could manage their symptoms with a significantly reduced dosage, with similar symptom control and quality of life to those on continuous treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

An electronic medical record-based intervention to improve quality of care for gastro-esophageal reflux disease (GERD) and atypical presentations of GERD.

Author: PlayerMarty S, GillJames M, MainousArch G, EverettCharles J, KoopmanRichelle J, DiamondJames J, LiebermanMichael I, ChenYing Xia

GERD diagnosis
GERD treatment

Gastroesophageal reflux disease (GERD) is common but often missed and untreated in primary care settings. GERD can also have less obvious symptoms like chronic cough and asthma, which may be overlooked by doctors. This study aimed to develop and evaluate a program to improve the diagnosis and treatment of GERD and atypical GERD in primary care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

The effects of dose and timing of esomeprazole administration on 24-h, daytime and night-time acid inhibition in healthy volunteers.

Author: Wilder-SmithC, RöhssK, Bokelund SinghS, SagarM, NagyP

Improved acid inhibition

A randomized, seven-way crossover study in healthy volunteers evaluated the pharmacodynamic effects of various esomeprazole dosage and timing regimens. Esomeprazole 20 mg twice daily provided superior acid inhibition compared to all once-daily regimens. Dosing before breakfast improved 24-h and daytime acid inhibition compared to other dosing times. Night-time acid inhibition was improved with esomeprazole 40 mg once daily administered before dinner or at bedtime.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: a systematic review.

Author: van der PolRachel J, SmitsMarije J, van WijkMichiel P, OmariTaher I, TabbersMerit M, BenningaMarc A

Reduced gastric acidity
Ineffective for infants
Lack of long-term safety data

PPIs are not effective in reducing GERD symptoms in infants. Placebo-controlled trials in older children are lacking. Although PPIs seem to be well tolerated during short-term use, evidence supporting the safety of PPIs is lacking. For infants, PPIs were more effective in 1 study (compared with hydrolyzed formula), not effective in 2 studies, and equally effective in 2 studies (compared with placebo) for the reduction of GERD symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the LOTUS randomized clinical trial.

Author: GalmicheJean-Paul, HatlebakkJan, AttwoodStephen, EllChristian, FioccaRoberto, EklundStefan, LångströmGöran, LindTore, LundellLars,

GERD remission
Reduced acid regurgitation
Reduced heartburn
Bloating
Dysphagia
Flatulence

Both drug-induced acid suppression with esomeprazole and laparoscopic antireflux surgery (LARS) achieved long-term remission in most patients with GERD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Surgical treatment of gastroesophageal reflux disease: total or partial fundoplication? systematic review and meta-analysis.

Author: RamosRodrigo F, LustosaSuzana Angélica S, AlmeidaCarlos Augusto P de, SilvaCarolina P da, MatosDelcio

Treatment of GERD

While gastroesophageal reflux disease (GERD) is common, there is much debate about surgical treatments. Doctors face a challenge in deciding whether to use a full or partial fundoplication (a surgical procedure that tightens the muscle at the top of the stomach) for GERD because of limited research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Patient satisfaction with medication for gastroesophageal reflux disease: a systematic review.

Author: van ZantenSander Jo, HendersonCatherine, HughesNesta

GERD treatment

More than one-half of patients were satisfied with their PPI medication in trials, and more patients were satisfied with PPIs than other medication types. An association between patient satisfaction and symptom resolution was found, suggesting that patient satisfaction is a useful end point for evaluating GERD treatment success.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Randomised clinical trial: a comparison between a GerdQ-based algorithm and an endoscopy-based approach for the diagnosis and initial treatment of GERD.

Author: JonassonC, MoumB, BangC, AndersenK R, HatlebakkJ G

Cost effective
GERD treatment
Not superior

A symptom-based approach using GerdQ reduced health care costs without loss in efficacy. Patients with high likelihood GERD benefited from empirical treatment. An algorithm based on GerdQ may provide physicians with a tool for a more structured care of patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Structured management strategy based on the Gastro-oesophageal Reflux Disease (GERD) Questionnaire (GerdQ) vs. usual primary care for GERD: pooled analysis of five cluster-randomised European studies.

Author: PonceJ, GarriguesV, AgréusL, TabaglioE, GschwantlerM, GuallarE, TafallaM, NuevoJ, HatlebakkJ

GERD management

A structured management approach to gastro-oesophageal disease (GERD) was more effective than standard treatment in improving outcomes and reducing the need for treatment revision.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

Influence of "GERD" label on parents' decision to medicate infants.

Author: SchererLaura D, Zikmund-FisherBrian J, FagerlinAngela, TariniBeth A

Overtreatment

Labeling an otherwise healthy infant as having GERD increased parents' interest in medicating their infant. This suggests that the use of disease labels may promote overtreatment by causing people to believe that ineffective medications are both useful and necessary.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Impact of transoral incisionless fundoplication (TIF) on subjective and objective GERD indices: a systematic review of the published literature.

Author: WendlingMark R, MelvinW Scott, PerryKyle A

GERD treatment

Gastroesophageal reflux disease (GERD) is a common condition that is often treated with endoluminal treatments. This study will investigate the safety, efficacy, and durability of transoral incisionless fundoplication (TIF), a new procedure for treating GERD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Rabeprazole 10 mg versus 20 mg in preventing relapse of gastroesophageal reflux disease: a meta-analysis.

Author: ZhuHai-di, WangHeng, XiaXian-ming, XuShu-man, LanYao

Reduced endoscopic relapse

This review compared the efficacies of rabeprazole 10 and 20 mg/d for GERD maintenance treatment over 1 or 5 years. Rabeprazole 20 mg/d was superior to rabeprazole 10 mg/d in preventing endoscopic relapse of erosive GERD, but the two dosages were equivalent in symptomatic relief over 1 year.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Distinguishing the impact of dexlansoprazole on heartburn vs. regurgitation in patients with gastro-oesophageal reflux disease.

Author: PeuraD A, PilmerB, HuntB, ModyR, PerezM C

Heartburn improvement
Regurgitation improvement

Dexlansoprazole appears to be effective in improving both heartburn and regurgitation in patients with non-erosive GERD (NERD) and erosive oesophagitis (EE).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux.

Author: PalmieriB, MerighiA, CorbascioD, RottigniV, FistettoG, EspositoA

Proton pump inhibitors
Gastroesophageal reflux disease

While proton pump inhibitors (PPIs) are a major advancement in treating heartburn (GERD), many patients with GERD without visible inflammation (non-erosive reflux disease) experience only partial relief or need additional medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Laparoscopic surgery for gastro-esophageal acid reflux disease.

Author: SchijvenMarlies P, GisbertzSuzanne S, van Berge HenegouwenMark I

Laparoscopic Toupet fundoplication
GERD
Quality of life

Gastroesophageal reflux disease (GERD) can significantly impact quality of life. Treatment decisions depend on patient factors, the severity of reflux, and doctor preference. For patients with normal weight who are candidates for surgery, the laparoscopic Toupet fundoplication is the preferred surgical option. While other treatments exist, there is no clear evidence that they are better. More research is needed to compare different surgical techniques and assess the cost-effectiveness of these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Efficacy of transoral fundoplication vs omeprazole for treatment of regurgitation in a randomized controlled trial.

Author: HunterJohn G, KahrilasPeter J, BellReginald C W, WilsonErik B, TradKarim S, DolanJames P, PerryKyle A, OelschlagerBrant K, SoperNathaniel J, SnyderBrad E, BurchMiguel A, MelvinWilliam Scott, ReavisKevin M, TurgeonDaniel G, HungnessEric S, DiggsBrian S

Reduced GERD symptoms

This prospective, sham-controlled trial examined the effectiveness of transoral esophagogastric fundoplication (TF) for treating gastroesophageal reflux disease (GERD) in patients who experience troublesome regurgitation despite proton pump inhibitor (PPI) therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Lifestyle Intervention in Gastroesophageal Reflux Disease.

Author: Ness-JensenEivind, HveemKristian, El-SeragHashem, LagergrenJesper

GERD treatment

Gastroesophageal reflux disease (GERD) affects a large portion of the population and is associated with lifestyle factors like obesity and smoking. This systematic review examines the role of lifestyle interventions in the treatment of GERD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Breathing training on lower esophageal sphincter as a complementary treatment of gastroesophageal reflux disease (GERD): a systematic review.

Author: CasaleM, SabatinoL, MoffaA, CapuanoF, LuccarelliV, VitaliM, RibolsiM, CicalaM, SalvinelliF

Reduced GERD symptoms
Long-term PPI concerns

Gastroesophageal reflux disease (GERD) is a common digestive problem that can be challenging to cure. While proton pump inhibitors (PPIs) are the standard treatment, they aren't effective for everyone, and long-term use has raised concerns. Recent research suggests that exercises to strengthen breathing muscles (inspiratory muscle training) may help by increasing pressure in the lower esophagus, reducing GERD symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

PRISM, a Patient-Reported Outcome Instrument, Accurately Measures Symptom Change in Refractory Gastroesophageal Reflux Disease.

Author: FullerGarth, BolusRoger, WhitmanCynthia, TalleyJennifer, ErderM Haim, JosephAlain, SilbergDebra G, SpiegelBrennan

This study examines the limitations of existing patient-reported outcome (PRO) instruments for gastroesophageal reflux disease (GERD). The study highlights the need for more accurate and reliable PRO instruments to assess treatment outcomes in GERD patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Validation StudyResearch to assess the validity and reliability of new measurement methods or diagnostic tests.

Language : English

52.

Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease.

Author: FassRonnie, CahnFrederick, ScottiDennis J, GregoryDavid A

Improved GERD symptoms
Reduced PPI use
Reduced erosive esophagitis

This systematic review and meta-analysis determined the efficacy of the Stretta procedure in treating patients with GERD. The review found that the Stretta procedure significantly improves subjective and objective clinical endpoints and therefore should be considered as a viable alternative in managing GERD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Treatment of gastroesophageal reflux disease using radiofrequency ablation (Stretta procedure): An interim analysis of a randomized trial.

Author: KalapalaRakesh, ShahHarshal, NabiZaheer, DarisettySantosh, TalukdarRupjyoti, Nageshwar ReddyD

GERD treatment

Gastroesophageal reflux disease (GERD) is a common condition affecting millions worldwide. While medications like proton pump inhibitors (PPIs) are used, they can have long-term side effects. Surgery, called fundoplication, can also be used but its benefits may not last. This study focuses on Stretta therapy as a potential alternative treatment for GERD.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

54.

Management of failure after surgery for gastro-esophageal reflux disease.

Author: GronnierC, DegrandiO, ColletD

ST-GERD treatment
Surgical treatment
ST-GERD failure

Surgery for gastro-esophageal reflux disease (GERD) is a good option for people who haven't responded to medications, but it can fail in 2-20% of cases. Failure is often due to the wrong initial diagnosis or surgical errors. Treatment for failed surgery can be difficult and requires a careful evaluation to determine the cause of the problem. A multidisciplinary approach is important to find the best treatment for each person.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

55.

GASTROESOPHAGEAL REFLUX DISEASE IN OVERWEIGHT VARIOUS DEGREES.

Author: KrolevetsT S, LivzanM A, LaptevaI V

GERD treatment
Persistence of symptoms

Ursodeoxycholic acid (UDCA) improved treatment outcomes for gastroesophageal reflux disease (GERD) in patients with obesity and overweight.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Dual Delayed-Release Dexlansoprazole for Healing and Maintenance of Healed Erosive Esophagitis: A Safety Study in Adolescents.

Author: GremseDavid, GoldBenjamin D, PilmerBetsy, HuntBarbara, KorczowskiBartosz, PerezMaria Claudia

Heal EE
Reduce heartburn

This study examines the increase in heartburn symptoms and erosive esophagitis (EE) with age in children and adolescents with gastroesophageal reflux disease (GERD), focusing on the use of dexlansoprazole, a proton pump inhibitor, in patients aged 12 years and older.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

A Randomized Placebo-Controlled <i>N</i>-of-1 Trial: The Effect of Proton Pump Inhibitor in the Management of Gastroesophageal Reflux Disease.

Author: Sierra-ArangoFernando, CastañoD M, ForeroJennifer D, Pérez-RiverosErika D, Ardila DuarteGerardo, BoteroMaria L, CárdenasAndres, De la Hoz-ValleJose

GERD treatment

Gastroesophageal reflux disease (GERD), or heartburn, is a common condition that can lead to serious problems like cancer. While medications that reduce stomach acid (PPIs) are often effective, some people continue to have heartburn. This study investigated whether doubling the dose of a specific PPI medication (esomeprazole) was more effective in treating heartburn in a single person.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

The treatment efficacy of adding prokinetics to PPIs for gastroesophageal reflux disease: a meta-analysis.

Author: XiLiting, ZhuJinzhou, ZhangHuixian, MuktialiMerlin, LiYouming, WuAirong

Prokinetic-PPI combination therapy

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder. Proton pump inhibitors (PPIs) are first-line drugs for GERD. For those who fail to respond to PPIs, adding prokinetics to PPIs is recommended and several trials have been conducted to evaluate the efficacy of prokinetic-PPI combination therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

Surgical treatment of GERD: systematic review and meta-analysis.

Author: McKinleySophia K, DirksRebecca C, WalshDanielle, HollandsCeleste, ArthurLauren E, RodriguezNoe, JhangJoyce, Abou-SettaAhmed, PryorAurora, StefanidisDimitrios, SlaterBethany J

GERD treatment

Gastroesophageal reflux disease (GERD) has a high worldwide prevalence. This review assessed outcomes of antireflux surgery versus medical management of GERD in adults and children, robotic versus laparoscopic fundoplication, complete versus partial fundoplication, and minimal versus maximal dissection in pediatric patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Does omeprazole improve asthma-control in poorly-controlled asthmatic children with gastro-esophageal reflux.

Author: YagoubiAbdelghani, LaidYoucef, SmatiLeila, Nafissa BenhallaKeltoum, BenhassineFadila

Asthma control

GER is prevalent in poorly controlled asthmatic children, and efficient GER treatment can improve asthma control.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

61.

Randomized clinical trial: A double-blind, proof-of-concept, phase 2 study evaluating the efficacy and safety of vonoprazan 20 or 40 mg versus esomeprazole 40 mg in patients with symptomatic gastro-esophageal reflux disease and partial response to a healing dose of a proton-pump inhibitor.

Author: TackJan, VladimirovBorislav, HornyIvo, ChongChui Fung, EisnerJessica, CzerniakRichard, TakanamiYohei

GERD treatment

This randomized, double-blind, proof-of-concept, phase 2 clinical trial of patients with gastro-esophageal reflux disease (GERD) found that vonoprazan, a novel potassium-competitive acid blocker, did not demonstrate a statistically significant difference in efficacy and safety compared to esomeprazole, a proton-pump inhibitor (PPI).

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

What is the efficacy of dietary, nutraceutical, and probiotic interventions for the management of gastroesophageal reflux disease symptoms? A systematic literature review and meta-analysis.

Author: MartinZoe, SpryGeorgia, HoultJen, MaimoneIsabella R, TangXueying, CrichtonMegan, MarshallSkye

GERD symptom relief

Limited evidence suggests that dietary interventions for GERD symptoms may be effective, with some studies showing improvements with a test-based elimination diet, low nickel diet, probiotic yogurt, psyllium husk, and specific supplements.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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