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Efficacy of interferon treatment for patients with chronic hepatitis C: comparison of response in cirrhotics, fibrotics, or nonfibrotics.

Author: AlbertD, BainV G, CraigJ R, EhrinpreisM N, EversonG T, JensenD M, JohT, WittK, van LeeuwenD J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effectiveness of interferon therapy for chronic hepatitis C in patients with different stages of liver disease (no fibrosis, fibrosis, and cirrhosis). All groups showed similar rates of virus clearance and improvement in liver histology. While sustained ALT normalization was lower in cirrhotic patients, the study suggests that virus clearance may occur without ALT normalization in this group. Overall, both fibrotic and cirrhotic patients benefited from interferon therapy, indicating that liver cirrhosis should not exclude patients from treatment.
Paper Details　
Original Abstract of the Article :
Chronic hepatitis C patients (472 patients) were treated with consensus interferon (CIFN) or interferon (IFN) alfa-2b for 6 months in a large multicenter trial. Efficacy was assessed by clearance of hepatitis C virus (HCV) RNA using reverse transcription polymerase chain reaction (RT-PCR) (<100 copi...See full text at original site
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引用元：
https://doi.org/10.1002/hep.510300116

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Hepatitis C: Interferon Treatment for Different Stages of Liver Disease

Hepatitis C, a viral infection that affects the liver, can be likened to a slow but relentless sandstorm, gradually eroding the health of the organ. This study explores the effectiveness of interferon treatment for chronic hepatitis C patients with different stages of liver disease, from nonfibrotics to those with cirrhosis. The researchers, like explorers mapping the terrain of liver disease, analyzed the response to interferon treatment in these different groups, seeking to understand the impact of liver damage on treatment effectiveness.

Finding Hope in the Desert of Liver Disease

The study offers encouraging news for those battling chronic hepatitis C. It shows that interferon treatment can be effective for both non-cirrhotic and cirrhotic patients, offering a glimmer of hope in the fight against this challenging disease. While sustained ALT response rates were similar across the groups, the study highlights that cirrhotic patients may clear the virus without normalization of ALT levels, suggesting the need for careful monitoring of treatment outcomes in this group. The study also notes that interferon therapy was generally well-tolerated across all groups, with more cirrhotic patients requiring dose reduction due to thrombocytopenia.

Navigating the Desert of Liver Health

The study underscores the importance of personalized treatment approaches for chronic hepatitis C. It highlights the need for close monitoring and individualized treatment plans, ensuring that the best possible outcome is achieved for each patient. The study also encourages continued research into new and more effective treatment options for this complex and often challenging disease, seeking to create new oases of hope for those facing the relentless sandstorm of hepatitis C.

Dr.Camel's Conclusion

This study, like a guidepost in the desert of hepatitis C, sheds light on the effectiveness of interferon treatment across different stages of liver disease. It underscores the importance of personalized care, careful monitoring, and the ongoing pursuit of new and improved treatment options for those facing the challenges of this persistent viral infection.

Date :
  1. Date Completed 1999-07-29
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

10385666

DOI: Digital Object Identifier

10.1002/hep.510300116

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Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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