Effects of a small dose of triazolam on P300.

Author: EnomotoT, HayakawaT, OkawaM, OkuboJ, UchiyamaM, UrataJ

Paper Details 
Original Abstract of the Article :
Ten healthy men (mean age, 33.9 years) participated in two experimental sessions cross-overed randomly in a double-blind manner: one with the placebo and another with 0.125 mg of triazolam (TRZ). Resting electroencephalography and event-related potential under oddball paradigm were recorded before t...See full text at original site
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引用元:
https://doi.org/10.1046/j.1440-1819.1999.00530.x

データ提供:米国国立医学図書館(NLM)

The Effects of Triazolam on Cognitive Function: A Look at the P300 Wave

In the realm of psychopharmacology, understanding the impact of drugs on cognitive function is a critical endeavor. This study examines the effects of triazolam, a benzodiazepine used for sleep disorders, on the P300 wave, an electrophysiological marker of cognitive processing. The study used a double-blind, crossover design to compare the effects of triazolam and a placebo on the P300 wave in healthy individuals. This study aimed to investigate how triazolam affects cognitive function, even in the absence of sedation or apparent sleepiness.

Triazolam's Impact on Cognitive Function: Beyond Sedation

The study found that triazolam, even in small doses, caused cognitive dysfunction as evidenced by changes in the P300 wave, even in the absence of overt sedation or sleepiness. The effects were most prominent 6 hours after administration. These findings suggest that triazolam's effects on cognitive function might be more widespread than previously thought and could have implications for individuals taking the drug for sleep disorders. This study emphasizes the need for further research to understand the subtle cognitive effects of commonly used medications.

Navigating the Complexities of Medication Effects

This research provides valuable insights into the potential cognitive effects of medications. While triazolam is often prescribed for sleep disorders, it's crucial to be aware of its potential cognitive side effects. This underscores the importance of careful monitoring for any changes in cognitive function, especially in individuals taking medications that can affect the brain. This knowledge empowers individuals to make informed decisions about their health and treatment options.

Dr.Camel's Conclusion

Just as the vast desert can be deceiving, the effects of medication can be more nuanced than we initially perceive. This study reveals the hidden effects of triazolam on cognitive function, highlighting the importance of a comprehensive understanding of medication effects. It's crucial to remember that even seemingly benign medications can have unexpected impacts on our mental processes, emphasizing the importance of attentive medical care and proactive monitoring.

Date :
  1. Date Completed 1999-10-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

10459684

DOI: Digital Object Identifier

10.1046/j.1440-1819.1999.00530.x

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