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Effects of OspA vaccination on Lyme disease serologic testing.

Author: Aguero-RosenfeldM E, CarbonaroC A, NadelmanR B, NowakowskiJ, RobergeJ, WormserG P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that OspA vaccination did not interfere with the interpretation of immunoblots for Borrelia burgdorferi antibodies in patients who developed early Lyme disease. Vaccines induced enzyme-linked immunosorbent assay reactivity but did not fulfill Centers for Disease Control and Prevention criteria for positivity on immunoblots.
Paper Details　
Original Abstract of the Article :
This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA re...See full text at original site
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引用元：
https://doi.org/10.1128/JCM.37.11.3718-3721.1999

データ提供：米国国立医学図書館（NLM）

OspA Vaccination and Lyme Disease Serology: Navigating the Labyrinth of Testing

Lyme disease, a tick-borne illness that can affect various organs, poses a significant challenge in the field of [infectious diseases]. This study examines the effects of OspA vaccination on Lyme disease serological testing. The research explores the potential impact of vaccination on diagnostic accuracy and the interpretation of test results.

A Complex Landscape: Understanding the Impact of Vaccination on Lyme Disease Serology

The study reveals that OspA vaccination can lead to reactivity in Lyme disease serological tests, but this reactivity does not interfere with the interpretation of test results for individuals who develop Lyme disease. It's like navigating a complex desert, where the landscape can be deceiving but ultimately leads to a clear path.

A Guiding Compass: Interpreting Lyme Disease Serology Tests

This research provides valuable insights for clinicians when interpreting Lyme disease serological tests in individuals who have received OspA vaccination. Understanding the potential impact of vaccination on test results can help ensure accurate diagnosis and appropriate treatment.

Dr.Camel's Conclusion

This study serves as a guiding compass in the vast desert of Lyme disease diagnostics. By understanding the impact of OspA vaccination on serological testing, we can navigate the complexities of diagnosis and ensure patients receive accurate and timely care.

Date :
  1. Date Completed 1999-11-30
  2. Date Revised 2020-07-24
Further Info :

Pubmed ID

10523583

DOI: Digital Object Identifier

10.1128/JCM.37.11.3718-3721.1999

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・Effective treatment of lyme disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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