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The Prosorba column for treatment of refractory rheumatoid arthritis: a randomized, double-blind, sham-controlled trial.

Author: BaldassareA R, BlockJ A, CaldwellJ R, CannonG W, DealC, EvansS, FelsonD T, FleischmannR, FurstD E, GendreauR M, HarrisE R, LaValleyM P, MattesonE L, RothS H, SchumacherH R, WeismanM H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Apheresis with the Prosorba column is an effective treatment for rheumatoid arthritis in patients who have failed other treatments. It showed a 31.9% response rate compared to 11.4% in the sham-treated group.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate the efficacy and safety of the Prosorba column as a treatment for rheumatoid arthritis (RA) in patients with active and treatment-resistant (refractory) disease. METHODS: A sham-controlled, randomized, double-blind, multicenter trial of Prosorba versus sham apheresis was perf...See full text at original site
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引用元：
https://doi.org/10.1002/1529-0131(199910)42:10<2153::AID-ANR16>3.0.CO;2-W

データ提供：米国国立医学図書館（NLM）

Prosorba Column for Refractory Rheumatoid Arthritis: A Promising Therapeutic Option

Rheumatoid arthritis (RA), a chronic autoimmune disease characterized by joint inflammation and pain, can significantly impact quality of life. This randomized, double-blind, sham-controlled trial evaluates the efficacy and safety of the Prosorba column, an apheresis device that removes inflammatory mediators from the blood, as a treatment for refractory RA. The researchers found that patients treated with the Prosorba column experienced a significantly higher rate of improvement in RA symptoms compared to those receiving sham apheresis. The study highlights the potential of the Prosorba column as a therapeutic option for patients with refractory RA who have not responded to conventional treatments.

A New Path for Refractory Rheumatoid Arthritis: Exploring the Prosorba Column

The study provides compelling evidence for the efficacy of the Prosorba column in treating refractory RA. The findings suggest that this apheresis device, which removes inflammatory mediators from the blood, can offer a significant improvement in RA symptoms for patients who have not responded to conventional treatments.

Navigating the Desert of RA: Seeking Effective Therapies

Imagine traversing a vast desert, where the landscape is unforgiving and the journey is fraught with challenges. This analogy reflects the experience of individuals living with RA, a chronic inflammatory disease that can significantly impact quality of life. This study offers hope by demonstrating the potential of the Prosorba column to alleviate RA symptoms, providing a new path toward improved health and well-being.

Dr.Camel's Conclusion

This randomized controlled trial provides compelling evidence for the efficacy of the Prosorba column in treating refractory rheumatoid arthritis. The findings suggest that this apheresis device can offer a significant improvement in RA symptoms for patients who have not responded to conventional treatments, providing a promising therapeutic option for those seeking relief from the debilitating effects of this chronic disease.

Date :
  1. Date Completed 1999-11-02
  2. Date Revised 2007-11-14
Further Info :

Pubmed ID

10524687

DOI: Digital Object Identifier

10.1002/1529-0131(199910)42:10<2153::AID-ANR16>3.0.CO;2-W

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・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

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