Effective treatment of rheumatoid arthritis: A Synthesis of Findings from 127 Studies

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Original Abstract of the Article

Major Research Findings

This article presents research findings on various treatments for rheumatoid arthritis (RA), including established treatments and promising new options. The research highlights the efficacy of drugs like DMARDs (disease-modifying antirheumatic drugs), biologics, and JAK inhibitors in managing RA.

DMARDs are crucial for slowing down RA progression, with several studies confirming their effectiveness. For example, 39 compared four different treatment strategies for early RA, demonstrating the superiority of DMARD-inclusive strategies in both clinical and radiological outcomes.

However, some patients may not respond to DMARDs, necessitating alternative options like biologics. These agents target inflammatory cytokines such as TNF-α and have proven effective. 72 showed that biologics were more effective than conventional DMARDs in early RA patients.

Recently, JAK inhibitors have emerged as a novel therapeutic avenue. These medications inhibit JAK proteins, thereby reducing inflammation. A systematic review and meta-analysis in 115 confirmed the efficacy and safety of JAK inhibitors in RA patients who had not achieved satisfactory results with conventional or biologic DMARDs.

However, biologics and JAK inhibitors come with challenges like infection risks and potential side effects. Therefore, careful selection of the appropriate treatment based on individual patient characteristics is paramount.

Treatment Summary

Treating rheumatoid arthritis involves numerous options tailored to each patient's specific needs. Here's a summary of key treatments highlighted in the research:

91 suggested that prolonged intensive DMARD treatment (PRINT) might lead to higher remission rates and lower relapse rates in severe RA patients.

109 explored the potential impact of disease duration and prior DMARD use on treatment outcomes in established RA. This research indicated a possible influence of these factors on therapeutic response.

113 investigated the different effects of tocilizumab (TCZ) versus methotrexate (MTX) monotherapy on connective tissue remodeling in early RA patients. This study suggests that TCZ therapy might affect connective tissue remodeling compared to MTX monotherapy.

39 , the BeSt study, compared four different treatment strategies for early RA, revealing improvements in both clinical and radiological outcomes across all strategies with intensive monitoring.

25 examined the TICORA study, which investigated the potential of a tight control strategy for RA. This study suggests that aggressive treatment strategies can effectively suppress RA activity and lead to favorable outcomes compared to routine outpatient care.

43 conducted a systematic review and meta-analysis to assess the efficacy of infliximab and methotrexate combination therapy for RA. This review suggested that this combination therapy could be a valuable treatment option for RA.

121 presents a systematic review of randomized clinical trials investigating the efficacy and safety of tocilizumab in RA subjects. This review confirmed tocilizumab's effectiveness and safety in RA treatment.

86 conducted a systematic review and indirect pairwise meta-analysis to explore optimal treatment strategies with biologics in early RA. This review suggested that biologics could be valuable options for RA treatment, but it didn't definitively determine which biologic is superior.

116 is a systematic review examining the effectiveness of intra-articular therapy with methotrexate or tumor necrosis factor inhibitors in RA. The review suggests that these intra-articular therapies could be viable alternatives for patients who don't respond to steroid injections.

19 evaluated the efficacy of combining DMARDs and corticosteroids in early RA. This research indicated that this combination therapy might be a valuable option for early RA treatment.

85 is an abridged version of a Cochrane systematic review on balneotherapy (spa therapy) for RA. This review suggests that balneotherapy might be a potentially effective treatment option for RA.

67 examined the effectiveness of adding low-dose prednisone to a methotrexate-based tight control strategy for early RA. This study suggests that low-dose prednisone addition could further enhance the effectiveness of an aggressive treatment strategy.

58 conducted a meta-analysis comparing the efficacy of various biologic antirheumatic agents in RA patients who did not respond to conventional DMARDs or anti-TNF agents. This meta-analysis suggested that biologics could be effective options for treating RA.

70 showcases a study on the effectiveness of etanercept for RA treatment. Etanercept, a TNF-α inhibitor, holds potential as an effective treatment option for RA.

30 revealed that even patients with stable long-standing RA might experience disease deterioration despite intensive treatment with traditional DMARDs. This study emphasizes the importance of early intervention with the aim of completely suppressing inflammation in RA.

26 presents a randomized controlled trial evaluating the combination therapy of methotrexate and infliximab in early RA patients. This trial suggests that infliximab and methotrexate combination therapy could be an effective treatment option for early RA compared to methotrexate alone.

55 investigated the long-term radiographic outcomes of early RA patients treated with a combination of three DMARDs versus a single DMARD. This study found that the combination therapy showed superior long-term radiographic outcomes compared to single DMARD therapy.

is a systematic review of literature on the economic burden of RA in the era of biologics. This review indicated that the introduction of biologics improved clinical outcomes in RA and redefined traditional RA cost structures.

107 is the FINCH 2 randomized clinical trial assessing the effects of filgotinib versus placebo in patients with moderate to severe RA unresponsive to biologic DMARDs. This trial suggests that filgotinib might be a valuable option for patients with RA who have not responded to biologic DMARDs.

56 , the IMAGE trial, investigated the efficacy of rituximab combined with methotrexate in early active RA patients. This trial suggests that rituximab combined with methotrexate might help to inhibit joint damage and improve clinical outcomes in early active RA patients.

115 is a systematic review and meta-analysis evaluating the efficacy and safety of jakinibs in RA. This review and meta-analysis confirmed the efficacy and safety of jakinibs for RA patients who have not achieved satisfactory results with conventional or biologic DMARDs.

40 highlights the importance of exercise therapy in managing RA. Exercise therapy plays a crucial role in RA treatment.

38 presents a systematic review assessing the effectiveness of rituximab in RA treatment. Rituximab holds potential as a valuable alternative for RA patients who have not responded to TNF-α inhibitors.

97 is a study protocol for the TITRATE trial, investigating whether intensive management improves remission rates in patients with intermediate RA. This trial suggests that intensive management might lead to higher remission rates in these patients.

93 is a Cochrane systematic review and network meta-analysis evaluating the efficacy of biologic or tofacitinib monotherapy in RA patients who have failed traditional DMARDs, including methotrexate (MTX). This review suggests that biologic or tofacitinib monotherapy might be effective options for RA patients who haven't responded to conventional DMARDs.

87 examines the trial-based cost-effectiveness of abatacept for RA patients in Italy. This study suggests that abatacept could be a cost-effective treatment option for RA.

72 is a randomized trial comparing biologic versus conventional combination treatment for early RA and its impact on work loss. This trial showed that biologic treatments led to superior radiological outcomes compared to a combination of conventional DMARDs over a two-year period.

27 is a randomized, double-blind, placebo-controlled trial examining the effects of very early infliximab treatment alongside methotrexate in early RA patients with a poor prognosis. This trial demonstrated that infliximab and methotrexate combination therapy reduced MRI evidence of synovitis and damage in early poor-prognosis RA patients, with sustained benefits after infliximab withdrawal.

10 is a study on the COBRA (Combination therapy in rheumatoid arthritis) scheme for early RA patients. This trial showed that the COBRA scheme, which includes sulfasalazine, prednisolone, and methotrexate, was superior to sulfasalazine alone in reducing disease activity, articular damage on radiographs, and side effects over a 1.5-year period.

80 is the TACIT trial and associated systematic reviews comparing tumor necrosis factor inhibitors with intensive combination therapy using conventional DMARDs in established RA. This trial and reviews suggest that TNF inhibitors could be valuable options for treating RA compared to intensive combination therapy with conventional DMARDs.

29 is the BeSt study, comparing four different treatment strategies for early RA. This study demonstrated improvements in clinical and radiological outcomes across all strategies with intensive monitoring.

62 presents a post-hoc analysis of randomized clinical trial data on the effects of abatacept in biologic-naive RA patients. This analysis found that early RA patients had higher remission rates with abatacept compared to patients with ≥10 years of disease.

28 is the BROSG (British Rheumatoid Outcome Study Group) randomized controlled trial comparing the effectiveness and cost-effectiveness of aggressive versus symptomatic therapy in established RA. This trial suggests that aggressive treatment might improve RA outcomes compared to symptomatic treatment.

112 is a systematic review exploring the use of TNF inhibitors in RA and their implications for periodontal status. This review suggests that TNF inhibitors might improve periodontal health in RA patients.

57 is a randomized study examining the effects of infliximab therapy on body fat mass in early RA patients. This study found that infliximab therapy might increase body fat mass in early RA patients, independent of changes in disease activity and levels of leptin and adiponectin.

68 is a systematic review of tocilizumab for RA, a biologic agent targeting the interleukin-6 receptor. Tocilizumab holds promise as a new treatment strategy for RA patients who haven't achieved satisfactory outcomes with at least one anti-TNF therapy.

74 is a systematic review examining the mid-term outcomes of total ankle arthroplasty and ankle fusion in RA. This review provides insights into the clinical outcomes and complications of both interventions for RA patients.

127 is the NORD-STAR trial, an investigator-initiated randomized controlled trial comparing certolizumab pegol, abatacept, tocilizumab, and active conventional treatment in early RA patients. This trial found that the three biologics (certolizumab pegol, abatacept, and tocilizumab) might be effective treatment options for early RA compared to active conventional therapy.

63 is a consensus document on the use of rituximab in RA. This document highlights that rituximab is a potentially effective treatment option for RA, but its specific mechanism of action and lack of clear management guidelines require caution.

Benefits and Risks

Benefits Summary

Early RA treatment is crucial for minimizing joint damage and improving quality of life. Research consistently demonstrates the effectiveness of various treatments for RA, including DMARDs, biologics, and JAK inhibitors. These medications help control joint inflammation, reduce pain and swelling, and improve joint function. Some medications even have the potential to slow down joint damage progression.

Risk Summary

RA treatment involves various risks, including increased infection susceptibility and potential side effects. DMARDs can elevate infection risks. Biologics carry a heightened infection risk, including the possibility of severe infections. Side effects can include liver dysfunction, blood disorders, and allergic reactions. JAK inhibitors also pose risks like increased infection susceptibility, thrombosis risk, and liver dysfunction. These risks vary depending on factors like the drug type, dosage, and individual patient characteristics. Therefore, prior to initiating treatment, it's crucial to have a comprehensive discussion with a healthcare professional to understand the risks and benefits involved.

Comparison Across Studies

Similarities Across Studies

Many studies consistently emphasize the importance of early intervention in RA treatment. Additionally, the research collectively shows that new treatment options, such as biologics and JAK inhibitors, are becoming increasingly effective alongside conventional DMARDs. Moreover, these studies underscore the significance of personalized treatment approaches based on individual patient characteristics.

Differences Across Studies

Each study differs in terms of the RA stages targeted, treatment methods employed, and evaluation criteria used. This variability makes direct comparison of research findings challenging. Furthermore, some studies have limited sample sizes, potentially affecting the generalizability of the results. Additionally, variations in research designs and methodologies could influence the interpretation of findings.

Consistency and Contradictions in Results

While numerous studies consistently demonstrate the importance of early treatment and the effectiveness of drugs like DMARDs, biologics, and JAK inhibitors, direct comparisons of results are difficult due to differences in patient populations, treatment methods, and evaluation criteria. Therefore, results may exhibit both consistency and contradictions.

For instance, 91 found prolonged intensive DMARD treatment to be effective, while 30 suggested that even with intensive traditional DMARD therapy, RA patients might experience disease deterioration. These discrepancies demonstrate that even the same treatment can yield varying outcomes depending on patient characteristics and research design. It's crucial to consider these factors when interpreting research results.

Considerations for Applying Findings in Real-World Settings

Tailoring RA treatment to individual patient characteristics is essential, making direct application of research findings to real-world scenarios challenging. Before starting treatment, comprehensive discussions with a healthcare professional are crucial to understand individual conditions and weigh the risks and benefits. It's equally important to adhere to healthcare provider instructions and undergo regular check-ups during treatment.

Current Research Limitations

Research on RA treatment still faces several challenges. For example, long-term effectiveness and safety evaluations may be inadequate in some cases. Further research is necessary, including the development of novel treatments and improvements to existing therapies.

Future Research Directions

Future research on RA treatment should prioritize the following areas:

  • Long-term effectiveness and safety evaluations
  • Development of personalized treatment approaches
  • Assessment of treatment cost-effectiveness
  • Development of new treatment options

Conclusion

Early intervention in RA is crucial for minimizing joint damage and enhancing quality of life. Research consistently shows the effectiveness of various RA treatments, including DMARDs, biologics, and JAK inhibitors. However, these medications also carry risks like increased infection susceptibility and side effects. Therefore, it's crucial to consult with a healthcare professional before starting treatment to understand individual conditions and weigh the risks and benefits. Regular check-ups and adherence to healthcare provider instructions are also essential during treatment. Continued research promises further advancements in RA treatment options. If you are experiencing rheumatoid arthritis, please seek medical guidance and support. Don't hesitate to discuss your concerns with a healthcare professional.

Treatment List

  • DMARDs
  • Biologics
  • TNF-α inhibitors
  • JAK inhibitors
  • Methotrexate (MTX)
  • Tocilizumab (TCZ)
  • Infliximab
  • Etanercept
  • Rituximab
  • Abatacept
  • Certolizumab pegol
  • Filgotinib
  • Sulfasalazine
  • Prednisolone
  • Corticosteroids
  • Balneotherapy (Spa therapy)
  • Exercise therapy
Keywords
Benefit Keywords
Complete responses
Prolonged remission
Slower destructive processes
1
Good results
Less severe joint condition
2
Improved rheumatoid arthritis symptoms
3
RA improvement
Relatively safe
4
Type II collagen for RA
5
Improved rheumatoid arthritis treatment
7
Effective for rheumatoid arthritis
8
MTX effective for RA
9
Improved rheumatoid arthritis treatment
10
Enhanced efficacy
Improved RA treatment
Improved rheumatoid arthritis treatment
Reduced joint damage
11
Efficacious treatment for RA
12
Rheumatoid arthritis treatment
13
Improved rheumatoid arthritis treatment
14
Reduced joint damage
16
Reduced GI bleeding
17
Greater efficacy than placebo
Reduced gastrointestinal bleeding
Reduced ulceration
Similar efficacy to naproxen
18
Effective RA treatment
19
Etanercept efficacy
20
Reduced work disability
21
RA treatment
22
RA treatment
23
Improved long-term outcome
Limited joint damage
24
Improved outcome in RA
25
RA treatment
26
Rheumatoid arthritis treatment
27
Improved disease activity
Symptom control
28
Improved rheumatoid arthritis treatment
29
RA treatment
30
Improve employability
31
Durable clinical responses
32
Improved function
Reduced disease activity
Slowed radiographic progression
33
Sustained remission
34
Reduced joint damage
Rheumatoid arthritis treatment
35
JRA treatment
36
Improved outcomes
37
Improved rheumatoid arthritis treatment
38
Improved rheumatoid arthritis treatment
39
Improved rheumatoid arthritis treatment
40
Inhibition of joint damage progression
41
Improved rheumatoid arthritis treatment
42
Improved rheumatoid arthritis treatment
43
Improved rheumatoid arthritis treatment
44
Improved function
Pain relief
46
RA treatment
47
RA treatment
48
RA treatment
49
UA/early RA treatment
50
Improved function
Improved pain
51
Better clinical outcomes
53
Improved clinical outcome
Improved physical function
Reduced structural damage
54
RA treatment
55
Improved clinical outcomes
Reduced joint damage
56
RA treatment
57
RA treatment
58
RA treatment
59
No increased risk of infection
No increased risk of malignancy
60
Cost-effective
Improved RA
61
RA treatment
62
RA treatment
63
Improved RA management
64
Treatment of rheumatoid arthritis
65
Improved RA management
66
Improved remission
Reduced disability
Reduced disease activity
Reduced joint damage
Reduced need for additional drugs
67
Treatment of rheumatoid arthritis
68
Treatment of early RA
69
ACR50 response
Disease remission
Physical function improvement
RA treatment
Radiographic progression slowing
70
RA treatment
71
RA treatment
72
DAS28 remission
DAS44 remission
Radiographic non-progression
Reduced synovitis
Remission induction
73
Clinical improvement
Improved ankle function
74
PsA treatment
75
RA treatment
76
RA treatment
77
Anti-tumor necrosis factor agents
78
RA treatment
79
Equivalent clinical benefits
Lower costs
80
Improved RA management
Potential for CVD prevention
RA treatment
81
bDMARDs
82
Rituximab
83
Biologic agents
84
RA treatment
86
Lower total costs
87
Improved RA treatment
Potential for better outcomes
RA treatment
88
Drug-free remission
Functional improvement
Normalized survival
Radiographic damage prevention
89
Effective treatment
Improved RA
90
RA remission
Reduced RA flares
91
Effective treatment strategy
GC remission induction
92
RA treatment
94
RA treatment
95
Improved RA treatment
96
RA treatment
97
RA treatment
98
Biologic agents
RA treatment
99
Improved RA treatment
100
DMARD therapy
RA treatment
Tight disease control
101
RA remission
102
Prognosis assessment
RA treatment
103
RA treatment
Tofacitinib
104
MTX combination therapy
RA treatment
105
Disease improvement
106
RA response
107
Improved disease control
Improved functional capacity
Improved remission
108
Improved clinical outcomes
Reduced hospitalizations
Reduced work disability
110
Improved RA treatment
111
Periodontitis treatment
RA treatment
112
MTX and TCZ for RA
113
Biological DMARDs for RA
114
RA improvement
Well tolerated
115
IA DMARDs
RA treatment
116
Medicinal plants
Natural alternative
Potential for RA treatment
RA treatment
117
RA treatment
118
RA pain relief
Wrist function improvement
119
IL-1 antagonists
RA treatment
120
RA activity
TCZ
121
Diagnosis
Prognosis prediction
Treatment monitoring
122
RA treatment
123
Improved quality of life
Improved work outcomes
124
RA treatment
125
Improved RA response
126
Improved clinical remission
Reduced radiographic progression
127
Risk Keywords
Complications
2
Dizziness
GI symptoms
4
Ineffective treatment
Side effects
5
MTX toxicity
9
Corticosteroid dependence
Limited evidence
Need for replication
11
Joint pain flare
12
None reported
13
Limited evidence
15
Increased MI risk
17
Increased risk of MI
18
Treatment failures
19
No significant risk
21
Pneumonia
Serious infections
26
Deterioration in function
28
Rheumatoid arthritis
29
C-reactive protein levels
HAQ deterioration
30
Cancer
Death
Serious adverse events
Serious infections
32
Radiographic progression
34
Combination therapy withdrawal
35
Antibodies to infliximab
Infusion reactions
36
Rheumatoid arthritis
38
Rheumatoid arthritis
39
Rheumatoid arthritis
40
Rheumatoid arthritis
42
Rheumatoid arthritis
43
Rheumatoid arthritis
44
Disease flare
45
Infection risk
Liver damage
46
Over-treatment
47
Complications
Paucity of trials
51
No delay in RA development
No effect on remission
52
Increased infection risk
64
Adverse events
67
Infections
Withdrawals
70
Implant failure
Non-union
74
Rheumatoid arthritis
78
Limited remission
Serious adverse events
80
Needs further research
Unclear benefits of TNFi
81
Rheumatoid arthritis
82
Rheumatoid arthritis
83
Rheumatoid arthritis
84
Ineffective treatment
85
Needs further research
Unclear effectiveness and safety
88
Dropout rate
89
High cost
Long-term safety concerns
90
Medication cost
99
Side effects
106
Herpes zoster
Retinal vein occlusion
107
Reduced response to therapy
109
Anti-drug antibodies
114
Adverse events
Infections
115
Needs further research
Potential for interactions
Side effects
Unclear effectiveness
117
Lipid profiles
121
Heterogeneity
126
Literature analysis of 127 papers
Positive Content
121
Neutral Content
1
Negative Content
5
Article Type
65
30
53
39
126
1.

[Treatment experience with rheumatoid arthritis patients during remission].

Author: SorokaN F

Complete responses
Prolonged remission
Slower destructive processes

A study of 94 rheumatoid arthritis (RA) patients found that a combined treatment regimen, addressing psychological factors and strengthening the immune system, led to more frequent and longer-lasting remissions. Destructive processes in the joints slowed down during remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

2.

Long-term study of management of rheumatoid arthritis.

Author: MillionR, KellgrenJ H, PooleP, JaysonM I

Good results
Less severe joint condition
Complications

A 10-year study comparing a program of rest and medication with a program of maintained activity and medication for rheumatoid arthritis found no significant difference in overall outcomes, except that the steroid group showed better clinical and radiological outcomes for several joints.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Second line (disease modifying) treatment in rheumatoid arthritis: which drug for which patient?

Author: CapellH A, PorterD R, MadhokR, HunterJ A

Improved rheumatoid arthritis symptoms

Gold, penicillamine, and sulphasalazine were equally effective in treating rheumatoid arthritis. Neither gender nor age influenced the response to treatment, but patients with a longer disease duration were more likely to stop treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial.

Author: KloppenburgM, BreedveldF C, TerwielJ P, MalleeC, DijkmansB A

RA improvement
Relatively safe
Dizziness
GI symptoms

Minocycline was found to be beneficial and relatively safe for treating rheumatoid arthritis (RA) in a 26-week study. The drug showed statistically significant improvement compared to placebo. The study involved 80 patients with active RA who had been previously treated with at least one disease-modifying antirheumatic drug.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Oral type II collagen treatment in early rheumatoid arthritis. A double-blind, placebo-controlled, randomized trial.

Author: SieperJ, KaryS, SörensenH, AltenR, EggensU, HügeW, HiepeF, KühneA, ListingJ, UlbrichN, BraunJ, ZinkA, MitchisonN A

Type II collagen for RA
Ineffective treatment
Side effects

Oral type II collagen was only effective in a minority of patients with early rheumatoid arthritis (RA). Further research is needed to identify patients who are most likely to respond to this therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Treatment of rheumatoid arthritis with methotrexate alone, sulfasalazine and hydroxychloroquine, or a combination of all three medications.

Author: O'DellJ R, HaireC E, EriksonN, DrymalskiW, PalmerW, EckhoffP J, GarwoodV, MaloleyP, KlassenL W, WeesS, KleinH, MooreG F

Rheumatoid arthritis (RA) is a common condition that causes significant health problems. While single medications like methotrexate are often used, many patients do not respond well to these treatments. Despite limited research, many patients are treated with combinations of medications, even though there is limited evidence for their effectiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate.

Author: O'DellJ R, HaireC, EriksonN, DrymalskiW, PalmerW, MaloleyP, KlassenL W, WeesS, MooreG F

Improved rheumatoid arthritis treatment

A study of rheumatoid arthritis (RA) patients found that combining methotrexate, sulfasalazine, and hydroxychloroquine (triple therapy) significantly improved multiple clinical measures compared to methotrexate alone or a combination of sulfasalazine and hydroxychloroquine, especially for patients who had not responded well to those treatments. The study suggests that triple therapy is a valuable option for RA patients who haven't achieved satisfactory results with other medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo-controlled trial.

Author: O'DellJ R, HaireC E, PalmerW, DrymalskiW, WeesS, BlakelyK, ChurchillM, EckhoffP J, WeaverA, DoudD, EriksonN, DietzF, OlsonR, MaloleyP, KlassenL W, MooreG F

Effective for rheumatoid arthritis

Minocycline was superior to placebo in treating seropositive rheumatoid arthritis (RA) within the first year of disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy.

Author: WeinblattM E, MaierA L, FraserP A, CoblynJ S

MTX effective for RA
MTX toxicity

Long-term treatment with methotrexate was effective in managing rheumatoid arthritis, leading to significant improvement in pain, swelling, and global assessments. The study suggests that methotrexate is a viable option for long-term rheumatoid arthritis management.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[Combination therapy in early rheumatoid arthritis: the COBRA study].

Author: BoersM, VerhoevenA C, van der LindenS

Improved rheumatoid arthritis treatment

A study of early rheumatoid arthritis (RA) found that combining sulfasalazine, prednisolone, and methotrexate for the first six months (COBRA scheme) was more effective than sulfasalazine alone over 1.5 years. The combination treatment resulted in less disease activity, less joint damage, and fewer side effects, while costing the same or less. The study recommends more aggressive treatment for early RA with a reassessment of the use of corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Dutch

12.

The Prosorba column for treatment of refractory rheumatoid arthritis: a randomized, double-blind, sham-controlled trial.

Author: FelsonD T, LaValleyM P, BaldassareA R, BlockJ A, CaldwellJ R, CannonG W, DealC, EvansS, FleischmannR, GendreauR M, HarrisE R, MattesonE L, RothS H, SchumacherH R, WeismanM H, FurstD E

Efficacious treatment for RA
Joint pain flare

Apheresis with the Prosorba column is an effective treatment for rheumatoid arthritis in patients who have failed other treatments. It showed a 31.9% response rate compared to 11.4% in the sham-treated group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

Combination therapy versus monotherapy for the treatment of patients with rheumatoid arthritis.

Author: CalgüneriM, PayS, CalişkanerZ, ApraşS, KirazS, ErtenliI, CobankaraV

Rheumatoid arthritis treatment
None reported

Combination therapy with disease-modifying antirheumatic drugs (DMARDs) was found to be more effective than monotherapy in treating rheumatoid arthritis (RA). The combination of methotrexate (MTX), sulfasalazine (SSZ), and hydroxychloroquine (HCQ) was the most effective treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group.

Author: MainiR, St ClairE W, BreedveldF, FurstD, KaldenJ, WeismanM, SmolenJ, EmeryP, HarrimanG, FeldmannM, LipskyP

Improved rheumatoid arthritis treatment

This study investigated whether infliximab, an antibody that targets TNFalpha, could provide additional benefit to patients with active rheumatoid arthritis who were not responding well to methotrexate, a standard treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Yttrium radiosynoviorthesis in the treatment of knee arthritis in rheumatoid arthritis: a systematic review.

Author: Heuft-DorenboschL L, de VetH C, van der LindenS

Limited evidence

There is no strong evidence to support the use of yttrium synovectomy in chronic knee arthritis in patients with rheumatoid arthritis compared to placebo or intra-articular steroid treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Progression of radiographic joint erosion during low dose corticosteroid treatment of rheumatoid arthritis.

Author: PaulusH E, Di PrimeoD, SandaM, LynchJ M, SchwartzB A, SharpJ T, GenantH K, WeissmanB N

Reduced joint damage

Low-dose prednisone did not prevent progressive radiographic damage in patients with rheumatoid arthritis, suggesting that the risk/benefit ratio of chronic low-dose prednisone in early RA remains uncertain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Rofecoxib for the treatment of rheumatoid arthritis.

Author: GarnerS, FidanD, FrankishR, JuddM, TowheedT, WellsG, TugwellP

Reduced GI bleeding
Increased MI risk

This review assessed the efficacy and toxicity of rofecoxib for treating rheumatoid arthritis. Two randomized controlled trials were included. Rofecoxib demonstrated a greater degree of efficacy than placebo, while having a comparable safety profile. Rofecoxib also demonstrated a similar degree of efficacy as naproxen, but with a significantly lower rate of ulceration and gastrointestinal bleeding. However, rofecoxib was associated with a greater risk for myocardial infarction, but the exact significance and pathophysiology of this possible relationship is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Rofecoxib for the treatment of rheumatoid arthritis.

Author: GarnerS, FidanD, FrankishR, JuddM, TowheedT, WellsG, TugwellP

Greater efficacy than placebo
Reduced gastrointestinal bleeding
Reduced ulceration
Similar efficacy to naproxen
Increased risk of MI

This review assessed the efficacy and toxicity of rofecoxib for treating rheumatoid arthritis. Two randomized controlled trials were included. Rofecoxib demonstrated a greater degree of efficacy than placebo, while having a comparable safety profile. Rofecoxib also demonstrated a similar degree of efficacy as naproxen, but with a significantly lower rate of ulceration and gastrointestinal bleeding. However, rofecoxib was associated with a greater risk for myocardial infarction, but the exact significance and pathophysiology of this possible relationship is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Treatment of early RA in clinical practice: a comparative study of two different DMARD/corticosteroid options.

Author: SvenssonB, AhlménM, ForslindK

Effective RA treatment
Treatment failures

Patients who did not complete their first DMARD/CS treatment option had a reduced rate of individual response and remission. Treatment failures were more frequent in the sulfasalazine plus optional CS group than in the CS plus optional methotrexate treatment group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Etanercept for the treatment of rheumatoid arthritis.

Author: BlumenauerB, JuddM, CranneyA, BurlsA, CoyleD, HochbergM, TugwellP, WellsG

Etanercept efficacy

Etanercept 25 mg SC twice weekly was more efficacious than control treatment for ACR 20, 50 and 70 at 6 months, and over 12 months it slowed joint damage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Impact of initial aggressive drug treatment with a combination of disease-modifying antirheumatic drugs on the development of work disability in early rheumatoid arthritis: a five-year randomized followup trial.

Author: PuolakkaKari, KautiainenHannu, MöttönenTimo, HannonenPekka, KorpelaMarkku, JulkunenHeikki, LuukkainenReijo, VuoriKaisa, PaimelaLeena, BlåfieldHarri, HakalaMarkku, Leirisalo-RepoMarjatta

Reduced work disability
No significant risk

Patients with early rheumatoid arthritis (RA) who received a combination of disease-modifying antirheumatic drugs (DMARDs) had a significantly lower cumulative duration of work disability than those who received a single DMARD over 5 years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

The Utrecht experience with different treatment strategies in early rheumatoid arthritis.

Author: VerstappenS M, JacobsJ W, BijlsmaJ W,

RA treatment

This study investigated different approaches to treating early rheumatoid arthritis (RA). Early treatment with disease-modifying antirheumatic drugs (DMARDs) showed initial benefits compared to a delayed approach, but these advantages were not sustained after 5 years. Among the early DMARD strategies, starting with methotrexate (MTX) or injectable gold resulted in better outcomes after two years, although more patients discontinued gold treatment compared to MTX. The study recommends that methotrexate is the preferred initial DMARD, with treatment tailored to individual patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial.

Author: KeystoneEdward C, KavanaughArthur F, SharpJohn T, TannenbaumHyman, HuaYe, TeohLeah S, FischkoffSteven A, ChartashElliot K

RA treatment

This study investigated the effects of adalimumab, a medication that blocks tumor necrosis factor (TNF), in patients with active rheumatoid arthritis (RA) who were also taking methotrexate (MTX). The study aimed to see if adalimumab could slow down joint damage, reduce symptoms, and improve physical function in these patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Retardation of joint damage in patients with early rheumatoid arthritis by initial aggressive treatment with disease-modifying antirheumatic drugs: five-year experience from the FIN-RACo study.

Author: KorpelaMarkku, LaasonenLeena, HannonenPekka, KautiainenHannu, Leirisalo-RepoMarjatta, HakalaMarkku, PaimelaLeena, BlåfieldHarri, PuolakkaKari, MöttönenTimo,

Improved long-term outcome
Limited joint damage

This study evaluated the long-term effectiveness of combination DMARD therapy versus single DMARD therapy in patients with early rheumatoid arthritis (RA). The study found that combination DMARD therapy for the first two years significantly limited peripheral joint damage for at least five years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial.

Author: GrigorCatriona, CapellHilary, StirlingAnne, McMahonAlex D, LockPeter, VallanceRamsay, KincaidWilma, PorterDuncan

Improved outcome in RA

While medications are used to treat rheumatoid arthritis (RA), many patients don’t respond well. This study aims to determine if a more intensive outpatient program, focusing on closely managing disease activity, is more effective than standard outpatient care.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial.

Author: St ClairE William, van der HeijdeDésirée M F M, SmolenJosef S, MainiRavinder N, BathonJoan M, EmeryPaul, KeystoneEdward, SchiffMichael, KaldenJoachim R, WangBen, DewoodyKimberly, WeissRoberta, BakerDaniel,

RA treatment
Pneumonia
Serious infections

Combination therapy with methotrexate (MTX) and infliximab provides greater clinical, radiographic, and functional benefits than MTX alone for patients with active rheumatoid arthritis (RA) in its early stages. However, infliximab therapy is associated with a significantly higher incidence of serious infections, especially pneumonia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial.

Author: QuinnMark A, ConaghanPhilip G, O'ConnorPhilip J, KarimZunaid, GreensteinAdam, BrownAndrew, BrownClare, FraserAlexander, JarretStephen, EmeryPaul

Rheumatoid arthritis treatment

This 12-month study investigated the effectiveness of using infliximab (an anti-TNFalpha drug) in combination with standard treatment to achieve remission in patients with early rheumatoid arthritis (RA) who had a poor prognosis. The study primarily looked at joint inflammation (synovitis) using MRI and continued follow-up for another 12 months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

The British Rheumatoid Outcome Study Group (BROSG) randomised controlled trial to compare the effectiveness and cost-effectiveness of aggressive versus symptomatic therapy in established rheumatoid arthritis.

Author: SymmonsD, TrickerK, RobertsC, DaviesL, DawesP, ScottD L

Improved disease activity
Symptom control
Deterioration in function

A trial comparing symptomatic and aggressive treatment for established, stable rheumatoid arthritis (RA) showed no benefit of aggressive treatment. Symptomatic treatment was more cost-effective.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial.

Author: Goekoop-RuitermanY P M, de Vries-BouwstraJ K, AllaartC F, van ZebenD, KerstensP J S M, HazesJ M W, ZwindermanA H, RondayH K, HanK H, WestedtM L, GerardsA H, van GroenendaelJ H L M, LemsW F, van KrugtenM V, BreedveldF C, DijkmansB A C

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

While several treatments for rheumatoid arthritis (RA) have shown benefits, the best approach for preventing long-term joint damage and decline in function is still unclear. This study compares the clinical and radiological outcomes of four different treatment strategies with close monitoring of all patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Patients with stable long-standing rheumatoid arthritis continue to deteriorate despite intensified treatment with traditional disease modifying anti-rheumatic drugs--results of the British Rheumatoid Outcome Study Group randomized controlled clinical trial.

Author: SymmonsD, TrickerK, HarrisonM, RobertsC, DavisM, DawesP, HassellA, KnightS, MulherinD, ScottD L,

RA treatment
C-reactive protein levels
HAQ deterioration

The trial showed no additional benefit of intensified treatment with traditional disease modifying anti-rheumatic drugs (DMARDs) in patients with stable, established rheumatoid arthritis. Pending further evidence, the model of shared care with annual hospital review is as good as 4-monthly hospital review for these patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Infliximab treatment maintains employability in patients with early rheumatoid arthritis.

Author: SmolenJosef S, HanChenglong, van der HeijdeDésirée, EmeryPaul, BathonJoan M, KeystoneEdward, KaldenJoachim R, SchiffMichael, BalaMohan, BakerDaniel, HanJohn, MainiRavinder N, St ClairE William

Improve employability

Patients with early RA who were treated with MTX plus infliximab had a higher probability of maintaining their employability compared with those who were treated with MTX alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience.

Author: MorelandLarry W, WeinblattMichael E, KeystoneEdward C, KremerJoel M, MartinRichard W, SchiffMichael H, WhitmoreJames B, WhiteBarbara W

Durable clinical responses
Cancer
Death
Serious adverse events
Serious infections

The safety profile of etanercept was consistent over time, with rates of adverse events similar to those reported for patients with RA in general. Durable clinical responses were observed in some patients for 7 years or more.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.

Author: van der HeijdeDésirée, KlareskogLars, Rodriguez-ValverdeVicente, CodreanuCatalin, BolosiuHoratiu, Melo-GomesJose, Tornero-MolinaJesus, WajdulaJoseph, PedersenRonald, FatenejadSaeed,

Improved function
Reduced disease activity
Slowed radiographic progression

Etanercept in combination with methotrexate (MTX) was more effective than either monotherapy in reducing disease activity, slowing radiographic progression, and improving function in patients with rheumatoid arthritis (RA) over a 2-year period. No increase in toxicity was associated with combination treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Sustained remission and reduced radiographic progression with combination disease modifying antirheumatic drugs in early rheumatoid arthritis.

Author: MäkinenHeidi, KautiainenHannu, HannonenPekka, MöttönenTimo, Leirisalo-RepoMarjatta, LaasonenLeena, KorpelaMarkku, BlåfieldHarri, HakolaMikko, SokkaTuulikki

Sustained remission
Radiographic progression

Combination therapy with disease-modifying antirheumatic drugs (DMARD) led to a higher rate of remission at 2 years in patients with early rheumatoid arthritis compared to single DMARD therapy. Remission was more likely to be sustained with combination therapy. Sustained remission was associated with protection against radiographic joint damage.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial.

Author: Goekoop-RuitermanYvonne P M, de Vries-BouwstraJeska K, AllaartCornelia F, van ZebenDerkjen, KerstensPit J S M, HazesJ Mieke W, ZwindermanAelko H, PeetersAndré J, de Jonge-BokJohanna M, MalléeConstant, de BeusWim M, de SonnavillePeter B J, EwalsJacques A P M, BreedveldFerdinand C, DijkmansBen A C

Reduced joint damage
Rheumatoid arthritis treatment
Combination therapy withdrawal

Initial combination therapies in patients with early rheumatoid arthritis may provide earlier clinical improvement and less progression of joint damage, but all treatment strategies eventually showed similar clinical improvements. This randomized controlled trial involving 508 patients found that all treatment groups, including those receiving sequential monotherapy, step-up combination therapy, and initial combination therapy, showed significant improvements in functional ability and disease activity after two years.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis.

Author: RupertoNicolino, LovellDaniel J, CutticaRuben, WilkinsonNick, WooPatricia, EspadaGraciela, WoutersCarine, SilvermanEarl D, BaloghZsolt, HenricksonMichael, ApazMaria-Teresa, BaildamEileen, FasthAnders, GerloniValeria, LahdennePekka, PrieurAnne-Marie, RavelliAngelo, SaurenmannRotraud K, GamirMaria Luz, WulffraatNico, MarodiLaszlo, PettyRoss E, JoosRik, ZulianFrancesco, McCurdyDeborah, MyonesBarry L, NagyKalman, ReumanPeter, SzerIlona, TraversSuzanne, BeutlerAnna, KeenanGreg, ClarkJason, VisvanathanSudha, FasanmadeAdedigbo, RaychaudhuriAparna, MendelsohnAlan, MartiniAlberto, GianniniEdward H,

JRA treatment
Antibodies to infliximab
Infusion reactions

Infliximab showed durable efficacy for juvenile rheumatoid arthritis (JRA) at 1 year, with both the 3 mg/kg and 6 mg/kg doses achieving significant improvements in disease activity. However, the 3 mg/kg dose was associated with more frequent serious adverse events, infusion reactions, and antibody development, suggesting a more favorable risk/benefit profile for the 6 mg/kg dose.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Factorial randomised controlled trial of glucocorticoids and combination disease modifying drugs in early rheumatoid arthritis.

Author: ChoyE H S, SmithC M, FarewellV, WalkerD, HassellA, ChauL, ScottD L,

Improved outcomes

This study compares different treatment approaches for early rheumatoid arthritis (RA), considering the need for more aggressive treatment compared to using a single medication. The study aims to determine the relative effectiveness of combining two medications, one medication with steroids, and two medications with steroids in treating RA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

[Rituximab in patients with rheumatoid arthritis: systematic review].

Author: BrodszkyValentin, CzirjákLászló, GéherPál, HodinkaLászló, KárpátiKrisztián, PéntekMárta, PoórGyula, SzekaneczZoltán, GulácsiLászló

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Biological treatments are a newer approach to treating rheumatoid arthritis (RA). Three medications that block tumor necrosis factor (TNF) -- adalimumab, etanercept, and infliximab -- are approved for RA in Hungary. Rituximab, a medication that targets B cells, is a newer biological treatment that has been used for lymphoma and is now approved for RA in patients who have not responded to TNF blockers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Hungarian

39.

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial.

Author: Goekoop-RuitermanY P M, de Vries-BouwstraJ K, AllaartC F, van ZebenD, KerstensP J S M, HazesJ M W, ZwindermanA H, RondayH K, HanK H, WestedtM L, GerardsA H, van GroenendaelJ H L M, LemsW F, van KrugtenM V, BreedveldF C, DijkmansB A C

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

While several treatments for rheumatoid arthritis (RA) have shown benefits, the best approach for preventing long-term joint damage and decline in function is still unclear. This study compares the clinical and radiological outcomes of four different treatment strategies with close monitoring of all patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

WITHDRAWN: Dynamic exercise therapy for treating rheumatoid arthritis.

Author: Van den EndeC H M, Vliet VlielandT P M, MunnekeM, HazesJ M W

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting joints and tendons, causing pain, swelling, and limited movement, eventually leading to joint damage. Exercise therapy is a crucial part of RA treatment at all stages of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies.

Author: KeystoneE, EmeryP, PeterfyC G, TakP P, CohenS, GenoveseM C, DougadosM, BurmesterG R, GreenwaldM, KvienT K, WilliamsS, HagertyD, CravetsM W, ShawT

Inhibition of joint damage progression

Rituximab treatment caused significant reduction in joint damage progression compared with placebo in patients with rheumatoid arthritis.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

43.

Infliximab and methotrexate in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of dosage regimens.

Author: ZintzarasElias, DahabrehIssa J, GiannouliStavroula, VoulgarelisMichael, MoutsopoulosHaralampos M

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Methotrexate (MTX) is the preferred medication for treating active rheumatoid arthritis (RA), due to its long-term effectiveness. However, many patients don't achieve complete remission and continue to have symptoms even at the highest tolerated dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Anakinra for rheumatoid arthritis.

Author: MertensMarty, SinghJasvinder A

Improved rheumatoid arthritis treatment
Rheumatoid arthritis

Newer treatments called "biologics" that target specific inflammation-causing molecules in rheumatoid arthritis (RA) have significantly improved treatment options. Anakinra, a medication that blocks interleukin-1, is approved by the FDA for moderate to severe RA that hasn't responded to standard treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Withdrawal of disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a systematic review and meta-analysis.

Author: O'MahonyRachel, RichardsAlison, DeightonChris, ScottDavid

Disease flare

Patients who withdrew from DMARD had a significantly worse risk of disease flare or deterioration than those who continued DMARD treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Rheumatoid arthritis.

Author: Walker-BoneKaren, FarrowSarah

Improved function
Pain relief
Infection risk
Liver damage

Several drug treatments are available for rheumatoid arthritis, including adalimumab, anakinra, antimalarial drugs, azathioprine, ciclosporin, corticosteroids, cyclophosphamide, etanercept, infliximab plus methotrexate, leflunomide, methotrexate (alone; or plus sulfasalazine plus hydroxychloroquine), oral gold, parenteral gold, penicillamine, and sulfasalazine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Use of risk stratification to target therapies in patients with recent onset arthritis; design of a prospective randomized multicenter controlled trial.

Author: ClaessenSusanne J J, HazesJohanna M W, HuismanMargriet A M, van ZebenDerkjen, LuimeJolanda J, WeelAngelique E A M

RA treatment
Over-treatment

Early and intensive treatment is key for achieving remission and preventing joint damage in people with rheumatoid arthritis. While combined treatments are most effective, doctors often start with methotrexate and short-term steroids. Intensive treatment should begin as soon as the first symptoms appear, but at this early stage, the criteria for diagnosis might not be met, which could lead to overtreatment. This study aims to determine the best initial treatment for people with early signs of persistent arthritis. To avoid both overtreatment and undertreatment, the intensity of treatment will be based on a prediction model that identifies people who are likely to develop persistent arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

48.

Therapeutic options for rheumatoid arthritis.

Author: FeelyMichael G, EricksonAlan, O'DellJames R

RA treatment

Rheumatoid arthritis (RA) is a chronic inflammatory condition that mainly affects the lining of joints. Untreated RA can lead to significant illness and a higher risk of death. New understanding of how RA works and new treatments have expanded the options for managing RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial.

Author: van VollenhovenR F, ErnestamS, GeborekP, PeterssonI F, CösterL, WaltbrandE, ZickertA, TheanderJ, ThörnerA, HellströmH, TelemanA, DackhammarC, AkreF, ForslindK, LjungL, OdingR, ChatzidionysiouA, WörnertM, BrattJ

RA treatment

New treatments for early rheumatoid arthritis are rapidly developing. This study compares the effects of adding either standard medications (sulfasalazine and hydroxychloroquine) or a TNF-inhibitor (infliximab) to methotrexate in people with early rheumatoid arthritis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial).

Author: EmeryP, DurezP, DougadosM, LegertonC W, BeckerJ-C, VratsanosG, GenantH K, PeterfyC, MitraP, OverfieldS, QiK, WesthovensR

UA/early RA treatment

Abatacept delayed progression of UA/very early RA in some patients. It inhibited radiographic and MRI progression and this effect was maintained for 6 months after treatment stopped.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Surgical interventions for the rheumatoid shoulder.

Author: ChristieAnne, DagfinrudHanne, Engen MatreKari, FlaattenHilde Iren, Ringen OsnesHanne, HagenKåre Birger

Improved function
Improved pain
Complications
Paucity of trials

The effects of surgical treatment for shoulder involvement in rheumatoid arthritis (RA) are largely unknown due to limited randomized controlled trials. One trial suggested that augmented subscapularis transposition may be more effective than subscapularis transposition alone in improving function and reducing pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

The Stop Arthritis Very Early (SAVE) trial, an international multicentre, randomised, double-blind, placebo-controlled trial on glucocorticoids in very early arthritis.

Author: MacholdKlaus P, LandewéRobert, SmolenJosef S, StammTanja A, van der HeijdeDésirée M, VerpoortKirsten N, BrickmannKerstin, Vázquez-MelladoJanitzia, KarateevDimitri E, BreedveldFerdinand C, EmeryPaul, HuizingaThomas W J

No delay in RA development
No effect on remission

Glucocorticoids did not delay remission or the development of rheumatoid arthritis (RA). Remission was rare in the first year of very early arthritis. Glucocorticoid treatment did not influence the need to start disease-modifying antirheumatic drugs (DMARDs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

Evidence for treating rheumatoid arthritis to target: results of a systematic literature search.

Author: SchoelsMonika, KnevelRachel, AletahaDaniel, BijlsmaJohannes W J, BreedveldFerdinand C, BoumpasDimitrios T, BurmesterGerd, CombeBernard, CutoloMaurizio, DougadosMaxime, EmeryPaul, van der HeijdeDesirée, HuizingaTom W J, KaldenJoachim, KeystoneEdward C, KvienTore K, Martin-MolaEmilio, MontecuccoCarlomaurizio, de WitMaarten, SmolenJosef S

Better clinical outcomes

This systematic review examined the evidence for a target-oriented approach to treating rheumatoid arthritis (RA). Seven strategic clinical trials were identified, all of which showed significantly better clinical outcomes with targeted approaches compared to routine approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

54.

Current evidence for a strategic approach to the management of rheumatoid arthritis with disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis.

Author: KnevelR, SchoelsM, HuizingaT W J, AletahaD, BurmesterG R, CombeB, LandewéR B, SmolenJ S, SokkaT, van der HeijdeD M F M

Improved clinical outcome
Improved physical function
Reduced structural damage

The study found that both intensive steering strategies and intensive medication strategies resulted in better clinical outcomes, improved physical function, and less structural damage than less intensive strategies in patients with early active rheumatoid arthritis (RA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis: the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial.

Author: RantalaihoVappu, KorpelaMarkku, LaasonenLeena, KautiainenHannu, JärvenpääSalme, HannonenPekka, Leirisalo-RepoMarjatta, BlåfieldHarri, PuolakkaKari, KarjalainenAnna, MöttönenTimo,

RA treatment

Early and intensive treatment for rheumatoid arthritis (RA) has been shown to slow joint damage for up to 5 years. This study examines the progression of joint damage beyond that time in people with early RA who initially received either a combination of three disease-modifying antirheumatic drugs (DMARDs) or a single DMARD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.

Author: TakP P, RigbyW F, Rubbert-RothA, PeterfyC G, van VollenhovenR F, StohlW, HesseyE, ChenA, TyrrellH, ShawT M,

Improved clinical outcomes
Reduced joint damage

This study assessed the efficacy and safety of rituximab in combination with methotrexate (MTX) for treating rheumatoid arthritis (RA). Rituximab 2×1000 mg + MTX was effective in reducing joint damage and improving clinical outcomes compared to MTX alone.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomised study over 21 months.

Author: EngvallInga-Lill, TengstrandBirgitta, BrismarKerstin, HafströmIngiäld

RA treatment

Rheumatoid arthritis (RA) can affect body composition and bone density. This study investigated whether medications that block tumor necrosis factor (TNF) could improve body composition and bone density in people with early RA, beyond the benefits of a combination of other medications that modify disease progression (DMARDs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Indirect comparisons of the efficacy of biological antirheumatic agents in rheumatoid arthritis in patients with an inadequate response to conventional disease-modifying antirheumatic drugs or to an anti-tumour necrosis factor agent: a meta-analysis.

Author: SalliotCarine, FinckhAxel, KatchamartWanruchada, LuYan, SunYe, BombardierClaire, KeystoneEdward

RA treatment

There are many new biological treatments available for rheumatoid arthritis (RA), but we don't have enough direct comparisons to know which one is best. This study aimed to compare the effectiveness of different biological drugs (anti-TNF agents, rituximab, abatacept, tocilizumab) in people with active RA who didn't respond well to methotrexate or anti-TNF treatments, using indirect comparisons.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

59.

[Large-joint synovectomy in the era of biological therapies].

Author: CarlH-D, RechJ

RA treatment

Since the mid-1980s, there's been a significant decline in joint-related surgeries for rheumatoid arthritis (RA), including joint replacements and procedures to preserve joints. This is due to advancements in early RA management and the development of more effective medical treatments. This review examines the current trends in orthopedic surgery for RA patients and explores the role of synovectomy, a procedure to remove inflamed joint lining, in the hips, knees, and shoulders in the era of biological RA therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

60.

Tumor necrosis factor therapy and the risk of serious infection and malignancy in patients with early rheumatoid arthritis: a meta-analysis of randomized controlled trials.

Author: ThompsonAndrew E, RiederScott W, PopeJanet E

No increased risk of infection
No increased risk of malignancy

Anti-tumor necrosis factor (anti-TNF) therapy did not increase the risk of serious infection or malignancy in patients with early rheumatoid arthritis (RA) who had not received treatment with disease-modifying antirheumatic drugs (DMARDs) or methotrexate (MTX).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor: a systematic review and economic evaluation.

Author: MalottkiK, BartonP, TsourapasA, UthmanA O, LiuZ, RouthK, ConnockM, JobanputraP, MooreD, Fry-SmithA, ChenY-F

Cost-effective
Improved RA

RTX and ABT are more effective than supportive care in patients with RA who have tried conventional agents and have failed to improve after trying a first tumour necrosis factor (TNF) inhibitor. At 6 months significantly more patients treated with RTX achieved ACR 20 [relative risk (RR) = 2.85, 95% confidence interval (CI) 2.08 to 3.91] and ACR70 (RR = 12.14, 95% CI 2.96 to 49.86) compared with those treated with the placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Greater remission rates in patients with early versus long-standing disease in biologic-naive rheumatoid arthritis patients treated with abatacept: a post hoc analysis of randomized clinical trial data.

Author: YaziciY, Moniz ReedD, KlemC, RosenblattL, WuG, KremerJ M

RA treatment

The goal of rheumatoid arthritis (RA) treatment is to achieve remission in as many patients as possible. This study compares the rates of remission and treatment outcomes in patients with early-onset RA (less than 10 years) and those with long-standing RA (10 years or more) who were treated with abatacept, a biologic drug, after not responding to methotrexate (MTX).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

63.

[Consensus on the Use of Rituximab in Rheumatoid Arthritis. A document with evidence-based recommendations. Grupo de Expertos en Rituximab. ].

Author: Martín MolaEmilio, HernándezBlanca, García-AriasMiriam, Alvaro-GraciaJosé María, BalsaAlejandro, ReinoJuan Gómez, Marenco de la FuenteJosé L, Martínez-TaboadaVíctor, IvorraJosé Andrés Román, SanmartíRaimon,

RA treatment

Recommendations for the use of rituximab in treating rheumatoid arthritis (RA) were established based on expert opinions and systematic reviews. While efficacy recommendations have a high degree of evidence, safety recommendations have a lower degree of evidence.

Consensus Development ConferenceA conference organized by the National Institutes of Health (NIH) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Spanish

64.

Should anti-TNF therapy be discontinued in rheumatoid arthritis patients undergoing elective orthopaedic surgery? A systematic review of the evidence.

Author: GohLeslie, JewellTeresa, LaversuchCatherine, SamantaAsh

Improved RA management
Increased infection risk

This study examines the impact of anti-TNF medications, which are widely used to treat rheumatoid arthritis (RA), on the risk of infection in RA patients undergoing surgery. While these medications are effective, there is conflicting information about their effects on infection risk. Studies suggest that patients taking anti-TNF medications may have a higher risk of infection, particularly early in treatment. The study recommends that these medications be stopped before surgery, but notes the risk of the disease flaring up again after treatment is restarted.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Indirect comparison of biological treatments in refractory rheumatoid arthritis.

Author: Gallego-GalisteoM, Villa-RubioA, Alegre-del ReyE, Márquez-FernándezE, Ramos-BáezJ J

Treatment of rheumatoid arthritis

Several biological treatments are available for rheumatoid arthritis (RA). This study compared the effectiveness of seven biological medications (adalimumab, etanercept, infliximab, abatacept, tocilizumab, golimumab, and certolizumab pegol) in patients with RA who did not respond well to previous standard medications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Effect of TNF inhibitors on lipid profile in rheumatoid arthritis: a systematic review with meta-analysis.

Author: DaïenClaire Immediato, DunyYohan, BarnetcheThomas, DaurèsJean-Pierre, CombeBernard, MorelJacques

Improved RA management

People with rheumatoid arthritis (RA) have a higher risk of heart disease. RA is associated with changes in blood fats due to inflammation. TNF-blocking medications (TNFi) are effective in reducing inflammation and heart problems in RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial.

Author: BakkerMarije F, JacobsJohannes W G, WelsingPaco M J, VerstappenSuzanne M M, TekstraJanneke, TonEvelien, GeurtsMonique A W, van der WerfJacobine H, van Albada-KuipersGrietje A, Jahangier-de VeenZalima N, van der VeenMaaike J, VerhoefCatharina M, LafeberFloris P J G, BijlsmaJohannes W J,

Improved remission
Reduced disability
Reduced disease activity
Reduced joint damage
Reduced need for additional drugs
Adverse events

Adding low-dose prednisone to a methotrexate (MTX)-based treatment strategy for tight control in early rheumatoid arthritis (RA) improves patient outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor.

Author: Navarro-MillánIris, SinghJasvinder A, CurtisJeffrey R

Treatment of rheumatoid arthritis

Tocilizumab (TCZ) is a new medication for rheumatoid arthritis (RA) patients who have not responded well to other treatments, like anti-TNF therapies. It blocks a specific inflammatory protein in the body.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial.

Author: MorelandLarry W, O'DellJames R, PaulusHarold E, CurtisJeffrey R, BathonJoan M, St ClairE William, BridgesS Louis, ZhangJie, McVieTheresa, HowardGeorge, van der HeijdeDésirée, CofieldStacey S,

Treatment of early RA

This study compares two approaches to treating early rheumatoid arthritis (RA): 1. **Intensive treatment:** All patients receive a combination of medications from the start. 2. **Step-up approach:** Patients initially receive a single medication (methotrexate, MTX). If their disease activity remains high after 24 weeks, they are switched to combination therapy. The study also investigates whether combining MTX with etanercept (a type of biologic drug) is more effective than combining MTX with sulfasalazine and hydroxychloroquine (two commonly used medications).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Etanercept for the treatment of rheumatoid arthritis.

Author: LethabyAnne, Lopez-OlivoMaria Angeles, MaxwellLara, BurlsAmanda, TugwellPeter, WellsGeorge A

ACR50 response
Disease remission
Physical function improvement
RA treatment
Radiographic progression slowing
Infections
Withdrawals

An updated Cochrane systematic review of 2842 participants found that etanercept 25 mg administered subcutaneously twice weekly together with methotrexate (MTX) was more efficacious than either etanercept or MTX monotherapy for ACR50 response and it slowed joint radiographic progression after up to three years of treatment for all participants. There was no evidence of a difference in the rates of infections between groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Therapies for active rheumatoid arthritis after methotrexate failure.

Author: O'DellJames R, MikulsTed R, TaylorThomas H, AhluwaliaVandana, BrophyMary, WarrenStuart R, LewRobert A, CannellaAmy C, KunkelGary, PhibbsCiaran S, AnisAslam H, LeathermanSarah, KeystoneEdward,

RA treatment

There are limited studies that directly compare conventional treatments (combinations of medications) with biologic drugs in rheumatoid arthritis (RA) patients whose disease isn't adequately controlled by methotrexate, a common situation in managing RA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, American Recovery and Reinvestment ActResearch and economic activity support funds provided under the American Recovery and Reinvestment Act of 2009.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

72.

Biological vs. conventional combination treatment and work loss in early rheumatoid arthritis: a randomized trial.

Author: ErikssonJonas K, NeoviusMartin, BrattJohan, PeterssonIngemar F, van VollenhovenRonald F, GeborekPierre, ErnestamSofia

RA treatment

New medications that block tumor necrosis factor (TNF) have improved treatment for rheumatoid arthritis (RA) but are expensive. These medications have shown better long-term results for joint damage compared to conventional medications after 2 years of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

Remission induction comparing infliximab and high-dose intravenous steroid, followed by treat-to-target: a double-blind, randomised, controlled trial in new-onset, treatment-naive, rheumatoid arthritis (the IDEA study).

Author: NamJ L, VilleneuveE, HensorE M A, ConaghanP G, KeenH I, BuchM H, GoughA K, GreenM J, HelliwellP S, KeenanA M, MorganA W, QuinnM, ReeceR, van der HeijdeD M, WakefieldR J, EmeryP

DAS28 remission
DAS44 remission
Radiographic non-progression
Reduced synovitis
Remission induction

Methotrexate (MTX) plus intravenous corticosteroid was comparable to MTX plus infliximab (IFX) in early rheumatoid arthritis (RA), with both achieving good disease control.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

74.

The mid-term outcome of total ankle arthroplasty and ankle fusion in rheumatoid arthritis: a systematic review.

Author: van HeiningenJacqueline, Vliet VlielandThea P M, van der HeideHuub J L

Clinical improvement
Improved ankle function
Implant failure
Non-union

A review of 17 observational studies on the effectiveness of arthroplasty or arthrodesis of the ankle in rheumatoid arthritis showed that both interventions demonstrate clinical improvement. While neither procedure appears to be superior to the other, the methodological quality of the studies was low, necessitating further research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

Safety of anti-tumor necrosis factor agents in psoriatic arthritis - an update.

Author: PalazziCarlo, D'AngeloSalvatore, LeccesePietro, PadulaAngela, OlivieriIgnazio

PsA treatment

Medications that block tumor necrosis factor (TNF) have revolutionized treatment for rheumatoid arthritis and spondyloarthritides (SpAs). For psoriatic arthritis (PsA), these medications are much more effective than conventional treatments in addressing all aspects of the disease, including spine, joints, tendons, fingers, and skin lesions. Understanding their safety is crucial for doctors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

A double-blind, randomized controlled trial to compare the effect of biannual peripheral magnetic resonance imaging, radiography and standard of care disease progression monitoring on pharmacotherapeutic escalation in rheumatoid and undifferentiated inflammatory arthritis: study protocol for a randomized controlled trial.

Author: TavaresRuben, BeattieKaren Anne, BensenWilliam George, BobbaRaja S, CividinoAlfred A, FinlayKaren, GoereeRon, HartLawrence Errol, JurriaansErik, LarcheMaggie J, ParasuNaveen, TarrideJean-Eric, WebberColin E, AdachiJonathan D

RA treatment

Rheumatoid arthritis (RA) can cause serious joint damage, sometimes within months of the first symptoms. Early treatment with medications can slow the progression of joint damage. This study investigates whether using MRI or X-rays to guide treatment decisions by rheumatologists for RA is better than relying on standard care alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

77.

Rituximab for rheumatoid arthrits treatment: a systematic review.

Author: de LemosLívia Lovato Pires, CostaJuliana de Oliveira, MachadoMarina Amaral de Ávila, AlmeidaAlessandra Maciel, BarbosaMariana Michel, KakehasiAdriana Maria, de AraújoVânia Eloísa, Guerra JúniorAugusto Afonso, AcurcioFrancisco de Assis

RA treatment

Rheumatoid arthritis (RA) is a chronic condition that causes inflammation in the joints, leading to disability. While several medications have proven effective, some patients don't respond well. Rituximab, a type of antibody medication, is used for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Down-titration and discontinuation strategies of tumor necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity.

Author: van HerwaardenNoortje, den BroederAlfons A, JacobsWilco, van der MaasAatke, BijlsmaJohannes W J, van VollenhovenRonald F, van den BemtBart J F

Anti-tumor necrosis factor agents
Rheumatoid arthritis

While anti-TNF medications are effective for rheumatoid arthritis (RA), they can have side effects and are expensive. This study explores the effectiveness of reducing the dose of these medications (down-titration) compared to continuing the standard dose to determine if lower doses can still provide benefits while reducing potential side effects and costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Failure in longterm treatment is rare in actively treated patients with rheumatoid arthritis, but may be predicted by high health assessment score at baseline and by residual disease activity at 3 and 6 months: the 5-year followup results of the randomized clinical NEO-RACo trial.

Author: RantalaihoVappu, KautiainenHannu, JärvenpääSalme, KorpelaMarkku, MalmiTimo, HannonenPekka, Kaipiainen-SeppänenOili, Yli-KerttulaTimo, MöttönenTimo, MustilaAnu, KarjalainenAnna, PaimelaLeena, UutelaToini, Leirisalo-RepoMarjatta,

RA treatment

While new treatments for rheumatoid arthritis (RA) have improved outcomes for most patients, some people still don't achieve remission, experience joint damage, and have limitations in function. This study aims to identify the factors that contribute to poor outcomes even with aggressive treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

80.

Randomised controlled trial of tumour necrosis factor inhibitors against combination intensive therapy with conventional disease-modifying antirheumatic drugs in established rheumatoid arthritis: the TACIT trial and associated systematic reviews.

Author: ScottDavid L, IbrahimFowzia, FarewellVern, O'KeeffeAidan G, MaMargaret, WalkerDavid, HeslinMargaret, PatelAnita, KingsleyGabrielle

Equivalent clinical benefits
Lower costs
Limited remission
Serious adverse events

Combination disease-modifying antirheumatic drugs (cDMARDs) were found to be as effective as tumor necrosis factor inhibitors (TNFis) in treating rheumatoid arthritis (RA), but at a lower cost. Patients who initially received cDMARDs experienced greater reductions in HAQ scores and increases in EQ-5D scores at 12 months. Both cDMARDs and TNFis resulted in similar rates of DAS28 remission.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

81.

Coronary Artery Disease Evaluation in Rheumatoid Arthritis (CADERA): study protocol for a randomized controlled trial.

Author: ErhayiemBara, PavittSue, BaxterPaul, AndrewsJacqueline, GreenwoodJohn P, BuchMaya H, PleinSven

Improved RA management
Potential for CVD prevention
RA treatment
Needs further research
Unclear benefits of TNFi

People with rheumatoid arthritis (RA) have a higher risk of heart disease than the general population. While early treatment and tight control of RA are important, it's not yet clear whether using TNF inhibitors, a specific type of medication, to achieve remission in RA offers additional benefits for preventing heart disease compared to standard treatment.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

82.

The 'Switch' study protocol: a randomised-controlled trial of switching to an alternative tumour-necrosis factor (TNF)-inhibitor drug or abatacept or rituximab in patients with rheumatoid arthritis who have failed an initial TNF-inhibitor drug.

Author: Navarro CoyNuria C, BrownSarah, BosworthAilsa, DaviesClaire T, EmeryPaul, EverettColin C, FernandezCatherine, GrayJanine C, HartleySuzanne, HulmeClaire, KeenanAnne-Maree, McCabeChristopher, RedmondAnthony, ReynoldsCatherine, ScottDavid, SharplesLinda D, PavittSue, BuchMaya H

bDMARDs
Rheumatoid arthritis

Rheumatoid arthritis (RA) is a common autoimmune disease affecting 1% of adults in the UK. While several new treatments (bDMARDs) exist, there is limited information on the best order to use them. The SWITCH trial aims to determine if other medications (a different TNF-inhibitor or abatacept) are as effective as rituximab in patients with RA who have not responded well to an initial TNF-inhibitor. The study highlights the need for more research to guide treatment decisions in patients with RA.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

83.

[The quality of life in patients with rheumatoid arthritis treated with rituximab].

Author: MazurovV I, AvlokhovaS R

Rituximab
Rheumatoid arthritis

This study compared the impact of two treatments for rheumatoid arthritis (RA) on quality of life: rituximab combined with methotrexate and methotrexate alone. Both groups showed a significant improvement in quality of life after one year of treatment. Rituximab was used in patients who hadn't responded well to other medications called TNF-α inhibitors.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

84.

Combination Therapy With and Without Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Trials.

Author: GraudalNiels, Hubeck-GraudalThorbjørn, FaurschouMikkel, BaslundBo, JürgensGesche

Biologic agents
Rheumatoid arthritis

This study compared the effectiveness of standard medications for rheumatoid arthritis (RA) with and without the addition of biologic drugs. Biologic drugs are significantly more expensive, costing about 100 times more than standard medications, but their effectiveness has not been proven to be superior.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

85.

Balneotherapy (or spa therapy) for rheumatoid arthritis. An abridged version of Cochrane Systematic Review.

Author: VerhagenA P, Bierma-ZeinstraS M, BoersM, CardosoJ R, LambeckJ, De BieR, De VetH C

Ineffective treatment

This systematic review evaluated the benefits and harms of balneotherapy in patients with rheumatoid arthritis (RA). The overall evidence was insufficient to show that balneotherapy was more effective than no treatment, or one type of bath was more effective than another.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Are All Biologics the Same? Optimal Treatment Strategies for Patients With Early Rheumatoid Arthritis: Systematic Review and Indirect Pairwise Meta-Analysis.

Author: AlbertDaniel A

RA treatment

A meta-analysis of six randomized controlled trials found that biologic agents in conjunction with a DMARD performed similarly in DMARD-naive RA patients. However, etanercept 50 mg appeared superior to adalimumab 40 mg, golimumab 50 mg, and infliximab 3 and 6 mg/kg at ACR20. Rituximab 1000 mg and etanercept 50 mg appeared superior to golimumab 100 mg at ACR50.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Trial-based cost-effectiveness of abatacept for rheumatoid arthritis patients in Italy.

Author: GaultneyJ, BenucciM, IannazzoS, NappiC, SionK, SabaterF J

Lower total costs

A cost-consequence analysis assessing the cost-effectiveness of abatacept relative to adalimumab for rheumatoid arthritis (RA) in Italy found that abatacept had lower total costs and health gains based on more stringent efficacy criteria. The health economic value of abatacept compared with adalimumab depended on the choice of health outcome.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Long-Term Outcomes of Patients With Recent-Onset Rheumatoid Arthritis After 10 Years of Tight Controlled Treatment: A Randomized Trial.

Author: MarkusseIris M, AkdemirGülsah, DirvenLinda, Goekoop-RuitermanYvonne P M, van GroenendaelJohannes H L M, HanK Huub, MolenaarT H Esmeralda, Le CessieSaskia, LemsWillem F, van der LubbePeter A H M, KerstensPit J S M, PeetersAndré J, RondayH Karel, de SonnavillePeter B J, SpeyerIrene, StijnenTheo, Ten WoldeSaskia, HuizingaTom W J, AllaartCornelia F

Drug-free remission
Functional improvement
Normalized survival
Radiographic damage prevention
Dropout rate

Initial combination therapy in patients with early rheumatoid arthritis resulted in faster clinical improvement, and targeted treatment determined long-term outcomes, with a 53% remission rate and a 14% drug-free remission rate after 10 years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

Comparative efficacy of biological agents in methotrexate-refractory rheumatoid arthritis patients: a Bayesian mixed treatment comparison.

Author: ChoiMiyoung, HyunMin Kyung, ChoiSeongmi, TchoeHa Jin, LeeSung Yeon, SonKyeong Min, KimMin-Jeong, JungYoung Ok, KimHyun Ah

Effective treatment
Improved RA
High cost
Long-term safety concerns

Biologic medications, which target inflammation, are effective treatments for rheumatoid arthritis (RA), but they are expensive and long-term safety concerns exist. This study compared the effectiveness of different biologic treatments to standard RA medications in patients who didn't respond to methotrexate (MTX).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

91.

High remission and low relapse with prolonged intensive DMARD therapy in rheumatoid arthritis (PRINT): A multicenter randomized clinical trial.

Author: LiRu, ZhaoJin-Xia, SuYin, HeJing, ChenLi-Na, GuFei, ZhaoCheng, DengXue-Rong, ZhouWei, HaoYan-Jie, XueYu, LiuHua-Xiang, ZhaoYi, ZouQing-Hua, LiuXiang-Yuan, ZhuPing, SunLing-Yun, ZhangZhuo-Li, ZouHe-Jian, LiXing-Fu, LiuYi, FangYong-Fei, KeystoneEdward, McInnesIain B, LiZhan-Guo

RA remission
Reduced RA flares

Intensive treatment with disease-modifying antirheumatic drugs can help patients with rheumatoid arthritis achieve remission. Patients who achieve remission have lower relapse rates. Leflunomide is a good option for maintenance treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

92.

Effectiveness of methotrexate with step-down glucocorticoid remission induction (COBRA Slim) versus other intensive treatment strategies for early rheumatoid arthritis in a treat-to-target approach: 1-year results of CareRA, a randomised pragmatic open-label superiority trial.

Author: VerschuerenPatrick, De CockDiederik, CorluyLuk, JoosRik, LangenakenChristine, TaelmanVeerle, RaemanFrank, RavelingienIsabelle, VandevyvereKlaas, LenaertsJan, GeensElke, GeusensPiet, VanhoofJohan, DurnezAnne, RemansJan, Vander CruyssenBert, Van EsscheEls, SileghemAn, De BrabanterGriet, JolyJohan, MeyfroidtSabrina, Van der ElstKristien, WesthovensRene

Effective treatment strategy
GC remission induction

This study examined different ways to combine disease-modifying antirheumatic drugs (DMARDs) with glucocorticoids (GCs) for treating early rheumatoid arthritis (ERA). The study looked at different combinations of DMARDs and strategies for using GCs to induce remission in patients with a poor prognosis. The study also examined the use of methotrexate (MTX) with or without GCs to induce remission in patients with a good prognosis. The study focused on the first year of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA).

Author: SinghJasvinder A, HossainAlomgir, Tanjong GhogomuElizabeth, MudanoAmy S, TugwellPeter, WellsGeorge A

This systematic review and network meta-analysis updated a previous Cochrane Overview on biologics for rheumatoid arthritis (RA), focusing on biologic monotherapy in patients who had failed treatment with traditional disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate (MTX).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Celecoxib for rheumatoid arthritis.

Author: FidahicMahir, Jelicic KadicAntonia, RadicMislav, PuljakLivia

RA treatment

Rheumatoid arthritis is a chronic autoimmune disorder that causes inflammation in joints and tendons. There is no cure, and treatment focuses on managing pain, stiffness, and mobility to achieve remission and improve function. Celecoxib is a medication used to treat rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

A systematic review on the role of eicosanoid pathways in rheumatoid arthritis.

Author: HoxhaMalvina

RA treatment

Rheumatoid arthritis is a condition where the body's immune system attacks the joints, causing inflammation, pain, and damage. While steroids and NSAIDs can reduce pain and inflammation, they don't stop the damage to cartilage and bone. Treatment options include disease-modifying medications, steroids, NSAIDs, and biological agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

The clinical effectiveness and cost-effectiveness of treat-to-target strategies in rheumatoid arthritis: a systematic review and cost-effectiveness analysis.

Author: WailooAllan, HockEmma S, StevensonMatt, Martyn-St JamesMarrissa, RawdinAndrew, SimpsonEmma, WongRuth, DracupNaila, ScottDavid L, YoungAdam

Improved RA treatment

"Treat to target" (TTT) is an approach for managing rheumatoid arthritis (RA) that involves setting clear goals for treatment, such as remission or low disease activity. This approach often includes regular checkups and rapid adjustments to medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial): study protocol for a randomised controlled trial.

Author: MartinNaomi H, IbrahimFowzia, TomBrian, GallowayJames, WailooAllan, ToshJonathan, LemppHeidi, ProtheroLouise, GeorgopoulouSofia, SturtJackie, ScottDavid L,

RA treatment

Untreated rheumatoid arthritis (RA) can worsen over time, causing disability and impacting quality of life. While aggressive treatment has been shown to be effective in early and established cases, there are no standard guidelines for people with RA who have moderate disease activity. This study aims to determine if intensive treatment for these patients leads to more remissions after 12 months. The study will also examine the impact on disability, quality of life, and the cost-effectiveness of this approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

98.

Medical Care Costs Associated With Rheumatoid Arthritis in the US: A Systematic Literature Review and Meta-Analysis.

Author: HreskoAndrew, LinTzu-Chieh, SolomonDaniel H

RA treatment

Rheumatoid arthritis (RA) is a serious and costly condition with no cure. Treatment options have expanded in recent years, including the use of biologic disease-modifying antirheumatic drugs (bDMARDs). This review examines the medical costs associated with different RA treatments, as there hasn't been a comprehensive review since the introduction of these new medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

99.

Do out-of-pocket costs affect medication adherence in adults with rheumatoid arthritis? A systematic review.

Author: HeidariParvaneh, CrossWendy, CrawfordKimberley

Biologic agents
RA treatment
Medication cost

People with chronic illnesses often struggle to manage their medications long-term, leading to non-adherence. While biologic medications have been a significant advancement for rheumatoid arthritis (RA), their high cost may limit their use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Early Targeted Combination Treatment With Conventional Synthetic Disease-Modifying Antirheumatic Drugs and Long-Term Outcomes in Rheumatoid Arthritis: Ten-Year Follow-Up Results of a Randomized Clinical Trial.

Author: RantalaihoVappu, SandströmTia, KoskiJuhani, HannonenPekka, MöttönenTimo, Kaipiainen-SeppänenOili, Yli-KerttulaTimo, KauppiMarkku J, UutelaToini, MalmiTimo, JulkunenHeikki, LaasonenLeena, KautiainenHannu, Leirisalo-RepoMarjatta,

Improved RA treatment

This study assessed the long-term outcomes of remission-targeted triple combination therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), prednisolone, and infliximab (IFX) or placebo for early rheumatoid arthritis (RA), examining the effectiveness of early add-on biologics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

101.

Update of French society for rheumatology recommendations for managing rheumatoid arthritis.

Author: DaienClaire, HuaCharlotte, Gaujoux-VialaCécile, CantagrelAlain, DubremetzMadeleine, DougadosMaxime, FautrelBruno, MarietteXavier, NayralNathalie, RichezChristophe, SarauxAlain, ThibaudGérard, WendlingDaniel, GossecLaure, CombeBernard

DMARD therapy
RA treatment
Tight disease control

New guidelines for managing rheumatoid arthritis (RA) emphasize the importance of shared decision-making between patients and doctors and a comprehensive approach that includes medication and non-medication treatments. Treatment should start as early as possible and aim to achieve remission, with methotrexate being the preferred initial medication. Treatment should be adjusted based on the patient's response and tolerance. While corticosteroids may be used in the short term, they should be gradually reduced once remission is achieved. Regular checkups for other health problems are also recommended.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

102.

Intensive therapy and remissions in rheumatoid arthritis: a systematic review.

Author: HughesCatherine D, ScottDavid L, IbrahimFowzia,

RA remission

A meta-analysis of 53 studies found that intensive treatment with combination DMARDs, biologics, or JAK inhibitors increased the frequency of remission in patients with rheumatoid arthritis compared to control non-intensive strategies. This benefit was observed in both early and established rheumatoid arthritis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews.

Author: ArcherRachel, HockEmma, HamiltonJean, StevensJohn, EssatMunira, PokuEdith, ClowesMark, PandorAbdullah, StevensonMatt

Prognosis assessment
RA treatment

Rheumatoid arthritis (RA) is a chronic condition that significantly impacts quality of life and is costly to manage. It's unclear which tests and assessments best predict how RA will progress and which patients will respond well to different medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

104.

Network meta-analysis of tofacitinib versus biologic treatments in moderate-to-severe rheumatoid arthritis patients.

Author: Camean-CastilloManuel, Gimeno-BallesterVicente, Rios-SanchezEsmeralda, Fenix-CaballeroSilvia, Vázquez-RealMiguel, Alegre-Del ReyEmilio

RA treatment
Tofacitinib

This study compared the effectiveness of different treatments for rheumatoid arthritis (RA), including biological DMARDs (disease-modifying antirheumatic drugs) used alone or with methotrexate, and tofacitinib, an oral medication that blocks certain proteins involved in inflammation. The study aims to determine which treatment options are most effective for patients with RA who don't respond well to traditional DMARDs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

105.

Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial.

Author: HuangRun-Yue, PanHu-Dan, WuJia-Qi, ZhouHua, LiZhan-Guo, QiuPing, ZhouYing-Yan, ChenXiu-Min, XieZhi-Xin, XiaoYao, HuangQing-Chun, LiuLiang

MTX combination therapy
RA treatment

Combining different conventional medications to treat rheumatoid arthritis (RA) is often effective but can have significant side effects. This study emphasizes the need for a safer and more effective alternative to expensive biological treatments, focusing on methotrexate (MTX) combination therapy. The aim is to find a combination of medications that provides a high level of effectiveness with fewer side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

106.

Patient Preferences for Disease-modifying Antirheumatic Drug Treatment in Rheumatoid Arthritis: A Systematic Review.

Author: DurandCaylib, EldomaMaysoon, MarshallDeborah A, BansbackNick, HazlewoodGlen S

Disease improvement
Side effects

Patients with rheumatoid arthritis (RA) generally place a high value on treatment benefits over other treatment attributes, including serious or minor side effects, cost, or route of administration. However, patient preferences vary, highlighting the need for individualized treatment choices.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

107.

Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial.

Author: GenoveseMark C, KalunianKenneth, GottenbergJacques-Eric, MozaffarianNeelufar, BartokBeatrix, MatzkiesFranziska, GaoJie, GuoYing, TassetChantal, SundyJohn S, de VlamKurt, WalkerDavid, TakeuchiTsutomu

RA response
Herpes zoster
Retinal vein occlusion

Filgotinib, a JAK1/JAK3 inhibitor, was found to be significantly more effective than placebo in achieving clinical response at week 12 in patients with active rheumatoid arthritis (RA) who had an inadequate response or intolerance to 1 or more biologic disease-modifying antirheumatic drugs (bDMARDs).

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

108.

Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics Alone for Early Rheumatoid Arthritis in Adults: a Systematic Review and Network Meta-analysis.

Author: DonahueKatrina E, SchulmanElizabeth R, GartlehnerGerald, JonasBeth L, Coker-SchwimmerEmmanuel, PatelSheila V, WeberRachel Palmieri, BannCarla M, ViswanathanMeera

Improved disease control
Improved functional capacity
Improved remission

Combination therapy with tumor necrosis factor (TNF) or non-TNF biologics plus methotrexate (MTX) was more effective than MTX monotherapy in reducing disease activity and improving remission in patients with early rheumatoid arthritis (RA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Effect of disease duration and prior disease-modifying antirheumatic drug use on treatment outcomes in patients with rheumatoid arthritis.

Author: AletahaDaniel, MaaJen-Fue, ChenSu, ParkSung-Hwan, NichollsDave, FlorentinusStefan, FurtnerDaniel, SmolenJosef S

Reduced response to therapy

Two randomized controlled trials of patients with established rheumatoid arthritis found that a greater number of prior disease-modifying antirheumatic drugs and longer disease duration were associated with smaller improvements in disease activity and lower American College of Rheumatology response rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

110.

Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era.

Author: HsiehPing-Hsuan, WuOlivia, GeueClaudia, McIntoshEmma, McInnesIain B, SiebertStefan

Improved clinical outcomes
Reduced hospitalizations
Reduced work disability

This systematic review mapped the existing evidence concerning cost of illness of rheumatoid arthritis (RA) in the biologic era. The study found that drug costs comprised the main component of direct costs, while indirect costs, primarily associated with absenteeism and work disability, accounted for a significant proportion of total costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

111.

Safety of repository corticotropin injection as an adjunctive therapy for the treatment of rheumatoid arthritis.

Author: FleischmannRoy, FurstDaniel E

Improved RA treatment

Disease-modifying antirheumatic drugs (DMARDs) are very helpful for rheumatoid arthritis (RA) patients, but some still don't achieve optimal results. This study focuses on the use of repository corticotropin injection (RCI) as a short-term treatment option for those with ongoing RA symptoms, even after starting DMARDs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

Use of TNF Inhibitors in Rheumatoid Arthritis and Implications for the Periodontal Status: For the Benefit of Both?

Author: ZamriFatima, de VriesTeun J

Periodontitis treatment
RA treatment

This review found that medications that block tumor necrosis factor-α (TNF-α), which are used to treat rheumatoid arthritis (RA), also improve gum health in people with RA. The study found that gum bleeding and inflammation improved quickly after starting these medications, while deeper improvements in gum health, such as reducing pocket depth and restoring gum attachment, took longer, occurring after several months of treatment. The researchers suggest that these medications work by reducing inflammation in the gums, leading to better gum health over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

Connective tissue remodelling is differently modulated by tocilizumab versus methotrexate monotherapy in patients with early rheumatoid arthritis: the AMBITION study.

Author: DrobinskiPatryk J, Bay-JensenAnne C, KarsdalMorten A, SardarSamra, SiebuhrAnne S

MTX and TCZ for RA

This study investigated the release of extracellular matrix (ECM) metabolites in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) and tocilizumab (TCZ) compared to placebo, aiming to understand treatment effects at the tissue level.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

114.

Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation.

Author: TikhonovaIrina A, YangHuiqin, BelloSegun, SalmonAndrew, RobinsonSophie, HemamiMohsen Rezaei, DodmanSophie, KharechkoAndriy, HaighRichard C, JaniMeghna, McDonaldTimothy J, HoyleMartin

Biological DMARDs for RA
Anti-drug antibodies

Rheumatoid arthritis is a chronic disease that causes inflammation and pain in the joints. People with severe RA may take biologic medications, but these can be less effective if the body develops antibodies against the drug. This study discusses how doctors monitor these treatments, using clinical assessments and blood tests, to determine if adjustments are needed or to understand why treatment isn't working.

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Efficacy and safety of jakinibs in rheumatoid arthritis: a systematic review and meta-analysis.

Author: YinYufeng, LiuMengru, ZhouErye, ChangXin, HeMichun, WangMingjun, WuJian

RA improvement
Well tolerated
Adverse events
Infections

This systematic review found that jakinibs are effective and well tolerated in patients with rheumatoid arthritis (RA) up to 24 weeks. Jakinibs increased the clinical response rate at 12 and 24 weeks, but also increased the risk of infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

116.

Intra-articular therapy with methotrexate or tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic review.

Author: SullivanMegan M, PhamMichael M, MarksLisa A, AslamFawad

IA DMARDs
RA treatment

Treating a single joint that's still inflamed in people who have otherwise well-controlled rheumatoid arthritis (RA) can be difficult. While steroid injections directly into the joint are often used, there's debate about whether other medications for RA, like DMARDs and biologics, can be used if injections don't work.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review.

Author: GandhiGopalsamy Rajiv, JothiGnanasekaran, MohanaThiruchenduran, VasconcelosAlan Bruno Silva, MontalvãoMonalisa Martins, HariharanGovindasamy, SridharanGurunagarajan, KumarPerumal Madan, GurgelRicardo Querioz, LiHua-Bin, ZhangJinming, GanRen-You

Medicinal plants
Natural alternative
Potential for RA treatment
RA treatment
Needs further research
Potential for interactions
Side effects
Unclear effectiveness

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can severely affect movement and quality of life. Current treatments focus on suppressing inflammation in the joints, but often have side effects. Herbal remedies are being explored as potential alternative treatments for RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis.

Author: JiangXiaofan, ZengJin, ChenFang, LiJuane

RA treatment

Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints. Methotrexate (MTX) is a common treatment for RA. This study will examine research to determine how well MTX works in treating RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

119.

Arthroscopic Synovectomy of the Wrist in Patients With Rheumatoid Arthritis: A Systematic Review of the Current Literature.

Author: d'AillyPhilip N, MuldersMarjolein A M, BisoendialRadjesh J, KuijperT Martijn, CoertJ Henk, SchepNiels W L

RA pain relief
Wrist function improvement

This systematic review evaluated functional outcomes and pain following arthroscopic synovectomy of the wrist in rheumatoid arthritis (RA) patients. The procedure showed promising results in improving pain and wrist function, with low complication rates. However, more research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

Effectiveness and adverse effects of anakinra in treatment of rheumatoid arthritis: a systematic review.

Author: BedaiwiM K, AlmaghlouthI, OmairM A

IL-1 antagonists
RA treatment

This review examines the effectiveness and potential side effects of medications called interleukin-1 antagonists for treating rheumatoid arthritis (RA). These medications block the action of a protein called interleukin-1, which plays a role in inflammation. The review aims to assess the benefits and risks of these medications for RA patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

121.

Randomized Clinical Trials on the Efficacy and Safety of Tocilizumab in Subjects with Rheumatoid Arthritis: A Systematic Review.

Author: SadeqAdel, ElnourAsim Ahmed, RamadanAzza, KidirIsraa Yousif, DonJudit, Al AmoodiAbdulla, Al MazroueiNadia, BarakaMohamed A, FarahFarah Hamad, AlkaabiMaisoun

RA activity
TCZ
Lipid profiles

Tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA), reducing disease activity and improving disability. TCZ may be associated with increased cholesterol levels but does not appear to increase the risk of serious adverse events.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

122.

Biomarkers for the diagnosis and treatment of rheumatoid arthritis - a systematic review.

Author: AbdelhafizD, BakerT, GlascowD A, AbdelhafizAh

Diagnosis
Prognosis prediction
Treatment monitoring

This systematic review explored the role of biomarkers for the diagnosis and treatment of rheumatoid arthritis (RA). C-reactive protein (CRP), rheumatoid factor (RF), anti-cyclic citrullinated protein (Anti-CCP), 14-3-3η protein, and the multi-biomarker disease activity (MBDA) score are helpful tools for diagnosis, monitoring of treatment, and predicting prognosis in RA patients. Further research is required to investigate novel biomarkers for pre-treatment selection of potentially responsive patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

123.

Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial.

Author: KrijbolderDoortje I, VerstappenMarloes, van DijkBastiaan T, DakkakYousra J, BurgersLeonie E, BoerAleid C, ParkYune Jung, de Witt-LuthMarianne E, VisserKaren, KokMarc R, MolenaarEsmeralda T H, de JongPascal H P, BöhringerStefan, HuizingaTom W J, AllaartCornelia F, NiemantsverdrietEllis, van der Helm-van MilAnnette H M

RA treatment

Rheumatoid arthritis (RA) is a chronic autoimmune disease that requires long-term treatment. Currently, treatment starts when arthritis is clearly present. This study will investigate whether starting treatment earlier, when people have joint pain but no clear arthritis, can prevent the development of arthritis or reduce the severity of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

124.

Effectiveness of ergonomic interventions on work activity limitations in adults with rheumatoid arthritis: A systematic review.

Author: JonesHeather, YoungMegan, GuytonKyndel, IdemotoEmily, FerraroAlicia, AlHereshRawan

Improved quality of life
Improved work outcomes

Rheumatoid arthritis (RA) is a major cause of disability in the US. Adjusting work environments to make them easier on the body (ergonomic interventions) can be helpful, and when used with medications, may improve work performance and overall quality of life for people with RA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

125.

Prevention of rheumatoid arthritis: A systematic literature review of preventive strategies in at-risk individuals.

Author: FrazzeiGiulia, MustersAnne, de VriesNiek, TasSander W, van VollenhovenRonald F

RA treatment

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and disability. Before RA develops, there's a preclinical stage where people with a genetic predisposition accumulate factors that increase their risk. Treating people at risk before they develop RA could potentially prevent or delay the disease and have a positive impact on their lives and society.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

126.

Compared efficacy of rituximab, abatacept, and tocilizumab in patients with rheumatoid arthritis refractory to methotrexate or TNF inhibitors agents: a systematic review and network meta-analysis.

Author: PugliesiAlisson, de OliveiraAmanda Borges, OliveiraAna Beatrice, XavierRicardo, da MotaLicia Maria Henrique, BertoloManoel Barros, Gonzalez-GayMiguel Angel, CiteraGustavo, de CarvalhoLuiz Sergio Fernandes

Improved RA response
Heterogeneity

Abatacept was associated with a higher chance of achieving an ACR70 response than tocilizumab in patients with rheumatoid arthritis (RA) refractory to methotrexate (MTX) or tumor necrosis factor inhibitor (TNFi) therapy.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

127.

Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial.

Author: ØstergaardMikkel, van VollenhovenRonald F, RudinAnna, HetlandMerete Lund, HeibergMarte Schrumpf, NordströmDan C, NurmohamedMichael T, GudbjornssonBjorn, ØrnbjergLykke Midtbøll, BøyesenPernille, LendKristina, Hørslev-PetersenKim, UhligTill, SokkaTuulikki, GrondalGerdur, KrabbeSimon, LindqvistJoakim, GjertssonInger, GlinatsiDaniel, KapetanovicMeliha Crnkic, AgaAnna-Birgitte, FaustiniFrancesca, ParmannePinja, LorenzenTove, GiovanniCagnotto, BackJohan, HendricksOliver, VedderDaisy, RannioTuomas, GrenholmEmma, LjosåMaud Kristine, BrodinEli, LindegaardHanne, SöderberghAnnika, RizkMilad, KastbomAlf, LarssonPer, UhrenholtLine, JustSøren Andreas, StevensDavid J, Bay LaurbjergTrine, BaklandGunnstein, OlsenInge Christoffer, HaavardsholmEspen A, LampaJon,

Improved clinical remission
Reduced radiographic progression

Abatacept and certolizumab pegol were more effective than active conventional therapy in achieving clinical remission in patients with early rheumatoid arthritis.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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