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Effective treatment of murine cytomegalovirus infections with methylenecyclopropane analogues of nucleosides.

Author: HartlineC B, KernE R, QiuY L, RybakR J, ZemlickaJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Several new nucleoside analogues with a Z- or E-methylenecyclopropane structure exhibited significant activity against cytomegaloviruses in tissue culture. Some of these analogues demonstrated therapeutic efficacy in a murine cytomegalovirus infection model.
Paper Details　
Original Abstract of the Article :
A number of new nucleoside analogues with a Z- or E-methylenecyclopropane structure exhibited significant activity against human and murine cytomegaloviruses (HCMV, MCMV) in tissue culture that was generally comparable to, or greater than, 9-[(1-3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir, GCV...See full text at original site
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引用元：
https://doi.org/10.1016/s0166-3542(99)00043-1

データ提供：米国国立医学図書館（NLM）

Methylenecyclopropane Analogues: A New Weapon in the Desert of Viral Infections

Viral infections, like a relentless desert wind, can wreak havoc on our bodies. This research explores the potential of methylenecyclopropane analogues, a new class of antiviral compounds, to combat cytomegalovirus (CMV) infections, offering a potential weapon against these viral invaders.

A New Oasis in the Desert of Antiviral Therapy

This study, like a desert explorer discovering a hidden oasis, investigates the antiviral activity of methylenecyclopropane analogues against CMV, a virus that can cause serious health problems. The researchers found that these compounds exhibited potent antiviral activity against both human and murine CMV, showing promise as potential treatments for CMV infections.

Hope for a More Effective Antiviral Arsenal

This research highlights the potential of methylenecyclopropane analogues to expand our arsenal of antiviral agents. These compounds, like a newly discovered oasis, offer hope for more effective treatment options for CMV infections. This study underscores the importance of ongoing research and exploration in the fight against viral diseases.

Dr.Camel's Conclusion

This research reveals the promise of methylenecyclopropane analogues as potential antiviral agents, offering a potential oasis in the vast desert of viral infections. This study reminds us that continued exploration and innovation are crucial for developing new weapons against viral invaders, ensuring a healthier future for all.

Date :
  1. Date Completed 2000-01-13
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

10551375

DOI: Digital Object Identifier

10.1016/s0166-3542(99)00043-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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