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Inactivated hepatitis A vaccine in Chinese patients with chronic hepatitis B infection.

Author: SungJ J, TsangS W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hepatitis A vaccine is equally efficacious in patients with chronic hepatitis B infection, with similar seroconversion rates and geometric mean titres. Side effects were more common in HBV patients.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Hepatitis B (HBV)-infected patients have a higher morbidity and mortality when super-infected by hepatitis A (HAV). AIM: To evaluate the immunogenicity and safety of a commercial inactivated HAV vaccine in Chinese patients with chronic HBV infection. METHODS: Sixty-five HBV-infected pa...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1046/j.1365-2036.1999.00628.x

データ提供：米国国立医学図書館（NLM）

Hepatitis A Vaccination in Chronic Hepatitis B Patients

Hepatitis B (HBV) infection is a major public health concern, and individuals with chronic HBV infection are at increased risk of developing complications if they become super-infected with hepatitis A (HAV). This study investigates the immunogenicity and safety of an inactivated hepatitis A vaccine in Chinese patients with chronic HBV infection. The researchers conducted a prospective study, comparing the vaccine response in HBV-infected patients to that of healthy controls.

Hepatitis A Vaccine Efficacy in Chronic Hepatitis B Patients

The study found that the hepatitis A vaccine was equally efficacious in both HBV-infected patients and healthy controls. The seroconversion rates were comparable between the two groups, indicating that the vaccine effectively induced an immune response in patients with chronic HBV infection. However, the healthy controls had significantly higher geometric mean titres (GMTs) at week 24, suggesting that the immune response may be slightly weaker in HBV-infected patients.

Vaccination Strategies for HBV-Infected Individuals

This research provides important information for informing vaccination strategies in individuals with chronic HBV infection. The findings suggest that hepatitis A vaccination is safe and effective in this population, providing valuable protection against HAV infection. However, the slightly lower GMTs in HBV-infected patients suggest that careful monitoring and potentially adjusted vaccination schedules may be needed to optimize vaccine efficacy in this group.

Dr.Camel's Conclusion

This study, like a refreshing oasis in the desert of hepatitis B, offers valuable insights into the efficacy of hepatitis A vaccination in this vulnerable population. The findings suggest that vaccination is safe and effective, providing crucial protection against HAV infection. It's a reminder that even in the face of chronic illness, preventive measures like vaccination can play a vital role in safeguarding health.

Date :
  1. Date Completed 1999-12-22
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10571600

DOI: Digital Object Identifier

10.1046/j.1365-2036.1999.00628.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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