Side Effects of hepatitis a vaccine: A Synthesis of Findings from 25 Studies

  1. Home
  2. Side Effects of hepatitis a vaccine
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of hepatitis a vaccine: A Synthesis of Findings from 25 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of hepatitis a vaccine: A Synthesis of Findings from 25 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Numerous studies have confirmed that hepatitis A vaccine is safe and effective for people of all ages, from children to adults. 12 , 20 , 25 , 14 , 13 , 21 , 2 , 1 , 8 , 18 , 9 , 17 , 10 , 3 , 4 , 11 , 15 , 6 , 16 , 19 , 24 , 5 , 23 , 22 , .

Reasons for Side Effects

Vaccine side effects are caused by the body's reaction to the components of the vaccine. Hepatitis A vaccines are made by weakening or inactivating the virus, so the virus itself cannot cause infection. However, the immune system may overreact to the components of the vaccine. As a result, side effects such as fever, pain and swelling at the injection site may occur. 15 .

Common Side Effects

Injection Site Reactions

Pain, swelling and redness may occur at the site where the hepatitis A vaccine was injected. 15 , 23 .

Systemic Reactions

Systemic reactions such as fever, fatigue, headache, muscle aches, and joint pain may occur. 15 , 23 .

Gastrointestinal Reactions

Gastrointestinal reactions such as nausea, vomiting, and diarrhea may occur. 6 .

Countermeasures for Side Effects

Injection Site Reactions

Cold compresses and pain relievers can be effective for injection site pain and swelling. If symptoms are severe, consult a doctor. 15 , 23 .

Systemic Reactions

Fever reducers can be effective for fever. If symptoms are severe, consult a doctor. 15 , 23 .

Gastrointestinal Reactions

If you have severe nausea or diarrhea, make sure to stay hydrated. If symptoms persist, consult a doctor. 6 .

Comparison between Studies

Commonalities of Studies

Many studies have shown that hepatitis A vaccine is safe and effective. In addition, it is known that side effects after vaccination are generally mild and often resolve within a short period of time.

Differences of Studies

Since vaccines, administration methods, target ages, and other factors vary between studies, there are differences in the incidence and symptoms of side effects. For example, 15 reports side effects such as injection site reactions and fever after vaccination of 2-month-old infants, while 3 shows little side effects after vaccination of 18-47-month-old infants. As you can see, it is important to note that the incidence and symptoms of side effects may vary depending on the target age and vaccine.

Points to Note Regarding Applications in Real Life

Hepatitis A vaccine is an effective preventative measure for those at high risk of hepatitis A infection. However, it is important to understand the risks of side effects associated with vaccines. Before vaccination, it is important to consult a doctor and make a decision about whether or not to get vaccinated based on your health condition and risk factors.

Limitations of Current Research

Although much progress has been made in research on the safety and effectiveness of hepatitis A vaccine, the long-term effects of the vaccine and the effectiveness of the vaccine on various populations are not yet fully understood. Therefore, further research is needed.

Future Research Directions

Future research should evaluate the long-term safety and effectiveness of hepatitis A vaccine. Also, by investigating the effectiveness of the vaccine on people of different ages and health conditions, we can expect to lead to the development of safer and more effective vaccines.

Conclusion

Numerous studies have shown that hepatitis A vaccine is a safe and effective preventive measure for people at high risk of hepatitis A infection. When considering vaccination, it is important to consult a doctor to consider the risks of side effects and your health status.

Literature analysis of 25 papers
Positive Content
24
Neutral Content
0
Negative Content
1
Article Type
7
1
0
2
25
1.

Immunogenicity and side-effects of the inactivated hepatitis A vaccine in periodic fever, aphthous stomatitis, pharyngitis, and adenitis patients.

Author: MaritsiDespoina N, SyrmouAreti, VartzelisGeorge, DiamantopoulosStavros, TsoliaMaria N

HAV vaccination

Two doses of the inactivated hepatitis A virus (HAV) vaccine were well-tolerated and effective in children with periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA). The seroprotection rates were comparable to those observed in healthy controls.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

2.

Immunogenicity and safety of the inactivated hepatitis A vaccine in children with juvenile idiopathic arthritis on methotrexate treatment: a matched case-control study.

Author: MaritsiDespoina N, CoffinSusan E, ArgyriIoanna, VartzelisGeorge, SpyridisNick, TsoliaMaria N

Improved immunity

Two doses of inactivated HAV vaccine were well tolerated and immunogenic in most immunosuppressed children with JIA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Immunogenicity and safety of a pediatric dose of a virosomal hepatitis A vaccine in healthy children in India.

Author: JainHemat, KumavatVandana, SinghTejinder, VersteilenAmanda, SarneckiMichal

Hepatitis A prevention
Immune response

A study compared the immunogenicity and safety of a virosomal hepatitis A vaccine (HAVpur Junior) and an aluminum-adsorbed vaccine (Havrix 720 Junior) in Indian children. Both vaccines induced similar immune responses and were well tolerated. The study supports the use of HAVpur Junior in Indian childhood vaccination schedules.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Concomitant administration of hepatitis A vaccine with measles/mumps/rubella/varicella and pneumococcal vaccines in healthy 12- to 23-month-old children.

Author: YetmanRobert J, ShepardJulie S, DukeAnton, StekJon E, PetreczMaria, KlopferStephanie O, KuterBarbara J, SchödelFlorian P, LeeAndrew W

Hepatitis A vaccination
Measles/mumps/rubella/varicella vaccination
Pneumococcal vaccination
Dehydration
Febrile seizure
Gastroenteritis

This study compared the safety and effectiveness of giving a hepatitis A vaccine concurrently with other vaccines (measles/mumps/rubella/varicella and pneumococcal) vs. giving it separately. The results showed that the antibody responses were non-inferior in both groups, and the safety profile was acceptable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

An open, prospective, randomized study comparing the immunogenicity and safety of two inactivated hepatitis A pediatric vaccines in toddlers, children and adolescents in China.

Author: LiRong Cheng, LiYanping, YiNong, HuangLirong, WanZongju, ZhangYanping, RasuliAnvar

Hepatitis A vaccine efficacy
Hepatitis A vaccine safety

The inactivated hepatitis A vaccine AVAXIM 80U Pediatric was found to be safe and not inferior to HAVRIX 720 vaccine in terms of seroprotection rate one month after booster vaccination.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Real-life versus package insert: a post-marketing study on adverse-event rates of the virosomal hepatitis A vaccine Epaxal® in healthy travellers.

Author: HatzChristoph, BeckBernhard, SteffenRobert, GentonBlaise, d'AcremontValérie, LoutanLouis, HartmannKatharina, HerzogChristian

Over-reporting of events

This study investigated the reporting rates of adverse events (AEs) associated with the virosomal hepatitis A vaccine Epaxal(®). The study found that solicited reporting resulted in significantly higher rates of AEs compared to unsolicited reporting. The results suggest that actual reporting rates of AEs may be substantially lower than described in the package insert.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention: a pooled analysis of 11 clinical trials.

Author: DescampsDominique, HardtKarin, SpiessensBart, IzurietaPatricia, VerstraetenThomas, BreuerThomas, DubinGary

Cervical cancer prevention

A pooled analysis of safety data from almost 30,000 girls and women aged 10 years and older who received the HPV-16/18 AS04-adjuvanted cervical cancer vaccine Cervarix showed that the vaccine had a favorable safety profile across all age groups (10-14, 15-25, and >25 years). While solicited local and general symptoms were more frequent in the vaccine group compared to controls, compliance with the three-dose schedule was high and did not differ between groups. There were no clinically relevant differences between the vaccine and control groups in rates of serious adverse events (2.8% vs. 3.1%), medically significant conditions (19.4% vs. 21.4%), new onset of chronic diseases (1.7% in both groups), or new onset of autoimmune diseases (0.4% vs. 0.3%). Similarly, no differences were observed in pregnancy outcomes or withdrawal rates due to adverse events or serious adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

[The study on the 0, 12 month vaccination schedule' of Healive inactivated hepatitis A vaccine in children].

Author: RenYin-hai, ChenJiang-ting, WuWen-ting, GongXue-jie, ZhangYu-cheng, XueWei-hua, RenYi-feng, HanLian-jun, KangWen-xue, LiSheng-ping, LiuChong-bai

Hepatitis A vaccine efficacy
Safe vaccine

Healive inactivated hepatitis A vaccine is safe and highly immunogenic in children. A dose of 250 U is considered appropriate for children, and the vaccine can be used for emergency vaccination.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

10.

[Vaccinations for the traveler].

Author: Van LaethemY

Travel safety

For long distance journeys, vaccinations against tetanus, diphtheria, polio, and hepatitis A are recommended. Typhoid fever vaccine is recommended for longer stays or adventurous travelers. Yellow fever vaccine is mandatory for certain African and South American countries and administered in specialized centers. Vaccinations against hepatitis B, meningococcal meningitis, rabies, and encephalitis may also be recommended depending on the destination.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

11.

[Vaccinations for the traveller].

Author: Van LaethemY

Disease prevention
Side effects

This article provides recommendations for vaccinations prior to long-distance travel, highlighting the importance of vaccines for tetanus, diphtheria, polio, hepatitis A, and yellow fever.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

12.

[The investigation on the safety and immunogenicity of inactived hepatitis A vaccine AVAXIM].

Author: HuangG, WanZ, LiR

Good immunogenicity
Good safety
Mild local pain

AVAXIM, an inactivated hepatitis A vaccine, is safe and immunogenic in both children and adults. After two doses, the vaccine resulted in seroconversion rates of 98.15% in children and 94.17% in adults. The most common side effect was local pain.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

13.

Safety and efficacy of hepatitis A vaccination in liver transplantation recipients.

Author: ArslanM, WiesnerR H, PoteruchaJ J, ZeinN N

Hepatitis A vaccine efficacy
Hepatitis A vaccine safety

Vaccination against hepatitis A has proven safe and effective in healthy individuals and those with chronic liver disease. The safety and effectiveness of hepatitis A vaccines in liver transplant recipients have not been established. This study aims to assess the safety and efficacy of inactivated hepatitis A vaccine in liver transplant recipients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Need for vaccination of susceptible food handlers against hepatitis A in Taiwan.

Author: YuM I, LeeS D, LuR H, ChanC Y, WangY J, ChangF Y, LoK J

Effective hepatitis A prevention

This study examined the prevalence of hepatitis A antibodies in Taiwan, a country with improved hygiene and socioeconomic conditions. The study also looked at the effectiveness and safety of a hepatitis A vaccine in the Taiwanese population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Clinical trial to evaluate immunogenicity and safety of inactivated hepatitis A vaccination starting at 2-month-old children.

Author: KanraG, YalçinS S, CeyhanM, YurdakökK

Hepatitis A protection

Hepatitis A vaccine was found to be safe and immunogenic in infants, but it should be used after the disappearance of maternal antibodies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Immunogenicity and reactogenicity of an inactivated hepatitis A vaccine in Indian adults.

Author: DasK, JainA, GuptaR K, KarP

High immunogenicity
Well tolerated
Erythema
Local pain
Low-grade fever

The inactivated hepatitis A vaccine in a three-injection protocol was safe, well tolerated, and highly immunogenic in adult Indian subjects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Tolerance and immunogenicity of the simultaneous administration of virosome hepatitis A and yellow fever vaccines.

Author: BovierP A, AlthausB, GlueckR, ChippauxA, LoutanL

Immunogenic
Safe
Well-tolerated
Mild local reactions

Simultaneous administration of an IRIV-HAV vaccine and a yellow fever vaccine (YFV) was found to be immunogenic, safe, and well-tolerated, with no cross-interference between the two vaccines.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

Inactivated hepatitis A vaccine in Chinese patients with chronic hepatitis B infection.

Author: TsangS W, SungJ J

Efficacious for HBV-infected patients
Side effects

Hepatitis A vaccine is equally efficacious in patients with chronic hepatitis B infection, with similar seroconversion rates and geometric mean titres. Side effects were more common in HBV patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Safety and immunogenicity of hepatitis A vaccine in infants: a candidate for inclusion in the childhood vaccination programme.

Author: PiazzaM, SafaryA, VegnenteA, SonciniR, PensatiP, SardoM, OrlandoR, TosoneG, PicciottoL

Increased immunity
Safe and well-tolerated

This study found that a single dose of inactivated hepatitis A vaccine followed by a booster dose was immunogenic, safe, and well tolerated in infants.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Seroprevalence of hepatitis A virus in Mumbai, and immunogenicity and safety of hepatitis A vaccine.

Author: DhawanP S, ShahS S, AlvaresJ F, KherA, Shankaran, KandothP W, ShethP N, KamathH, KamathA, KoppikarG V, KalroR H

Hepatitis A vaccine immunogenic
Hepatitis A vaccine safe
Minor side effects

The seroprevalence of hepatitis A was high in Mumbai, with lower rates in higher socio-economic groups. A hepatitis A vaccine was found to be safe and immunogenic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Viral hepatitis in older adults.

Author: MarcusE L, Tur-KaspaR

Antiviral therapy for chronic HCV
Hepatitis A vaccine available
Interferon therapy for chronic HBV
Interferon side effects

This review discusses the epidemiology, manifestations, therapy, and prevention of viral hepatitis in older people. The authors recommend immunization against hepatitis A and interferon therapy for patients with chronic HBV infection who have evidence of ongoing viral replication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Inactivated hepatitis A vaccine in healthy Chinese adults.

Author: LoY C, LeeS S, WongK H, LimW L

Hepatitis A vaccine

Inactivated hepatitis A vaccine was highly immunogenic, safe, and well-tolerated in healthy Chinese adults. Seroconversion occurred in 100% of recipients after two doses, with no statistically significant difference between the two vaccination regimens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Safety and immunogenicity of an inactivated hepatitis A vaccine in preschool children.

Author: BalcarekK B, BagleyM R, PassR F, SchiffE R, KrauseD S

Hepatitis A prevention
Immunogenicity
Local reactions
Systemic side effects

An inactivated hepatitis A vaccine is safe and effective in young children, with all children developing antibodies after three doses. Local reactions occurred in 29.8% of children, and minor systemic side effects were seen in 47%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

A trial of the reactogenicity and immunogenicity of an inactivated hepatitis A vaccine.

Author: GreenM S, CohenD, LermanY, SjogrenM, BinnL N, ZurS, SleponR, RobinG, HokeC, BancroftW

Highly immunogenic
No significant side effects

A new inactivated hepatitis A vaccine showed high immunogenicity and no significant side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

25.

Immunogenicity of inactivated hepatitis A vaccine in children.

Author: LeeS D, LoK J, ChanC Y, YuM Y, WangY J, SafaryA

Hepatitis A prevention

Inactivated hepatitis A vaccine was safe and immunogenic in healthy children, with seroconversion rates of 97% after the first dose and 100% after the second and booster doses. No significant side effects were observed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.