Both raloxifene and estrogen reduce major cardiovascular risk factors in healthy postmenopausal women: A 2-year, placebo-controlled study.

Author: CohenF, KenemansP, KluftC, MeijerP, MijatovicV, NetelenbosC, StehouwerC D, WattsS, de Valk-de RooG W

Paper Details 
Original Abstract of the Article :
Currently raloxifene, a selective estrogen receptor modulator, is being investigated as a potential alternative for postmenopausal hormone replacement to prevent osteoporosis and cardiovascular disease. We compared the 2-year effects of raloxifene on a wide range of cardiovascular risk factors with ...See full text at original site
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引用元:
https://doi.org/10.1161/01.atv.19.12.2993

データ提供:米国国立医学図書館(NLM)

Raloxifene vs. Estrogen: Navigating the Desert of Menopause

Menopause, like a desert oasis that has dried up, marks a significant change in a woman's life, often accompanied by various challenges. This study, like a well-equipped caravan, delves into the effects of raloxifene, a selective estrogen receptor modulator, compared to conjugated equine estrogens (CEEs) on cardiovascular risk factors in postmenopausal women. The researchers, like skilled cartographers, sought to determine whether raloxifene could offer a safe and effective alternative to traditional hormone replacement therapy.

Similar Destinations, Different Paths

The study's findings, like a map revealing two different routes to the same destination, show that both raloxifene and CEEs effectively reduced low-density lipoprotein cholesterol levels and fibrinogen levels, crucial factors for heart health. However, the two medications differed in their effects on other cardiovascular risk factors, with CEEs showing a greater impact on high-density lipoprotein cholesterol, triglycerides, and plasminogen activator inhibitor-1.

Choosing the Right Path in the Desert of Menopause

Navigating the desert of menopause requires careful planning and understanding of the different options available. This study highlights the potential benefits and risks of both raloxifene and estrogen therapy. It emphasizes the importance of consulting with healthcare professionals to make informed decisions based on individual needs and risk factors.

Dr. Camel's Conclusion

This research, like a compass guiding us through the complexities of menopause, reveals the intricate relationship between hormone therapy and cardiovascular health. It emphasizes the importance of personalized medical guidance, considering individual needs and risk factors, to navigate the desert of menopause safely and effectively.
Date :
  1. Date Completed 1999-12-27
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10591680

DOI: Digital Object Identifier

10.1161/01.atv.19.12.2993

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