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Clinical pharmacokinetics of doxazosin in a controlled-release gastrointestinal therapeutic system (GITS) formulation.
Author: ChungM, MeredithP, PuenteJ, SweeneyM, VashiV
Original Abstract of the Article :
A controlled-release gastrointestinal therapeutic system (GITS) formulation of doxazosin mesylate, a long-acting selective alpha1-adrenoceptor antagonist, was developed to enhance the pharmacokinetic profile and simplify the titration schedule by precisely controlling drug delivery rate, permitting ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1046/j.1365-2125.1999.00067.x
データ提供:米国国立医学図書館(NLM)
Navigating the Desert of Doxazosin Delivery
Finding the right way to deliver medication is essential for maximizing therapeutic effectiveness and minimizing side effects. This study explores the pharmacokinetics of doxazosin, a drug used to treat high blood pressure, when administered in a controlled-release gastrointestinal therapeutic system (GITS) formulation. This is like finding a more efficient and reliable way to transport water through a vast desert landscape, aiming for optimal delivery and utilization.
The study evaluated the pharmacokinetics and bioavailability of doxazosin GITS, examining the effects of food, age, gender, and multiple dosing. The researchers found that doxazosin GITS provided a more predictable and controlled drug release profile, offering a potential advantage over standard doxazosin formulations. This discovery is like finding a more efficient and reliable method for transporting water across a desert, ensuring optimal hydration and utilization.
A More Efficient Route for Drug Delivery
The study findings suggest that doxazosin GITS could provide a more predictable and controlled drug release profile, potentially leading to improved therapeutic efficacy and reduced side effects. This discovery is like finding a more efficient and reliable path through the desert, ensuring that medication reaches its destination in a timely and controlled manner.
A Journey Towards Optimized Drug Delivery
The study highlights the ongoing journey toward optimized drug delivery systems, seeking to maximize therapeutic efficacy and minimize side effects. The development of doxazosin GITS represents a significant step in this direction, offering a potential alternative to standard formulations and potentially enhancing patient outcomes. This research is like exploring a vast and intricate desert, seeking to uncover new and more efficient pathways for drug delivery.
Dr. Camel's Conclusion
This study provides valuable insights into the pharmacokinetics of doxazosin GITS, suggesting that this formulation could offer a more predictable and controlled drug release profile. This discovery is like finding a new and more efficient caravan route across the desert of drug delivery, leading to more effective and tailored treatments for patients.
Date :
- Date Completed 2000-01-11
- Date Revised 2019-05-13
Further Info :
Related Literature
English
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