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Doxazosin GITS compared with doxazosin standard and placebo in patients with mild hypertension.

Author: OsI, StokkeH P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the efficacy and tolerability of a new controlled-release formulation of doxazosin (doxazosin GITS) with standard doxazosin and placebo in patients with mild hypertension. Doxazosin GITS was found to be as effective as standard doxazosin in lowering blood pressure and was well tolerated, with minimal need for titration.
Paper Details　
Original Abstract of the Article :
Doxazosin, an effective treatment for mild-to-moderate hypertension and benign prostatic hyperplasia, in its standard formulation requires a multiple-step titration regimen to minimize the potential for first-dose effects. A new controlled-release gastrointestinal therapeutic system (GITS) formulati...See full text at original site
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引用元：
https://doi.org/10.1080/080370599439724

データ提供：米国国立医学図書館（NLM）

Doxazosin GITS for Mild Hypertension

Hypertension, or high blood pressure, is a major public health concern, affecting millions worldwide. This study investigates the efficacy and safety of a new controlled-release formulation of doxazosin, a medication used to treat hypertension, in patients with mild hypertension. Researchers compared the effectiveness and tolerability of this new formulation, called doxazosin GITS, to standard doxazosin and placebo.

A New Approach to Hypertension Treatment

The study found that doxazosin GITS was as effective as standard doxazosin in lowering blood pressure in patients with mild hypertension. The controlled-release formulation provided comparable blood pressure reductions while minimizing the need for titration, simplifying the treatment regimen and potentially improving patient adherence.

Improving Patient Care and Medication Adherence

This research highlights the importance of developing innovative drug formulations that enhance treatment efficacy and improve patient compliance. By optimizing drug delivery systems and simplifying treatment regimens, we can make it easier for patients to manage their health conditions. It's like finding a smoother path through a desert – a more comfortable journey can lead to better outcomes.

Dr.Camel's Conclusion

This study showcases the potential of innovative drug formulations to improve patient care and medication adherence. By continually seeking ways to enhance treatment options, we can empower individuals to take control of their health and improve their overall well-being. Just as a desert traveler seeks a reliable source of water, we must strive to provide patients with effective and convenient treatment solutions.

Date :
  1. Date Completed 1999-12-16
  2. Date Revised 2019-11-03
Further Info :

Pubmed ID

10595697

DOI: Digital Object Identifier

10.1080/080370599439724

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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