Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group.

Author: BreedveldF, EmeryP, FeldmannM, FurstD, HarrimanG, KaldenJ, LipskyP, MainiR, SmolenJ, St ClairE W, WeismanM

Paper Details 
Original Abstract of the Article :
Not all patients with rheumatoid arthritis can tolerate or respond to methotrexate, a standard treatment for this disease. There is evidence that antitumour necrosis factor alpha (TNFalpha) is efficacious in relief of signs and symptoms. We therefore investigated whether infliximab, a chimeric human...See full text at original site
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引用元:
https://doi.org/10.1016/s0140-6736(99)05246-0

データ提供:米国国立医学図書館(NLM)

Infliximab: A Potential Game-Changer for Rheumatoid Arthritis Treatment

This study, akin to a journey across a vast, unforgiving desert, explores the potential of infliximab, a chimeric anti-tumor necrosis factor alpha monoclonal antibody, in treating rheumatoid arthritis (RA) patients who have not responded well to methotrexate. The researchers conducted a randomized, phase III trial to assess the efficacy of infliximab in combination with methotrexate. Their findings suggest that infliximab can provide additional clinical benefit to patients with active RA, offering a promising alternative for those who haven't experienced satisfactory results with methotrexate alone. This study sheds light on the potential of infliximab as a valuable therapeutic option for RA patients.

Infliximab: A Beacon of Hope for Rheumatoid Arthritis Patients

The study's findings demonstrate the potential of infliximab to provide significant relief for RA patients who haven't responded well to methotrexate. This finding is crucial, as not all RA patients tolerate or respond to methotrexate, leaving them with limited treatment options. The study suggests that infliximab, in combination with methotrexate, could provide a more effective treatment approach for these patients, potentially leading to significant improvements in their quality of life.

Navigating the Desert of Rheumatoid Arthritis: Finding Relief Through Research

Rheumatoid arthritis is a chronic inflammatory disease that can significantly impact quality of life. This study offers hope for RA patients who have struggled to find effective treatment options. The findings highlight the potential of infliximab as a valuable addition to existing treatments, potentially providing substantial relief from the debilitating symptoms of RA. The study underscores the importance of ongoing research and the development of new treatments for complex conditions like RA.

Dr.Camel's Conclusion

This research marks a significant step forward in the fight against rheumatoid arthritis. The study's findings offer new hope for patients who have struggled to find effective treatments, highlighting the potential of infliximab as a valuable therapeutic option. It underscores the importance of ongoing research and the development of new treatments for complex diseases like RA, enabling those affected to navigate the challenging journey of this condition with greater ease.

Date :
  1. Date Completed 2000-01-18
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

10622295

DOI: Digital Object Identifier

10.1016/s0140-6736(99)05246-0

Related Literature

SNS
PICO Info
in preparation
Languages

English

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