Paper Details

  1. Home
  2. Paper Details

Comparison of standard and high dosage recombinant interferon alpha 2b for treatment of children with chronic hepatitis B infection.

Author: GürakanF, KoçakN, OzenH, YüceA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A 6-month course of interferon alpha 2b was well-tolerated by children with chronic hepatitis B virus (HBV) infection. High dosage interferon led to sustained suppression of HBV in 60% of patients, while standard dosage resulted in suppression in 33% of patients.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Interferon is currently the most useful therapeutic agent for chronic viral hepatitis. The aim of this study was to compare the efficacy of standard and high dosages of interferon in children with chronic hepatitis B virus (HBV) infection. METHODS: Thirty children with chronic hepatitis...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00006454-200001000-00011

データ提供：米国国立医学図書館（NLM）

Interferon Therapy for Hepatitis B: Finding the Sweet Spot

The field of [hepatitis B treatment] is constantly evolving, and this study focuses on finding the most effective dose of [interferon alpha 2b] for children with chronic hepatitis B infection. It's a bit like finding the perfect oasis in a vast desert: the right dose can make all the difference.

Higher Dose Interferon May Be More Effective

This study compared the effects of two different doses of interferon on children with chronic hepatitis B. The results showed that a higher dose of interferon led to a greater clearance of HBV DNA and HBeAg, suggesting that a higher dose might be more effective. This is like a more potent spring in a desert: it provides more water for survival.

Potential for Improved Treatment

The study indicates that higher doses of interferon may be more effective in treating chronic hepatitis B in children. It's important to note that further research is needed to confirm this finding. It's like a treasure hunt in the desert: we need to dig deeper to find the optimal solution.

Dr.Camel's Conclusion

This research shines a light on the potential benefits of higher doses of interferon in treating chronic hepatitis B in children. It's a step towards finding the oasis of effective treatment in the desert of this challenging disease. Further research is essential to solidify these findings and ensure the best possible outcomes for our young patients.

Date :
  1. Date Completed 2000-03-09
  2. Date Revised 2019-08-18
Further Info :

Pubmed ID

10643851

DOI: Digital Object Identifier

10.1097/00006454-200001000-00011

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.