Effective treatment of degenerative nerve diseases: A Synthesis of Findings from 96 Studies

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Original Abstract of the Article

Major research findings

Chronic hepatitis B (CHB) is a serious liver disease that can lead to cirrhosis and liver cancer. Various treatment combinations of peginterferon (PEG-IFN) and nucleos(t)ide analogues have been evaluated for CHB, but the optimal regimen remains unclear. 77

PEG-IFN has shown promise in treating CHB, particularly when combined with nucleotide analogues. 72 In patients with low viral loads, PEG-IFN plus nucleotide analogue therapy may lead to functional cure, marked by the loss of hepatitis B surface antigen (HBsAg) with or without the development of antibodies against HBsAg (anti-HBs). 72

However, treatment is not always recommended for patients with low viral loads, as there is ongoing debate about the necessity of treatment in such cases. 72 Further research is needed to determine the optimal prophylactic antiviral protocol for patients with lymphoma treated with rituximab-containing chemotherapies, as HBV reactivation poses a serious risk. 66

Treatment summary

Treatment for chronic hepatitis B may involve interferon monotherapy, nucleoside(t) analogue monotherapy, or combination therapy of interferon and nucleoside(t) analogues. 59 75 85 94

PEG-IFN, while effective on its own, can potentially achieve HBsAg loss when combined with nucleoside(t) analogues. 72 73 Lamivudine or other antiviral drugs are recommended for prophylaxis in lymphoma patients undergoing rituximab-containing chemotherapy. 66

Benefits and risks

Benefit Summary

Treatment for chronic hepatitis B can suppress liver inflammation and damage, thereby reducing the risk of developing cirrhosis and liver cancer. 52 68 Treatment can also lower viral load and improve liver function. 7 9 75

Risk Summary

Interferon can cause side effects such as fatigue, fever, muscle aches, and gastrointestinal problems. 8 10 94 23 While generally safe, nucleoside(t) analogues can lead to the emergence of drug-resistant viruses. 53

Comparison of studies

Commonalities between studies

Many studies highlight the effectiveness of interferon and nucleoside(t) analogues in treating chronic hepatitis B. 8 1 50 53 59 68

Differences between studies

There is variation across studies regarding interferon administration methods, duration of treatment, efficacy, and side effects. 8 10 94 23

Consistency and contradictions in results

While many studies support the efficacy of interferon and nucleoside(t) analogues in treating chronic hepatitis B, some studies report conflicting findings regarding interferon's effectiveness and side effects. 8 10 94 23

Considerations for real-world application

Tailoring treatment to each individual patient's condition is crucial when managing chronic hepatitis B. 67 Consult with a physician before starting treatment to fully understand the potential risks and benefits.

Limitations of current research

While treatment for chronic hepatitis B has significantly advanced in recent years, challenges remain. 53 59 68 For example, there is a lack of research evaluating the long-term efficacy and safety of treatments. 75 Furthermore, more research is needed to understand factors like genetics and immune status that may influence treatment outcomes. 49

Future research directions

Further research is essential for advancing chronic hepatitis B treatment. This includes studies evaluating long-term efficacy and safety, developing personalized treatments tailored to individual patients, and finding ways to prevent the emergence of drug-resistant viruses. 52 54 68

Conclusion

Chronic hepatitis B is a serious liver disease, but advancements in treatment options allow many patients to effectively manage their condition and live healthy lives. 64 95 If you are infected or suspect you may be infected with the hepatitis B virus, consulting a physician for appropriate testing and treatment is critical.

Treatment List

Interferon, nucleoside(t) analogues, PEG-interferon, lamivudine, entecavir, tenofovir, telbivudine, famciclovir, hepatitis B immunoglobulin (HBIg), chemotherapy, vaccine.

Keywords
Benefit Keywords
Ly-IFN antiviral
1
Hepatitis B treatment
2
Delta hepatitis treatment
3
Hepatitis B treatment
4
Hepatitis B treatment
5
Aminotransferase normalization
Improved liver inflammation
Viral DNA clearance
6
Hepatitis B treatment
7
Hepatitis B treatment
8
Hepatitis B treatment
9
Effective treatment for chronic hepatitis B
10
Complete response
Normalization of aminotransferase
Partial response
11
Hepatitis B treatment
12
Improved hepatitis B
Viral elimination
13
Improved liver histology
Reduced viral DNA
14
HBeAg seroconversion
HBsAg seroconversion
15
Clinical improvement
HBe seroconversion
HBsAg seroconversion
16
HBV-DNA clearance
HBeAg clearance
Improvement in liver disease
20
Hepatitis B treatment
21
Hepatitis B treatment
22
Effective treatment
Reduced HBV markers
23
Alanine aminotransferase normalization
Antibody development
Carrier state eradication
Viral replication termination
24
Effective treatment
25
Improves histologic scores
Speeds termination of replication
26
Improved liver function
Reduced HBV-DNA levels
27
HBV replication inhibition
Improved immune response
Reduced side effects
28
HBV DNA suppression
Hepatitis B treatment
29
Improved graft survival
Reduced hepatitis B recurrence
30
Prevents chronic HBV
32
Prevent HBV recurrence
33
HBV DNA loss
HBeAg clearance
34
Chronic hepatitis B treatment
35
Reduced viral relapse
36
Lamivudine for hepatitis B
37
Hepatitis B treatment
38
Hepatitis B treatment
39
Hepatitis B treatment
40
HBeAg clearance
41
Improved liver function
Reduced hepatitis B viral load
42
ALT normalization
43
Hepatitis B treatment
44
HBeAg clearance
Seroconversion to anti-HBe
45
Hepatitis B treatment
46
Improved viral suppression
47
Improved CHB treatment
Reduced HBV DNA levels
48
Improves biochemical response
Improves virological response
49
Improved HBV suppression
50
Improved biochemical response
Improved seroconversion rates
Improved virological response
51
Improved CHB treatment
Reduced HCC risk
52
Improved chronic HBV infection treatment
53
Histological improvement
54
HBV treatment
55
HCC mortality reduction
HCC recurrence reduction
57
Hepatitis B treatment
58
Treatment of chronic hepatitis B
59
HBsAg clearance
Sustained response
60
Hepatitis B prevention
Telbivudine efficacy
61
Hepatitis B treatment
62
Reduced liver inflammation
Reversed liver fibrosis
Suppressed viral replication
65
HBV reactivation prevention
66
Improved liver function
67
Antiviral therapy for HBV
68
Improved hepatitis treatment
69
Acute HBV infection treatment
70
Virological rebound reduction
71
Hepatitis B cure
72
HBsAg clearance
73
CHB treatment
74
Cirrhosis progression reduction
Viral load reduction
75
HBsAg loss
76
Improved CHB response
77
HCC treatment
Improved survival
78
CHB infection treatment
79
HBV treatment
80
HBeAg seroconversion
81
Reduced MTCT of HBV
82
Safe discontinuation
83
Improved CHB treatment
84
Increased hepatitis B cure rate
85
Improved hepatitis B treatment
86
Reduced risk of cirrhosis
Reduced risk of hepatic decompensation
Reduced risk of mortality
88
Reduced CR
Reduced HBVr
89
CHB QALY improvement
90
HBeAg Loss
91
Improved immune response
Increased anti-HBs
92
Antiviral treatment
93
Improved HBV response
94
Hepatitis B care
95
CHB treatment
ETV efficacy
TAF efficacy
96
Risk Keywords
HBV reactivation
1
Hepatitis exacerbation
2
Cirrhosis
Relapse
4
Prolonged therapy needed
Viral DNA reactivation
6
Hepatic decompensation
8
Hepatitis reactivation
11
Viral DNA recurrence
14
Hepatitis-like illness
15
HBe reactivation
16
Cirrhosis
Severe liver disease
19
Poor tolerability
20
Amylase elevation
Creatine kinase elevation
Elevated alanine aminotransferase
HBV DNA reappearance
Lipase elevation
21
Virus persistence
22
Escape mutants
28
None reported
29
Long-term safety implications
Resistance
40
Relapse
41
Depression
Flu-like symptoms
Neutropenia
Psychosis
Thrombocytopenia
42
Insufficient data
Unsatisfactory response rates
45
Hepatic flare
Liver transplantation
46
Drug resistance
47
Chronic hepatitis B
48
Adverse events
50
Emergent resistance
51
NA resistance
52
Chronic HBV infection
53
Entecavir resistance
Hepatitis flare
54
Anemia
Neutropenia
Treatment relapse
56
Biochemical relapse
Virological relapse
60
Lack of financial resources
64
Viral resistance
65
Adverse events
66
Drug resistance risk
71
ALT increases
75
Clinical relapse
83
Hepatocellular carcinoma
88
None
91
Virological reactivation
92
Cirrhosis
Hepatocellular carcinoma
Mortality
93
Bone tissue
Renal function
96
Literature analysis of 96 papers
Positive Content
90
Neutral Content
3
Negative Content
3
Article Type
59
32
25
17
96
1.

Anti-HBe-positive chronic hepatitis B with HBV-DNA in the serum response to a 6-month course of lymphoblastoid interferon.

Author: PastoreG, SantantonioT, MilellaM, MonnoL, MarianoN, MoschettaR, PolliceL

Ly-IFN antiviral
HBV reactivation

A study of 18 patients with chronic hepatitis B found that interferon alpha treatment (5 MU/m2 three times a week for 6 months) effectively reduced hepatitis B virus (HBV) DNA levels and improved liver function. However, after stopping treatment, the virus reappeared in 89% of patients within 17 months. The study concluded that interferon alpha provides a temporary benefit for chronic hepatitis B and that a 6-month treatment regimen is insufficient to eliminate the virus from the liver cells.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Possible prevention of chronic hepatitis B by early interferon therapy.

Author: TrépoC, CheminI, PetitM A, ChossegrosP, ZoulimF, ChevallierP, SepetjanM

Hepatitis B treatment
Hepatitis exacerbation

A study of 15 patients with prolonged hepatitis B infection investigated the effectiveness of interferon therapy. Of the 6 patients who received interferon, 5 completely cleared the infection during treatment, with a rise in liver enzymes and temporary worsening of hepatitis. Two patients in the placebo group also cleared the infection. These results suggest that interferon treatment may prevent prolonged hepatitis B from becoming chronic. Further research is needed to confirm these findings and encourage more proactive screening for hepatitis B.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Use of alpha-interferon in the treatment of chronic delta hepatitis.

Author: HadziyannisS J

Delta hepatitis treatment

This review examines the treatment of chronic delta hepatitis, a serious liver infection with limited treatment options. While alpha-interferon (alpha-IFN) can temporarily improve liver function, its effects are not long-lasting. Analysis of five studies showed that alpha-IFN significantly normalized liver enzymes during treatment, but did not maintain these improvements after stopping treatment. The optimal treatment schedule appears to be a higher dose of alpha-IFN (5 MU daily or 9 MU three times a week) for at least a year, leading to remission in 50-70% of patients. However, no factors have been identified that predict response to alpha-IFN, and no alternative treatments are currently available. Further research is needed to develop more effective therapies for chronic delta hepatitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Treatment with interferon of chronic hepatitis B associated with antibody to hepatitis B e antigen.

Author: BrunettoM R, OliveriF, DemartiniA, CalvoP, ManziniP, CerenziaM T, BoninoF

Hepatitis B treatment
Cirrhosis
Relapse

A study of 90 patients with chronic anti-HBe-positive hepatitis B found that interferon therapy inhibited viral replication and normalized ALT levels in about 70% of patients. However, the effect was transient and relapses occurred in 41-90% of patients. The study suggests that interferon is less effective in advanced anti-HBe-positive hepatitis compared to HBeAg-positive patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Short-term prednisolone followed by recombinant human alpha-interferon alone or combined with adenine-arabinoside in chronic hepatitis B. A prospective and randomized trial.

Author: BrissotP, JacquelinetC, JouanolleH, DavidV, GuyaderD, GuéguenM, BlayauM, LescoatG, MessnerM, DeugnierY

Hepatitis B treatment

This study compared two treatment regimens for chronic hepatitis B: a course of prednisolone followed by interferon (group 1) and prednisolone followed by a combination of adenine-arabinoside and interferon (group 2). Both treatments were well-tolerated, with significant side effects leading to early discontinuation of interferon occurring in only four patients in group 2. Both groups showed similar improvements in liver function, with 59% of patients experiencing a sustained decrease in hepatitis B virus levels and a significant reduction in liver enzymes. These findings suggest that interferon, alone or in combination with adenine-arabinoside, may be a beneficial treatment for chronic hepatitis B.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Problems in the management of chronic hepatitis B with interferon: experience in a randomized, multicentre study.

Author: RealdiG, FattovichG, PastoreG, CareddaF, NoventaF, SantantonioT, MoroniM, CriscuoloD, MaladornoD, RuggeM

Aminotransferase normalization
Improved liver inflammation
Viral DNA clearance
Prolonged therapy needed
Viral DNA reactivation

This study investigated the effectiveness of interferon-alfa 2a in treating chronic hepatitis B in 82 patients. Interferon significantly increased the rate of virus clearance and normalized liver enzyme levels compared to no treatment, with these benefits persisting for 16 months. While the virus reactivated in a significant number of patients in both groups, interferon showed improvement in liver inflammation. Factors predicting successful treatment included higher initial liver enzyme levels, female sex, and less severe liver scarring. The study suggests that interferon is a beneficial treatment for chronic hepatitis B, but longer treatment duration may be needed for sustained viral suppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Treatment of chronic hepatitis B with interferon alfa-2b.

Author: MüllerR, BaumgartenR, MarkusR, SchulzM, WittenbergH, Hintsche-KilgerB, FenglerJ D, Von WussowP, MeiselH, KleinH

Hepatitis B treatment

This study evaluated the effectiveness of interferon-alfa 2b in treating 58 patients with chronic hepatitis B. While 32% of the patients treated with interferon showed a partial response to therapy, with a significant decrease in viral markers and normalized liver enzymes, only 11% of untreated patients showed similar improvements. No patients experienced a reactivation of hepatitis after the virus was cleared. The study concludes that interferon-alfa 2b is a potential treatment for chronic hepatitis B, but further research is needed to optimize treatment and assess long-term outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Experience with interferon in chronic hepatitis B in Egypt.

Author: WakedI, AminM, Abd el FattahS, OsmanL M, SabbourM S

Hepatitis B treatment
Hepatic decompensation

This study compared the effectiveness of interferon-alpha 2b treatment to no treatment in 40 patients with chronic hepatitis B. Interferon treatment significantly increased the rate of clearing the virus, with 81% of treated patients experiencing viral clearance compared to 33% in the control group. While both treatment groups showed changes in other viral markers, these changes were more frequent in the interferon group. The study found that the duration of hepatitis B infection influenced the effectiveness of treatment, with those who had the virus for shorter periods experiencing a greater response. While interferon was effective in improving liver function, a significant increase in liver enzymes during treatment was associated with liver failure in a few cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

[Treatment of chronic hepatitis B with interferon alpha-2b].

Author: MüllerR, BaumgartenR, MarkusR, SchulzM, WittenbergH, Hintsche-KilgerB, FenglerJ D, von WussowP, MeiselH, KleinH

Hepatitis B treatment

A study of 58 patients with chronic hepatitis B found that interferon alpha 2b treatment led to complete remission in one patient and partial remission in eight patients. Three untreated patients also showed remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

10.

A randomized, controlled trial of interferon alfa-2b alone and after prednisone withdrawal for the treatment of chronic hepatitis B. The Hepatitis Interventional Therapy Group.

Author: PerrilloR P, SchiffE R, DavisG L, BodenheimerH C, LindsayK, PayneJ, DienstagJ L, O'BrienC, TamburroC, JacobsonI M, SamplinerR, FeitD, LefkowitchJ, KuhnsM, MeschievitzC, SanghviB, AlbrechtJ, GibasA,

Effective treatment for chronic hepatitis B

This study compared different treatments for chronic hepatitis B, including interferon alone and in combination with prednisone, to a placebo and no treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

[Treatment of chronic hepatitis B with interferon alpha-2b].

Author: BaumgartenR, MüllerR, MarkusR, Hintsche-KilgerB, FenglerJ D, MeiselH

Complete response
Normalization of aminotransferase
Partial response
Hepatitis reactivation

This study evaluated the effectiveness of interferon-alfa 2b treatment in 58 patients with chronic hepatitis B. While 32% of patients treated with interferon experienced a partial response, showing a decrease in viral markers and normalized liver enzymes, only 11% of untreated patients showed similar improvements. No patients experienced a reactivation of hepatitis after the virus was cleared. The study concludes that interferon-alfa 2b is a potential treatment for chronic hepatitis B, but further research is needed to optimize treatment and assess long-term outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

Histological improvement after anti-viral treatment for chronic hepatitis B virus infection.

Author: BrookM G, PetrovicL, McDonaldJ A, ScheuerP J, ThomasH C

Hepatitis B treatment

A study of 66 patients with chronic hepatitis B virus infection found that successful treatment with interferon or adenine arabinoside 5'-monophosphate was associated with the loss of both serum and hepatic markers of viral replication and a reduction in liver inflammation. This may prevent progression to cirrhosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Beta- and gamma-interferon in chronic active hepatitis B. A pilot trial of short-term combination therapy.

Author: CaselmannW H, EisenburgJ, HofschneiderP H, KoshyR

Improved hepatitis B
Viral elimination

This study investigated the effectiveness of a combination of beta- and gamma-interferon in treating 20 patients with chronic hepatitis B. The combination therapy was successful in 5 out of 10 patients, with 2 achieving complete clearance of the virus. The treatment was more effective in patients who had been infected for a shorter period (5 out of 6 responders). The study suggests that a combination of beta- and gamma-interferon may be a promising treatment option for chronic hepatitis B, especially when started early after infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen.

Author: BrunettoM R, OliveriF, RoccaG, CriscuoloD, ChiabergeE, CapalboM, DavidE, VermeG, BoninoF

Improved liver histology
Reduced viral DNA
Viral DNA recurrence

A study of 30 patients with chronic hepatitis B found that interferon alpha-2a treatment resulted in a rapid decrease in detectable hepatitis B virus DNA levels and normalized aminotransferase levels in eight patients. However, in seven patients, viral levels rebounded after treatment ended.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Loss of HBsAg with interferon therapy in chronic hepatitis B virus infection.

Author: AlexanderG J, BrahmJ, FaganE A, SmithH M, DanielsH M, EddlestonA L, WilliamsR

HBeAg seroconversion
HBsAg seroconversion
Hepatitis-like illness

A study of 46 male chronic hepatitis B carriers found that interferon treatment led to seroconversion from HBeAg to anti-HBe in 6 out of 23 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Long-term follow-up of antiviral combination therapy in chronic hepatitis B.

Author: De ManR A, SchalmS W, HeijtinkR A, BerkL, Den OudenJ, ten KateF J, ChamuleauR A, ReesinkH W

Clinical improvement
HBe seroconversion
HBsAg seroconversion
HBe reactivation

A study of patients with chronic hepatitis B e-positive hepatitis found that combination therapy with interferon and desciclovir was most effective in achieving HBe seroconversion, followed by interferon alone and acyclovir. Seroconversion was associated with initial low viral replication and transient aminotransferase elevations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Randomised controlled trial of lymphoblastoid interferon for chronic active hepatitis B.

Author: AndersonM G, HarrisonT J, AlexanderG, ZuckermanA J, Murray-LyonI M

This study investigated the effectiveness of interferon treatment for 30 men with chronic hepatitis B. Patients were randomly assigned to receive either interferon or no treatment. Interferon treatment was given daily for 28 days. While all patients experienced temporary side effects like fatigue and flu-like symptoms, interferon successfully suppressed the hepatitis B virus during treatment. However, this effect was only temporary, and after one year, there was no significant difference in viral markers between the treated and untreated groups. The study concludes that this daily interferon regimen was less effective than other treatments using interferon three times a week for three months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Randomised controlled trial of lymphoblastoid interferon for chronic active hepatitis B.

Author: AndersonM G, HarrisonT J, AlexanderG J, ZuckermanA J, Murray-LyonI M

This study investigated the effectiveness of interferon treatment for 30 men with chronic hepatitis B. Patients were randomly assigned to receive either interferon or no treatment. Interferon was given daily for 28 days. While all patients experienced temporary side effects like fatigue and flu-like symptoms, interferon successfully suppressed the hepatitis B virus during treatment. However, this effect was only temporary, and after one year, there was no significant difference in viral markers between the treated and untreated groups. The study concludes that this daily interferon regimen was less effective than other treatments using interferon three times a week for three months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Treatment of chronic delta hepatitis with alpha-2 recombinant interferon.

Author: RizzettoM, RosinaF, SaraccoG, BellandoP C, ActisG C, BoninoF, SmedileA, TrincheroP, SansalvadoreF, PintusC

Cirrhosis
Severe liver disease

This study investigates the potential of interferon (IFN) as a treatment for chronic hepatitis D infection, a serious liver disease caused by a virus that relies on hepatitis B for survival. Previous treatments for hepatitis D have been ineffective, but the availability of large amounts of interferon offers hope for a new treatment option. The study aims to evaluate the safety and effectiveness of interferon in treating chronic hepatitis D.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Lymphoblastoid interferon therapy of chronic HBV infection. A comparison of 12 vs. 24 weeks of thrice weekly treatment.

Author: ScullyL J, SheinR, KarayiannisP, McDonaldJ A, ThomasH C

HBV-DNA clearance
HBeAg clearance
Improvement in liver disease
Poor tolerability

A study of 40 patients with chronic hepatitis B infection compared 12-week and 24-week courses of interferon treatment. While both treatment durations were effective in 59% of male patients, the 24-week course was poorly tolerated and no more effective than the 12-week course. No female patients responded to treatment. Factors associated with a positive response included high AST levels, short duration of illness, and a history of acute hepatitis. The study concluded that a 12-week course of interferon is effective in some patients with chronic hepatitis B, but tolerability and individual patient characteristics should be considered.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

A preliminary trial of lamivudine for chronic hepatitis B infection.

Author: DienstagJ L, PerrilloR P, SchiffE R, BartholomewM, VicaryC, RubinM

Hepatitis B treatment
Amylase elevation
Creatine kinase elevation
Elevated alanine aminotransferase
HBV DNA reappearance
Lipase elevation

Daily doses of 100 mg and 300 mg of lamivudine reduced HBV DNA to undetectable levels in 100% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

22.

PreS1 antigen/antibody patterns following interferon therapy in acute and chronic hepatitis B.

Author: PetitM A, ZoulimF, BerthillonP, CapelF, LiJ, DauguetC, FerrariC, TrépoC

Hepatitis B treatment
Virus persistence

This study of 50 hepatitis B patients found that preS1 antigen expression rebounded after antiviral therapy in patients with chronic active hepatitis B, suggesting the possibility of relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Low dose alpha interferon treatment in chronic hepatitis B virus infection.

Author: MüllerR, BaumgartenR, MarkusR, SchulzM, WittenbergH, Hintsche-KilgerB, FenglerJ D, von WussowP, MeiselH, KleinH

Effective treatment
Reduced HBV markers

Interferon alfa-2b treatment for chronic viral hepatitis B resulted in complete response in one patient and partial response in 32% of treated patients, significantly higher than the spontaneous remission rate in the control group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

To treat or not to treat? The judicious use of interferon-alpha-2a for the treatment of chronic hepatitis B.

Author: RyffJ C

Effective treatment

A meta-analysis of 3 trials with 416 patients showed that interferon-alpha-2a is effective in treating chronic active hepatitis B. The recommended dose is 4.5 MIU thrice weekly for 6 months. Regular monitoring of viral markers and liver function is crucial for determining treatment success and adjusting treatment as needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

26.

Prolonged and high dose recombinant interferon alpha-2b alone or after prednisone priming accelerates termination of active viral replication in children with chronic hepatitis B infection.

Author: VajroP, TedescoM, FontanellaA, De VincenzoA, VecchioneR, AmmendolaR, TerraccianoL M, NovissimoA, VegnenteA

Improves histologic scores
Speeds termination of replication

A prolonged course of high-dose interferon in children with chronic hepatitis B infection significantly sped up the termination of active viral replication, but had a limited impact on response rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Subcutaneously administered recombinant human beta-interferon in the treatment of chronic hepatitis B virus infection.

Author: GuanR, YeohK G, YapI, KangJ Y, WeeA, SmithR

Improved liver function
Reduced HBV-DNA levels

Subcutaneously administered rINF-beta ser was well tolerated. At the end of 6 months, HBV-DNA was undetectable in 20% of patients in the low-dose group and 40% in the high-dose group. One year after completion of treatment, HBV-DNA was undetectable in 50% and 30% of patients in the low-dose and high-dose groups, respectively.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Immunotherapy of chronic hepatitis B by anti HBV vaccine.

Author: PolS, CouillinI, MichelM L, DrissF, NalpasB, CarnotF, BerthelotP, BréchotC

HBV replication inhibition
Improved immune response
Reduced side effects
Escape mutants

This study investigated the potential of vaccine therapy for chronic hepatitis B virus (HBV) infection. The study found that vaccine therapy was effective in reducing or eliminating HBV DNA in a significant number of patients, with or without additional interferon treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Comparison of standard and high dosage recombinant interferon alpha 2b for treatment of children with chronic hepatitis B infection.

Author: GürakanF, KoçakN, OzenH, YüceA

HBV DNA suppression
Hepatitis B treatment
None reported

A 6-month course of interferon alpha 2b was well-tolerated by children with chronic hepatitis B virus (HBV) infection. High dosage interferon led to sustained suppression of HBV in 60% of patients, while standard dosage resulted in suppression in 33% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Antiviral drugs in chronic hepatitis B: review and meta-analysis.

Author: MalaguarneraM, RestucciaS, FerlitoL, MazzoleniG, GiugnoI, PistoneG

This study reviewed 20 trials of antiviral drugs for chronic hepatitis B. While adenine arabinoside and its monophosphate were not effective, combination therapy with cortisone showed promising results (45-66% remission). Lamivudine had limited long-term effects due to the development of resistant virus strains. Famciclovir reduced viral levels by 50% and normalized liver enzymes in 30% of patients. Ganciclovir had temporary benefits. While no antiviral drug has replaced interferon as the primary treatment, they offer potential as they target the cause of the disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

32.

Interferon-alpha in the treatment of acute prolonged hepatitis B virus infection.

Author: KunduS S, KunduA K, PalN K

Prevents chronic HBV

Acute hepatitis B infection usually clears up on its own within 4-12 weeks. Currently, there is no specific treatment for acute hepatitis B. This study examines the effectiveness of interferon-alpha therapy in treating prolonged acute hepatitis B, aiming to prevent it from becoming chronic.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Randomized trial of lamivudine versus hepatitis B immunoglobulin for long-term prophylaxis of hepatitis B recurrence after liver transplantation.

Author: NaoumovN V, LopesA R, BurraP, CaccamoL, IemmoloR M, de ManR A, BassendineM, O'GradyJ G, PortmannB C, AnschuetzG, BarrettC A, WilliamsR, AtkinsM

Prevent HBV recurrence

Substitution of hepatitis B immunoglobulin (HBIg) with lamivudine was effective in preventing hepatitis B virus (HBV) recurrence in low-risk liver transplant recipients, offering a convenient and cost-effective alternative for long-term HBV prophylaxis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B.

Author: MellerupM T, KrogsgaardK, MathurinP, GluudC, PoynardT

HBV DNA loss
HBeAg clearance

Pretreatment with glucocorticosteroids before treatment with alfa interferon in patients with hepatitis B 'e' antigen positive chronic hepatitis B may be more effective than treatment with alfa interferon alone with regard to loss of hepatitis B 'e' antigen and hepatitis B virus DNA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

[Famciclovir treatment of patients with chronic hepatitis B virus infection].

Author: LiLi, ShaoQing, ZhangJian, JiDong

Chronic hepatitis B treatment

Famciclovir was effective and safe for the treatment of chronic hepatitis B virus (HBV) infection, achieving a negative serum HBV DNA in 40.62% of patients compared to 37.93% and 67.90% for interferon alpha and lamivudine, respectively.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

36.

Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: a randomized controlled trial.

Author: ChungYoung-Hwa, SongByung-Cheol, LeeGeun Chan, ShinJung Woo, RyuSoo Hyung, JungSung Ae, YooKwon, LeeHan Chu, LeeYung Sang, SuhDong Jin

Reduced viral relapse

Hepatitis B often returns after interferon treatment. This study investigated whether customizing the length of interferon treatment based on the amount of virus in the blood could reduce the risk of the virus returning in patients with chronic hepatitis B who responded well to treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Lamivudine and 24 weeks of lamivudine/interferon combination therapy for hepatitis B e antigen-positive chronic hepatitis B in interferon nonresponders.

Author: SchiffEugene R, DienstagJules L, KarayalcinSelim, GrimmIan S, PerrilloRobert P, HusaPetr, de ManR A, GoodmanZachary, CondreayLynn D, CrowtherLynn M, WoessnerMary A, McPhillipsPenny J, BrownNathaniel A,

Lamivudine for hepatitis B

The study assesses the effectiveness of lamivudine treatment, with or without added interferon, in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B who had failed interferon therapy previously.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

38.

Efficacy of intramuscular matrine in the treatment of chronic hepatitis B.

Author: LongYao, LinXiao-Tian, ZengKun-Lun, ZhangLian

Hepatitis B treatment

The study investigated the efficacy of intramuscular matrine in the treatment of chronic hepatitis B.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Predictors of virologic response to Lamivudine treatment in children with chronic hepatitis B infection.

Author: HomXenia, LittleNancy R, GardnerStephen D, JonasMaureen M

Hepatitis B treatment

Lamivudine was found to be superior to placebo in reducing hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in children with chronic hepatitis B.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B.

Author: MarcellinPatrick, LauGeorge K K, BoninoFerruccio, FarciPatrizia, HadziyannisStephanos, JinRui, LuZhi-Meng, PiratvisuthTeerha, GermanidisGeorgios, YurdaydinCihan, DiagoMoises, GurelSelim, LaiMing-Yang, ButtonPeter, PluckNigel,

Hepatitis B treatment
Long-term safety implications
Resistance

Current treatments for chronic hepatitis B in people who don’t have a specific type of the virus (HBeAg-negative) often don’t lead to a lasting response. As a result, antiviral medications are often taken indefinitely, which can lead to resistance and unknown long-term side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial.

Author: JanssenHarry L A, van ZonneveldMonika, SenturkHakan, ZeuzemStefan, AkarcaUlus S, CakalogluYilmaz, SimonChristopher, SoThomas M K, GerkenGuido, de ManRobert A, NiestersHubert G M, ZondervanPieter, HansenBettina, SchalmSolko W,

HBeAg clearance
Relapse

Pegylated interferon alfa-2b is effective for HBeAg-positive chronic hepatitis B. Combination with lamivudine in the regimen used is not superior to monotherapy. HBV genotype is an important predictor of response to treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

42.

The safety of pegylated interferon alpha-2b in the treatment of chronic hepatitis B: predictive factors for dose reduction and treatment discontinuation.

Author: van ZonneveldM, FlinkH J, VerheyE, SenturkH, ZeuzemS, AkarcaU S, CakalogluY, SimonC, SoT M K, GerkenG, de ManR A, HansenB E, SchalmS W, JanssenH L A,

Improved liver function
Reduced hepatitis B viral load
Depression
Flu-like symptoms
Neutropenia
Psychosis
Thrombocytopenia

Pegylated interferon alfa-2b is a safe treatment for chronic hepatitis B with compensated liver disease. The most frequent side effects were flu-like symptoms, headache, and fatigue. Dose reduction or early treatment discontinuation was more likely in patients with cirrhosis or low neutrophil count at baseline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Lamivudine treatment in HBeAg-negative chronic hepatitis B patients with low level viraemia.

Author: BozkayaHakan, YurdaydinCihan, IdilmanRamazan, TüzünAli, CinarKubilay, ErkanOzlem, BozdayiA Mithat, ErdenEsra, UzunYusuf, CetinkayaHülya, UzunalimogluOzden

ALT normalization

Low viraemic HBeAg-negative patients with high ALT present with minimal/mild histological activity. Inactive carriers cannot be differentiated from low viraemic patients with high ALT based on HBV DNA determination. Lamivudine treatment can be effective in some cases, but observation rather than prompt treatment is more logical due to mild histological changes and low response rate to treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B.

Author: LauGeorge K K, PiratvisuthTeerha, LuoKang Xian, MarcellinPatrick, ThongsawatSatawat, CooksleyGraham, GaneEdward, FriedMichael W, ChowWan Cheng, PaikSeung Woon, ChangWen Yu, BergThomas, FlisiakRobert, McCloudPhilip, PluckNigel,

Hepatitis B treatment

This study compares the efficacy and safety of pegylated interferon alfa plus lamivudine, pegylated interferon alfa without lamivudine, and lamivudine alone in treating hepatitis B e antigen (HBeAg)-positive chronic hepatitis B.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

45.

Sequential combination of glucocorticosteroids and alfa interferon versus alfa interferon alone for HBeAg-positive chronic hepatitis B.

Author: MellerupM T, KrogsgaardK, MathurinP, GluudC, PoynardT

HBeAg clearance
Seroconversion to anti-HBe
Insufficient data
Unsatisfactory response rates

Pretreatment with glucocorticosteroids before treatment with alfa interferon in patients with hepatitis B 'e' antigen positive chronic hepatitis B may be more effective than treatment with alfa interferon alone with regard to loss of hepatitis B 'e' antigen and hepatitis B virus DNA, but evidence for effect on clinical outcomes is lacking.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Posttreatment exacerbation of hepatitis B virus (HBV) infection in long-term HBV trials of emtricitabine.

Author: MondouE, SorbelJ, AndersonJ, Mommeja-MarinH, RigneyA, RousseauF

Hepatitis B treatment
Hepatic flare
Liver transplantation

Posttreatment exacerbation of hepatitis B virus (HBV) infection occurred in 23% of patients in long-term HBV trials of emtricitabine. Patients with advanced liver disease are at risk for hepatic flare with decompensation if active treatment is withdrawn.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Systematic review: treatment of chronic hepatitis B virus infection by pegylated interferon.

Author: HuiA Y, ChanH L-Y, CheungA Y-K, CooksleyG, SungJ J-Y

Improved viral suppression
Drug resistance

This study found that peginterferon-alpha treatment of at least 6 months should be considered as one of the first-line therapeutic options for hepatitis B virus infection.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update.

Author: KeeffeEmmet B, DieterichDouglas T, HanSteven-Huy B, JacobsonIra M, MartinPaul, SchiffEugene R, TobiasHillel, WrightTeresa L

Improved CHB treatment
Reduced HBV DNA levels
Chronic hepatitis B

Chronic hepatitis B (CHB) is a serious public health issue, with 25% of those infected as newborns dying prematurely from liver complications. This updated treatment guideline for CHB, based on scientific evidence, emphasizes the importance of monitoring viral levels and achieving the lowest possible levels with antiviral medications. Treatment is recommended for patients with high viral levels, with different thresholds based on the type of infection and liver health. Several antiviral drugs are approved, each with advantages and disadvantages, including effectiveness, safety, potential for resistance, ease of use, and cost.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Predicting response to peginterferon alpha-2a, lamivudine and the two combined for HBeAg-negative chronic hepatitis B.

Author: BoninoF, MarcellinP, LauG K K, HadziyannisS, JinR, PiratvisuthT, GermanidisG, YurdaydinC, DiagoM, GurelS, LaiM-Y, BrunettoM R, FarciP, PopescuM, McCloudP,

Improves biochemical response
Improves virological response

This study compared the efficacy of peginterferon alpha-2a with or without lamivudine to lamivudine alone in treating HBeAg-negative chronic hepatitis B, finding that the combination therapy was more effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

50.

Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial.

Author: ChanHenry L Y, HeathcoteE Jenny, MarcellinPatrick, LaiChing-Lung, ChoMong, MoonYoung M, ChaoYou-Chen, MyersRobert P, MinukGerald Y, JeffersLennox, SievertWilliam, BzowejNatalie, HarbGeorge, KaiserRalf, QiaoXin-Jian, BrownNathaniel A,

Improved HBV suppression
Adverse events

This study found that telbivudine demonstrated greater and more consistent hepatitis B virus (HBV) DNA suppression than adefovir after 24 weeks of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Systematic review: combination therapies for treatment-naïve chronic hepatitis B.

Author: KumarM, SarinS K

Improved biochemical response
Improved seroconversion rates
Improved virological response
Emergent resistance

Combination therapies for treatment-naïve chronic hepatitis B (CHB) are showing promise. Combining nucleos(t)ide analogues with a good resistance profile to a nucleos(t)ide analogue with a lower genetic barrier to resistance decreases the risk of emergent resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Meta-analysis: Treatment of hepatitis B infection reduces risk of hepatocellular carcinoma.

Author: SungJ J Y, TsoiK K F, WongV W S, LiK C T, ChanH L Y

Improved CHB treatment
Reduced HCC risk
NA resistance

Interferon or nucleoside/tide analogue treatment significantly reduces the risk of hepatocellular carcinoma in patients with chronic hepatitis B infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

53.

A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update.

Author: KeeffeEmmet B, DieterichDouglas T, HanSteven-Huy B, JacobsonIra M, MartinPaul, SchiffEugene R, TobiasHillel

Improved chronic HBV infection treatment
Chronic HBV infection

Chronic hepatitis B infection is a major health issue globally and in the US. Treatment guidelines for hepatitis B have been updated based on new research, improved testing, and new medications. The goal of treatment is to reduce the levels of hepatitis B virus in the blood to very low or undetectable levels. Several medications are available, but entecavir, peginterferon alfa-2a, and tenofovir are preferred first-line options. The choice of medication depends on factors like effectiveness, safety, the risk of resistance, how the medication is given, and cost.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Efficacy of entecavir treatment for lamivudine-resistant hepatitis B over 3 years: histological improvement or entecavir resistance?

Author: SuzukiYoshiyuki, SuzukiFumitaka, KawamuraYusuke, YatsujiHiromi, SezakiHitomi, HosakaTetsuya, AkutaNorio, KobayashiMasahiro, SaitohSatoshi, AraseYasuji, IkedaKenji, KobayashiMariko, MiyakawaYuzo, KumadaHiromitsu

Histological improvement
Entecavir resistance
Hepatitis flare

Entecavir in the long term would be useful for histological improvement of breakthrough hepatitis induced by lamivudine-resistant HBV mutants in patients with chronic hepatitis B. However, the relatively high rate of entecavir resistance is a concern.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

A 24-week, parallel-group, open-label, randomized clinical trial comparing the early antiviral efficacy of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive chronic hepatitis B virus infection in adult Chinese patients.

Author: ZhengMing-Hua, ShiKe-Qing, DaiZhi-Juan, YeChao, ChenYong-Ping

HBV treatment

The development of drug-resistant hepatitis B virus (HBV) and the potential return of the virus after treatment with certain medications highlight the need for new treatments that effectively suppress the virus, especially in the early stages of infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

A randomized trial of peginterferon alpha-2a with or without ribavirin for HBeAg-negative chronic hepatitis B.

Author: RijckborstVincent, ter BorgMartijn J, CakalogluYilmaz, FerenciPeter, TabakFehmi, AkdoganMeral, SimonKrzysztof, Raptopoulou-GigiMaria, OrmeciNecati, ZondervanPieter E, VerheyElke, van VuurenAnneke J, HansenBettina E, JanssenHarry L A,

Anemia
Neutropenia
Treatment relapse

Combination therapy with peginterferon alpha-2a and ribavirin did not improve the sustained response rate in HBeAg-negative chronic hepatitis B patients compared to monotherapy with peginterferon alpha-2a. Both treatment groups showed a decrease in serum HBV DNA and HBsAg levels during treatment, but HBV DNA levels relapsed after treatment discontinuation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma: a meta-analysis.

Author: MiaoRuo-Yu, ZhaoHai-Tao, YangHua-Yu, MaoYi-Lei, LuXin, ZhaoYi, LiuChang-Ning, ZhongShou-Xian, SangXin-Ting, HuangJie-Fu

HCC mortality reduction
HCC recurrence reduction

This meta-analysis found that postoperative antiviral therapy, interferon in particular, may serve as a favorable alternative to reduce recurrence and mortality in patients with HBV/HCV related HCCs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review.

Author: ZhaoShushan, TangLanhua, FanXuegong, ChenLizhang, ZhouRongrong, DaiXiahong

Hepatitis B treatment

This article discusses the lack of conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (LdT) in the treatment of chronic hepatitis B.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Review article: current antiviral therapy of chronic hepatitis B.

Author: AyoubW S, KeeffeE B

Treatment of chronic hepatitis B

Treatment goals for chronic hepatitis B are changing. The aim is to suppress the hepatitis B virus (HBV) long-term to prevent liver damage and cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir.

Author: HadziyannisStephanos J, SevastianosVassilios, RaptiIrene, VassilopoulosDimitrios, HadziyannisEmilia

HBsAg clearance
Sustained response
Biochemical relapse
Virological relapse

Discontinuing adefovir dipivoxil therapy after 4 or 5 years in HBeAg-negative patients with chronic hepatitis B (CHB) resulted in sustained response in 55% of patients, with 39% experiencing HBsAg clearance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

[Efficacy and safety of telbivudine treatment to block mother-to-child transmission of hepatitis B virus: a meta-analysis].

Author: XuHe-xiangg, WangLi-juan, YuYa-xin, WuYa-ping, XuYun-fang, LiuXin-xiang, ChenYong

Hepatitis B prevention
Telbivudine efficacy

Telbivudine treatment was effective and safe in preventing mother-to-child transmission of HBV from chronically infected mothers with a high degree of infectivity late in pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

62.

Suppression of HBV by tenofovir in HBV/HIV coinfected patients: a systematic review and meta-analysis.

Author: PriceHuw, DunnDavid, PillayDeenan, Bani-SadrFirouze, de Vries-SluijsTheodora, JainMamta K, KuzushitaNoriyoshi, MaussStefan, NúñezMarina, NüeschReto, PetersMarion, ReibergerThomas, StephanChristoph, TanLionel, GilsonRichard

Hepatitis B treatment

Hepatitis B is common in people with HIV, and has become a more significant concern as treatments for HIV have improved. Tenofovir (TDF) is a powerful medication for hepatitis B, with a low risk of resistance. However, there are still questions about TDF's use, including how many people successfully reduce their viral levels, how long the effect lasts, and whether it's less effective for people who have previously used other hepatitis B medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

[Dynamic change of hepatitis B surface antigen expression in chronic hepatitis B patients during the natural recovery course and the short-term antivirus treatment].

Author: LiuJing, LiuTing, WuYuan-kai, KeWei-min, DengZi-de, GaoZhi-liang

The study found that neither natural recovery from an acute flare-up of chronic hepatitis B nor short-term antiviral treatment to resolve the flare-up had any influence on hepatitis B surface antigen (HBsAg) levels.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

64.

Barriers to care and treatment for patients with chronic viral hepatitis in Europe: a systematic review.

Author: PapatheodoridisGeorge V, TsochatzisEmmanuel, HardtkeSvenja, WedemeyerHeiner

Lack of financial resources

Significant barriers to treatment exist for chronic hepatitis B (HBV) and C virus (HCV) patients in Europe.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Management of chronic hepatitis B in children: an unresolved issue.

Author: Della CorteClaudia, NobiliValerio, ComparcolaDonatella, CainelliFrancesca, VentoSandro

Reduced liver inflammation
Reversed liver fibrosis
Suppressed viral replication
Viral resistance

While chronic hepatitis B virus (HBV) infection in childhood typically has a benign course, a small percentage develop cirrhosis or hepatocellular carcinoma. This review discusses the natural history and treatment of chronic HBV in children, focusing on key aspects and unanswered questions regarding management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

66.

Entecavir vs lamivudine for prevention of hepatitis B virus reactivation among patients with untreated diffuse large B-cell lymphoma receiving R-CHOP chemotherapy: a randomized clinical trial.

Author: HuangHe, LiXueying, ZhuJun, YeSheng, ZhangHongyu, WangWei, WuXiangyuan, PengJiewen, XuBing, LinYingcheng, CaoYabing, LiHaoran, LinSuxia, LiuQing, LinTongyu

HBV reactivation prevention
Adverse events

Entecavir was more effective than lamivudine in preventing hepatitis B virus (HBV) reactivation in patients with diffuse large B-cell lymphoma undergoing R-CHOP chemotherapy.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

67.

Cost-Effectiveness Analysis of Alternative Antiviral Strategies for the Treatment of HBeAg-Positive and HBeAg-Negative Chronic Hepatitis B in the United Kingdom.

Author: BerminghamSarah L, HughesRalph, FenuElisabetta, SawyerLaura M, BoxallElizabeth, T KennedyPatrick, DusheikoGeoff, Hill-CawthorneGrant, ThomasHoward

Improved liver function

Pegylated interferon alpha-2a (peg-IFN α-2a) followed by tenofovir disoproxil fumarate or entecavir is the most effective and cost-effective treatment strategy for chronic hepatitis B (CHB).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

68.

Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis.

Author: LokAnna S F, McMahonBrian J, BrownRobert S, WongJohn B, AhmedAhmed T, FarahWigdan, AlmasriJehad, AlahdabFares, BenkhadraKhalid, MouchliMohamed A, SinghSiddharth, MohamedEssa A, Abu DabrhAbd Moain, ProkopLarry J, WangZhen, MuradMohammad Hassan, MohammedKhaled

Antiviral therapy for HBV

This systematic review examines the use of antiviral therapy for chronic hepatitis B viral (HBV) infection. The study provides evidence-based recommendations on when to start treatment, which medications are most effective, and when treatment can be safely stopped.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Interventions to optimise the care continuum for chronic viral hepatitis: a systematic review and meta-analyses.

Author: ZhouKali, FitzpatrickThomas, WalshNick, KimJi Young, ChouRoger, LackeyMellanye, ScottJulia, LoYing-Ru, TuckerJoseph D

Improved hepatitis treatment

New treatments for hepatitis B and C have revolutionized care for these diseases, but patients need to stay in treatment for these medications to be fully effective. This study examined different strategies to improve testing, engagement in care, treatment uptake, adherence to treatment, and achieving remission or a cure for these viral infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Pharmacological interventions for acute hepatitis B infection: an attempted network meta-analysis.

Author: MantzoukisKonstantinos, Rodríguez-PerálvarezManuel, BuzzettiElena, ThorburnDouglas, DavidsonBrian R, TsochatzisEmmanuel, GurusamyKurinchi Selvan

Acute HBV infection treatment

Hepatitis B virus (HBV) infection can cause symptoms or be without symptoms. Beyond chronic infection, acute HBV can lead to severe liver inflammation or liver failure. The best treatment for acute HBV infection is still debated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Entecavir to Telbivudine Switch Therapy in Entecavir-Treated Patients with Undetectable Hepatitis B Viral DNA.

Author: KimDong Hyun, ChoiJong Won, SeoJeong Hun, ChoYong Suk, WonSun Young, ParkByung Kyu, JeonHan Ho, ShinSang Yun, LeeChun Kyon

Virological rebound reduction
Drug resistance risk

This study examined the long-term effectiveness of switching from entecavir (ETV) to telbivudine (LdT) for treating chronic hepatitis B. The study found that switching to LdT resulted in virological rebound in 16.7% of patients. The study concluded that switching to LdT is not recommended after initial treatment with ETV.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.

Author: de NietAnnikki, JansenLouis, StelmaFemke, WillemseSophie B, KuikenSjoerd D, WeijerSebastiaan, van NieuwkerkCarin M J, ZaaijerHans L, MolenkampRichard, TakkenbergR Bart, KootMaarten, VerheijJoanne, BeuersUlrich, ReesinkHendrik W

Hepatitis B cure

This study investigates the effectiveness of peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in achieving HBsAg loss in patients with chronic hepatitis B and a low viral load. While antiviral treatment is not currently recommended for these patients, the study aims to assess whether achieving a functional cure is possible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

HBsAg clearance in chronic hepatitis B patients with add-on pegylated interferon alfa-2a to ongoing tenofovir treatment: A randomized controlled study.

Author: Al AshgarHamad, PeedikayilMusthafa C, Al QuaizMohammed, Al SohaibaniFahad, Al FaddaAbdulrahman, KhanMohammed Q, ThoralssonEinar, Al ThawadiSahar, Al JedaiAhmed, Al KahtaniKhalid

HBsAg clearance

The study investigated whether adding PEGylated interferon (PEG IFN) to tenofovir treatment for chronic hepatitis B virus (HBV) infection can improve HBsAg clearance, the ideal endpoint for HBV treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

74.

Addition of nucleoside analogues to peg-IFNα-2a enhances virological response in chronic hepatitis B patients without early response to peg-IFNα-2a: a randomized controlled trial.

Author: XuYan, WangXu, LiuZhenhua, ZhouChangyu, QiWenqian, JiaoJian, YuFan, GuoHonghua, ZhaoPing, WangJiangbin

CHB treatment

The main treatments for chronic hepatitis B (CHB) are pegylated interferon alpha (PEG-IFN-α) and nucleos(t)ide analogs (NAs). While effective, PEG-IFN-α has limited effectiveness and NAs require long-term use. New treatments are urgently needed, especially for people who don't respond well to these medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

75.

Treatment of chronic hepatitis B naïve patients with a therapeutic vaccine containing HBs and HBc antigens (a randomized, open and treatment controlled phase III clinical trial).

Author: Al MahtabMamun, AkbarSheikh Mohammad Fazle, AguilarJulio Cesar, GuillenGerardo, PentonEuduaro, TueroAngela, YoshidaOsamu, HiasaYoichi, OnjiMorikazu

Cirrhosis progression reduction
Viral load reduction
ALT increases

Nasvac, a therapeutic vaccine candidate containing both hepatitis B surface antigen (HBsAg) and core antigen (HBcAg), induced a superior reduction of the viral load under the limit of detection compared to pegylated interferon (Peg-IFN) treatment in chronic hepatitis B patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

76.

Hepatitis B Surface Antigen Loss with Tenofovir Disoproxil Fumarate Plus Peginterferon Alfa-2a: Week 120 Analysis.

Author: AhnSang Hoon, MarcellinPatrick, MaXiaoli, CaruntuFlorin A, TakWon Young, ElkhashabMagdy, ChuangWan-Long, TabakFehmi, MehtaRajiv, PetersenJörg, GuyerWilliam, JumpBelinda, ChanAlain, SubramanianMani, CransGerald, FungScott, ButiMaria, GaetaGiovanni B, HuiAric J, PapatheodoridisGeorge, FlisiakRobert, ChanHenry L Y

HBsAg loss

A study evaluating the achievement of HBsAg loss with a finite course of oral antiviral therapy found that significantly higher rates of HBsAg loss at 72 weeks post-treatment were demonstrated when tenofovir disoproxil fumarate (TDF) was combined with pegylated interferon (PEG-IFN) for 48 weeks compared with either monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

77.

Low hepatitis B surface antigen and HBV DNA levels predict response to the addition of pegylated interferon to entecavir in hepatitis B e antigen positive chronic hepatitis B.

Author: LiemKin Seng, van CampenhoutMargo J H, XieQing, BrouwerWillem Pieter, ChiHeng, QiXun, ChenLiang, TabakFehmi, HansenBettina E, JanssenHarry L A

Improved CHB response

Peginterferon (PEG-IFN) add-on to entecavir (ETV) therapy was associated with a higher response compared to ETV monotherapy in patients with HBeAg positive chronic hepatitis B (CHB). Response doubled in PEG-IFN naive patients with HBsAg below 4000 IU/mL and HBV DNA below 50 IU/mL.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

Antiviral treatment for treatment-naïve chronic hepatitis B: systematic review and network meta-analysis of randomized controlled trials.

Author: WongWilliam W L, PechivanoglouPetros, WongJosephine, BieleckiJoanna M, HainesAlex, ErmanAysegul, SaeedYasmin, PhoonArcturus, TadrousMina, YounisMona, RayadNoha Z, RacValeria, JanssenHarry L A, KrahnMurray D

CHB infection treatment

Chronic hepatitis B (CHB) infection is a significant global health concern, often without symptoms until the disease is advanced. Treatment aims to improve survival and quality of life by preventing liver damage and cancer. This review examines the effectiveness of available treatments for CHB.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

80.

Lamivudine vs placebo or no treatment in preventing the transmission of hepatitis B virus during pregnancy: a systematic review and meta-analysis.

Author: ZhaoPeng, QianXueqian, SuChang, YangXiaofu, BaiXiaoxia

HBV treatment

Hepatitis B virus (HBV) infection is a major health concern, especially in developing countries, where nearly half the population lives in areas with high rates of transmission. The most common way HBV spreads is from mother to child. While antiviral treatments are available, their effectiveness is still being debated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Effects of IFN monotherapy versus combined therapy on HBeAg seroconversion or seroclearance in HBeAg-positive chronic hepatitis B patients: A meta-analysis.

Author: ZhuFeng, ZhangQiongfang, ZhangQiongyue, ZhangDazhi

HBeAg seroconversion

This study aims to evaluate the effectiveness of combination therapy (interferon (IFN) plus nucleos(t)ide analogues (NAs)) compared to IFN monotherapy in achieving hepatitis B e-antigen (HBeAg) seroconversion or seroclearance in HBeAg-positive chronic hepatitis B (CHB) patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Efficacy of oral antiviral drugs to prevent mother-to-child transmission of hepatitis B virus: a network meta-analysis.

Author: JiaFang, DengFuxue, TongShiwen, LiShiying, RenHong, YinWenwei

Reduced MTCT of HBV

This network analysis compared the efficacy of available treatments to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV), considering the importance of preventing HBV infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

83.

Combining Hepatitis B Virus RNA and Hepatitis B Core-Related Antigen: Guidance for Safely Stopping Nucleos(t)ide Analogues in Hepatitis B e Antigen-Positive Patients With Chronic Hepatitis B.

Author: FanRong, PengJie, XieQing, TanDeming, XuMin, NiuJunqi, WangHao, RenHong, ChenXinyue, WangMaorong, ShengJifang, TangHong, BaiXuefan, WuYaobo, ZhouBin, SunJian, HouJinlin,

Safe discontinuation
Clinical relapse

This study investigated whether combining hepatitis B virus (HBV) RNA and hepatitis B core-related antigen (HBcrAg) could predict off-treatment outcomes in patients with chronic hepatitis B (CHB) who stopped nucleos(t)ide analogue therapy. The combination of HBV RNA and HBcrAg was found to be a satisfactory predictor of clinical relapse and HBsAg loss after treatment cessation.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

84.

Nucleos(t)ide analogues for the treatment of chronic hepatitis B: a systematic review with network meta-analysis.

Author: GengJinSong, BaoHaiNi, ChenYaLan, ShiLiLi, GengJing, WangQing, YuHao

Improved CHB treatment

This study evaluated the effectiveness and safety of nucleos(t)ide analogues for the treatment of chronic hepatitis B (CHB), considering their role in managing this major global health problem.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Effect of combination treatment based on interferon and nucleos(t)ide analogues on functional cure of chronic hepatitis B: a systematic review and meta-analysis.

Author: LiuJiaye, WangTingyan, ZhangWei, ChengYongqian, HeQing, WangFu-Sheng

Increased hepatitis B cure rate

The priority for antiviral treatment in patients with chronic hepatitis B (CHB) is to increase the likelihood of functional cure. The study aimed to evaluate the efficacy of different combination strategies of antiviral treatment based on interferon (IFN) and nucleos(t)ide analogues (NAs) in adults with CHB.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.

Author: TanMingjuan, BhadoriaAjeet S, CuiFuqiang, TanAlex, Van HoltenJudith, EasterbrookPhilippa, FordNathan, HanQin, LuYing, BulterysMarc, HutinYvan

Improved hepatitis B treatment

Only a small proportion of the estimated 257 million people living with chronic hepatitis B virus (HBV) infection worldwide are diagnosed and treated. The study aimed to estimate the proportion of people with chronic HBV infection who are eligible for antiviral treatment worldwide, based on WHO guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Peginterferon Alfa-2a (40KD) Plus Lamivudine or Entecavir in Children With Immune-Tolerant Chronic Hepatitis B.

Author: Mieli-VerganiGiorgina, BansalSanjay, DanielJames F, KansuAydan, KellyDeirdre, MartinCarmen, TizzardSarah, WirthStefan, ZhouJulian, VerganiDiego

A randomized controlled trial showed that antiviral therapy in children and adolescents with immune-tolerant chronic hepatitis B was effective and safe, with promising results for improving liver function and reducing viral load.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

88.

Systematic review with meta-analysis: the impact of functional cure on clinical outcomes in patients with chronic hepatitis B.

Author: VittalAnusha, SharmaDisha, HuAlvin, MajeedNehna A, TerryNancy, AuhSungyoung, GhanyMarc G

Reduced risk of cirrhosis
Reduced risk of hepatic decompensation
Reduced risk of mortality
Hepatocellular carcinoma

This systematic review assessed the impact of hepatitis B surface antigen (HBsAg) loss on clinical outcomes in chronic hepatitis B virus (HBV) infection. HBsAg loss was associated with a reduced risk of hepatocellular carcinoma (HCC), incident cirrhosis, hepatic decompensation, and mortality. However, more research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Entecavir Prevents HBV Reactivation During Direct Acting Antivirals for HCV/HBV Dual Infection: A Randomized Trial.

Author: ChengPin-Nan, LiuChun-Jen, ChenChi-Yi, TsengKuo-Chih, LoChing-Chu, PengCheng-Yuan, LinChih-Lin, ChiuHung-Chih, ChiuYen-Cheng, ChenPei-Jer

Reduced CR
Reduced HBVr

This randomized controlled trial investigated strategies to prevent hepatitis B virus (HBV) reactivation during direct-acting antiviral (DAA) treatment of hepatitis C virus (HCV)/HBV dual infection. Co-administration of entecavir with DAA for 12 weeks was effective in preventing HBV reactivation.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

Economic Evaluation of Oral Nucleos(t)ide Analogues for Patients with Chronic Hepatitis B in Thailand.

Author: DilokthornsakulPiyameth, SawangjitRatree, TangkijvanichPisit, ChayanupatkulManeerat, TanwandeeTawesak, SukeepaisarnjaroenWattana, SriutthaPajaree, PermsuwanUnchalee

CHB QALY improvement

Tenofovir alafenamide fumarate (TAF), tenofovir disoproxil fumarate (TDF), and lamivudine with TAF or TDF rescue are cost-effective options for chronic hepatitis B (CHB) treatment in Thailand. LAM/TAF is the most cost-effective option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

91.

Clearance of Hepatitis B e Antigen in Untreated Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-analysis.

Author: MoharebAmir M, LiuAnne F, KimArthur Y, CoffiePatrick A, KouaméMenan Gérard, FreedbergKenneth A, BoydAnders, HyleEmily P

HBeAg Loss
None

This systematic review and meta-analysis evaluated the rate of hepatitis B e antigen (HBeAg) loss in untreated chronic hepatitis B virus (HBV) infection. 26 cohort studies were included. The pooled rate of HBeAg loss was 6.46/100 person-years, with variations by region and age group.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

93.

Virological Changes of Chronic Hepatitis B Patients with Minimally Elevated Levels of Alanine Aminotransferase: A Meta-Analysis and Systematic Review.

Author: ChenXiyao, ZhengXingrong, WuHewei, ZhangBoxiang, PengLiang, XieChan

Antiviral treatment
Cirrhosis
Hepatocellular carcinoma
Mortality

This systematic review and meta-analysis examines the need for antiviral treatment in chronic hepatitis B (CHB) patients with normal or minimally increased alanine aminotransferase (ALT) levels. While these patients are still at risk for complications, the initiation of antiviral treatment is debated.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

94.

The effectiveness of combination therapy with interferon and nucleoside analogs in pediatric patients with chronic hepatitis B: a systematic review and meta-analysis.

Author: LiMin, LiQinghong, QuJianhui, YangHuiyin, LvTingting, KongYuanyuan, ZhangHongfei

Improved HBV response

A meta-analysis of 17 studies found that combination therapy with interferon and nucleos(t)ide analogs was more effective than interferon monotherapy in suppressing viral load and improving serological response in children with chronic hepatitis B. The combination therapy was associated with increased rates of HBV DNA undetectable, HBeAg clearance, HBeAg seroconversion, and alanine transaminase normalization. More research is needed to compare the efficacy of combination therapy with nucleos(t)ide analog monotherapy.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

95.

How nurses contribute to the elimination of hepatitis B? A systematic review and meta-analysis.

Author: LiCaixia, ZhangMengxing, KarthijekanKarthikesu, FuXia

Hepatitis B care

Hepatitis B is a major health concern, affecting millions of people worldwide. While there are challenges in preventing, diagnosing, treating, and managing hepatitis B, nurses play a critical role in providing care. Despite this, the contributions of nurses in hepatitis B care have been overlooked.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

96.

Renal and bone side effects of long-term use of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide fumarate in patients with Hepatitis B: a network meta-analysis.

Author: LiuZekun, ZhaoZhenzhen, MaXuefeng, LiuShousheng, XinYongning

CHB treatment
ETV efficacy
TAF efficacy
Bone tissue
Renal function

This meta-analysis found that long-term administration of tenofovir disoproxil fumarate (TDF) resulted in greater adverse effects on both renal function and bone tissue compared to entecavir (ETV) and tenofovir alafenamide fumarate (TAF) for chronic hepatitis B patients.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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