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Effect of adjunctive paroxetine on serum levels and side-effects of tricyclic antidepressants in depressive inpatients.

Author: AngersbachD, HacklH J, LeuchtS, SteimerW, ZimmerR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Adding paroxetine to amitriptyline or imipramine treatment for depression significantly increased the serum levels of the metabolites nortriptyline and desipramine. While the combination therapy was generally well tolerated, careful monitoring of blood levels is crucial.
Paper Details　
Original Abstract of the Article :
RATIONALE: Previous studies showed that adjunctive paroxetine increases tricyclic antidepressant (TCA) serum levels by inhibiting cytochrome P4502D6. This effect has, however, been examined only in experimental studies using low doses of TCAs in healthy volunteers. OBJECTIVE: The present study inve...See full text at original site
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引用元：
https://doi.org/10.1007/s002130050006

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2000-03-28
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

10672631

DOI: Digital Object Identifier

10.1007/s002130050006

Related Literature

Article Analysis
・Side Effects of paroxetine
SNS
PICO Info
in preparation
Languages

English

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