Side Effects of paroxetine: A Synthesis of Findings from 17 Studies

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Original Abstract of the Article

Major Research Findings

Paroxetine is a selective serotonin reuptake inhibitor (SSRI) commonly used for treating depression. Several studies have examined the effectiveness and side effects of paroxetine. According to 2 , paroxetine proves effective in managing depression, although it can cause side effects like nausea, agitation, and drowsiness. Additionally, paroxetine may worsen thyroid hormone resistance beta (RTHβ). 17 . Further research has revealed that paroxetine can potentially lead to sexual dysfunction. 9 , 10 , 5 .

Reasons for Side Effects

The side effects of paroxetine are linked to its influence on serotonin levels. Serotonin is a neurotransmitter that plays a role in mood, sleep, appetite, and sexual function. Paroxetine elevates serotonin levels in the brain, contributing to the improvement of depressive symptoms. However, an excess of serotonin can potentially lead to side effects.

Common Side Effects

Nausea

Nausea has been documented as a side effect of paroxetine. 2 .

Agitation

Agitation has been reported as a side effect of paroxetine. 2 .

Somnolence

Somnolence has been reported as a side effect of paroxetine. 2 .

Sexual Dysfunction

Sexual dysfunction has been reported as a side effect of paroxetine. 9 , 10 , 5 .

Weight Gain

Weight gain has been reported as a side effect of paroxetine. 1 .

Side Effect Management

Nausea

To mitigate nausea from paroxetine, consider taking it with meals or at bedtime. 2 .

Agitation

To minimize agitation from paroxetine, limit your intake of caffeine and alcohol. 2 .

Somnolence

To reduce drowsiness from paroxetine, consider taking naps or consuming coffee or tea. 2 .

Sexual Dysfunction

To address sexual dysfunction from paroxetine, discuss with your doctor the possibility of trying different antidepressants or getting a prescription for sexual dysfunction medication. 9 , 10 , 5 .

Weight Gain

To manage weight gain from paroxetine, consider following a diet and exercise program. 1 .

Comparison Across Studies

Commonalities

Multiple studies have shown paroxetine's effectiveness in treating depression. Additionally, they consistently report side effects such as nausea, agitation, and somnolence.

Differences

The prevalence and nature of paroxetine side effects vary among studies. For instance, 2 mentions nausea, agitation, and somnolence as side effects of paroxetine, while 4 reports side effects like headache, tremor, and psychomotor retardation.

Real-Life Application Considerations

Paroxetine is an effective medication for treating depression, but it's crucial to be aware of its potential side effects. Consulting your doctor and adhering to their instructions when taking paroxetine is vital. Furthermore, paroxetine should not be used by pregnant or breastfeeding women. Paroxetine can interact with alcohol and other medications, so it's essential to consult your doctor before taking it.

Limitations of Current Research

Research on the side effects of paroxetine is still in progress. Notably, there's a lack of comprehensive understanding regarding the long-term side effects of paroxetine when used for extended periods.

Future Research Directions

Further research on the side effects of paroxetine is necessary. This includes investigating long-term side effects, strategies to mitigate paroxetine-related side effects, and interactions between paroxetine and other medications.

Conclusion

Paroxetine is an effective treatment for depression, but it can cause side effects. Consulting your doctor and adhering to their instructions when taking paroxetine is crucial. More research on the side effects of paroxetine is warranted.

Literature analysis of 17 papers
Positive Content
11
Neutral Content
2
Negative Content
4
Article Type
5
0
0
0
16
1.

Are selective serotonin reuptake inhibitors well tolerated in somatizing depressives?

Author: LindenR D, WilcoxC S, HeiserJ F, CavanaughE, WisselinkP G

Depression treatment
Gastrointestinal side effects

This retrospective study evaluated the predictive value of baseline gastrointestinal symptoms for the development of gastrointestinal side effects during treatment with paroxetine or fluoxetine. Only baseline appetite loss was significantly associated with subsequent gastrointestinal side effects on paroxetine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression.

Author: GoldenRobert N, NemeroffCharles B, McSorleyPaul, PittsCornelius D, DubéEric M

Improved tolerability

Paroxetine controlled-release (CR) has been developed to improve general tolerability, particularly gastrointestinal tolerability, in patients taking antidepressants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Antidepressant treatment of premature ejaculation: discontinuation rates and prevalence of side effects for dapoxetine and paroxetine in a naturalistic setting.

Author: JernP, JohanssonA, PihaJ, WestbergL, SanttilaP

Premature ejaculation

A retrospective study investigating SSRI discontinuation for premature ejaculation (PE) treatment revealed high discontinuation rates, with dapoxetine having the highest. Paroxetine was found to be more effective and better tolerated than dapoxetine, suggesting a need for further research to develop improved PE treatment alternatives.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Lower side effects of milnacipran than paroxetine in the treatment of major depression disorder among Han Chinese in Taiwan.

Author: ChangTing-Ting, LêngChhian-Hui, WuJo Yung-Wei, LeeSheng-Yu, WangYu-Shan, ChenYi-Chyan, LuRu-Band

Depression treatment
Side effects

Milnacipran, a dual-action antidepressant, showed similar efficacy to paroxetine in treating major depressive disorder. Milnacipran was associated with fewer side effects such as headache, tremor, and psychomotor retardation compared to paroxetine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Incidence of sexual side effects in refractory depression during treatment with citalopram or paroxetine.

Author: LandénMikael, HögbergPer, ThaseMichael E

Sexual dysfunction

This study highlights the underreporting of sexual dysfunction in clinical trials due to the use of non-leading questions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Antidepressant side effects in depression patients treated in a naturalistic setting: a study of bupropion, moclobemide, paroxetine, sertraline, and venlafaxine.

Author: VanderkooyJ D, KennedySidney H, BagbyR Michael

Depression treatment
Central nervous system side effects
Gastrointestinal side effects
Sexual side effects

The TSES was a simple, clinician-administered antidepressant side-effect scale. Paroxetine differed from the other antidepressants on a measure of sexual dysfunction.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Effect of adjunctive paroxetine on serum levels and side-effects of tricyclic antidepressants in depressive inpatients.

Author: LeuchtS, HacklH J, SteimerW, AngersbachD, ZimmerR

Antidepressant combination
Depression treatment
TCA efficacy
Delirium
Medication interaction
TCA serum levels

Adding paroxetine to amitriptyline or imipramine treatment for depression significantly increased the serum levels of the metabolites nortriptyline and desipramine. While the combination therapy was generally well tolerated, careful monitoring of blood levels is crucial.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Paroxetine potentiates the central nervous system side effects of perphenazine: contribution of cytochrome P4502D6 inhibition in vivo.

Author: OzdemirV, NaranjoC A, HerrmannN, ReedK, SellersE M, KalowW

CYP2D6 inhibition
Drug interactions

This study assessed the impact of paroxetine, a CYP2D6 inhibitor, on perphenazine kinetics and central nervous system effects in humans. Paroxetine significantly inhibited CYP2D6 activity, leading to increased perphenazine levels and potential for enhanced central nervous system effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A naturalistic study of paroxetine in premenstrual syndrome: efficacy and side-effects during ten cycles of treatment.

Author: SundbladC, WikanderI, AnderschB, ErikssonE

Reduced PMS symptoms
Anorgasmia
Dry mouth
Nausea
Reduced libido
Sedation

Paroxetine treatment was effective in reducing PMS symptoms in 18 women, with benefits lasting for 10 menstrual cycles. Common side effects included sedation, dry mouth, and nausea, but reduced libido and anorgasmia persisted.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline.

Author: ModellJ G, KatholiC R, ModellJ D, DePalmaR L

Improved sexual function
Increased libido
Decreased sexual function

SSRI-induced adverse sexual effects appear to be the rule rather than the exception and may be substantially underreported. In contrast, prosexual effects were reported by the majority of patients treated with bupropion.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Tolerance and side-effects of paroxetine in elderly depressed patients.

Author: GhoseK

Improved mood
Well tolerated
Gastrointestinal symptoms
Skin rash

Paroxetine is an antidepressant that has fewer side effects than other antidepressants. A study of 12 elderly patients found that paroxetine was well-tolerated at doses of 15mg and 30mg per day. There were no significant changes in blood pressure, heart rate, or other measures of function. However, patients in the 30mg group showed a significant improvement in their symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Extra pyramidal side effects associated with paroxetine.

Author: NicholsonS D

Paranoid psychosis treatment
Extrapyramidal side effects

A 29-year-old man developed severe extrapyramidal side effects after paroxetine was added to his trifluoperazine regimen. The side effects remitted after the medication was withdrawn and did not recur when trifluoperazine was resumed.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Antidepressant and Neuroprotective Effects of 3-Hydroxy Paroxetine, an Analog of Paroxetine in Rats.

Author: Hernández-ArrambidePedro Efraín, Carrasco-CarballoAlan, ParraIrving, Chamorro-ArenasDelfino, MartínezIsabel, LunaFélix, Sartillo-PiscilFernando, TizabiYousef, MendietaLiliana

Antidepressant effects
Neuroprotective effects
PX use
Side effects

3HPX, a hydroxylated analog of paroxetine, was synthesized and compared to paroxetine in silico and in vivo for its potential antidepressant and neuroprotective effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

A case of mood disorder with severe side effects of antidepressants in association with resistance to thyroid hormone beta with a THRB mutation.

Author: Komahashi-SasakiHazuki, Yasui-FurukoriNorio, MaeharaRyo, HasegawaChie, ShimodaKazutaka

Improved depression
Clonus
Disturbance of consciousness
Poor tolerability to antidepressants

This case report suggests that individuals with resistance to thyroid hormone beta may experience poor tolerability to antidepressants and that low doses of quetiapine may be beneficial for treating depression.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

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