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Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats.

Author: FletcherP J, KapurS, SillsT L, WadenbergM G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amoxapine, an antidepressant, has antipsychotic-like activity. It is similar to atypical antipsychotics in its 5-HT(2)/D(2) receptor occupancy profile. Antipsychotic compounds reverse the deficit in sensory gating mechanisms seen in schizophrenics.
Paper Details　
Original Abstract of the Article :
The dibenzoxazepine amoxapine was introduced as an antidepressant but has shown antipsychoticlike activity in a number of animal screening tests. A recent positron emission tomography study showed a 5-HT(2)/D(2) receptor occupancy profile of amoxapine that is very similar to that of established atyp...See full text at original site
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引用元：
https://doi.org/10.1016/s0006-3223(99)00267-x

データ提供：米国国立医学図書館（NLM）

Amoxapine: Antipsychotic Effects Without Catalepsy

This research examines the potential antipsychotic effects of amoxapine, a medication traditionally used as an antidepressant. The study, like a desert explorer discovering a new and unexpected use for a familiar plant, investigates the antipsychotic properties of amoxapine using the prepulse inhibition (PPI) of the acoustic startle reflex test in rats. The authors aimed to determine if amoxapine could effectively reduce psychotic symptoms without inducing catalepsy, a motor side effect often associated with conventional antipsychotics.

A Novel Approach to Antipsychotic Treatment

This research demonstrates that amoxapine exhibits antipsychotic-like effects in rats without inducing catalepsy. This finding is like discovering a new and effective route through a desert, offering a potentially safer and more tolerable option for treating psychotic symptoms. The study suggests that amoxapine could be a valuable therapeutic option for patients with schizophrenia, particularly those who experience motor side effects from conventional antipsychotics.

Navigating the Challenges of Schizophrenia

This research provides a promising avenue for exploring new treatment strategies for schizophrenia. It's like finding a hidden spring in the desert, offering a potential solution to a complex and challenging problem. The study encourages further research into the therapeutic potential of amoxapine for treating psychotic symptoms and minimizing the risk of motor side effects.

Dr. Camel's Conclusion

This research delves into the intriguing world of amoxapine and its potential as a novel antipsychotic agent. It's like discovering a hidden oasis in the desert—a potential source of relief and comfort for patients suffering from schizophrenia. The study's findings provide a promising starting point for further research and exploration of amoxapine's therapeutic applications.
Date :
  1. Date Completed 2000-05-09
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

10745061

DOI: Digital Object Identifier

10.1016/s0006-3223(99)00267-x

Related Literature

Article Analysis
・Effects of amoxapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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