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Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group.

Author: BrownR A, ChellyJ E, DershwitzM, HahneW F, KovacA L, McKenzieR, MingusM, MonkT G, PearmanM H, PhilipB K, SungY F, WetchlerB V

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the efficacy and safety of i.v. dolasetron mesylate in patients undergoing outpatient surgery with general anaesthesia. Dolasetron provided well-tolerated, safe, and effective prophylaxis for post-operative nausea and vomiting with maximum effectiveness observed at a dose of 12.5 mg.
Paper Details　
Original Abstract of the Article :
In a multicentre, randomized, double-blind, placebo-controlled dose-ranging study, 1030 patients undergoing outpatient surgery with general anaesthesia received i.v. dolasetron mesylate (12.5, 25, 50, or 100 mg) or placebo. The principal outcome measure was the proportion of patients who were free o...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2346.2000.00594.x

データ提供：米国国立医学図書館（NLM）

Dolasetron for Postoperative Nausea and Vomiting Prevention

Postoperative nausea and vomiting (PONV) is a common and unpleasant side effect of surgery, often causing discomfort and delaying recovery. This research investigates the effectiveness of dolasetron mesylate, a 5-HT3 receptor antagonist, in preventing PONV following outpatient surgery with general anesthesia. The authors conducted a multicenter, randomized, double-blind, placebo-controlled trial, finding that dolasetron significantly reduced the incidence of PONV compared to placebo. This study highlights the potential for dolasetron to be a valuable tool for preventing PONV, improving patient comfort and facilitating a smoother recovery.

Dolasetron: A Powerful Weapon Against PONV

The study's findings demonstrate the effectiveness of dolasetron in preventing PONV, offering a significant improvement in patient comfort and recovery. It's like finding a powerful antidote to a desert venom, offering protection from a potentially debilitating condition. This research underscores the importance of proactive measures to minimize postoperative discomfort.

Improving Patient Experience

The study's focus on improving patient experience highlights the importance of considering the holistic aspects of healthcare. By minimizing PONV, dolasetron can contribute to a more positive and comfortable recovery process for patients. It's like creating a more welcoming oasis in the desert of postoperative recovery, fostering a sense of well-being and facilitating a smoother transition back to normalcy.

Dr. Camel's Conclusion

This research showcases the effectiveness of dolasetron in preventing PONV, offering a significant improvement in patient comfort and recovery. This study underscores the importance of proactive measures to address the challenges of postoperative nausea and vomiting, ultimately leading to a more positive and efficient recovery experience for patients.
Date :
  1. Date Completed 2000-05-02
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

10758440

DOI: Digital Object Identifier

10.1046/j.1365-2346.2000.00594.x

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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