Effects of dolasetron injection: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major Research Findings

Dolasetron is a medication that has been shown to be effective in preventing postoperative nausea and vomiting (PONV), a common complication after surgery. 20 found that combining dolasetron with dexamethasone was more effective than dolasetron alone in reducing the incidence and severity of emetic symptoms and improving patient satisfaction. A study published in 6 demonstrated that dolasetron was a safe and effective preventive treatment for PONV in women undergoing outpatient laparoscopic gynecologic surgery. Several studies have also indicated that dolasetron is comparable or superior to other 5-HT3 receptor antagonists, such as ondansetron, in preventing PONV. 7 , 15 , 16 . Moreover, research suggests that dolasetron is effective in preventing nausea and vomiting caused by chemotherapy, particularly those involving cisplatin, and might be more beneficial than traditional antiemetics like metoclopramide. 8 , 5 . Further research is needed to assess dolasetron's potential in preventing radiation-induced nausea and vomiting. 12 .

Benefits and Risks

Benefit Summary

Dolasetron has been shown to effectively prevent nausea and vomiting after surgery, as well as those induced by chemotherapy and potentially radiation therapy. Several studies highlight its comparable or superior efficacy compared to other 5-HT3 receptor antagonists. Additionally, dolasetron has demonstrated effectiveness exceeding traditional antiemetics like metoclopramide.

Risk Summary

While generally considered safe, dolasetron may cause side effects such as headache, dizziness, and diarrhea. It is important to note that dolasetron can potentially affect the electrical activity of the heart, leading to a prolonged QT interval. This prolongation can increase the risk of irregular heartbeats. Individuals with heart problems or those taking medications for heart conditions should consult their physician before using dolasetron.

Comparison Between Studies

Commonalities Between Studies

These studies consistently show that dolasetron is effective in preventing postoperative nausea and vomiting. A common finding across many studies is that dolasetron is comparable or superior to other 5-HT3 receptor antagonists in terms of effectiveness.

Differences Between Studies

The studies vary in terms of dolasetron dosage, administration methods, patient populations, and outcome measures. This makes direct comparison of results challenging. For example, while 20 shows that combining dolasetron with dexamethasone is effective, 6 suggests that dolasetron alone is effective. The study in 29 focuses on comparing the pharmacokinetics of oral and intravenous dolasetron administration.

Consistency and Contradictions in Results

The studies demonstrate a consistent finding that dolasetron is effective in preventing postoperative nausea and vomiting. However, the optimal dosage and administration method remain unclear. Further research is needed to investigate potential interactions between dolasetron and other medications.

Considerations for Real-Life Application

While numerous studies support dolasetron's effectiveness in preventing postoperative nausea and vomiting, it is important to remember that dolasetron may pose higher risks to individuals with heart problems or those taking heart medications. Consulting a physician before using dolasetron is crucial.

Limitations of Current Research

Many studies on dolasetron are relatively small, necessitating larger-scale research. The long-term safety and efficacy of dolasetron remain unestablished. Further research is required to investigate potential interactions with other medications.

Future Research Directions

Future research should focus on identifying the optimal dosage and administration method for dolasetron. Long-term follow-up studies are necessary to assess long-term safety and efficacy. Pharmacodynamic studies are crucial to determine potential interactions with other medications.

Conclusion

Numerous studies have shown dolasetron's effectiveness in preventing postoperative nausea and vomiting. However, individuals with heart problems or those taking heart medications may experience higher risks when using dolasetron. Consulting a physician before using dolasetron is essential. Further research regarding dolasetron is necessary.

Literature analysis of 29 papers
Positive Content
28
Neutral Content
0
Negative Content
1
Article Type
18
0
0
4
29
1.

Single-blind study of the effects of intravenous dolasetron mesylate versus ondansetron on electrocardiographic parameters in normal volunteers.

Author: BenedictC R, ArbogastR, MartinL, PattonL, MorrillB, HahneW

Nausea and vomiting treatment
QTc interval prolongation
Ventricular depolarization

This study examined the effects of intravenous dolasetron mesylate on electrocardiogram (ECG) intervals in healthy volunteers. Dolasetron mesylate and ondansetron both prolonged the QTc interval, but dolasetron mesylate primarily affected ventricular depolarization, while ondansetron mainly affected ventricular repolarization.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Prevention of acute emesis in cancer patients following high-dose cisplatin with the combination of oral dolasetron and dexamethasone.

Author: KrisM G, PendergrassK B, NavariR M, GroteT H, NelsonA M, ThomasV, FergusonB B, AllmanD S, PizzoB A, BakerT W, FernandoI J, ChernoffS B

Prevents acute emesis

This study evaluated the effectiveness of a combination of oral dolasetron and dexamethasone in preventing acute emesis in cancer patients receiving cisplatin.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Stratified administration of serotonin 5-HT3 receptor antagonists (setrons) for chemotherapy-induced emesis. Economic implications.

Author: SanchezL A, HoldsworthM, BartelS B

CIE prevention

Serotonin 5-HT3 receptor antagonists are effective for preventing chemotherapy-induced emesis (CIE). Dose stratification can improve both clinical and economic outcomes. Strategies for cost-effective use include using lower doses, oral formulations, and guidelines for appropriate use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Cost-effectiveness of prophylactic dolasetron or droperidol vs rescue therapy in the prevention of PONV in ambulatory gynecologic surgery.

Author: FrighettoL, LoewenP S, DolmanJ, MarraC A

Cost-effective

Dolasetron and droperidol given intraoperatively were more cost-effective than no prophylaxis for post-operative nausea and vomiting (PONV) in patients undergoing ambulatory gynecologic surgery. Droperidol was slightly more cost-effective than dolasetron.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

A double-blind, multicentre comparison of intravenous dolasetron mesilate and metoclopramide in the prevention of nausea and vomiting in cancer patients receiving high-dose cisplatin chemotherapy.

Author: ChevallierB, CappelaereP, SplinterT, FabbroM, WendlingJ L, CalsL, CatimelG, GiovanniniM, KhayatD, BastitP, ClaverieN

Reduced nausea and vomiting
Mild headache

Dolasetron mesilate was effective for the prevention of CINV with high-dose cisplatin. Single i.v. doses of dolasetron mesilate were more effective than 7 mg/kg metoclopramide in preventing nausea and vomiting induced by highly emetogenic cisplatin-containing chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Intravenous dolasetron for the prevention of postoperative nausea and vomiting after outpatient laparoscopic gynecologic surgery.

Author: GraczykS G, McKenzieR, KallarS, HickokC B, MelsonT, MorrillB, HahneW F, BrownR A

High patient satisfaction
Reduced nausea and vomiting
Mild headache

Dolasetron mesylate salt was effective and well tolerated for the prevention of PONV resulting from laparoscopic gynecologic surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Intravenous dolasetron and ondansetron in prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study.

Author: KorttilaK, ClergueF, LeeserJ, FeissP, OlthoffD, Payeur-MichelC, WesselP, NaveS, HahneW, BrownR

PONV prevention

The study compares the efficacy of intravenous dolasetron and ondansetron for the prevention of postoperative nausea and vomiting (PONV) when administered at induction of anesthesia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Antiemetic efficacy of two different single intravenous doses of dolasetron in patients receiving high-dose cisplatin-containing chemotherapy.

Author: YeildingA, BertoliL, EisenbergP, PleziaP, ModianoM R, AlbertsD S, KhojastehA, CramerM B, HahneW F

Antiemetic effectiveness
High complete response rate
Longer time to emesis
Diarrhea
Headache

Dolasetron mesylate 1.8 mg/kg was more effective than 0.6 mg/kg in preventing nausea and vomiting in patients receiving high-dose cisplatin chemotherapy for the first time. Complete responses were achieved in 55% of patients receiving 1.8 mg/kg compared to 31% receiving 0.6 mg/kg. The most common side effects were mild headache and diarrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Intravenous dolasetron mesilate in the prevention of postoperative nausea and vomiting in females undergoing gynecological surgery.

Author: DiemunschP, D'HollanderA, PaxtonL, SchoefflerP, WesselP, NavéS, BrownR A, HahneW F

Effective treatment
Well tolerated
Mild adverse events

Dolasetron mesilate was effective and well-tolerated in preventing post-operative nausea and vomiting (PONV) in women undergoing gynecologic surgery under general anesthesia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Pharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized children.

Author: LermanJ, SimsC, SikichN, GowR, ChinC, DempseyE, HowardD R, KeungA C

Dolasetron mesylate was safe and well-tolerated in children from 2 to 12 years of age. The active metabolite, MDL 74,156, is produced within 10 minutes of administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Palonosetron.

Author: SiddiquiM Asif A, ScottLesley J

Nausea and vomiting prevention
Reduced side effects

Palonosetron is a medication used to prevent nausea and vomiting caused by chemotherapy. This study found that palonosetron was effective in preventing both acute and delayed nausea and vomiting in patients receiving chemotherapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

A double-blind, placebo-controlled trial of i.v. dolasetron mesilate in the prevention of radiotherapy-induced nausea and vomiting in cancer patients.

Author: BeyP, WilkinsonP M, ResbeutM, BourdinS, Le FlochO, HahneW, ClaverieN

Emesis control
Radiotherapy induced emesis
Well-tolerated
Mild to moderate events

Dolasetron mesilate was effective and well-tolerated in the control of single, high-dose radiotherapy-induced emesis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Preliminary pharmacokinetics of intravenous and subcutaneous dolasetron and pharmacodynamics of subcutaneous dolasetron in healthy cats.

Author: HerndonAndrea K, QuimbyJessica M, SiebergLiberty G, DavisLeigh, CaressAmber L, LigasSabina, HansenRyan J, WittenburgLuke A, GustafsonDanial L

Antiemetic effect

Dolasetron is a drug that is used to prevent nausea and vomiting. This study looked at the effects of giving dolasetron to cats. The study found that dolasetron did not prevent vomiting in cats, and more research is needed to determine if a higher dose would be effective.

Clinical Trial, VeterinaryClinical trials involving animals. They are conducted to evaluate the safety and efficacy of new drugs and treatments and contribute to the advancement of veterinary medicine.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Efficacy of single-dose intravenous dolasetron versus ondansetron in the prevention of postoperative nausea and vomiting.

Author: WalkerJ B

Postoperative nausea and vomiting prevention
Adverse events

This study discussed the use of 5-hydroxytryptamine3-receptor antagonists, such as ondansetron, dolasetron, and granisetron, in preventing postoperative nausea and vomiting (PONV) and avoiding adverse events associated with traditional antiemetics.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group.

Author: KovacA L, ScuderiP E, BoernerT F, ChellyJ E, GoldbergM E, HantlerC B, HahneW F, BrownR A

Reduced nausea and vomiting
Adverse events

Dolasetron is an effective treatment for postoperative nausea and vomiting (PONV) with a safety profile similar to placebo. The 12.5 mg dose was as effective as larger doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Effects of granisetron with doxorubicin or epirubicin on ECG intervals.

Author: JantunenI T, KatajaV V, MuhonenT T, ParviainenT

Nausea and vomiting prevention
Minor PR interval prolongation

Granisetron, a 5-HT3 receptor antagonist, slightly increased PR interval duration in a clinical trial with cancer patients. This minor change did not seem to be of clinical relevance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Single-blind study of the effects of intravenous dolasetron mesylate versus ondansetron on electrocardiographic parameters in normal volunteers.

Author: BenedictC R, ArbogastR, MartinL, PattonL, MorrillB, HahneW

Nausea and vomiting treatment
QTc interval prolongation
Ventricular depolarization

This study examined the effects of intravenous dolasetron mesylate on electrocardiogram (ECG) intervals in healthy volunteers. Dolasetron mesylate and ondansetron both prolonged the QTc interval, but dolasetron mesylate primarily affected ventricular depolarization, while ondansetron mainly affected ventricular repolarization.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

[Prevention of post-operative nausea and vomiting. Randomised comparison of dolasetron versus dolasetron plus dexamethasone].

Author: PiperS N, TriemJ G, RöhmK D, KrankeP, MaleckW H, BoldtJ

Postoperative nausea and vomiting treatment

Combining oral dolasetron with intravenous dexamethasone significantly improves the antiemetic efficacy of dolasetron for postoperative nausea and vomiting (PONV), with a number-needed-to-treat of about 6.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

21.

Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group.

Author: PhilipB K, PearmanM H, KovacA L, ChellyJ E, WetchlerB V, McKenzieR, MonkT G, DershwitzM, MingusM, SungY F, HahneW F, BrownR A

Prevent PONV
Mild side effects

This study investigated the efficacy and safety of i.v. dolasetron mesylate in patients undergoing outpatient surgery with general anaesthesia. Dolasetron provided well-tolerated, safe, and effective prophylaxis for post-operative nausea and vomiting with maximum effectiveness observed at a dose of 12.5 mg.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Dose-ranging evaluation of the antiemetic efficacy of intravenous dolasetron in patients receiving chemotherapy with doxorubicin or cyclophosphamide.

Author: HeskethP J, GandaraD R, HeskethA M, FacadaA, PerezE A, WebberL M, MartinL A, CramerM B, HahneW F

Prevention of chemotherapy-induced nausea
Side effects

Dolasetron, a selective 5-HT3 antagonist, was found to be safe and effective in preventing emesis induced by doxorubicin and/or cyclophosphamide in cancer patients. 61% of patients experienced complete control of emesis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A double-blind, placebo-controlled, dose-ranging safety evaluation of single-dose intravenous dolasetron in healthy male volunteers.

Author: HuntT L, CramerM, ShahA, StewartW, BenedictC R, HahneW F

Dolasetron safe
ECG changes

Dolasetron mesylate was well tolerated in healthy male volunteers at doses up to 5.0 mg/kg. The most common adverse events were mild and included headache, dizziness, increased appetite, and nausea. Transient and asymptomatic ECG changes were observed in some subjects at doses of 3.0 mg/kg or higher.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Prophylactic intravenous ondansetron and dolasetron in intrathecal morphine-induced pruritus: a randomized, double-blinded, placebo-controlled study.

Author: IatrouChristos A, DragoumanisChristos K, VogiatzakiTheodosia D, VretzakisGeorge I, SimopoulosConstantinos E, DimitriouVasilios K

Reduced pruritus

Ondansetron and dolasetron were evaluated for the prevention of intrathecal morphine-induced pruritus in a prospective, randomized, double-blind, placebo-controlled study. The incidence and severity of pruritus was significantly less frequent in the ondansetron and dolasetron groups compared with placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

[Dolasetron, droperidol and a combination of both in prevention of postoperative nausea and vomiting after extracapsular cataract extraction under general anesthesia].

Author: EberhartL H, LindenthalM, SeelingW, GäckleH, GeorgieffM

PONV prevention

Low-dose droperidol, dolasetron, and a combination of both drugs were effective in the prevention of PONV after extracapsular cataract extraction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

26.

Intravenous dolasetron mesilate ameliorates postoperative nausea and vomiting.

Author: DiemunschP, LeeserJ, FeissP, D'HollanderA, BradburnB G, PaxtonD, WhitmoreJ, PanouillotP, NavéS, BrownR A, HahneW F

Effective PONV treatment
High patient satisfaction
High physician satisfaction
Mild headache

Dolasetron mesilate was both effective and safe in treating postoperative nausea and vomiting (PONV) in adult patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparative efficacy of oral and intravenous granisetron for the prevention of acute chemotherapy-induced emesis.

Author: PerezE A

5-HT3 receptor antagonists
Chemotherapy-induced emesis
Granisetron
Oral therapy
Constipation
Headache

Oral granisetron was as effective as intravenous granisetron in the treatment of chemotherapy-induced emesis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

29.

Pharmacokinetics and safety of single intravenous and oral doses of dolasetron mesylate in healthy women.

Author: KeungA C, LandriaultH, LefebvreM, GossardD, DempseyE E, JuneauM, DimmittD, CastlesM, RobertsL, SpenardJ

Safe for women
Abdominal cramps
Constipation
Dizziness
Headache
Hot flushes

Dolasetron, a 5-HT3 antagonist antiemetic, was found to have similar pharmacokinetics in healthy women and men, and was well-tolerated in both genders.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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