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Androgens versus placebo or no treatment for idiopathic oligo/asthenospermia.

Author: HughesE, LilfordR, VailA, VandekerckhoveP

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines the evidence for using androgens to treat oligo-astheno-teratospermia (low sperm count, reduced motility, and abnormal morphology) of unknown cause. While androgens are thought to play a role in sperm production and maturation, exogenous testosterone can suppress sperm production. The review explores the use of "stimulatory" androgens (mesterolone and testosterone undecanoate), which aim to directly stimulate sperm production or influence sperm transport and maturation, and "rebound" androgens, which are used to suppress sperm production and then allow for a rebound effect after treatment stops. The review analyzes the available evidence for both approaches.
Paper Details　
Original Abstract of the Article :
Oligo-astheno-teratospermia (sperm of low concentration, reduced motility and increased abnormal morphology) of unknown cause is common and the need for treatment is felt by patients and doctors alike. As a result, a variety of empirical, non-specific treatments have been used in an attempt to impro...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD000150

データ提供：米国国立医学図書館（NLM）

Androgens: A Shifting Sandscape in the Desert of Male Infertility

The [male infertility] landscape is often characterized by a search for effective treatments to improve sperm quality and fertility. This review examines the evidence for the use of androgens in the treatment of idiopathic oligo/asthenospermia. The authors aimed to assess the efficacy of androgens in improving semen characteristics and fertility, considering both stimulatory and rebound androgen therapy approaches.

A Complex Terrain: Androgens and Spermatogenesis

The review highlights the complex relationship between androgens and spermatogenesis. While exogenous testosterone can suppress FSH and LH secretion, potentially affecting spermatogenesis, certain androgens, such as mesterolone and testosterone undecanoate, have been proposed to exert a direct stimulatory effect on spermatogenesis. The study also explores the potential of rebound androgen therapy, where androgens are administered to suppress gonadotropin secretion, followed by discontinuation of therapy to induce a surge of FSH and LH, potentially promoting spermatogenesis.

Navigating the Dunes of Infertility Treatment

This review underscores the need for a cautious approach to androgen therapy in the treatment of male infertility. It emphasizes the importance of carefully considering the potential risks and benefits of androgen therapy, particularly the potential for negative feedback on the pituitary-gonadal axis. The authors advocate for further research to clarify the mechanisms of action of various androgen therapies and to develop more effective and targeted treatments for male infertility.

Dr. Camel's Conclusion

The desert of male infertility is often a challenging and stressful terrain. This review, like a guidepost in the desert, offers insights into the complex role of androgens in fertility. We must continue to explore the shifting sandscape of infertility treatment, seeking to find the most effective and safe paths to parenthood. As a camel who has traversed the desert, I know that the journey is often long and arduous, but with patience, determination, and a willingness to adapt, we can overcome the obstacles and reach our destination.

Date :
  1. Date Completed 2000-07-06
  2. Date Revised 2018-12-21
Further Info :

Pubmed ID

10796496

DOI: Digital Object Identifier

10.1002/14651858.CD000150

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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