Effective treatment of infertility: A Synthesis of Findings from 53 Studies

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Original Abstract of the Article

Major findings of research

The best treatment for infertility depends on the individual circumstances of the patient and their partner. Some studies have shown that certain treatments are superior to others. For example, one study found that in vitro fertilization (IVF) resulted in higher pregnancy rates than other treatments for patients with severe bilateral tubal disease. However, other studies have shown that IVF does not have a statistically significant effect on patients with other causes of infertility. 9

Another study found that time-limited hydrotubation combined with clomiphene citrate resulted in a higher clinical pregnancy rate per cycle in women with unexplained infertility than clomiphene citrate alone. 34

Further, IVF has shown to have higher pregnancy rates and fewer treatment cycles than FSH/IUI for the treatment of unexplained infertility. This study focused on older women (aged 38 to 42 years) and suggests that IVF may be more effective with age. 32

Treatment Summary

Treatments for unexplained infertility include expectant management, IUI, and IVF. Expectant management is the process of waiting for a natural pregnancy to occur. IUI is the process of injecting sperm directly into the uterus. IVF is the process of fertilizing eggs outside the body and transferring them to the uterus. 19

Clomiphene is the current first-line infertility treatment in women with the polycystic ovary syndrome. Clomiphene is a selective estrogen receptor modulator that may improve semen quality by stimulating hormone synthesis and spermatogenesis. 49

Treatments for ovulatory infertility include anti-estrogens such as clomiphene, tamoxifen, dexamethasone, bromocriptine, and aromatase inhibitors (AIs).

Male factor infertility accounts for about 50% of infertility. The treatment for idiopathic male infertility is empirical. Urinary, purified, and recombinant gonadotropins have been used to improve sperm parameters in idiopathic male infertility with the goal of increasing pregnancy rates. Research addressing pregnancy rates in partners of men treated with gonadotropins has had conflicting results and needs to be analyzed. 20

Benefits and Risks

Benefits Summary

The benefits of infertility treatment include improved pregnancy rates, shorter time to pregnancy, and fewer treatment cycles. 7

Risks Summary

The risks of infertility treatment include the risk of multiple pregnancy, the risk of miscarriage, and the risk of ovarian hyperstimulation syndrome (OHSS). 32

Comparison between studies

Commonalities between studies

Many studies have shown that IVF results in higher pregnancy rates than other treatments. 7

Differences between studies

The effects of IVF vary from study to study. While some studies have shown that IVF is more effective than other treatments, other studies have shown that it is only marginally effective. These differences may be due to differences in study methodology, patient populations, or treatments. 9

Consistency and Contradictions in the Findings

There are both consistent and contradictory findings in research on infertility treatments. Some studies have shown that certain treatments are more effective than others, but other studies have not found such effects. These differences may be due to differences in study methodology, patient populations, or treatments. 7

Things to Keep in Mind When Applying the Findings to Real Life

Infertility treatment is dependent upon the unique circumstances of the patient and their partner. It is important to discuss the benefits and risks of treatment options with your doctor. 9

Limitations of Current Research

There are several limitations to research on infertility treatments. For example, some studies have small sample sizes, which may make the results difficult to generalize. In addition, some studies may have a biased design that makes the results less reliable. 7

Future research directions needed

Future research on infertility treatment needs to be more comprehensive and involve more rigorous study designs. Research that compares the effectiveness of different treatment options is also necessary. 7

Conclusion

Infertility treatment is dependent upon the unique circumstances of the patient and their partner. It is important to discuss the benefits and risks of treatment options with your doctor. 7

Infertility can be a stressful experience for many. However, treatments are constantly improving and the chances of pregnancy are increasing. If you are struggling with infertility, consult your doctor and discuss treatment options. 7

List of treatments

Expectant management, IUI, IVF, clomiphene, tamoxifen, dexamethasone, bromocriptine, aromatase inhibitors (AI), gonadotropins, time-limited hydrotubation

Keywords
Benefit Keywords
Improved fertility
1
Infertility treatment
2
Laparoscopic surgery efficacy
Pregnancy rates
3
Increased pregnancy rate
4
Effective treatment
Increased pregnancy rate
5
Improved understanding of IVF treatment
6
Infertility treatment
7
Improved unexplained infertility treatment
8
Higher pregnancy rate
Lower cost
9
Improved male infertility treatment
11
Improved fertilization rates
Increased pregnancy rates
Male factor infertility treatment
12
Azoospermia treatment
13
Infertility treatment
14
Infertility treatment
15
CC and IUI effective for infertility
Gonadotrophins and IUI more effective
16
Anovulation treatment
17
Reduce anxiety
Reduce depression
18
Infertility treatment
19
Improved male infertility treatment
20
Improved male infertility treatment
21
Infertility treatment
22
Improved male infertility treatment
23
Improved male infertility treatment
24
Improved male infertility treatment
25
Depression alleviation
26
Improved infertility treatment
28
Improved fertility
29
Improved infertility treatment
30
Cost-effective
Increased pregnancy rate
31
Increase pregnancy rate
Reduce treatment cycles
32
Higher live birth rate
Higher ovulation rate
33
Increased pregnancy rate
34
IVF treatment
OHSS prevention
35
Infertility treatment
36
Infertility treatment
37
Infertility treatment
38
IUI
Ovarian stimulation
39
Improved fertility preservation
Increased fertility options
40
ART
Male infertility treatment
41
Improved fertility
42
Higher pregnancy rate
43
Sperm production
44
Live birth rate
46
Improved pregnancy rate
47
Male infertility treatment
48
Male infertility treatment
49
Improved sperm quality
Increased pregnancy rates
50
Infertility treatment
51
Clinical pregnancy (glucocorticoid)
52
Infertility treatment
53
Risk Keywords
Endometriosis
4
Polyspermic fertilization
12
Resistance to clomiphene citrate
17
Methodological bias
18
Male infertility
20
Male infertility
21
Oligo-astheno-teratospermia
23
Male infertility
24
Idiopathic infertility
25
Infertility
26
Infertility
28
None mentioned
31
Unexplained infertility
32
Congenital anomalies
Dizziness
Fatigue
Hot flushes
33
Psychological adaptation
36
Unexplained infertility
39
Fertilization failure
43
Literature analysis of 53 papers
Positive Content
50
Neutral Content
2
Negative Content
1
Article Type
18
16
30
25
52
1.

Empirical therapy of the male with clomiphene in couples with unexplained infertility.

Author: CheckJ H, ChaseJ S, NowrooziK, WuC H, AdelsonH G

Improved fertility

A study of 100 couples with unexplained infertility found that clomiphene citrate treatment of the male partner significantly improved pregnancy rates (58%) compared to placebo (16%). The mechanism of action is unclear, but potential explanations include improved sperm quality or seminal plasma changes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Ovulation induction with gonadotropins as sole treatment in infertile couples with open tubes: a randomized prospective comparison between intrauterine insemination and timed vaginal intercourse.

Author: MelisG B, PaolettiA M, AjossaS, GuerrieroS, DepauG F, MaisV

Infertility treatment

Ovulation induction with gonadotropins alone may be as effective as ovulation induction with gonadotropins associated with intrauterine insemination (IUI) in couples with unexplained and mild male factor infertility.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Surgical treatment of endometriosis-associated infertility: meta-analysis compared with survival analysis.

Author: AdamsonG D, PastaD J

Laparoscopic surgery efficacy
Pregnancy rates

Surgery was superior to medical treatment for minimal and mild endometriosis associated with infertility. For moderate and severe disease, surgery is usually used, with laparoscopy achieving results equivalent to laparotomy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

4.

Clinical pregnancy and male subfertility; the ESHRE multicentre trial on the treatment of male subfertility. European Society of Human Reproduction and Embryology.

Author: CrosignaniP G, WaltersD E

Increased pregnancy rate
Endometriosis

Assisted procreation methods (IUI, GIFT, or IVF) were more effective than intra-peritoneal insemination (IPI) or ovulation induction alone in treating male infertility.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The choice of the most appropriate microfertilization technique for human male factor infertility.

Author: TrounsonA O

Effective treatment
Increased pregnancy rate

Gamete intrafallopian transfer was more effective than in vitro fertilization in treating male infertility. Microdrop insemination was more effective than conventional insemination in achieving fertilization and pregnancy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

In vitro fertilization and embryo transfer: a randomized controlled trial.

Author: JarrellJ F, LabelleR, GoereeR, MilnerR, CollinsJ

Improved understanding of IVF treatment

While IVF is now used for various types of infertility, its effectiveness compared to other treatments or spontaneous pregnancy has not been rigorously studied.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

A randomized trial of in vitro fertilization versus conventional treatment for infertility.

Author: SolimanS, DayaS, CollinsJ, JarrellJ

Infertility treatment

In vitro fertilization (IVF) treatment was significantly beneficial in patients with severe bilateral tubal disease. For couples with other causes of infertility, a larger sample size or meta-analysis is needed to confirm efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Prospective randomized trial comparing the outcome and cost of in vitro fertilization with that of a traditional treatment algorithm as first-line therapy for couples with infertility.

Author: KarandeV C, KornA, MorrisR, RaoR, BalinM, RinehartJ, DohnK, GleicherN

Higher pregnancy rate
Lower cost

A standard infertility treatment algorithm resulted in higher pregnancy rates and lower costs than in vitro fertilization.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis.

Author: GoverdeA J, McDonnellJ, VermeidenJ P, SchatsR, RuttenF F, SchoemakerJ

The study compared intrauterine insemination (IUI) and in-vitro fertilization (IVF) for treating infertility, exploring the effectiveness and cost-effectiveness of each approach.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Intra-cytoplasmic sperm injection versus partial zona dissection, subzonal insemination and conventional techniques for oocyte insemination during in vitro fertilisation.

Author: van RumsteM M, EversJ L, FarquharC M, BlakeD A

Improved fertilization rates
Increased pregnancy rates
Male factor infertility treatment
Polyspermic fertilization

This study discusses the use of assisted fertilization techniques, including partial zona dissection (PZD), subzonal microinjection of spermatozoa into the perivitelline space (SUZI), and intra-cytoplasmatic sperm injection (ICSI), for treating male factor infertility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Techniques for surgical retrieval of sperm prior to ICSI for azoospermia.

Author: Van PerperstratenA M, ProctorM L, PhillipsonG, JohnsonN P

Azoospermia treatment

Intra-cytoplasmic sperm injection (ICSI) has transformed treatment for obstructive and non-obstructive azoospermia, the most severe form of male factor infertility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

In vitro fertilisation for unexplained subfertility.

Author: PandianZ, BhattacharyaS, NikolaouD, ValeL, TempletonA

Infertility treatment

The study compares the effectiveness of in-vitro fertilization (IVF) to other treatments for unexplained infertility, highlighting the need for a more rigorous evaluation of IVF's effectiveness against other options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

The effectiveness of IVF in unexplained infertility: a systematic Cochrane review. 2002,.

Author: PandianZabeena, BhattacharyaSiladitya, NikolaouDimitrios, ValeLuke, TempletonAllan

Infertility treatment

This review examined whether IVF is more effective than other treatments for unexplained infertility in terms of achieving a live birth. The treatments compared were: expectant management (waiting), clomiphene citrate (CC), intrauterine insemination (IUI), IUI with controlled ovarian stimulation, and gamete intrafallopian transfer (GIFT).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Systematic review of the treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination.

Author: CostelloMichael F

CC and IUI effective for infertility
Gonadotrophins and IUI more effective

Clomiphene citrate (CC) combined with intrauterine insemination (IUI) was more effective than timed intercourse in the natural cycle for achieving pregnancy in couples with ovulatory infertility. However, treatment with gonadotropins and IUI was superior to CC and IUI.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Oral anti-oestrogens and medical adjuncts for subfertility associated with anovulation.

Author: BeckJ I, BoothroydC, ProctorM, FarquharC, HughesE

Anovulation treatment
Resistance to clomiphene citrate

Anovulation (lack of ovulation) is a common cause of infertility in women. The first-line treatment is with medications that block estrogen, such as clomiphene citrate. However, some women do not respond well to this treatment. Alternative and additional treatments include tamoxifen, dexamethasone, bromocriptine, and aromatase inhibitors (AIs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Differential efficacy of group and individual/couple psychotherapy with infertile patients.

Author: de LizT M, StraussB

Reduce anxiety
Reduce depression
Methodological bias

Psychotherapy for infertile patients may reduce anxiety and depression and is associated with similar conception rates compared to psychological interventions given to patients not receiving specific medical care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

In vitro fertilisation for unexplained subfertility.

Author: PandianZ, BhattacharyaS, ValeL, TempletonA

Infertility treatment

The study highlighted the need to evaluate the effectiveness of in vitro fertilisation (IVF) against other treatment options in couples with unexplained infertility, given the variable live-birth rates and concerns about complications and costs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Gonadotrophins for idiopathic male factor subfertility.

Author: AttiaA M, Al-InanyH G, ProctorM L

Improved male infertility treatment
Male infertility

Male infertility accounts for half of all infertility cases. Treating unexplained male infertility is largely based on trial and error. Gonadotropins (hormones) have been used to improve sperm quality with the aim of increasing pregnancy rates. However, research on the effectiveness of gonadotropins for improving pregnancy rates in partners of men undergoing treatment has yielded conflicting results and needs further analysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Medical treatment to improve sperm quality.

Author: IsidoriAndrea M, PozzaCarlotta, GianfrilliDaniele, IsidoriAldo

Improved male infertility treatment
Male infertility

Male infertility accounts for about 30% of cases. While treatable causes like hormone problems, varicoceles, infections, and blockages should be addressed, many aspects of male infertility remain unclear. While assisted reproductive technologies have become popular, recent research shows the importance of good sperm quality for successful pregnancies. This review of studies found that while results vary, gonadotropins, anti-estrogens, carnitine, and trace elements may improve sperm quality, but their impact on pregnancy rates is debated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Techniques for surgical retrieval of sperm prior to ICSI for azoospermia.

Author: Van PeperstratenA, ProctorM L, JohnsonN P, PhilipsonG

Infertility treatment

The study discussed the treatment of azoospermia, the most severe form of male factor infertility, with intra-cytoplasmic sperm injection (ICSI), noting that sperm can be retrieved for ICSI from either the epididymis or the testis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Gonadotrophins for idiopathic male factor subfertility.

Author: AttiaA M, Al-InanyH G, FarquharC, ProctorM

Improved male infertility treatment
Male infertility

Male infertility accounts for half of all infertility cases. Treating unexplained male infertility is largely based on trial and error. Gonadotropins (hormones) have been used to improve sperm quality with the aim of increasing pregnancy rates. However, research on the effectiveness of gonadotropins for improving pregnancy rates in partners of men undergoing treatment has yielded conflicting results and needs further analysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

[Sperm parameters in male idiopathic infertility after treatment with prelox].

Author: NikolovaV, StanislavovR, VatevI, NalbanskiB, PŭnevskaM

Improved male infertility treatment
Idiopathic infertility

Male infertility is diagnosed after examining sperm quality and conducting a physical examination. In about 30% of cases, the cause remains unknown even after thorough testing, leading to a diagnosis of unexplained infertility. This study investigates the effects of Prelox treatment on sperm parameters in 50 men with unexplained infertility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Bulgarian

26.

Effects of a psychological intervention on depression in infertile couples.

Author: NoorbalaAhmad A, RamazanzadehFatemeh, MalekafzaliHossein, AbediniaNasrin, ForooshaniAbbas R, ShariatMamak, JafarabadiMina

Depression alleviation
Infertility

Psychological intervention was found to be useful in alleviating depression in infertile couples before they received infertility treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Techniques for surgical retrieval of sperm prior to intra-cytoplasmic sperm injection (ICSI) for azoospermia.

Author: Van PeperstratenA, ProctorM L, JohnsonN P, PhilipsonG

Azoospermia, the absence of sperm in ejaculated semen, is a common cause of male infertility. Intra-cytoplasmic sperm injection (ICSI) has become a successful treatment for azoospermia, allowing sperm to be retrieved from either the epididymis or the testes depending on the cause.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Psychological and social aspects of pregnancy, childbirth and early parenting after assisted conception: a systematic review.

Author: HammarbergK, FisherJ R W, WynterK H

Improved infertility treatment
Infertility

Infertility affects emotional well-being, life satisfaction, and self-esteem. Failing to have a successful pregnancy with assisted reproductive technology (ART) is linked to lower life satisfaction, reduced confidence, and emotional distress. This study investigates whether these negative effects persist after a successful pregnancy and live birth.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Preconception lifestyle advice for people with subfertility.

Author: AndersonKirsty, NormanRobert J, MiddletonPhilippa

Improved fertility

This article discusses the need for a guideline on preconception advice for people presenting for infertility treatment, considering factors such as weight, diet, smoking, and other lifestyle factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

In vitro fertilisation for unexplained subfertility.

Author: PandianZabeena, GibreelAhmed, BhattacharyaSiladitya

Improved infertility treatment

This study examines the effectiveness of in vitro fertilization (IVF) compared to other treatment options for unexplained infertility, recognizing the increasing interest in less-invasive approaches and the need to address concerns about costs and multiple pregnancies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

A randomised controlled trial of intra-uterine insemination versus in vitro fertilisation in patients with idiopathic or mild male infertility.

Author: ElzeinyHossam, GarrettClaire, ToledoManuela, SternKate, McBainJohn, BakerHugh William Gordon

Cost-effective
Increased pregnancy rate
None mentioned

IVF is more successful and cost-effective than IUI using the same doses of FSH.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

A randomized clinical trial to determine optimal infertility treatment in older couples: the Forty and Over Treatment Trial (FORT-T).

Author: GoldmanMarlene B, ThorntonKim L, RyleyDavid, AlperMichael M, FungJune L, HornsteinMark D, ReindollarRichard H

Increase pregnancy rate
Reduce treatment cycles
Unexplained infertility

A randomized controlled trial of 154 couples with unexplained infertility found that immediate IVF resulted in higher pregnancy rates and fewer treatment cycles than two cycles of controlled ovarian hyperstimulation/IUI followed by IVF. The cumulative clinical pregnancy rates per couple after two cycles of treatment were 21.6% for CC/IUI, 17.3% for FSH/IUI, and 49.0% for immediate IVF. After all treatments, 71.4% of couples had conceived a clinically recognized pregnancy, and 46.1% had delivered at least one live-born baby. 84.2% of all live-born infants resulting from treatment were achieved via IVF.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

33.

Letrozole versus clomiphene for infertility in the polycystic ovary syndrome.

Author: LegroRichard S, BrzyskiRobert G, DiamondMichael P, CoutifarisChristos, SchlaffWilliam D, CassonPeter, ChristmanGregory M, HuangHao, YanQingshang, AlveroRuben, HaisenlederDaniel J, BarnhartKurt T, BatesG Wright, UsadiRebecca, LucidiScott, BakerValerie, TrussellJ C, KrawetzStephen A, SnyderPeter, OhlDana, SantoroNanette, EisenbergEsther, ZhangHeping,

Higher live birth rate
Higher ovulation rate
Congenital anomalies
Dizziness
Fatigue
Hot flushes

Letrozole was associated with higher live-birth and ovulation rates than clomiphene in infertile women with polycystic ovary syndrome.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

34.

Time-limited hydrotubation combined with clomiphene citrate treatment for unexplained infertility.

Author: YapcaO E, DelibasI B, KaracaI, KumtepeY, KadanaliS

Increased pregnancy rate

This study evaluated time-limited hydrotubation combined with clomiphene citrate as treatment for unexplained infertility. The study found that the frequency of clinical pregnancy per cycle was significantly greater in patients treated with hydrotubation and clomiphene citrate compared with clomiphene citrate alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

35.

Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy.

Author: AbbaraAli, JayasenaChanna N, ChristopoulosGeorgios, NarayanaswamyShakunthala, Izzi-EngbeayaChioma, NijherGurjinder M K, ComninosAlexander N, PetersDeborah, BuckleyAdam, RatnasabapathyRisheka, PragueJulia K, SalimRehan, LaveryStuart A, BloomStephen R, SzigetiMatyas, AshbyDeborah A, TrewGeoffrey H, DhilloWaljit S

IVF treatment
OHSS prevention

A phase 2, multi-dose, open-label, randomized clinical trial of 60 women undergoing IVF treatment at high risk of developing OHSS found that kisspeptin-54 is a promising approach to effectively and safely trigger oocyte maturation.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Male psychological adaptation to unsuccessful medically assisted reproduction treatments: a systematic review.

Author: MartinsMariana Veloso, Basto-PereiraMiguel, PedroJuliana, PetersonBrennan, AlmeidaVasco, SchmidtLone, CostaMaria Emília

Infertility treatment
Psychological adaptation

This systematic review examines the psychological adaptation of men to infertility and related treatments, given that men also experience emotional challenges during fertility treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Baseline anatomical assessment of the uterus and ovaries in infertile women: a systematic review of the evidence on which assessment methods are the safest and most effective in terms of improving fertility outcomes.

Author: ArmstrongSarah C, ShowellMarian, StewartElizabeth A, RebarRobert W, VanderpoelSheryl, FarquharCynthia M

Infertility treatment

This review examines how to best assess the uterus and ovaries of women who are having difficulty getting pregnant, to identify the cause of infertility and improve the chances of having a baby. This review is part of a World Health Organization effort to provide guidance on infertility diagnosis and treatment worldwide. Helping women with infertility can improve their emotional well-being and reduce negative consequences like social stigma and relationship problems.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Metabolomics as a tool to identify biomarkers to predict and improve outcomes in reproductive medicine: a systematic review.

Author: Bracewell-MilnesTimothy, SasoSrdjan, AbdallaHossam, NikolauDimitrios, Norman-TaylorJulian, JohnsonMark, HolmesElaine, ThumMeen-Yau

Infertility treatment

Infertility can have a significant impact on people's lives. With low success rates for fertility treatments, researchers are looking for ways to improve these treatments. This study investigates the use of metabolomics, which studies the chemicals in body fluids, to understand the causes of infertility at a molecular level.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial.

Author: FarquharCynthia M, LiuEmily, ArmstrongSarah, ArrollNicola, LensenSarah, BrownJulie

IUI
Ovarian stimulation
Unexplained infertility

This abstract discusses the lack of evidence supporting the effectiveness of intrauterine insemination (IUI) with ovarian stimulation as a treatment for unexplained infertility.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Establishing reproductive potential and advances in fertility preservation techniques for XY individuals with differences in sex development.

Author: IslamRumana, LaneSheila, WilliamsSuzannah A, BeckerChristian M, ConwayGerard S, CreightonSarah M

Improved fertility preservation
Increased fertility options

This article discusses the potential of fertility preservation techniques for individuals with differences in sex development (DSD). The authors argue that fertility preservation should be considered for individuals with DSD who have functioning gonads.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

41.

[Antioxidant therapy improves the results of -test in infertile men during a preparation for assisted reproductive technology (IVF/ICSI)].

Author: PopovaA Yu, OvchinnikovR I, GamidovS I

ART
Male infertility treatment

Male infertility affects 45-50% of couples who can't have children. In many cases, the cause is unknown. Assisted reproductive technologies (ART) have made it possible for many couples, including men who were previously considered unable to have children, to have a baby.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

42.

Effectiveness of Stem Cell Therapy in the Treatment of Ovarian Disorders and Female Infertility: A Systematic Review.

Author: AhmadianShahin, MahdipourMahdi, PazhangMohammad, SheshpariSepideh, MobarakHalimeh, BedateAlberto Miranda, RahbarghaziReza, NouriMohammad

Improved fertility

Stem cell therapy is a promising treatment for ovarian disorders. This study summarizes current research on stem cell therapy for ovarian disorders and analyzes recent developments in this area.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Higher clinical pregnancy rate with in-vitro fertilization versus intracytoplasmic sperm injection in treatment of non-male factor infertility: Systematic review and meta-analysis.

Author: AbbasAhmed M, HusseinReda S, ElsenityMohamed A, SamahaIhab I, El EtribyKarim A, Abd El-GhanyMohamed F, KhalifaMansour A, AbdelrheemShaimaa S, AhmedAmal Abdrabbo, KhodryMostafa M

Higher pregnancy rate
Fertilization failure

The meta-analysis found no difference between intracytoplasmic sperm injection (ICSI) and in-vitro fertilization (IVF) in terms of fertilization rate, implantation rate, and live birth rate for non-male factor infertility. However, IVF had a significantly higher clinical pregnancy rate and a higher risk of total fertilization failure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Prospects for FSH Treatment of Male Infertility.

Author: SimoniManuela, BriganteGiulia, RochiraVincenzo, SantiDaniele, CasariniLivio

Sperm production

FSH may be helpful in increasing sperm production in infertile men, although evidence supporting its use is weak. Further research is needed to define the optimal dosage, treatment length, and selection criteria for patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

In vitro fertilization outcomes in women with polycystic ovary syndrome: A meta-analysis.

Author: TangKefu, WuLei, LuoYing, GongBo

This review examined the efficacy and safety of IVF for treating infertility in women with PCOS, considering the significant increase in IVF use for this population and changes in treatment strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

46.

Intrauterine insemination + controlled ovarian hyperstimulation versus in vitro fertilisation in unexplained infertility: a systematic review and meta-analysis.

Author: NandiAnupa, RajaGangopadhyay, WhiteDavinia, TarekEl-Toukhy

Live birth rate

This systematic review assessed the relative efficacy of intrauterine insemination (IUI) with controlled ovarian hyperstimulation (COH) compared with in vitro fertilization (IVF) in couples with unexplained infertility. The results showed that IVF was associated with a statistically significant higher live birth rate compared with IUI+COH. However, the quality of evidence was moderate to low due to inconsistency and imprecision across the trials. Further research is needed to guide clinical practice.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Should intrauterine inseminations still be proposed in cases of unexplained infertility? Retrospective study and literature review.

Author: MervielPhilippe, LabarreMarion, JamesPandora, BouéeSarah, ChabaudJean-Jacques, RocheSylvie, CabryRosalie, SchefflerFlorence, LourdelEmmanuelle, BenkhalifaMoncef, CopinHenri, DrapierHortense, BeauvillardDamien

Improved pregnancy rate

This retrospective study compared the clinical pregnancy rate per cycle (CPR/c) in intrauterine insemination (IUI) and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) for unexplained infertility. IVF/ICSI resulted in significantly higher pregnancy and live birth rates than IUI in all age groups except women aged 40 and over. The study recommends IVF/ICSI as the preferred treatment for unexplained infertility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

49.

Clomiphene citrate for male infertility: A systematic review and meta-analysis.

Author: HuijbenManou, HuijsmansRoel L N, LockM Tycho W T, de KempVincent F, de KortLaetitia M O, van BredaJetske H M K

Male infertility treatment

Male infertility is a common problem worldwide. Clomiphene citrate is a medication that can help women ovulate, but we need more research to determine if it can improve sperm quality in men.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

51.

Intracytoplasmic sperm injection does not improve the outcome of IVF treatments in patients with advanced maternal age or low oocyte number: A randomized controlled trial.

Author: FancsovitsPeter, LehnerAdam, KaszasZita, NemesAnnamaria, DudasBeata, JooKata, MurberAkos, Berkes-BaraEva, FekecsGyorgyi, UrbancsekJanos

Infertility treatment

This study examines the use of intracytoplasmic sperm injection (ICSI) in cases of non-male factor infertility. ICSI is often used for severe male factor infertility, but its effectiveness for other causes of infertility is not fully proven.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

52.

Glucocorticoid supplementation during ovulation induction for assisted reproductive technology: a systematic review and meta-analysis.

Author: LinLi, LiTaoqiong, ChenLu, ShaChunli, GaoWujiang, WeiHong, ZhuXiaolan

Clinical pregnancy (glucocorticoid)

Glucocorticoid therapy during ovarian stimulation did not significantly improve pregnancy outcomes in women undergoing IVF/ICSI.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

53.

Intracytoplasmic sperm injection versus conventional in vitro fertilisation in couples with males presenting with normal total sperm count and motility.

Author: CuttingElizabeth, HortaFabrizzio, DangVinh, van RumsteMinouche Me, MolBen Willem J

Infertility treatment

This review updated a previous review comparing intracytoplasmic sperm injection (ICSI) with conventional in vitro fertilisation (c-IVF) for couples with males presenting with normal total sperm count and motility.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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