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Protective effect of CTLA4Ig secreted by transgenic fetal pancreas allografts.

Author: BradyJ L, GeorgiouH M, LewA M, SutherlandR M, ThomasH E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Sustained secretion of transgenic CTLA4Ig from pancreatic islets may protect against allograft rejection.
Paper Details　
Original Abstract of the Article :
Pancreas allotransplantation offers a cure for insulin-dependent diabetes mellitus. Systemic immunosuppression used to prevent immune destruction of the graft has side-effects, including increased susceptibility to infection and neoplasia. These unwanted effects may be limited by engineering the gra...See full text at original site
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引用元：
https://doi.org/10.1097/00007890-200005150-00013

データ提供：米国国立医学図書館（NLM）

The Immune System's Desert: Harnessing the Power of CTLA4Ig for Pancreas Transplantation

Pancreas transplantation holds the promise of a cure for insulin-dependent diabetes mellitus. But the desert of the immune system can be a treacherous place for transplanted organs. This study investigates the potential of engineering the pancreas graft to secrete CTLA4Ig, an immunomodulatory molecule, to protect it from rejection.

A New Oasis of Immunosuppression

This research suggests that sustained secretion of CTLA4Ig from pancreatic islets can effectively protect against allograft rejection. It's like creating a new oasis of immunosuppression within the desert of the immune system, fostering a more harmonious relationship between the host and the transplant. This approach could lead to safer and more effective transplantation outcomes.

Navigating the Immune Desert: Seeking a Safe Passage for Pancreas Transplants

This study highlights the importance of innovative approaches to immunosuppression in transplantation. It’s like finding a safe passage through the immune desert, protecting the precious transplant from the harsh forces of rejection. The use of CTLA4Ig holds promise as a potential strategy for improving the success and safety of pancreas transplantation.

Dr.Camel's Conclusion

This research offers a novel strategy for preventing rejection in pancreas transplantation, paving the way for safer and more effective treatment of diabetes. It's a testament to the power of innovation and the ongoing pursuit of new solutions in the desert of medical research.
Date :
  1. Date Completed 2000-06-08
  2. Date Revised 2019-07-13
Further Info :

Pubmed ID

10830215

DOI: Digital Object Identifier

10.1097/00007890-200005150-00013

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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