Side Effects of abatacept injection: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Major Research Findings

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Reasons for Side Effects

Abatacept injections work by suppressing the immune system, which increases the risk of side effects such as infections. 5 Abatacept also inhibits cell growth and differentiation, which can lead to side effects such as infections, malignancies, and liver dysfunction. 5

Common Side Effects

Injection Site Reactions

Injection site reactions have been reported as a side effect of abatacept injections. 5 Injection site reactions are usually mild and resolve within a few days. 5

Infections

Infections have been reported as a side effect of abatacept injections. 5 Abatacept increases the risk of infections because it suppresses the immune system. 5 Infections can range from mild to severe. 5

Countermeasures for Side Effects

Injection Site Reactions

Injection site reactions are usually mild and resolve within a few days. 5 If you are concerned about injection site reactions, talk to your doctor. 5

Infections

To prevent infections, it is important to practice good hygiene, such as washing your hands and gargling. 5 It is also important to consult your doctor regularly and have your health checked. 5

Comparison Between Studies

Commonalities in Studies

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Differences in Studies

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Cautions Regarding Application to Real Life

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Limitations of Current Research

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Future Research Directions Needed

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Conclusion

Abatacept injections have been found to be effective and safe in treating autoimmune disorders in children. 5 Abatacept injections are used to treat autoimmune disorders such as rheumatoid arthritis, Crohn's disease, and psoriasis. 5 Abatacept works by suppressing the immune system, which reduces inflammation. 5

Literature analysis of 6 papers
Positive Content
6
Neutral Content
0
Negative Content
0
Article Type
0
0
0
3
6
3.

Safety of biologic therapies for the treatment of juvenile idiopathic arthritis.

Author: HorneffGerd

Improved juvenile idiopathic arthritis symptoms
Autoimmune disorders
Infections
Malignancies

The safety profiles of approved biologics, the TNF-α inhibitors etanercept and adalimumab, and the IL-6-inhibitor tocilizumab are highly acceptable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Emerging therapies for noninfectious uveitis: what may be coming to the clinics.

Author: MayaJose R, SadiqMohammad A, ZapataLiz J, HanoutMostafa, SarwarSalman, RajagopalanNithya, GuinnKathleen E, SepahYasir J, NguyenQuan Dong

Abatacept for NIU
EGP-437 for NIU
ESBA 105 for NIU
Gevokizumab for NIU
Sarilumab for NIU
Secukinumab for NIU
Sirolimus for NIU
Tocilizumab for NIU
Voclosporin for NIU

This review discusses emerging therapeutic agents and drug delivery systems for noninfectious uveitis (NIU), focusing on agents targeting specific pathways involved in inflammation. These include monoclonal antibodies against interleukins, antibody fragments against inflammatory cytokines, and T-cell inhibitors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Biologics in children's autoimmune disorders: efficacy and safety.

Author: BredaLuciana, Del TortoMarianna, De SanctisSara, ChiarelliFrancesco

Improved JIA
Infections
Injection site reactions

Biologic drugs are a type of medication that targets specific parts of the immune system. They are used to treat a variety of autoimmune diseases, including juvenile idiopathic arthritis (JIA). This review discussed the current state of biologic drugs for treating JIA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Protective effect of CTLA4Ig secreted by transgenic fetal pancreas allografts.

Author: SutherlandR M, BradyJ L, GeorgiouH M, ThomasH E, LewA M

Cure for diabetes
Reduced immunosuppression side effects
Graft rejection

Sustained secretion of transgenic CTLA4Ig from pancreatic islets may protect against allograft rejection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

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