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Long-term sustained delivery of 3'-azido-2',3'-dideoxythymidine in vivo by means of HA and TCP delivery devices.

Author: BenghuzziH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

TCP and HA ceramic implants can be used effectively to deliver AZT in amounts capable of eliciting physiological responses in vivo.
Paper Details　
Original Abstract of the Article :
This study will attempt to determine the amount of circulating drug, when provided at sustained levels over an extended period of time, which provides efficacy and reduces the toxic side effects seen with the use of AZT in vivo. Two ceramic delivery systems were selected for this investigation namel...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/10834256

データ提供：米国国立医学図書館（NLM）

Sustained Delivery of AZT: A New Oasis for HIV Treatment

This study focuses on developing a sustained delivery system for 3'-azido-2',3'-dideoxythymidine (AZT), a crucial medication for managing HIV infection. Imagine a camel caravan traversing a vast desert, seeking to find a way to provide a consistent source of vital supplies for its journey. The researchers investigated the use of hydroxyapatite (HA) and tricalcium-phosphate (TCP) ceramic implants as potential delivery devices for AZT, aiming to provide a sustained and controlled release of the drug over an extended period.

A New Path for AZT Delivery: A Sustainable Approach

The study demonstrated that both HA and TCP ceramic implants can effectively deliver AZT in vivo, with TCP implants releasing significantly higher levels of the drug compared to HA implants. This is like discovering a new oasis in the desert, offering a steady source of water and resources. The findings suggest that ceramic delivery systems could potentially provide a more controlled and sustained release of AZT, leading to improved treatment outcomes and reduced side effects.

Innovating for a Healthier Future: A Continuous Quest

This study highlights the importance of developing innovative drug delivery systems to improve treatment outcomes for chronic diseases. It's a reminder that the journey towards better health requires a continuous quest for new and improved methods to deliver vital medications. Further research is needed to refine and optimize these ceramic delivery systems for a wide range of medications, potentially revolutionizing drug delivery and improving patient care.

Dr.Camel's Conclusion

This study presents a promising solution for delivering essential medications like AZT. It's like finding a new oasis in the desert, offering a sustainable and reliable source of vital resources. This research inspires us to continue seeking innovative solutions to improve drug delivery and patient care, just as a camel caravan persists in its journey through the vast and challenging desert.

Date :
  1. Date Completed 2000-06-28
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

10834256

DOI: Digital Object Identifier

10834256

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