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Efficacy of omeprazole for the treatment of symptomatic acid reflux disease without esophagitis.

Author: BenjaminS B, JoelssonB, PeuraD, RichterJ E, WhippleJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Patients with symptomatic GERD require profound acid suppression to achieve symptomatic relief. Omeprazole, 20 mg once daily, was superior to omeprazole, 10 mg once daily, and to placebo in providing early and sustained resolution of heartburn, as well as treatment of other troublesome GERD symptoms.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Up to three quarters of patients with gastroesophageal reflux disease (GERD) have symptoms, such as heartburn, but no macroscopic evidence of erosive esophagitis, making symptomatic GERD a common clinical problem in the primary care setting. OBJECTIVE: To compare the efficacy and safety...See full text at original site
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引用元：
https://doi.org/10.1001/archinte.160.12.1810

データ提供：米国国立医学図書館（NLM）

Omeprazole: A Beacon of Hope for Symptomatic GERD Without Esophagitis

Gastroesophageal reflux disease (GERD) is a common condition that can cause uncomfortable symptoms like heartburn and acid regurgitation. This study investigates the efficacy of omeprazole, a proton pump inhibitor, in treating symptomatic GERD without erosive esophagitis, a condition that often requires more aggressive treatment.

A Dose-Dependent Approach to GERD Relief

The study reveals that omeprazole, particularly at a dose of 20 mg once daily, is significantly more effective than placebo in providing rapid and sustained relief from heartburn and other GERD symptoms. This research is like discovering a hidden oasis in the desert of GERD treatment, offering a potentially effective and well-tolerated solution for managing symptoms without resorting to more invasive approaches.

Easing the Burden of GERD

The findings of this study provide valuable information for healthcare professionals and individuals suffering from symptomatic GERD. It highlights the importance of adequate acid suppression in achieving symptom relief and emphasizes the potential role of omeprazole as a safe and effective treatment option. This research is like a compass, guiding us towards a more effective and personalized approach to managing GERD symptoms.

Dr. Camel's Conclusion

This research reveals the effectiveness of omeprazole, a proton pump inhibitor, in providing rapid and sustained relief from GERD symptoms, particularly in those without erosive esophagitis. The study emphasizes the importance of adequate acid suppression and highlights the potential role of omeprazole as a safe and effective treatment option. This research is like a beacon of hope in the desert of GERD management, guiding us towards a more effective and personalized approach to easing the burden of this common condition.

Date :
  1. Date Completed 2000-07-14
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

10871975

DOI: Digital Object Identifier

10.1001/archinte.160.12.1810

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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