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Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension.

Author: JonesR, KeoghA M, MacdonaldP S, PennyR, ScroopeF, WallmanL L, WeberC, WilliamsonD J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to investigate the effects of bosentan, a drug that blocks endothelin receptors, on blood flow in patients with isolated pulmonary hypertension (PHT). The study was designed because high levels of endothelin-1 (ET-1) are thought to contribute to the development of PHT.
Paper Details　
Original Abstract of the Article :
Few treatments are available for isolated pulmonary hypertension (PHT), which has a high morbidity and mortality. This trial was designed to assess the hemodynamic effects of bosentan, an endothelin receptor antagonist, in patients with PHT, in which local overproduction of endothelin-1 (ET-1) is th...See full text at original site
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引用元：
https://doi.org/10.1161/01.cir.102.4.411

データ提供：米国国立医学図書館（NLM）

Bosentan: A Potential Treatment for Pulmonary Hypertension

Pulmonary hypertension (PHT), a serious condition characterized by high blood pressure in the arteries of the lungs, poses significant health risks. The limited treatment options available for this condition highlight the need for novel therapeutic approaches. This study investigates the hemodynamic effects of bosentan, an endothelin receptor antagonist, in patients with PHT. The researchers believe that excessive production of endothelin-1 (ET-1) plays a crucial role in the development of PHT.

Bosentan's Potential: A Glimpse of Hope for Pulmonary Hypertension

The study's design focused on evaluating the hemodynamic effects of bosentan in patients with PHT. While the results of this specific trial are not detailed in the abstract, the study's aim is to assess the potential of bosentan as a therapeutic agent for this challenging condition. This research holds promise for developing new treatment strategies for PHT.

Understanding the Role of Endothelin-1: A Key to Finding Solutions

The researchers' focus on the role of endothelin-1 in PHT highlights the importance of understanding the intricate mechanisms underlying this condition. By targeting specific pathways involved in the disease, researchers can develop more effective and personalized treatment approaches.

Dr.Camel's Conclusion

This study, like a journey through the heart of a desert oasis, offers a glimpse of hope for patients struggling with pulmonary hypertension. The investigation into the role of bosentan as a therapeutic agent provides a promising avenue for future research and development, paving the way for more effective treatments for this serious condition.
Date :
  1. Date Completed 2000-08-15
  2. Date Revised 2019-06-23
Further Info :

Pubmed ID

10908213

DOI: Digital Object Identifier

10.1161/01.cir.102.4.411

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・Effective treatment of pulmonary hypertension
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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