Effective treatment of pulmonary hypertension: A Synthesis of Findings from 37 Studies

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Original Abstract of the Article

Major Research Findings

Recent studies have made significant advancements in the treatment of pulmonary hypertension, revealing various treatment approaches that potentially improve symptoms and enhance the quality of life for patients. For instance, research 1 demonstrated that a drug called epoprostenol, when compared to conventional treatment, effectively improved exercise capacity and overall quality of life. Additionally, a meta-analysis study 23 indicated that targeted therapies employed for pulmonary hypertension show promise in improving exercise capacity, hemodynamic parameters, functional status, and clinical symptoms. Notably, a meta-analysis 30 highlighted a new treatment approach called pulmonary artery denervation, suggesting its potential for symptom improvement in pulmonary hypertension.

Treatment Summary

The specific treatment for pulmonary hypertension depends on its cause and severity. Some of the primary treatment approaches include:

  • 1 Treatment with epoprostenol
  • 23 Targeted therapies
  • 30 Pulmonary artery denervation therapy
  • 17 Treatment with inhaled prostacyclin
  • 20 Balloon pulmonary angioplasty
  • 12 Treatment with bosentan
  • 6 Treatment with losartan or nifedipine
  • 27 Treatment with sildenafil
  • 10 Treatment with simvastatin

Benefits and Risks

Benefit Summary

Treatments for pulmonary hypertension have the potential to provide various benefits, including improvements in exercise capacity, hemodynamic parameters, functional status, symptom management, and potentially improved survival rates.

Risk Summary

It's crucial to be aware of potential risks associated with pulmonary hypertension treatments. These risks may include side effects such as headache, anemia, and bronchitis. Additionally, some therapies might have adverse effects on liver function. It's essential to consult with your doctor before starting treatment and thoroughly discuss potential risks and benefits together.

Comparison of Studies

Commonalities in Studies

A large number of research studies suggest the effectiveness of various treatments for pulmonary hypertension, particularly highlighting improvements in exercise capacity and hemodynamic parameters.

Differences in Studies

Due to variations in treatment approaches, evaluation methods, patient population size, and patient characteristics, the results obtained from different studies may differ. It is crucial to interpret results carefully and consider the specific context of each research study.

Consistency and Contradictions in Results

While numerous studies demonstrate the effectiveness of pulmonary hypertension treatments, some research findings indicate limited efficacy or high risks of side effects. Therefore, it is essential to consult with your doctor and explore personalized treatment options that best suit your individual circumstances.

Considerations for Real-Life Application

Treatment effectiveness for pulmonary hypertension can vary greatly depending on numerous factors. Therefore, it is critical to work closely with your doctor to determine the best treatment approach, monitor the treatment's effectiveness, and carefully observe any potential side effects.

Limitations of Current Research

Ongoing research on pulmonary hypertension treatments is still in progress, with a need for further investigations, particularly regarding long-term effectiveness and safety. Long-term studies are crucial to understand the lasting impact of these treatments.

Future Research Directions

To improve the efficacy of pulmonary hypertension treatments, the following areas of research are essential:

  • Long-term studies evaluating effectiveness and safety
  • Developing effective treatments for various causes of pulmonary hypertension
  • Research focusing on personalized treatment approaches tailored to individual patients

Conclusion

Significant progress has been made in treating pulmonary hypertension, providing a beacon of hope for many patients. However, it is essential to remember that not all treatments are equally effective for everyone, and potential side effects exist. Always consult with your doctor to explore personalized treatment options that best suit your needs.

Treatment List

  • Epoprostenol
  • Targeted therapies
  • Pulmonary artery denervation therapy
  • Inhaled prostacyclin
  • Balloon pulmonary angioplasty
  • Bosentan
  • Losartan
  • Nifedipine
  • Sildenafil
  • Simvastatin
  • Macitentan
  • Ambrisentan
  • Mirabegron
Keywords
Benefit Keywords
Improved survival
Pulmonary hypertension treatment
1
Pulmonary hypertension treatment
3
Improved PAH treatment
4
Improved dyspnea
Improved exercise capacity
5
PHT treatment
6
Pulmonary hypertension treatment
7
PPHN treatment
8
HAPH treatment
9
Reduced N-terminal pro-B-type natriuretic peptide levels
Reduced right ventricular mass
10
Abrisentan PAH
11
PPHN treatment
12
Hyperthyroidism treatment
Reduced PA pressures
13
Early delivery
Targeted treatments
14
Pulmonary hypertension treatment
15
Exercise capacity
Improved hemodynamics
16
CTEPH treatment
Pulmonary hypertension treatment
17
Improved PVR
Well tolerated
18
Improved chronic thromboembolic pulmonary hypertension treatment
19
CTEPH treatment
20
Improved exercise capacity
21
PAH treatment
PAH-targeted drugs
22
Improved clinical symptoms
Improved exercise capacity
Improved functional status
Improved haemodynamics
23
Echocardiography screening
Pulmonary hypertension diagnosis
24
PoPH treatment
25
Improved hemodynamics
Improved survival
26
COPD-PH treatment
27
PAH risk assessment
28
Hemodynamic improvement
29
6-minute walking distance improvement
Cardiac output improvement
PVR reduction
mPAP reduction
30
Lower failure rate
31
Early detection
Early treatment
32
Improved clinical status
Improved functional status
33
PH improvement
34
Cardiac function
Cardiopulmonary hemodynamics
Liver transplantation
35
Improved BPA technique
36
Decreased CI
Decreased NT-proBNP
Decreased PVR
Increased 6WMD
Reduced NT-proBNP
Reduced PVR
Reduced mPAP
37
Risk Keywords
Sepsis
Thrombotic events
1
Pulmonary arterial hypertension
4
Increased mortality
5
None
12
Long-term outcome uncertain
13
Pregnancy
Pulmonary hypertension
14
Disagreement on effectiveness
15
In-hospital mortality
Postoperative residual hypertension
17
Decreased hemoglobin
Peripheral edema
18
Increased mortality
Treatment discontinuation
21
Abnormal liver function
31
Limited responsiveness
32
High risk
33
Pulmonary vascular injury
36
Anemia
Bronchitis
Headache
37
Literature analysis of 37 papers
Positive Content
33
Neutral Content
4
Negative Content
0
Article Type
13
14
15
8
35
1.

A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension.

Author: BarstR J, RubinL J, LongW A, McGoonM D, RichS, BadeschD B, GrovesB M, TapsonV F, BourgeR C, BrundageB H, KoernerS K, LanglebenD, KellerC A, MuraliS, UretskyB F, ClaytonL M, JöbsisM M, BlackburnS D, ShortinoD, CrowJ W,

Improved survival
Pulmonary hypertension treatment
Sepsis
Thrombotic events

Continuous intravenous infusion of epoprostenol plus conventional therapy improved exercise capacity, quality of life, hemodynamics, and survival in patients with severe primary pulmonary hypertension compared to conventional therapy alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

2.

Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension.

Author: WilliamsonD J, WallmanL L, JonesR, KeoghA M, ScroopeF, PennyR, WeberC, MacdonaldP S

This study aimed to investigate the effects of bosentan, a drug that blocks endothelin receptors, on blood flow in patients with isolated pulmonary hypertension (PHT). The study was designed because high levels of endothelin-1 (ET-1) are thought to contribute to the development of PHT.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

The efficacy and tolerability of sildenafil in patients with moderate-to-severe pulmonary hypertension.

Author: BharaniAnil, MathewVivek, SahuAshutosh, LuniaBasant

Pulmonary hypertension treatment

The study aimed to evaluate the utility of oral sildenafil in patients with pulmonary hypertension of varied etiology, poorly controlled on conventional treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology.

Author: MacchiaAlejandro, MarchioliRoberto, MarfisiRosaMaria, ScaranoMarco, LevantesiGiacomo, TavazziLuigi, TognoniGianni

Improved dyspnea
Improved exercise capacity
Increased mortality

Treatment of pulmonary hypertension with prostacyclins, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors did not show a significant survival advantage.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Comparative effects of losartan and nifedipine therapy on exercise capacity, Doppler echocardiographic parameters and endothelin levels in patients with secondary pulmonary hypertension.

Author: BozbaşSerife Savaş, BozbaşHüseyin, AtarAsli, UlubayGaye, Oner EyüboğluFüsun

PHT treatment

Pulmonary hypertension (PHT) is a serious condition with high mortality rates. This study investigated whether losartan, a medication that blocks the renin-angiotensin system, is as effective as nifedipine in treating secondary PHT.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Systematic review of trials using vasodilators in pulmonary arterial hypertension: why a new approach is needed.

Author: MacchiaAlejandro, MarchioliRoberto, TognoniGianni, ScaranoMarco, MarfisiRosamaria, TavazziLuigi, RichStuart

Pulmonary hypertension treatment

This meta-analysis examined the effects of various treatments for pulmonary hypertension on 6-minute walk distance, hemodynamics, and survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Neonatal pulmonary hypertension.

Author: SteinhornRobin H

PPHN treatment

This review discusses persistent pulmonary hypertension of the newborn, a condition affecting 2 per 1000 term infants and complicating >10% of neonates with respiratory failure. It reviews the vascular abnormalities associated with this condition and examines the evidence for current and emerging therapies, including inhaled nitric oxide, high-frequency ventilation, surfactant, extracorporeal life support, phosphodiesterase inhibitors, and reactive oxygen species scavengers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Phosphodiesterase type 5 inhibitors for high-altitude pulmonary hypertension: a meta-analysis.

Author: JinBo, LuoXin-Ping, NiHuan-Chun, ShiHai-Ming

HAPH treatment

This study examines the potential use of selective phosphodiesterase type 5 (PDE5) inhibitors for treating high-altitude pulmonary hypertension (HAPH), a public health concern in mountainous areas. While preliminary studies suggest beneficial effects, further research is needed to confirm their efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Simvastatin as a treatment for pulmonary hypertension trial.

Author: WilkinsMartin R, AliOmar, BradlowWilliam, WhartonJohn, TaegtmeyerAnne, RhodesChristopher J, GhofraniHossein A, HowardLuke, NihoyannopoulosPetros, MohiaddinRaad H, GibbsJ Simon R,

Reduced N-terminal pro-B-type natriuretic peptide levels
Reduced right ventricular mass

Simvastatin, added to conventional therapy, showed a small and transient early reduction in right ventricular (RV) mass and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in patients with pulmonary arterial hypertension (PAH). While RV mass decreased by 5.2 g and NT-proBNP levels decreased by 75 fmol/ml in the simvastatin group after 6 months, these effects were not sustained over 12 months.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

ARIES-3: ambrisentan therapy in a diverse population of patients with pulmonary hypertension.

Author: BadeschDavid B, FeldmanJeremy, KeoghAnne, MathierMichael A, OudizRonald J, ShapiroShelley, FarberHarrison W, McGoonMichael, FrostAdaani, AllardMartine, DespainDarrin, DuftonChristopher, RubinLewis J,

Abrisentan PAH

Ambrisentan, an endothelin receptor antagonist, was well tolerated and demonstrated benefits in patients with pulmonary arterial hypertension (PAH) of various etiologies, including those receiving other pulmonary hypertension therapies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

A randomized, double-blind, placebo-controlled, prospective study of bosentan for the treatment of persistent pulmonary hypertension of the newborn.

Author: MohamedW A, IsmailM

PPHN treatment
None

Bosentan demonstrated significant efficacy as an adjuvant therapy for persistent pulmonary hypertension of the newborn (PPHN), leading to a favorable outcome in 87.5% of treated patients compared to 20% in the placebo group. Bosentan was well tolerated, with no drug-related adverse events observed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Hyperthyroidism and pulmonary hypertension: an important association.

Author: VallabhajosulaSailaja, RadhiSaba, CevikCihan, AlalawiRaed, RajRishi, NugentKenneth

Hyperthyroidism treatment
Reduced PA pressures
Long-term outcome uncertain

Hyperthyroidism is associated with pulmonary hypertension, and treatment of hyperthyroidism can reduce pulmonary artery pressures. This review summarizes the literature on this association and highlights the need for further research on long-term outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Pregnancy and pulmonary hypertension.

Author: PieperPetronella G, LameijerHeleen, HoendermisElke S

Early delivery
Targeted treatments
Pregnancy
Pulmonary hypertension

Pulmonary hypertension during pregnancy poses serious risks to both mother and child. This review examines the use of targeted treatments for pulmonary arterial hypertension during pregnancy and finds that mortality has decreased since previous reviews. However, despite improved prognosis, pregnancy is still discouraged for women with pulmonary hypertension, and termination should be considered if pregnancy occurs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Ambrisentan May Improve Exercise Tolerance and Cardiac Function in Patients With Pulmonary Hypertension.

Author: LiXue-Qin, LiYun-Jing, WangYong

Pulmonary hypertension treatment
Disagreement on effectiveness

Pulmonary hypertension (PH) is a serious condition with limited treatment options. This meta-analysis examines the clinical efficacy of ambrisentan in treating PH, addressing the debate surrounding its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Long-term safety and efficacy of imatinib in pulmonary arterial hypertension.

Author: FrostAdaani E, BarstRobyn J, HoeperMarius M, ChangHyuk-Jae, FrantzRobert P, FukumotoYoshihiro, GaliéNazzareno, HassounPaul M, KloseHans, MatsubaraHiromi, MorrellNicholas W, PeacockAndrew J, PfeiferMichael, SimonneauGérald, TapsonVictor F, TorresFernando, Dario VizzaCarmine, LawrenceDavid, YangWei, FelserJames M, QuinnDeborah A, GhofraniHossein-Ardeschir

Exercise capacity
Improved hemodynamics

Imatinib, a protein kinase inhibitor, has shown promise in improving hemodynamics and exercise capacity in pulmonary arterial hypertension (PAH) patients who have not responded well to conventional PAH therapies.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

A prospective, randomized study of inhaled prostacyclin versus nitric oxide in patients with residual pulmonary hypertension after pulmonary endarterectomy.

Author: AbeShinichiro, IshidaKeiichi, MasudaMasahisa, UedaHideki, KohnoHiroki, MatsuuraKaoru, TamuraYusaku, WatanabeMichiko, MatsumiyaGoro

CTEPH treatment
Pulmonary hypertension treatment
In-hospital mortality
Postoperative residual hypertension

This prospective study compared the effects of inhaled epoprostenol sodium (PGI<sub>2</sub>) and NO on pulmonary hemodynamics, systemic hemodynamics, and gas exchange in patients with residual pulmonary hypertension after pulmonary endarterectomy (PEA).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Macitentan for the treatment of inoperable chronic thromboembolic pulmonary hypertension (MERIT-1): results from the multicentre, phase 2, randomised, double-blind, placebo-controlled study.

Author: GhofraniHossein-Ardeschir, SimonneauGérald, D'ArminiAndrea M, FedulloPeter, HowardLuke S, JaïsXavier, JenkinsDavid P, JingZhi-Cheng, MadaniMichael M, MartinNicolas, MayerEckhard, PapadakisKelly, RichardDominik, KimNick H,

Improved PVR
Well tolerated
Decreased hemoglobin
Peripheral edema

Macitentan significantly improved pulmonary vascular resistance (PVR) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) and was well tolerated.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: A systematic review.

Author: TanabeNobuhiro, KawakamiTakashi, SatohToru, MatsubaraHiromi, NakanishiNorifumi, OginoHitoshi, TamuraYuichi, TsujinoIchizo, OgawaAiko, SakaoSeiichiro, NishizakiMari, IshidaKeiichi, IchimuraYasunori, YoshidaMasahiro, TatsumiKoichiro

CTEPH treatment

A systematic review of balloon pulmonary angioplasty (BPA) for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or residual pulmonary hypertension after pulmonary endarterectomy (PEA) found that BPA is a safe and effective treatment option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Pulmonary hypertension-targeted therapies in heart failure: A systematic review and meta-analysis.

Author: GuayCharles-Antoine, Morin-ThibaultLouis-Vincent, BonnetSebastien, LacasseYves, LambertCaroline, LegaJean-Christophe, ProvencherSteeve

Improved exercise capacity
Increased mortality
Treatment discontinuation

PH-targeted therapies, especially phosphodiesterase-5 inhibitors, may improve exercise capacity in patients with HF but may also increase adverse outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Use of vasodilators for the treatment of pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis: A systematic review.

Author: OgawaAiko, SakaoSeiichiro, TanabeNobuhiro, MatsubaraHiromi, TatsumiKoichiro

PAH treatment
PAH-targeted drugs

While there are medications available for pulmonary arterial hypertension (PAH), their effectiveness and safety for people with rare conditions like pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis (PVOD/PCH) are not well understood.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

A meta-analysis of randomized controlled trials in targeted treatments of chronic thromboembolic pulmonary hypertension.

Author: ZhangJing, LiJing-Meng, HuangZan-Sheng, XuJian-Cheng, FanYe

Improved clinical symptoms
Improved exercise capacity
Improved functional status
Improved haemodynamics

Targeted treatments approved for pulmonary arterial hypertension (PAH) are associated with improvement in exercise capacity, haemodynamic parameters, functional status and clinical symptoms in patients with chronic thromboembolic pulmonary hypertension (CTEPH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Ambrisentan in portopulmonary hypertension: A multicenter, open-label trial.

Author: PrestonIoana R, BurgerCharles D, BartolomeSonja, SafdarZeenat, KrowkaMichael, SoodNamita, FordHubert J, BattarjeeWejdan F, ChakinalaMurali M, Gomberg-MaitlandMardi, HillNicholas S

PoPH treatment

A study is evaluating the efficacy and safety of ambrisentan, a drug used for Group 1 pulmonary arterial hypertension (PAH), in treating portopulmonary hypertension (PoPH), a subset of Group 1 PAH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Vasomodulators and Liver Transplantation for Portopulmonary Hypertension: Evidence From a Systematic Review and Meta-Analysis.

Author: DerooRebecca, TrépoEric, HolvoetTom, De PauwMichel, GeertsAnja, VerhelstXavier, ColleIsabelle, Van VlierbergheHans, FallonMichael B, RaevensSarah

Improved hemodynamics
Improved survival

Vasomodulator therapy and liver transplantation are options for treating portopulmonary hypertension (PoPH), which has a poor prognosis. This study aims to provide a summary of the effects of these treatments on pulmonary hemodynamics and survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Efficacy and safety of Sildenafil treatment in pulmonary hypertension caused by chronic obstructive pulmonary disease: A meta-analysis.

Author: HaoYingying, ZhuYingwei, MaoYimin, XuJingduan, HeXuegai, HuangShenshen, WangMin, QiuJiayong

COPD-PH treatment

Pulmonary hypertension (PH) is a severe and prevalent complication of chronic obstructive pulmonary disease (COPD), with low quality of life and poor prognosis. This study was designed to evaluate the efficacy and safety of Sildenafil in the treatment of PH caused by COPD (COPD-PH) and provide reference for clinical treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

28.

Prediction Models and Scores in Pulmonary Hypertension: A Review.

Author: MouratoglouSophia Anastasia, BayoumyAhmed A, NoordegraafAnton Vonk

PAH risk assessment

This study discussed the importance of risk assessment in pulmonary arterial hypertension (PAH) patients, considering the need for individualized treatment approaches to manage this serious disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Treatment of pulmonary hypertension in patients with Hereditary Hemorrhagic Telangiectasia - A case series and systematic review.

Author: AbstonEric, HonStephanie, Rodriguez-LopezJosanna, MollMatt, LanutiMichael, FarberHarrison W, WilsonKevin C

Hemodynamic improvement

Pulmonary vasodilator therapy effectively improves the hemodynamics of patients with HHT-PAH and is not associated with an increased risk of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

A Meta-analysis of the efficacy of pulmonary artery denervation in the treatment of pulmonary hypertension.

Author: ZhengZhenzhen, ChenRiken, SunXishi, LuJianmin, WangDonghao, LiuHaimin, ChenMinshan, ChenHuimin, HongCheng

6-minute walking distance improvement
Cardiac output improvement
PVR reduction
mPAP reduction

This meta-analysis evaluated the effects of pulmonary artery denervation (PADN) for pulmonary hypertension (pH). PADN treatment improved 6-minute walking distance, reduced mean pulmonary artery pressure (mPAP), and pulmonary vascular resistance (PVR), and improved cardiac output compared to the control group. No significant effect was observed on left ventricular end-systolic diameter, readmission rate, mortality rate, or cardiac function. PADN is an effective treatment method for pH and is worthy of clinical promotion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn: a Metaanalysis.

Author: LiLing-Xue, WeiBing, YangMing, LiMo, JiaJing-Jing

Lower failure rate
Abnormal liver function

This meta-analysis evaluated the efficacy and safety of bosentan in the treatment of persistent pulmonary hypertension of the newborn (PPHN). Bosentan was found to be effective in the treatment of PPHN, but attention should be paid to adverse reactions such as abnormal liver function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

32.

Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults.

Author: TsujimotoYasushi, KumasawaJunji, ShimizuSayaka, NakanoYoshio, KataokaYuki, TsujimotoHiraku, KonoMichihiko, OkabayashiShinji, ImuraHaruki, MizutaTakahiro

Early detection
Early treatment
Limited responsiveness

Pulmonary hypertension (PH) is a major cause of morbidity and mortality, leading to decreased exercise capacity, right ventricular overload, and ultimately heart failure. Early detection and treatment are recommended, but many patients are diagnosed at a later stage due to nonspecific early symptoms. This review discusses the accuracy of echocardiography for diagnosing PH, exploring the uncertainty surrounding its diagnostic accuracy compared to right-heart catheterization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Reversed Potts Shunt Outcome in Suprasystemic Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.

Author: MendelBrian, ChristiantoChristianto, AngelliaPhoniex, HoliyonoIndra, PrakosoRadityo, SiagianSisca Natalia

Improved clinical status
Improved functional status
High risk

This meta-analysis reviewed the clinical, laboratory, and hemodynamic parameters after a reversed Potts shunt in patients with suprasystemic pulmonary hypertension. While the shunt improved clinical and functional status, it was associated with a high risk of complications, suggesting it should be considered as a last resort for drug-resistant pulmonary hypertension.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

34.

β3 adrenergic agonist treatment in chronic pulmonary hypertension associated with heart failure (SPHERE-HF): a double blind, placebo-controlled, randomized clinical trial.

Author: García-ÁlvarezAna, BlancoIsabel, García-LunarInés, JordàPaloma, Rodriguez-AriasJuan J, Fernández-FrieraLeticia, ZegriIsabel, NucheJorge, Gomez-BuenoManuel, PratSusanna, PujadasSandra, Sole-GonzalezEduard, Garcia-CossioMaria D, RivasMercedes, TorrecillaEstefanía, PeredaDaniel, SanchezJavier, García-PavíaPablo, Segovia-CuberoJavier, DelgadoJuan F, MirabetSonia, FusterValentín, BarberáJoan A, IbañezBorja,

PH improvement

This study investigates the effectiveness of mirabegron, a selective β3 adrenoreceptor agonist, in treating patients with combined pre- and post-capillary pulmonary hypertension (CpcPH). CpcPH is a serious condition associated with left heart disease and a poor prognosis.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Periprocedural Complications With Balloon Pulmonary Angioplasty: Analysis of Global Studies.

Author: JainNishant, SheikhMuhammad A, BajajDivyansh, TownsendWhitney, KrasuskiRichard, SecemskyEric, ChatterjeeSaurav, MolesVictor, AgarwalPrachi P, HaftJonathan, VisovattiScott H, CascinoThomas M, RosenfieldKenneth, NallamothuBrahmajee K, MclaughlinVallerie V, AggarwalVikas

Improved BPA technique
Pulmonary vascular injury

This review examines the evolution of balloon pulmonary angioplasty (BPA) as a treatment modality for patients with inoperable, medically refractory chronic thromboembolic pulmonary hypertension.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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