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Plasma levels and clinical effects of thioridazine and thiothixene.

Author: BerglingR, MjorndalT, OrelandL, RappW, WoldS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Thioridazine and thiothixene were both effective in treating schizophrenic patients, with no significant differences between the two drugs. Plasma levels of both drugs were correlated to dosage. However, plasma levels of thiothixene decreased significantly after eight weeks of treatment, indicating strong enzyme induction.
Paper Details　
Original Abstract of the Article :
The effects of thioridazine and thiothixene were studied by a double-blind technique on 40 schizophrenic patients. The doses were adjusted for optimal clinical and therapeutic effects and side effects were rated after three and eight weeks of treatment. No statistically significant differences were ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1002/j.1552-4604.1975.tb02354.x

データ提供：米国国立医学図書館（NLM）

Thioridazine and Thiothixene: Exploring Their Clinical Effects and Plasma Levels

The search for effective treatments for schizophrenia is a journey through a vast and sometimes confusing desert of mental health research. This study investigates the clinical effects and plasma levels of two antipsychotic medications, thioridazine and thiothixene, in patients with schizophrenia. The researchers conducted a double-blind study to compare the effectiveness of these drugs in treating symptoms and to assess their side effects.

No Significant Differences in Clinical Effects or Side Effects

The study found no significant differences in the clinical effects of thioridazine and thiothixene. Both drugs were generally well-tolerated, with no major differences in side effects observed. The study also found no clear correlation between plasma levels of either drug and their clinical effects.

Understanding Antipsychotic Metabolism

This research highlights the complexities of drug metabolism and its impact on clinical effectiveness. The study found that plasma levels of thiothixene decreased significantly over time, suggesting a strong enzyme induction effect. This finding emphasizes the importance of considering individual differences in drug metabolism when prescribing antipsychotic medications.

Dr. Camel's Conclusion

This study is a reminder that the journey through mental health research can be challenging and unpredictable. While thioridazine and thiothixene were found to be comparable in their clinical effects, the research highlights the need for personalized medicine approaches that consider individual differences in drug metabolism. As scientists continue to unravel the complexities of mental illness and its treatment, we may discover even more effective ways to help those who are struggling.

Date :
  1. Date Completed 1975-07-02
  2. Date Revised 2019-08-23
Further Info :

Pubmed ID

1091665

DOI: Digital Object Identifier

10.1002/j.1552-4604.1975.tb02354.x

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Languages

English

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