Effects of thiothixene: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Thiothixene is a typical antipsychotic medication used to treat schizophrenia and other psychiatric disorders. 9 Research on thiothixene has evaluated its clinical effectiveness in patients with chronic schizophrenia and compared it to trifluoperazine. Thiothixene has been shown to exhibit some antipsychotic activity, improving symptoms of schizophrenia. However, it can also cause movement disorders as a side effect, such as Parkinsonism, restlessness, and akathisia. 7 Thiothixene might influence neurotransmitter metabolism, potentially altering glucose metabolism in the brain. 3 Like other antipsychotics, thiothixene's effectiveness and side effects are related to plasma concentrations, making proper blood level management crucial for therapeutic benefits and minimizing adverse effects. 6 Thiothixene may also be used to treat delirium. 10

Benefits and Risks

Benefit Summary

Thiothixene may improve symptoms in chronic schizophrenia. It may also be used in combination with other antipsychotics to improve schizophrenia symptoms and alleviate symptoms of Parkinsonism. Additionally, thiothixene may be used to treat delirium. 10

Risk Summary

Thiothixene can cause movement disorders such as Parkinsonism, restlessness, and akathisia. 7 It may also influence neurotransmitter metabolism and alter glucose metabolism in the brain. 3 Like other antipsychotics, thiothixene has varying side effects among individuals.

Comparison Between Studies

Commonalities Among Studies

Several studies reported that thiothixene is effective in treating schizophrenia. 7 These studies also indicated that thiothixene may cause side effects like movement disorders. 7

Differences Between Studies

Research findings regarding thiothixene's clinical effects, side effects, dosages, and mechanisms of action show some variations. For instance, the dosage of thiothixene, treatment effectiveness, and severity of side effects differ across studies. 7 The effect of thiothixene on glucose metabolism in the brain also has varying findings. 3 These differences may be attributed to variations in patient populations, study designs, and assessment methods.

Consistency and Contradictions in Results

Thiothixene may be effective in treating schizophrenia, but it poses a risk of movement disorders as a side effect. 7 While some studies suggest that thiothixene might influence neurotransmitter metabolism, 3 further research is necessary to confirm this. The relationship between thiothixene's plasma levels and effectiveness has yielded consistent results in some studies, 6 but further validation is needed to draw definitive conclusions across all studies.

Considerations for Real-Life Applications

Thiothixene should be taken as prescribed by a doctor for the treatment of schizophrenia. It is crucial to take the correct dosage and follow the prescribed method of administration, considering the risk of side effects. 7 Thiothixene can interact with other medications, so it is vital to inform your doctor of all medications you are taking. 6 If you experience any mood changes, insomnia, movement disorders, or other symptoms while taking thiothixene, consult your doctor immediately. 7

Limitations of Current Research

Research on thiothixene is limited by small sample sizes and varying study designs, making it difficult to generalize the findings. 7 Further, research on thiothixene's mechanism of action and side effects is insufficient. 3 6 There is also a lack of comparative studies between thiothixene and other antipsychotics.

Future Research Directions

Further research is needed to clarify thiothixene's mechanism of action, side effects, and comparisons with other antipsychotics. 3 6 Conducting studies with larger sample sizes and standardized study designs can generate more reliable data regarding thiothixene's clinical effectiveness and risks. 7

Conclusion

Thiothixene may be effective in treating schizophrenia but carries the risk of movement disorders as a side effect. 7 When using thiothixene, it is crucial to adhere to doctor's instructions and be aware of the potential for side effects. 7 Further research is anticipated to provide insights into thiothixene's mechanism of action, side effects, and comparisons with other antipsychotics. 3 6

Literature analysis of 10 papers
Positive Content
5
Neutral Content
2
Negative Content
3
Article Type
2
0
1
1
10
1.

The comparison of the effects of DL-308, a potential new neuroleptic agent, and thioridazine on some psychological and physiological functions in healthy volunteers.

Author: SzabadiE, BradshawC M, GasznerP

Alpha-adrenolytic effects
Anticholinergic effects
Sedative properties
Sympathomimetic effects

DL-308, a new drug, and thioridazine both displayed sedative properties, with DL-308 being more potent. DL-308 also showed sympathomimetic properties, while both drugs had effects consistent with alpha-adrenolytic and possibly anticholinergic actions. DL-308 had a faster onset and shorter duration of action than thioridazine and had less impact on autonomic functions.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans.

Author: Hartigan-GoK, BatemanD N, NybergG, MårtenssonE, ThomasS H

Hypotension
Impaired psychomotor function
Prolonged QT interval

Thioridazine, in doses of 50 mg and 10 mg, was shown to have a dose-related effect on ventricular repolarization. The parent drug was responsible for a significant portion of these effects, with possible contributions from its metabolites.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of clozapine and thiothixene on glucose metabolic rate in schizophrenia.

Author: BuchsbaumM S, PotkinS G, MarshallJ F, LottenbergS, TengC, HehC W, TafallaR, ReynoldsC, AbelL, PlonL

Schizophrenia treatment

Clozapine and thiothixene, antipsychotic medications, have different effects on brain metabolism in patients with schizophrenia. Clozapine increased, while thiothixene decreased metabolic rates in the basal ganglia. These findings suggest that the drugs may have distinct mechanisms of action.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Importance of pharmacologic control in PET studies: effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia.

Author: BartlettE J, WolkinA, BrodieJ D, LaskaE M, WolfA P, SanfilipoM

Neuroleptic effects

Thiothixene and haloperidol, two neuroleptic drugs, had different metabolic effects on cerebral glucose utilization in chronic schizophrenic inpatients. Thiothixene increased whole-brain glucose utilization, while haloperidol decreased it. This highlights the importance of controlling for neuroleptic treatment effects in studies of brain metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Hemodynamic effects of thiothixene and chlorpromazine in schizophrenic patients at rest and during exercise.

Author: CarlssonC, DenckerS J, GrimbyG, HäggendalJ, JohnssonG

Chlorpromazine and thiothixene were found to have moderate effects on hemodynamic variables.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Plasma levels and clinical effects of thioridazine and thiothixene.

Author: BerglingR, MjorndalT, OrelandL, RappW, WoldS

Schizophrenia treatment
Enzyme induction

Thioridazine and thiothixene were both effective in treating schizophrenic patients, with no significant differences between the two drugs. Plasma levels of both drugs were correlated to dosage. However, plasma levels of thiothixene decreased significantly after eight weeks of treatment, indicating strong enzyme induction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Antipsychotic treatment of schizotypy and schizotypal personality disorder: a systematic review.

Author: JakobsenKlaus Damgaard, SkyumEva, HashemiNasseh, SchjerningOle, Fink-JensenAnders, NielsenJimmi

This study reviews the limited research on antipsychotic treatment for Schizotypal Personality Disorder (SPD), emphasizing the need for more high-quality studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Thiothixene in the Management of Delirium: A Case Series.

Author: LeungJonathan G, DareFolabo Y, FlowersLee M, MurphyLauren L, SukiennikEliza M, PhilbrickKemuel L, RasmussenKeith G

Effective for delirium
Safe
Further studies needed

Thiothixene could be a safe and effective pharmacologic treatment for agitation and psychosis due to delirium.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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