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A prospective study of interferon therapy modified by pre-treatment viral load in cirrhotic patients. Tokyo-Chiba Hepatitis Research Group.

Author: ArakawaY, HashimotoE, HayashiN, HirataK, ImazekiF, MatsuzakiK, MoriyamaM, OhashiY, OhkuboH, OmataM, ShibuyaA, ShiratoriY, TanakaN, YokosukaO, YoshidaH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Interferon therapy was effective in cirrhotic patients with low viral loads, with a 65% HCV-RNA negativity rate and a 40% sustained virological response. However, in patients with high viral loads, sustained response was scarcely achieved, indicating a potential cut-off level of HCV RNA load that cannot be eradicated.
Paper Details　
Original Abstract of the Article :
BACKGROUND/AIMS: The relative role of hepatitis C virus (HCV) load and subtype as predictors of the efficacy of interferon therapy has been clarified in patients with chronic hepatitis C, but the effectiveness of interferon therapy in cirrhotic patients is still unclear. METHODS: To resolve this is...See full text at original site
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引用元：
https://doi.org/10.1034/j.1600-0676.2000.020004271.x

データ提供：米国国立医学図書館（NLM）

Interferon Therapy: A Potential Oasis for Hepatitis C, But with Challenges in Cirrhotic Patients

Hepatitis C, a viral infection that can lead to liver damage, is like a persistent desert wind, threatening the health of millions. This study investigates the effectiveness of interferon therapy in cirrhotic patients with hepatitis C, specifically examining the impact of viral load on treatment outcomes.

Interferon Therapy: A Promising Oasis, But with Limitations

The results show that interferon therapy is more effective in cirrhotic patients with low viral loads, offering hope for these patients. However, the study also reveals that achieving sustained virological response in patients with high viral loads is challenging, even with extended treatment regimens.

Navigating the Desert of Hepatitis C Treatment

The study underscores the importance of considering viral load in treatment decisions and highlights the ongoing need for research to develop more effective therapies for patients with high viral loads.

Dr.Camel's Conclusion

Interferon therapy, like a shimmering oasis, offers hope for hepatitis C patients. However, the desert of this disease is vast, and the challenges in treating cirrhotic patients with high viral loads remain. This study emphasizes the importance of continued research to find new solutions for all patients struggling with hepatitis C.

Date :
  1. Date Completed 2000-12-22
  2. Date Revised 2019-09-21
Further Info :

Pubmed ID

10959805

DOI: Digital Object Identifier

10.1034/j.1600-0676.2000.020004271.x

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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