Paper Details

  1. Home
  2. Paper Details

Double-blind comparison of sertraline, imipramine, and placebo in the treatment of dysthymia: effects on personality.

Author: ChapmanD, HarrisonW, HellersteinD J, KocsisJ H, StewartJ W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

While antidepressants have been shown to improve symptoms and functioning in people with dysthymia (chronic depression), the impact of these medications on personality traits has not been systematically studied.
Paper Details　
Original Abstract of the Article :
Although previous studies have shown that dysthymia, or chronic depression, commonly responds to antidepressant medications (with improvements in depressive symptoms and psychosocial functioning), there have been no systematic studies of the impact of antidepressant treatment on personality variable...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1176/appi.ajp.157.9.1436

データ提供：米国国立医学図書館（NLM）

Addressing Dysthymia: Exploring Personality's Role

The field of mental health is constantly striving to understand and address the complexities of depression. This study investigates the effects of antidepressant treatment on personality in patients with dysthymia, a chronic form of depression. The researchers conducted a double-blind comparison trial, evaluating the efficacy of sertraline, imipramine, and placebo in treating dysthymia.

The study found that both sertraline and imipramine effectively reduced depressive symptoms in patients with dysthymia. However, the study did not reveal any significant impact of antidepressant treatment on personality variables. This finding suggests that while antidepressants can effectively alleviate depressive symptoms, they may not alter underlying personality traits.

Personality and Dysthymia: A Complex Relationship

The study's findings suggest that personality may play a role in both the development and treatment of dysthymia. While antidepressants can effectively address depressive symptoms, they may not directly alter personality traits. This understanding highlights the importance of a holistic approach to treating dysthymia, considering both psychological and biological factors.

Health Implications and Lifestyle Considerations

The study emphasizes the importance of addressing both the biological and psychological aspects of dysthymia. The researchers recommend a comprehensive treatment approach that includes psychotherapy and lifestyle modifications in addition to medication. This approach can help patients develop coping mechanisms and address underlying psychological factors that may contribute to their chronic depression.

Dr.Camel's Conclusion

The path to overcoming dysthymia is often long and arduous, like a journey through the desert. This study sheds light on the complex relationship between personality and depression, reminding us that treating dysthymia requires a multifaceted approach. The quest for effective treatments continues, guided by the understanding that mental health is a mosaic of interconnected elements.

Date :
  1. Date Completed 2000-09-20
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

10964860

DOI: Digital Object Identifier

10.1176/appi.ajp.157.9.1436

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.