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European hepatitis B immunoglobulin trials: prevention of recurrent hepatitis B after liver transplantation.

Author: KrügerM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This study reviews European studies on the use of hepatitis B immunoglobulin (HBIg) in preventing or reducing the severity of recurrent hepatitis B after orthotopic liver transplantation. The review found that HBIg is most effective when given in high doses for a long time and that the presence or absence of viral DNA in the recipient can influence the rate of recurrence.
Paper Details　
Original Abstract of the Article :
Orthotopic liver transplantation is used for treatment of liver cirrhosis and organ failure due to chronic hepatitis B infection. However, in the absence of effective antiviral therapy, patients can develop recurrent hepatitis B leading to graft failure. In this report, a review is presented of seve...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/10965959

データ提供：米国国立医学図書館（NLM）

Preventing Recurrence After Liver Transplantation: A Battle Against Hepatitis B

Liver transplantation, like a delicate sandcastle built on the shores of a stormy sea, requires careful attention and protection. This study focuses on the challenge of recurrent hepatitis B infection after liver transplantation, a complication that can jeopardize the success of the transplant. Researchers have been exploring ways to prevent this recurrence, and this study delves into the effectiveness of hepatitis B immunoglobulin (HBIg) in reducing the severity of recurrent infection. They reviewed several European studies and found that HBIg, when administered in high doses for a prolonged period, significantly lowered the rate of recurrence. The study also highlighted the importance of recipient characteristics, such as the presence of viral DNA, in influencing the effectiveness of HBIg.

A Shield Against Recurrence: Protecting the Sandcastle

This study underscores the importance of HBIg in preventing recurrent hepatitis B infection after liver transplantation. It emphasizes the critical role of dosage and duration of treatment, as well as the individual characteristics of the recipient. By optimizing these factors, healthcare providers can help protect the delicate balance of the transplanted liver and ensure its long-term survival.

The Promise of HBIg: An Oasis in the Stormy Sea

The use of HBIg offers hope for patients who have undergone liver transplantation, providing a shield against the threat of recurrent hepatitis B infection. This study highlights the effectiveness of HBIg and provides valuable insights into optimizing its administration for maximum benefit. With this knowledge, healthcare providers can better navigate the stormy sea of post-transplant complications, ensuring the survival and well-being of patients.

Dr.Camel's Conclusion

This study provides a comprehensive review of the efficacy of HBIg in preventing recurrent hepatitis B infection after liver transplantation, emphasizing the importance of high doses and long-term administration. The study highlights the potential of HBIg to protect the delicate balance of the transplanted liver and ensure its long-term survival.
Date :
  1. Date Completed 2000-12-22
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

10965959

DOI: Digital Object Identifier

10965959

SNS
PICO Info
in preparation
Languages

English

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