Oral 9-cis retinoic acid (Alitretinoin) in the treatment of myelodysplastic syndromes: results from a pilot study.

Author: BurnettA K, BurnettR, CastaigneS, ChomienneC, FenauxP, GanserA, HoelzerD, HofmannW K, KellW J, KowalC

Paper Details 
Original Abstract of the Article :
A multicenter phase II study was initiated to investigate the efficacy, toxicity and tolerability of an oral regimen of 9-cis retinoic acid (9CRA) as a differentiation-inducing agent stimulating both retinoic acid receptor (RAR) and retinoic X receptor (RXR). Thirty patients with myelodysplastic syn...See full text at original site
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引用元:
https://doi.org/10.1038/sj.leu.2401873

データ提供:米国国立医学図書館(NLM)

Navigating the Shifting Sands of Myelodysplastic Syndromes

The human blood system is a complex and dynamic landscape, much like a vast desert with its own intricate ecosystem. Myelodysplastic syndromes (MDS), a group of blood disorders, disrupt this delicate balance, causing the bone marrow to produce abnormal blood cells, much like a desert ecosystem struggling to thrive under harsh conditions. This study explores the potential of oral 9-cis retinoic acid (Alitretinoin) as a treatment for MDS, a strategy akin to introducing a new plant species to a desert environment to help restore balance.

A New Approach to Treating MDS

The researchers conducted a pilot study to evaluate the efficacy and safety of Alitretinoin, a rigorous investigation akin to carefully observing the impact of a new plant species on a desert ecosystem. While the study revealed modest responses, it highlighted the potential of Alitretinoin as a differentiation-inducing agent, a substance that may help to transform abnormal blood cells into healthy ones, like encouraging a desert plant to adapt and thrive.

A Potential Oasis for MDS Patients

This research offers a glimmer of hope for individuals with MDS, a condition that can significantly impact their quality of life. The findings suggest that Alitretinoin may have a role in treating MDS, potentially offering a path towards a healthier future.

Dr.Camel's Conclusion

This research, much like a caravan traversing the desert landscape of blood disorders, offers a new perspective on treating myelodysplastic syndromes. The study's findings, though modest, suggest that Alitretinoin may hold potential as a differentiation-inducing agent, a tool that could help to restore balance in the desert ecosystem of the blood.

Date :
  1. Date Completed 2000-10-06
  2. Date Revised 2019-09-15
Further Info :

Pubmed ID

10995004

DOI: Digital Object Identifier

10.1038/sj.leu.2401873

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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