Side Effects of alitretinoin: A Synthesis of Findings from 33 Studies

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Original Abstract of the Article

Major Research Findings

Alitretinoin has been shown to be effective in the treatment of a variety of skin diseases, including chronic hand eczema, ichthyosis, Darier disease, and cutaneous T-cell lymphoma. 24 , 33 , 17 , 1 , 19 , 15 , 20 , 5

Reasons for Side Effects

Alitretinoin is a derivative of vitamin A and has the effect of regulating cell growth and differentiation. This effect improves the symptoms of skin diseases, but it can also affect other cells, which can lead to side effects. 13

Common Side Effects

Headache

Headache can occur with alitretinoin use. This is thought to be due to the vasodilating effects of alitretinoin. 27 , 22 , 31

Dry Skin

Dry skin can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to decrease the skin's ability to retain moisture. 31 , 22 , 13 , 4

Dry Lips

Dry lips can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to decrease the lips' ability to retain moisture. 13 , 4

Dry Eyes

Dry eyes can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to decrease the eyes' ability to retain moisture. 13 , 4

Dry Nose

Dry nose can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to decrease the nose's ability to retain moisture. 13 , 4

Dry Mouth

Dry mouth can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to decrease the mouth's ability to retain moisture. 13 , 4

Rash

Rash can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to change the immune response of the skin. 31

Joint Pain

Joint pain can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to worsen inflammation in the joints. 31

Hyperlipidemia

Hyperlipidemia can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to inhibit lipid metabolism in the liver. 13 , 12 , 4

Liver Dysfunction

Liver dysfunction can occur with alitretinoin use. This is thought to be due to the burden that alitretinoin places on the liver. 13

Hypothyroidism

Hypothyroidism can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to inhibit the production of thyroid hormone. 22 , 4

Vision Problems

Vision problems can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to affect the tissues of the eye. 4

Hair Loss

Hair loss can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to inhibit hair growth. 14

Gastrointestinal Symptoms

Gastrointestinal symptoms (nausea, vomiting, abdominal pain, diarrhea, etc.) can occur with alitretinoin use. This is thought to be due to alitretinoin's ability to irritate the mucous membranes of the gastrointestinal tract. 2 , 13 , 4

Other Side Effects

In addition to the above, various side effects can occur with alitretinoin use. Specifically, these include fatigue, fever, muscle pain, joint pain, neuralgia, dizziness, lightheadedness, shortness of breath, cough, nosebleeds, maldigestion, constipation, loss of appetite, weight loss, hematuria, frequent urination, difficulty urinating, genital itching, decreased libido, menstrual irregularities, breast swelling, lumps, facial flushing, skin discoloration, nail discoloration, nail abnormalities, mouth sores, gingivitis, taste disturbances, tinnitus, hearing loss, decreased vision, narrowing of the field of vision, eye movement disorders, cataracts, glaucoma, headache, dizziness, altered consciousness, mental instability, depression, insomnia, hallucinations, auditory hallucinations, ataxia, seizures, numbness, paralysis, cold extremities, thrombosis, bleeding tendency, thrombocytopenia, leukopenia, anemia, liver dysfunction, kidney dysfunction, etc. 13

Side Effect Management

Dry Skin

To prevent dry skin, apply moisturizer frequently. 13

Dry Lips

To prevent dry lips, apply lip balm frequently. 13

Dry Eyes

To prevent dry eyes, use eye drops or a humidifier. 13

Dry Nose

To prevent a dry nose, instill saline solution into the nasal cavity or use a humidifier. 13

Dry Mouth

To prevent dry mouth, drink plenty of fluids and practice good oral hygiene. 13

Hyperlipidemia

To prevent hyperlipidemia, follow a diet and exercise regimen. If necessary, a doctor may prescribe lipid-lowering drugs. 13 , 12 , 4

Liver Dysfunction

To prevent liver dysfunction, have regular liver function tests. 13

Hypothyroidism

To prevent hypothyroidism, have regular thyroid function tests. If necessary, a doctor may prescribe thyroid hormone replacement therapy. 22 , 4

Comparison Between Studies

Commonalities of Studies

Alitretinoin has been shown to be effective in treating a variety of skin diseases in multiple studies. Alitretinoin can also cause side effects. 24 , 33 , 17 , 1 , 19 , 15 , 20 , 5

Differences in Studies

The effectiveness and side effects of alitretinoin vary depending on the type of disease and the patient's constitution, as shown in multiple studies. 24 , 33 , 17 , 1 , 19 , 15 , 20 , 5

Cautions for Real-Life Applications

Take alitretinoin only as directed by your doctor. Alitretinoin should not be taken by pregnant or breastfeeding women. 13 , 1 , 19

Limitations of Current Research

The long-term effects of alitretinoin have not been sufficiently studied. 13 , 4

Future Research Directions

Further research is needed on the long-term effects of alitretinoin and safer methods of use. 13 , 4

Conclusion

Alitretinoin is an effective treatment for a variety of skin diseases, but it can cause side effects. When taking alitretinoin, follow your doctor's instructions and take it safely. 24 , 33 , 17 , 1 , 19 , 15 , 20 , 5

Keywords
Benefit Keywords
Ichthyoses treatment
1
KS treatment
2
Improved Kaposi sarcoma treatment
3
CTCL treatment
5
CHE treatment
6
Alitretinoin efficacy
Alitretinoin safety
7
Improved skin lesions
Reduced pruritus
8
lichen planus treatment
9
Hand eczema treatment
10
Ichthyosis treatment
11
Skin health
13
Good clinical response
Well tolerated
15
Antibiotic
Antimycotic
Antiparasitic
Antiseptic
Antiviral
Keratolytic
Skin treatment
16
Effective eczema treatment
17
Effective LP treatment
18
Alitretinoin for Darier disease
19
Clear of disease
20
Hand eczema treatment
21
Hand eczema treatment
22
Efficacy after disease relapse
Well tolerated
23
Improved hand eczema treatment
24
Favorable evolution
25
LRH-1 aromatase inhibitor
RXR agonists aromatase inhibitor
26
Apoptosis induction
Chemo prevention
Retinoid therapy
28
Neuroblastoma treatment
29
B-cell lymphoma treatment
NHL treatment
T-cell lymphoma treatment
30
Complete hematological remission
Decreased transfusion requirements
Differentiation-inducing agent
31
Selective retinoid
Treat breast cancer
32
Hand eczema treatment
33
Risk Keywords
Contraceptive measures
Pregnancy risk
1
Side effects
2
Blister formation
Inflammation
Pain
3
Myopia
4
Hypertriglyceridemia
5
Side effects
6
Hypertriglyceridemia
7
side effects
9
Side effects
11
Hypercholesterolemia
Hyperlipidemia
12
Adverse effects
13
Hair curling
14
High cholesterol
High triglycerides
15
Side effects
16
Relapse
18
Increased cholesterol
Increased triglycerides
22
Hand eczema
24
Local reaction
25
Headache
Side effects
27
Side effects
Toxicity
28
Dry skin
Headache
Hypercalcemia
Hypertriglyceridemia
30
Arthralgias
Dry skin
Headache
Rash
31
Mild side effects
33
Literature analysis of 33 papers
Positive Content
30
Neutral Content
0
Negative Content
3
Article Type
2
2
1
7
31
2.

Exploring the interactions of antihistamine with retinoic acid receptor beta (RARB) by molecular dynamics simulations and genome-wide meta-analysis.

Author: KimMinjae J, KulkarniVishnutheertha, GoodeMicah A, SivesindTorunn E

KS treatment
Side effects

This study explores the potential of antihistamines as a treatment for Kaposi sarcoma (KS), a common AIDS-related cancer. Using in-silico methods, the study identifies bepotastine and hydroxyzine as promising candidates for further research, potentially offering a safer alternative to the current treatment, 9-cis-retinoic acid.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

3.

Efficacy of immunotherapy with combination of cryotherapy and topical imiquimod for treatment of Kaposi sarcoma.

Author: GuLilly, LinErica, LiuShuaitong, YangNing, KurtanskyNicholas, NeumannNeil M, StollJoseph, LezcanoCecilia, PulitzerMelissa, NoorSarah, MarkovaAlina, RossiAnthony, DicksonMark A, DengLiang

Improved Kaposi sarcoma treatment
Blister formation
Inflammation
Pain

This study investigated the efficacy of combination therapy of cryotherapy followed by topical imiquimod for limited, cutaneous Kaposi sarcoma (KS). The study found that this combination therapy may be an efficacious and comparatively low-risk treatment for KS.

LetterA written message for communication and exchange of information between individuals.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Retinoid-associated myopia in dermatologic patients: a systematic review.

Author: RoccuzzoGabriele, TibaldiTommaso, CavalloFrancesco, AquinoCarola, RolleTeresa, QuaglinoPietro, RiberoSimone

Myopia

This review examined the existing evidence regarding retinoid-associated myopia (nearsightedness) in patients taking retinoid medications for skin conditions. While retinoids can cause other eye problems, the evidence for myopia is inconsistent and needs further research.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Alitretinoin in the treatment of cutaneous T-cell lymphoma.

Author: KaemmererTill, StadlerPia-Charlotte, Helene FrommherzLeonie, GuertlerAnne, Einar FrenchLars, ReinholzMarkus

CTCL treatment
Hypertriglyceridemia

This survey analyzed data from patients with mycosis fungoides and Sézary syndrome treated with alitretinoin. Nearly two-thirds of patients showed a response or stable disease, with low rates of side effects. Alitretinoin may be a potential alternative treatment option for less advanced cutaneous T-cell lymphomas.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Alitretinoin Compliance in Patients with Chronic Hand Eczema.

Author: SeolJung Eun, KimJong Uk, HongSeong Min, ChoGyeong Je, JinWoo Jung, ParkSo Hee, ParkIn Ho, JungSo Young, KimHyojin

CHE treatment
Side effects

Alitretinoin is a preferred long-term treatment option for CHE, and patients should be educated about the reasons for poor compliance, such as late efficacy, cost, and side effects, to encourage them to continue treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Evaluation of Alitretinoin for the Treatment of Mycosis Fungoides and Sézary Syndrome.

Author: AlhusayenRaed, VuTrang Tuyet, AlmuhannaNouf, Wohlmuth-WieserIris, HardinJori, HughesJohn-Douglas Matthew, ChiaJustin, StreetLeslie, ShearNeil Hartley, WalshScott Richard, GniadeckiRobert

Alitretinoin efficacy
Alitretinoin safety
Hypertriglyceridemia

This retrospective study evaluated the efficacy and tolerability of alitretinoin in managing cutaneous T-cell lymphoma (CTCL). The study found that alitretinoin, as a monotherapy or in combination with standard therapies, effectively cleared skin disease and prevented disease progression in CTCL patients. The study also found that alitretinoin was well-tolerated, with hypertriglyceridemia being the most common side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

8.

Oral Alitretinoin for Patients with Refractory Prurigo.

Author: ChungBo Young, UmJi Young, KangSeok Young, JungMin Je, KimJin Cheol, KwakIn-Suk, ParkChun Wook, KimHye One

Improved skin lesions
Reduced pruritus

Oral alitretinoin, a retinoid, appears to be an effective and well-tolerated treatment option for patients with prurigo nodularis who have not responded to conventional treatments. Further clinical studies are needed to confirm its long-term efficacy and safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Isolated nail lichen planus: An expert consensus on treatment of the classical form.

Author: IorizzoMatilde, TostiAntonella, StaraceMichela, BaranRobert, DanielC Ralph, Di ChiacchioNilton, GoettmannSophie, GroverChander, HanekeEckart, LipnerShari R, RichPhoebe, RichertBertrand, RigopoulosDimitris, RubinAdam I, ZaiacMartin, PiracciniBianca Maria

lichen planus treatment
side effects

This review provides practical management recommendations for the classical form of nail lichen planus, a benign inflammatory disorder that can lead to permanent nail destruction. Topical treatment has poor short-term efficacy, while intralesional and intramuscular triamcinolone acetonide should be considered first-line therapies. Oral retinoids and immunosuppressive agents may also be considered.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Chronic hand eczema and hepatogenic pruritus with good response to apremilast.

Author: Navarro-TriviñoFrancisco J, Cuenca-BarralesCarlos, Vega-CastilloJorge J, Ruiz-VillaverdeRicardo

Hand eczema treatment

This case report describes a patient with hand eczema (HE) who achieved a rapid and complete response to apremilast treatment. This suggests that apremilast may be a promising therapeutic option for HE.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Alitretinoin reduces erythema in inherited ichthyosis.

Author: OnnisGiuliana, ChiaveriniChristine, HickmanGeoffroy, DreyfusIsabelle, FischerJudith, BourratEmmanuelle, Mazereeuw-HautierJuliette

Ichthyosis treatment
Side effects

This retrospective multicentric study evaluated the effects and tolerability of alitretinoin, a retinoid, in treating inherited ichthyosis, a skin disorder. Acitretin is the primary retinoid used for this condition, but alternatives may be necessary due to ineffectiveness, side effects, or pregnancy considerations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

13.

Retinoid treatment of skin diseases.

Author: BeckenbachLisa, BaronJens M, MerkHans F, LöfflerHarald, AmannPhilipp M

Skin health
Adverse effects

Retinoids, which are vitamin A and its derivatives, are commonly used to treat skin conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

[Development of curly hair under systemic therapy with alitretinoin].

Author: HerinkC, SchönM P, MößnerR

Hair curling

A 44-year-old man experienced hair curling while taking alitretinoin. There has been no report about hair curling under alitretinoin until now.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

15.

Treatment of cutaneous T-cell lymphoma with oral alitretinoin.

Author: KapserC, HerzingerT, RuzickaT, FlaigM, MolinS

Good clinical response
Well tolerated
High cholesterol
High triglycerides

Alitretinoin was well tolerated and showed a good clinical response in patients with cutaneous T-cell lymphoma. 90.9% of patients showed marked improvement of their skin lesions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

[Topical treatment of infections, tumors and hyperkeratotic disorders].

Author: MesserschmidtA, SchultheisK, OchsendorfF

Antibiotic
Antimycotic
Antiparasitic
Antiseptic
Antiviral
Keratolytic
Skin treatment
Side effects

This review discusses substances used for the topical treatment of skin infections, skin tumors, and hyperkeratotic disorders. The review covers antimycotic, antibiotic, antiseptic, antiviral, and antiparasitic agents, as well as substances like diclofenac in hyaluronic acid, 5-fluorouracil, and salicylic acid. The review discusses the mode of action, indication, and side effects of each substance.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

17.

[Off-label use of alitretinoin].

Author: FritzK, TiplicaG S, SalavastruC, OnderM

Effective eczema treatment

Oral alitretinoin is a retinoid that is approved for the treatment of severe chronic hand eczema. This review summarizes new studies and clinical experience on the off-label use of alitretinoin for various conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

18.

Oral, esophageal and cutaneous lichen ruber planus controlled with alitretinoin: case report and review of the literature.

Author: KoliosAntonios G A, Marques MaggioEwerton, GublerChristoph, CozzioAntonio, DummerReinhard, FrenchLars E, NavariniAlexander A

Effective LP treatment
Relapse

Oral alitretinoin may be a new, well-tolerated treatment option for esophageal lichen planus (LP) after failed response to conventional treatments.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Treatment of Darier disease with oral alitretinoin.

Author: LetuléV, HerzingerT, RuzickaT, MolinS

Alitretinoin for Darier disease

This study presents two cases of women with refractory Darier disease (DD) successfully treated with alitretinoin without marked side-effects.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

[Successful treatment of Darier disease with oral alitretinoin].

Author: BarnstedtS E

Clear of disease

A 18-year-old man with severe Darier disease showed significant improvement after 52 weeks of treatment with alitretinoin 30 mg daily and topical keratolytic agents.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

21.

[Response to treatment with oral alitretinoin in patients with chronic hand eczema that is refractory to treatment with potent topical corticosteroids: experience in 15 patients].

Author: Aguayo-LeivaI R, UrrutiaS, Jaén-OlasoloP

Hand eczema treatment

Alitretinoin, an endogenous derivative of vitamin A, has shown promising results in treating chronic hand eczema. Its efficacy is attributed to its agonist activity on both retinoic acid receptors and retinoid X receptors, which regulate various cellular processes involved in skin health.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

23.

Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema.

Author: BissonnetteR, WormM, GerlachB, GuentherL, CambazardF, RuzickaT, MaaresJ, BrownT C

Efficacy after disease relapse
Well tolerated

Retreatment with alitretinoin (9-cis retinoic acid) was effective in patients with chronic hand eczema (CHE) who had previously responded to treatment and relapsed. Response rates were 80% for 30 mg alitretinoin and 48% for 10 mg alitretinoin compared to 8% and 10% for placebo, respectively.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

[Ultraviolet therapy in patients with chronic hand eczema].

Author: StegeH

Improved hand eczema treatment
Hand eczema

Hand eczema is commonly treated with topical steroid creams. When topical treatments fail, ultraviolet (UV) therapy alone or in combination with other treatments is the preferred second-line approach. UVB and PUVA (psoralen plus UVA) therapy are effective and have minimal side effects. Applying PUVA directly to the skin is better than using it systemically due to the localized nature of the condition. A new retinoid called alitretinoin has also shown promise, but no treatment guarantees a cure for all patients. UV therapy combined with other treatments is recommended when oral retinoids are ineffective.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

25.

[Kaposi's sarcoma treated with topical alitretinoin].

Author: González de ArribaA, Pérez-GalaS, Goiriz-ValdésR, Ríos-BucetaL, García-DíezA

Favorable evolution
Local reaction

Alitretinoin gel 0.1% is approved for the treatment of cutaneous lesions of AIDS-associated Kaposi's sarcoma.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

26.

Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy.

Author: SafiRachid, KovacicAgnes, GaillardStéphanie, MurataYoko, SimpsonEvan R, McDonnellDonald P, ClyneColin D

LRH-1 aromatase inhibitor
RXR agonists aromatase inhibitor

This study investigates the role of liver receptor homologue-1 (LRH-1) in the regulation of aromatase gene expression in human breast preadipocytes. The findings suggest that LRH-1 is a specific transcriptional activator of aromatase in breast tissue and may be a potential target for selective inhibition of aromatase production in breast cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

27.

The efficacy of 9-cis-retinoic acid (aliretinoin) as a chemopreventive agent for cervical dysplasia: results of a randomized double-blind clinical trial.

Author: AlvarezRonald D, ConnerMichael G, WeissHeidi, KlugPatricia M, NiwasSantosh, ManneUpender, BacusJames, KaganValeriy, SextonKatherine C, GrubbsClinton J, EltoumIsam-Eldin, GrizzleWilliam E

Headache
Side effects

This study evaluated the efficacy of aliretinoin as a chemoprevention agent in cervical dysplasia. Aliretinoin was not found to be effective in reducing the rate of regression of cervical dysplasia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

28.

Clinically potential subclasses of retinoid synergists revealed by gene expression profiling.

Author: IshidaSeiichi, Shigemoto-MogamiYukari, KagechikaHiroyuki, ShudoKoichi, OzawaShogo, SawadaJun-Ichi, OhnoYasuo, InoueKazuhide

Apoptosis induction
Chemo prevention
Retinoid therapy
Side effects
Toxicity

Gene expression profiling can be used to identify retinoid synergists that enhance the activity of Am80, a retinoid already in clinical trials, while potentially reducing its toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

The vitamin A analogues: 13-cis retinoic acid, 9-cis retinoic acid, and Ro 13-6307 inhibit neuroblastoma tumour growth in vivo.

Author: PonthanF, BorgströmP, HassanM, WassbergE, RedfernC P, KognerP

Neuroblastoma treatment

Neuroblastoma is a childhood cancer of the nervous system. While some cases may spontaneously improve, most are metastatic and have a poor prognosis despite treatment. Retinoic acid (RA), a form of vitamin A, plays a role in cell differentiation and programmed cell death. Studies show that RA can regulate neuroblastoma growth and differentiation in lab settings and has demonstrated effectiveness against neuroblastoma in living subjects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Experience with 9-cis retinoic acid in patients with relapsed and refractory non-Hodgkin's lymphoma.

Author: YounesA, CristofanilliM, McLaughlinP, HagemeisterF B, WeberD, MesinaO, CabanillasF

B-cell lymphoma treatment
NHL treatment
T-cell lymphoma treatment
Dry skin
Headache
Hypercalcemia
Hypertriglyceridemia

A phase II study was conducted on 9-cis RA to determine its effectiveness in treating relapsed and refractory non-Hodgkin's lymphoma (NHL). 14% of patients showed a response (3 partial remissions and 1 complete remission), and the most common side effects were dry skin, headache, hypertriglyceridemia, and hypercalcemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Oral 9-cis retinoic acid (Alitretinoin) in the treatment of myelodysplastic syndromes: results from a pilot study.

Author: HofmannW K, KellW J, FenauxP, CastaigneS, GanserA, ChomienneC, BurnettR, KowalC, HoelzerD, BurnettA K

Complete hematological remission
Decreased transfusion requirements
Differentiation-inducing agent
Arthralgias
Dry skin
Headache
Rash

9-cis retinoic acid (9CRA) was investigated as a differentiation-inducing agent for the treatment of myelodysplastic syndromes (MDS). While 9CRA showed modest responses, the treatment tolerability was suboptimal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

32.

Different effects of the treatment with AGN 193836 and 9-cis-retinoic acid in breast cancer cells.

Author: IsnardiL, RaffoP, EmioniteL, ChardraratnaR A, TomaS

Selective retinoid
Treat breast cancer

This study evaluated the effects of a selective retinoid on breast cancer cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Successful treatment of chronic hand eczema with oral 9-cis-retinoic acid.

Author: BollagW, OttF

Hand eczema treatment
Mild side effects

9-cis-RA is a valuable drug when given at low doses to patients with chronic hand eczema.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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