Paper Details

  1. Home
  2. Paper Details

Effects of latanoprost and timolol-XE on hydrodynamics in the normal eye.

Author: BacaW, FribergT, KielJ W, MensahJ, RemkyA, SponselW E, TrigoY

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Latanoprost significantly reduces intraocular pressure and enhances pulsatile ocular perfusion compared to timolol-XE. In a study of 20 healthy adults, latanoprost resulted in a greater decrease in intraocular pressure and a 16.7% increase in mean pulsatile ocular blood flow compared to timolol-XE. Both drugs reduced intraocular pressure below episcleral venous pressure.
Paper Details　
Original Abstract of the Article :
PURPOSE: To compare the effects of latanoprost and timolol-XE on ocular pressure and perfusion in healthy adults, with respect to episcleral venous pressure. METHODS: A double-masked, placebo-controlled crossover study of weeklong bedtime treatment with one drop of drug, with placebo contralaterall...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0002-9394(00)00401-3

データ提供：米国国立医学図書館（NLM）

Comparing Latanoprost and Timolol-XE: A Desert Oasis of Ocular Pressure Relief

In the vast desert of ophthalmology, we strive to quench the thirst of those suffering from elevated ocular pressure. This research delves into the effects of two potent desert bloomers, latanoprost and timolol-XE, on ocular pressure and perfusion in healthy individuals. The study utilizes a double-masked, placebo-controlled crossover design, akin to traversing a dune-filled landscape, meticulously comparing the effects of each drug. The researchers discovered that latanoprost, a potent desert flower, exhibited a more significant decrease in intraocular pressure, particularly upon waking. However, both drugs effectively reduced intraocular pressure over a week-long treatment period. Notably, latanoprost was also associated with enhanced pulsatile ocular perfusion, like a vibrant oasis providing sustenance.

The Oasis of Enhanced Perfusion: A Sign of Hope?

This study suggests that latanoprost might be more advantageous than timolol-XE in managing ocular pressure, offering a potential oasis of improved ocular perfusion. This finding could be particularly significant for patients with certain eye conditions where enhanced perfusion is beneficial. However, further research is needed to fully understand the long-term implications of this finding.

A Glimpse into a Healthier Horizon: Navigating Ocular Pressure

While both drugs were effective in reducing ocular pressure, latanoprost's impact on perfusion is an intriguing observation. This research underscores the importance of meticulously selecting medications to optimize outcomes for patients. As with any medical decision, consulting with a healthcare professional is crucial in navigating the vast desert of ocular health.

Dr.Camel's Conclusion

The desert of ophthalmology offers unique challenges, but research like this sheds light on potential solutions. Latanoprost emerges as a promising oasis for ocular pressure management, offering a potential advantage over timolol-XE. This discovery is a beacon of hope, guiding us towards a healthier horizon for eye health.

Date :
  1. Date Completed 2000-11-01
  2. Date Revised 2019-06-27
Further Info :

Pubmed ID

11004288

DOI: Digital Object Identifier

10.1016/s0002-9394(00)00401-3

Related Literature

Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.