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Topical diltiazem and bethanechol decrease anal sphincter pressure and heal anal fissures without side effects.

Author: CarapetiE A, KammM A, PhillipsR K

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topical glyceryl trinitrate is a medication that can heal anal fissures, but a majority of patients experience headaches. Topical gels of diltiazem and bethanechol, which lower anal sphincter pressure, are being investigated for the treatment of chronic anal fissures.
Paper Details　
Original Abstract of the Article :
Topical glyceryl trinitrate heals anal fissures, but a majority of patients experience headache. Topical gels of the calcium channel blocker diltiazem and the cholinomimetic bethanechol significantly lower anal sphincter pressure in volunteers. This study investigated the use of these two new pharma...See full text at original site
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引用元：
https://doi.org/10.1007/BF02236630

データ提供：米国国立医学図書館（NLM）

Topical Diltiazem and Bethanechol: A New Hope for Anal Fissures

Anal fissures are a common and often painful condition, causing discomfort and affecting overall quality of life. This research explores the potential of [topical diltiazem and bethanechol] as new treatments for [anal fissures], offering an alternative to existing therapies. Imagine these medications as soothing desert winds, capable of alleviating the pain and discomfort associated with anal fissures.

The study investigated the effectiveness of [topical diltiazem and bethanechol] in [reducing anal sphincter pressure] and [healing anal fissures] in patients with [chronic anal fissures]. This research is like testing different desert remedies, looking for the most effective way to heal the wounds and restore comfort to the traveler's body.

New Treatment Options

The study found that [topical diltiazem and bethanechol] were both effective in [reducing anal sphincter pressure] and [healing anal fissures] without significant side effects. This suggests that these medications could offer a valuable new treatment option for patients with [anal fissures].

Improving Patient Comfort

This research holds promise for improving the quality of life for patients with [anal fissures]. By providing effective and well-tolerated treatments, we can alleviate the pain and discomfort associated with this condition and empower patients to live more comfortably.

Dr. Camel's Conclusion

This research is like a refreshing oasis in the desert of anal fissure treatment. It offers new hope and effective solutions, using topical diltiazem and bethanechol to heal anal fissures and restore comfort. This is a testament to the ongoing quest for better treatments and the potential of medical innovation to improve the lives of patients.

Date :
  1. Date Completed 2000-11-20
  2. Date Revised 2019-07-21
Further Info :

Pubmed ID

11052511

DOI: Digital Object Identifier

10.1007/BF02236630

Related Literature

Article Analysis
・Side Effects of bethanechol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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