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Chronic infection with hepatitis C virus in patients with elevated or persistently normal serum alanine aminotransferase levels: comparison of hepatic histology and response to interferon therapy.

Author: ContosM J, HofmannC M, LuketicV A, SanyalA J, ShiffmanM L, SterlingR K, StewartC A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Patients with chronic hepatitis C virus (HCV) infection and persistently normal serum alanine aminotransferase (ALT) levels responded to interferon (IFN) therapy similarly to patients with elevated ALT levels, suggesting that they may have milder liver disease.
Paper Details　
Original Abstract of the Article :
Ninety-five patients with chronic hepatitis C virus (HCV) infection, 35 with persistently normal serum alanine aminotransferase (ALT) levels, were randomized to treatment with daily interferon (IFN) for 3 months, followed by IFN 3 times weekly (TIW) for 12 months (group A) or TIW for 18 months (grou...See full text at original site
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引用元：
https://doi.org/10.1086/317612

データ提供：米国国立医学図書館（NLM）

Chronic Hepatitis C Virus Infection: Navigating the Desert of Liver Disease

The vast and treacherous desert of liver disease poses a significant threat to global health. This study investigates the impact of chronic hepatitis C virus (HCV) infection on patients with elevated or persistently normal serum alanine aminotransferase (ALT) levels, exploring the differences in liver histology and response to interferon therapy.

The researchers conducted a randomized controlled trial involving 95 patients with chronic HCV infection. They found that patients with elevated ALT levels had more advanced liver histology compared to those with normal ALT levels. However, both groups responded similarly to interferon therapy.

Understanding the Complexity of Chronic Hepatitis C Infection

The study highlights the complexity of chronic HCV infection, emphasizing the importance of considering both clinical and histological parameters when assessing disease severity. This is like recognizing the diverse landscapes of the desert, where a seemingly flat and uniform terrain can conceal underlying variations and challenges.

Improving Management Strategies for Chronic Hepatitis C

The study's findings underscore the need for individualized management strategies for patients with chronic HCV infection. This includes considering both clinical and histological factors to optimize treatment decisions and improve patient outcomes. This is like tailoring a travel route through the desert to suit the specific needs and capabilities of different travelers.

Dr.Camel's Conclusion

This study provides valuable insights into the diverse presentations of chronic HCV infection and the importance of personalized treatment approaches. It encourages further research to refine diagnostic and therapeutic strategies for this challenging condition.

Date :
  1. Date Completed 2001-01-11
  2. Date Revised 2007-11-14
Further Info :

Pubmed ID

11069229

DOI: Digital Object Identifier

10.1086/317612

Related Literature

Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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