Comparison of efficacy and side effects of combination therapy of angiotensin-converting enzyme inhibitor (benazepril) with calcium antagonist (either nifedipine or amlodipine) versus high-dose calcium antagonist monotherapy for systemic hypertension.

Author: FengZ, MesserliF H, OparilS

Paper Details 
Original Abstract of the Article :
The present 2 multicenter studies were designed to evaluate whether patients with essential hypertension derived equal benefits from use of combination therapy with a calcium antagonist and angiotensin-converting enzyme (ACE) inhibitor as from doubling the dose of the calcium antagonist. After a 2-w...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/s0002-9149(00)01199-1

データ提供:米国国立医学図書館(NLM)

Comparing Combination Therapy of ACE Inhibitor and Calcium Antagonist for Hypertension

This research delves into the world of hypertension management, a condition that can be as pervasive as a desert wind, affecting millions of people worldwide. The researchers investigated the effectiveness of combining an angiotensin-converting enzyme (ACE) inhibitor, benazepril, with a calcium antagonist, either nifedipine or amlodipine, to control blood pressure, much like finding the best combination of desert plants to build a sturdy shelter.

A Shelter from the Desert Storm of Hypertension: Combining Medications for Control

The study found that both doses of the calcium antagonist/ACE inhibitor combination therapy lowered diastolic blood pressure as much as the high dose of the calcium antagonist alone. This is like finding that a combination of desert plants provides the same level of protection as a larger, single plant. The researchers also found that the combination therapy had fewer side effects, like edema, compared to high-dose calcium antagonist monotherapy. This indicates that combining these medications could be a more effective and well-tolerated approach to treating hypertension.

Navigating the Desert of Hypertension: Finding the Right Path to Control

This research underscores the importance of personalized treatment approaches for hypertension. The study suggests that a combination of medications may offer a more effective and well-tolerated option for many patients, allowing them to achieve optimal blood pressure control with fewer side effects. This is like finding the best path through the desert, taking into account the unique challenges and conditions of each individual's journey.

Dr.Camel's Conclusion

This research highlights the need for ongoing research and innovation in the treatment of hypertension. Like a skilled desert traveler who constantly adapts to changing conditions, healthcare professionals must be vigilant in seeking new and effective ways to manage this common and potentially dangerous condition.
Date :
  1. Date Completed 2001-01-11
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

11090788

DOI: Digital Object Identifier

10.1016/s0002-9149(00)01199-1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.