Side Effects of nifedipine: A Synthesis of Findings from 22 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of nifedipine: A Synthesis of Findings from 22 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Amlodipine may be more effective and safer than nifedipine for treating hypertension during pregnancy. 21

Topical nifedipine is associated with shorter pain relief and a higher remission rate for acute anal fissure compared with topical diltiazem. 16

Nifedipine can cause various side effects including headache, dizziness, nausea, and facial flushing. 13

Combination therapy with nifedipine and ritodrine has a similar safety profile to ritodrine alone for preterm labor. 2

Reason for Side Effects

Nifedipine is a calcium channel blocker that dilates blood vessels and lowers blood pressure. This dilation can cause various side effects such as headache, dizziness, nausea, and facial flushing. Nifedipine can also cause gingival hyperplasia. This is believed to be caused by nifedipine's impact on gum cells, leading to increased production of proteins like collagen. 14

Common Side Effects

Headache

Headache is one of the most common side effects of nifedipine. 13

Dizziness

Nifedipine can cause dizziness. 13

Nausea

Nifedipine can cause nausea. 13

Facial Flushing

Nifedipine can cause facial flushing. 13

Gingival Hyperplasia

Nifedipine can cause gingival hyperplasia. 14

Edema

Nifedipine can cause edema. 6

Hypotension

Nifedipine can cause hypotension. 18

Tachycardia

Nifedipine can cause tachycardia. 18

Hepatic Injury

Nifedipine can cause hepatic injury. 18

Anaphylaxis

Nifedipine can cause anaphylaxis. 18

Countermeasures for Side Effects

Headache

If you have a severe headache, consult your doctor. You can also take headache medicine, but follow your doctor's instructions. 13

Dizziness

If you feel dizzy, be careful when getting up or moving around. 13

Nausea

If you have nausea, eat small meals frequently. It is also important to stay hydrated. 13

Facial Flushing

Facial flushing usually improves over time. However, if your facial flushing is severe, consult your doctor. 13

Gingival Hyperplasia

Consult a dentist for gingival hyperplasia. Gingival hyperplasia can be improved by maintaining oral hygiene. 14

Edema

If your edema is severe, consult your doctor. 6

Hypotension

If you have hypotension, consult your doctor. Hypotension can be improved by changing your position slowly. 18

Tachycardia

If you have tachycardia, consult your doctor. 18

Hepatic Injury

If you have hepatic injury, consult your doctor. 18

Anaphylaxis

If you experience symptoms of anaphylaxis, call an ambulance immediately. 18

Comparison between Studies

Commonalities between Studies

Several studies have shown that nifedipine is an effective treatment for various diseases such as hypertension and anal fissures. 21 16

Differences between Studies

Studies on nifedipine side effects have shown that the types and frequency of side effects vary between studies. This is thought to be due to varying factors such as the age, sex, and diseases of the study participants. The administration method and dosage of nifedipine can also influence side effects. 13 16

Points to Note Regarding Application to Real Life

Nifedipine is an effective drug for the treatment of various diseases, but it's important to remember that it has a risk of side effects. Before taking nifedipine, consult your doctor to confirm that it is the right medication for your condition. 21 16

Limitations of Current Research

There is still not enough research on the side effects of nifedipine. It is hoped that more research will be conducted in the future to deepen our understanding of nifedipine side effects. 13 16

Future Directions for Needed Research

Research on nifedipine side effects should investigate the types and frequencies of side effects in more detail. It is also important to investigate factors that may affect side effects such as the administration method and dosage of nifedipine, as well as its interaction with other drugs. 13 16

Conclusion

Nifedipine is an effective drug for the treatment of various diseases such as hypertension and anal fissures, but it is important to remember that it has a risk of side effects. Before taking nifedipine, consult your doctor to confirm that it is the right medication for your condition. There is still not enough research on the side effects of nifedipine. It is hoped that more research will be conducted in the future to deepen our understanding of nifedipine side effects. 21 16

Literature analysis of 22 papers
Positive Content
15
Neutral Content
2
Negative Content
5
Article Type
5
1
1
2
21
3.

Nifedipine versus ritodrine for suppression of preterm labor and analysis of side effects.

Author: JajuPurushottam Bankatlal, DhabadiVeena B

Effective tocolysis
Fewer side effects

Oral nifedipine is a more effective and well-tolerated tocolytic agent compared to intravenous ritodrine. It is associated with fewer side effects and comparable neonatal outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia.

Author: MageeLaura A, MiremadiSaman, LiJing, ChengCarol, EnsomMary H H, CarletonBruce, CôtéAnne-Marie, von DadelszenPeter

Co-administration of nifedipine and magnesium sulfate for preeclampsia did not increase the risk of serious magnesium-related effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Comparison of efficacy and side effects of combination therapy of angiotensin-converting enzyme inhibitor (benazepril) with calcium antagonist (either nifedipine or amlodipine) versus high-dose calcium antagonist monotherapy for systemic hypertension.

Author: MesserliF H, OparilS, FengZ

Blood pressure control
Reduces edema
Edema

This study compared the blood pressure lowering effects of combination therapy with a calcium antagonist and an ACE inhibitor to doubling the dose of the calcium antagonist in patients with essential hypertension. Combination therapy achieved similar blood pressure control with fewer side effects, such as edema.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Early side-effects of antihypertensive therapy: comparison of amlodipine and nifedipine retard.

Author: BremnerA D, FellP J, HosieJ, JamesI G, SaulP A, TaylorS H

Hypertension treatment
Flushing
Headache

Amlodipine and nifedipine retard were equally effective in treating mild hypertension in 97 patients. However, amlodipine was associated with significantly fewer side effects, such as headache and flushing, during the first 14 days of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Side effects of dihydropyridine therapy: comparison of amlodipine and nifedipine retard.

Author: HosieJ, BremnerA D, FellP J, JamesG V, SaulP A, TaylorS H

Hypertension treatment
Side effects

Amlodipine (5 mg once daily) was more tolerable than nifedipine retard (20 mg twice daily) in 97 patients with mild-to-moderate hypertension. Both drugs reduced blood pressure effectively, but nifedipine retard was associated with more side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparison of early side effects with amlodipine and nifedipine retard in hypertension.

Author: HosieJ, BremnerA D, FellP J, JamesI G, SaulP A, TaylorS H

Blood pressure control
Few side effects
Dizziness
Flushing
Headache

Amlodipine, a calcium antagonist, was more effective and better tolerated than nifedipine retard in treating mild to moderate hypertension. It was associated with fewer adverse effects and had the advantage of once-daily dosing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

10.

[Side effects of nifedipine in healthy probands within the scope of a discontinued bioavailability study].

Author: MeyerF P, BandittP, WaltherH

Cardiovascular side effects

Cardiovascular side effects associated with nifedipine retard dragees may occur at serum levels of 80 ng/ml or higher, as observed in a bioavailability study. A correlation between side effect severity and the area under the concentration vs. time curve (AUC) was suggested.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

11.

Randomized double-blind comparison of side effects of nicardipine and nifedipine in angina pectoris. The Nicardipine Investigators Group.

Author: DeWoodM A, WolbachR A

Dizziness
Edema
Flushing
Headache
Palpitations

Nicardipine and nifedipine are calcium channel blockers used to treat angina pectoris. This study compared the incidence of dizziness, flushing, headache, pedal edema, and palpitations. Patients who experienced these symptoms with nifedipine during a month-long open-label trial experienced a higher incidence of the same symptoms during a double-blind trial. Nicardipine was associated with a lower incidence of these side effects compared to nifedipine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Nifedipine in the prophylaxis of classic migraine: a crossover, double-masked, placebo-controlled study of headache frequency and side effects.

Author: McArthurJ C, MarekK, PestronkA, McArthurJ, PeroutkaS J

Migraine treatment
Side effects

Nifedipine, a calcium channel blocker, was evaluated for its effectiveness in treating migraine headaches. Nifedipine did not significantly reduce the frequency of headaches compared to placebo, but it caused significantly more side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Pharmacokinetics and acute side-effects of nifedipine given as slow-release tablets or liquid-filled capsules.

Author: SaanoV, RaatikainenO, ParonenP, KomulainenH

dizziness
headache
nausea
vomiting

Nifedipine, a calcium channel blocker, showed rapid absorption when administered as capsules, but tablets led to significantly lower peak concentrations and bioavailability. All volunteers experienced side effects, with headache being the most common and intense, suggesting a need for caution with the capsule formulation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

A Pilot, Prospective, Randomized-Controlled Study to Evaluate the Efficacy and Safety of Arsha Hita™ in the Treatment of Anal Fissures.

Author: B JGopikrishna, K RSahanasheela, ShettySuhas K, RaoPrasanna N, NarvekarSangam, NalawadeMegha, ChawdaMukesh B, ChitnisKruttika R, SeetharamanRajmohan, TripathiRaakhi K

Anal fissure pain relief
Bleeding reduction
Wound healing
No adverse events reported

Anal fissures are tears in the anal canal that can cause pain, bleeding, and spasms. This pilot study compared the effectiveness and safety of a traditional Indian medicine (Arsha Hita) to a standard treatment for anal fissures.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Amlodipine Induced Gum Hypertrophy: A Rare Case Report.

Author: ReddySuryanarayana Challa, MidhaNaresh, ChhabraVivek, KumarDeepak, BohraGopal Krishna

Gingival overgrowth treatment
Gingival hyperplasia

Drug-induced gingival overgrowth (DIGO) is a common side effect of certain medications, with nifedipine, a calcium channel blocker, being the most frequent culprit. This abstract notes that amlodipine, a newer calcium channel blocker, while generally having fewer side effects than nifedipine, has been associated with gum hyperplasia in rare cases.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

20.

Real clinical impact of drug-drug interactions of immunosuppressants in transplant patients.

Author: Gago-SánchezAna Isabel, FontPilar, CárdenasManuel, AumenteMaría Dolores, Del PradoJosé Ramón, CallejaMiguel Ángel

Reduced DDI-related ADEs
Transplant patient care
Hypertension
Nephrotoxicity

Real drug-drug interactions (DDIs) between immunosuppressants are prevalent in transplant patients, leading to adverse drug events. This highlights the importance of careful monitoring and management of DDI risks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

21.

Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis.

Author: YinJinjin, MeiZhengrong, ShiShengying, DuPeili, QinShumin

Hypertension treatment
Maternal safety
Pregnancy outcome

This systematic review and meta-analysis compared the antihypertensive efficacy, pregnancy outcome, and safety of amlodipine with nifedipine for hypertension during pregnancy. Amlodipine showed slightly superior efficacy, a decreased risk for maternal side effects, and no difference in pregnancy outcomes compared to nifedipine.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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