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Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels.

Author: AvezaatC J, BogersA J, MaassenVanDenBrinkA, SaxenaP R, de VriesR, van den BroekR W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Eletriptan and sumatriptan, used for migraine treatment, show selectivity for craniovascular vessels over coronary arteries. At therapeutic concentrations, both drugs contract the middle meningeal artery more than the coronary artery. While this suggests a limited propensity for adverse coronary side effects in patients with healthy coronary arteries, both drugs are still contraindicated in patients with coronary artery disease.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Eletriptan is a 5-HT(1B/1D) receptor agonist with proven efficacy in the acute treatment of migraine. OBJECTIVE: To assess the craniovascular selectivity of eletriptan and sumatriptan in blood vessels predictive of therapeutic efficacy (human middle meningeal artery) and adverse coronar...See full text at original site
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引用元：
https://doi.org/10.1212/wnl.55.10.1524

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Migraine Relief: A Tale of Two Triptans

Migraines, like a relentless sandstorm, can leave sufferers feeling lost and disoriented. This study sheds light on two important medications, eletriptan and sumatriptan, both of which are used to combat the debilitating effects of migraines. The researchers set out to determine how these medications selectively target blood vessels in the brain, the key to their effectiveness. Using human blood vessels from both the brain and the heart, the team meticulously measured the potency and efficacy of these medications. Their findings revealed that both eletriptan and sumatriptan were more potent in constricting the middle meningeal artery, a key player in migraine headaches, compared to coronary arteries. This selectivity is crucial because it minimizes the risk of adverse effects on the heart.

A More Targeted Approach: Navigating the Sandstorm with Precision

The research suggests that both eletriptan and sumatriptan offer a more targeted approach to treating migraines, selectively relieving pain without significantly impacting the heart. This finding is significant because it helps us understand the potential benefits and risks associated with these drugs, allowing for more informed treatment decisions.

The Oasis of Migraine Relief: A Beacon of Hope

This study provides valuable insights into the mechanisms of action of migraine medications. By understanding the specific effects of these drugs on different blood vessels, we can better navigate the desert of migraine relief, seeking out the oasis of pain relief with greater precision and safety.

Dr.Camel's Conclusion

This study provides evidence of the craniovascular selectivity of eletriptan and sumatriptan, highlighting the potential for targeted migraine therapy with reduced risk of adverse coronary side effects. This research contributes to our understanding of migraine treatment and underscores the importance of personalized medicine in tailoring therapies to the individual patient.
Date :
  1. Date Completed 2001-01-04
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

11094108

DOI: Digital Object Identifier

10.1212/wnl.55.10.1524

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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